Full Text Journal Articles by
Author Melanie Boxberg

Advertisement

Find full text journal articles






Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.

Moritz Jesinghaus, Maxime Schmitt, Corinna Lang, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Katja Steiger, Miguel Silva, Markus Tschurtschenthaler, Sebastian Lange, Sebastian Foersch, Karl F Becker, Dieter Saur, Helmut Friess, Kathrin Halfter, Jutta Engel, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Wilko Weichert,

The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a second major grading criterion, while condensing conventional grade into a 2-tiered system. So far it remains largely unexplored how these parameters interact with each other and whether they truly ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):969-978]

Cited: 0 times

View full text PDF listing >>



Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

Eva Bräunlein, Gaia Lupoli, Esam Abualrous, Niklas de Andrade Krätzig, Dario Gosmann, Franziska Füchsl, Lukas Wietbrock, Sebastian Lange, Thomas Engleitner, Huan Lan, Stefan Audehm, Manuel Effenberger, Melanie Boxberg, Katja Steiger, Yinshui Chang, Kai Yu, Cigdem Atay, Florian Bassermann, Wilko Weichert, Dirk Busch, Roland Rad, Christian Freund, Iris Antes, Angela Krackhardt,

Neoantigens derived from somatic mutations have been demonstrated to correlate with therapeutic responses mediated by treatment with immune checkpoint inhibitors. Neoantigens are therefore highly attractive targets for the development of personalized medicine approaches although their quality and associated immune responses is not yet well understood. In a case study of ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations.

Barbara Willvonseder, Fabian Stögbauer, Katja Steiger, Moritz Jesinghaus, Peer-Hendrik Kuhn, Christine Brambs, Jutta Engel, Holger Bronger, Georg Philipp Schmidt, Bernhard Haller, Wilko Weichert, Gisela Keller, Aurelia Noske, Nicole Pfarr, Melanie Boxberg,

<h4>Objective</h4>POLE-mutant, microsatellite-instable (MSI), p53-mutant and non-specific molecular profile (NSMP) are TCGA-defined molecular subgroups of endometrial cancer (EC). Hypothesizing that morphology and tumor immunology might differ depending on molecular background concerning composition and prognostic impact, we aimed to comprehensively interconnect morphologic, immunologic and molecular data.<h4>Methods</h4>TCGA-defined molecular groups were determined by immunohistochemistry ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2021, 70(6):1679-1689]

Cited: 0 times

View full text PDF listing >>



SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line.

Sabine Stöckl, Georg Lindner, Shushan Li, Philipp Schuster, Sebastian Haferkamp, Ferdinand Wagner, Peter M Prodinger, Gabriele Multhoff, Melanie Boxberg, Axel Hillmann, Richard J Bauer, Susanne Grässel,

As most chemotherapeutic drugs are ineffective in the treatment of chondrosarcoma, we studied the expression pattern and function of SOX9, the master transcription factor for chondrogenesis, in chondrosarcoma, to understand the basic molecular principles needed for engineering new targeted therapies. Our study shows an increase in SOX9 expression in chondrosarcoma ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(20):]

Cited: 1 time

View full text PDF listing >>



TP53 germline mutations in the context of families with hereditary breast and ovarian cancer: a clinical challenge.

Sabine Grill, Juliane Ramser, Heide Hellebrand, Nicole Pfarr, Melanie Boxberg, Christine Brambs, Nina Ditsch, Alfons Meindl, Eva Groß, Thomas Meitinger, Marion Kiechle, Anne S Quante,

<h4>Purpose</h4>TP53germline (g) mutations, associated with the Li-Fraumeni syndrome (LFS), have rarely been reported in the context of hereditary breast and ovarian cancer (HBOC). The prevalence and cancer risks in this target group are unknown and counseling remains challenging. Notably an extensive high-risk surveillance program is implemented, which evokes substantial psychological ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, 303(6):1557-1567]

Cited: 0 times

View full text PDF listing >>



MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.

Enkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, Martina Anton, Moritz Jesinghaus, Melanie Boxberg, Nicole Pfarr, Pidassa Bidola, Sebastian Uhrig, Ulrike Höckendorf, Anna-Lena Meinhardt, Adam Wahida, Irina Heid, Rickmer Braren, Ritu Mishra, Arne Warth, Thomas Muley, Patrina S P Poh, Xin Wang, Stefan Fröhling, Katja Steiger, Julia Slotta-Huspenina, Martijn van Griensven, Franz Pfeiffer, Sebastian Lange, Roland Rad, Magda Spella, Georgios T Stathopoulos, Jürgen Ruland, Florian Bassermann, Wilko Weichert, Andreas Strasser, Caterina Branca, Mathias Heikenwalder, Charles Swanton, Nicholas McGranahan, Philipp J Jost,

Evasion of programmed cell death represents a critical form of oncogene addiction in cancer cells. Understanding the molecular mechanisms underpinning cancer cell survival despite the oncogenic stress could provide a molecular basis for potential therapeutic interventions. Here we explore the role of pro-survival genes in cancer cell integrity during clonal ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4527]

Cited: 2 times

View full text PDF listing >>



Toll-like receptor 7/8-matured RNA-transduced dendritic cells as post-remission therapy in acute myeloid leukaemia: results of a phase I trial.

Felix S Lichtenegger, Frauke M Schnorfeil, Maurine Rothe, Katrin Deiser, Torben Altmann, Veit L Bücklein, Thomas Köhnke, Christian Augsberger, Nikola P Konstandin, Karsten Spiekermann, Andreas Moosmann, Stephan Boehm, Melanie Boxberg, Mirjam Hm Heemskerk, Dennis Goerlich, Georg Wittmann, Beate Wagner, Wolfgang Hiddemann, Dolores J Schendel, Gunnar Kvalheim, Iris Bigalke, Marion Subklewe,

Objectives:Innovative post-remission therapies are needed to eliminate residual AML cells. DC vaccination is a promising strategy to induce anti-leukaemic immune responses. Methods:We conducted a first-in-human phase I study using TLR7/8-matured DCs transfected with RNA encoding the two AML-associated antigens WT1 and PRAME as well as CMVpp65. AML patients in CR ... Read more >>

Clin Transl Immunology (Clinical & translational immunology)
[2020, 9(3):e1117]

Cited: 2 times

View full text PDF listing >>



[Parosteal low-grade osteosarcoma with focal differentiation].

Carolin Mogler, Carolin Knebel, Melanie Boxberg, Rüdiger von Eisenhart-Rothe, Klaus Wörtler, Katja Specht,

This case study deals with the case of a 16-year-old male patient with a low-grade parosteal osteosarcoma of the distal femur with focal differentiation. Case history, disease course, and surgery as well as the pathological workup with final diagnosis are presented. Relevant radiologic and pathologic differential diagnoses und diagnostic pitfalls ... Read more >>

Orthopade (Der Orthopade)
[2020, 49(3):273-276]

Cited: 0 times

View full text PDF listing >>



Systemic antitumor effect by regional hyperthermia combined with low-dose chemotherapy and immunologic correlates in an adolescent patient with rhabdomyosarcoma - a case report.

Rolf D Issels, Lars H Lindner, Michael von Bergwelt-Baildon, Peter Lang, Christoph Rischpler, Heinz Diem, Barbara Mosetter, Judith Eckl, Dolores J Schendel, Christoph Salat, Oliver Stötzer, Stefan Burdach, Irene von Luettichau-Teichert, Rupert Handgretinger, Jens Neumann, Thomas Kirchner, Katja Steiger, Melanie Boxberg, Ulrich Mansmann, Gabriele Multhoff, Elfriede Noessner,

Introduction: An abscopal effect is a clinical observation whereby a local treatment is associated with regression of metastatic cancer at a site distant from the primary location of treatment. Here, we describe the clinical systemic effect induced by regional hyperthermia combined with low-dose chemotherapy and provide immunologic correlates.Case presentation: A ... Read more >>

Int J Hyperthermia (International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group)
[2020, 37(1):55-65]

Cited: 1 time

View full text PDF listing >>



Pre-operative cellular dissociation grading in biopsies is highly predictive of post-operative tumour stage and patient outcome in head and neck squamous cell carcinoma.

Moritz Jesinghaus, Katja Steiger, Fabian Stögbauer, Bernhard Haller, Andreas Kolk, Ulrich Straßen, Anja Pickhard, Markus Wirth, Miguel Silva, Jan Budczies, Aaron Becker von Rose, Björn Konukiewitz, Peer Kuhn, Konrad Klinghammer, Hendrik Dapper, Stefan Münch, Stephanie E Combs, Wilko Weichert, Melanie Boxberg,

<h4>Background</h4>Pre-operative treatment planning in head and neck squamous cell carcinoma (HNSCC) is mainly dictated by clinical staging, which has major shortcomings. Histologic grading is irrelevant due to its lack of prognostic impact. Recently, a novel grading termed Cellular Dissociation Grade (CDG) based on Tumour Budding and Cell Nest Size was ... Read more >>

Br J Cancer (British journal of cancer)
[2020, 122(6):835-846]

Cited: 1 time

View full text PDF listing >>



Post-neoadjuvant cellular dissociation grading based on tumour budding and cell nest size is associated with therapy response and survival in oesophageal squamous cell carcinoma.

Moritz Jesinghaus, Melanie Boxberg, Dirk Wilhelm, Stefan Münch, Hendrik Dapper, Michael Quante, Christoph Schlag, Sebastian Lange, Jan Budczies, Björn Konukiewitz, Martin Mollenhauer, Anna Melissa Schlitter, Karl Friedrich Becker, Marcus Feith, Helmut Friess, Katja Steiger, Stephanie E Combs, Wilko Weichert,

<h4>Background</h4>Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant therapy.<h4>Methods</h4>We evaluated cell nest size ... Read more >>

Br J Cancer (British journal of cancer)
[2019, 121(12):1050-1057]

Cited: 0 times

View full text PDF listing >>



Morphomolecular analysis of the immune tumor microenvironment in human head and neck cancer.

Mohamed Badr, Korinna Jöhrens, Michael Allgäuer, Melanie Boxberg, Wilko Weichert, Ingeborg Tinhofer, Carsten Denkert, Peter Schirmacher, Albrecht Stenzinger, Jan Budczies,

Immunotherapy is effective in head and neck squamous cell carcinoma (HNSCC), but only a minority of patients responds to immune checkpoint blockade (ICB). To contribute to a better understanding of the underlying immune biology, we combined histomorphological evaluation and molecular analysis of the HNSCC immune microenvironment in the TCGA cohort. ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2019, 68(9):1443-1454]

Cited: 2 times

View full text PDF listing >>



Bradykinin Receptor B1 and C-Reactive Protein as Prognostic Factors for Pharyngocutaneous Fistula Development After Laryngectomy.

Isabelle Koob, Anja Pickhard, Maria Buchberger, Melanie Boxberg, Rudolf Reiter, Guido Piontek, Ulrich Straßen,

Pharyngocutaneous fistulae (PCF) are one of the most common complications after laryngectomy. Predisposing risk factors have been studied, yet knowledge to determine which patients are prone to developing a fistula remains scarce. This study aims to establish prognostic parameters to identify individual patients at risk for PCF development. As PCF ... Read more >>

Head Neck Pathol (Head and neck pathology)
[2020, 14(2):341-352]

Cited: 0 times

View full text PDF listing >>



Multi-task learning of a deep k-nearest neighbour network for histopathological image classification and retrieval

Tingying Peng, Melanie Boxberg, Wilko Weichert, Nassir Navab, Carsten Marr,

Deep neural networks have achieved tremendous success in image recognition, classification and object detection. However, deep learning is often criticised for its lack of transparency and general inability to rationalize its predictions. The issue of poor model interpretability becomes critical in medical applications, as a model that is not understood ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Intra-articular extra-axial chordoma of the wrist: a case report with review of the current literature.

Jan Neumann, Alexandra S Gersing, Thomas F Barth, Melanie Boxberg, Klaus Woertler,

Chordomas are rare bone malignancies that are thought to arise from remnants of the notochord and usually are located in the axial skeleton. Immunophenotypical matching neoplasms primarily found in appendicular locations, referred to as extra-axial chordoma, are rarely encountered by radiologists, surgeons, and pathologists. Only a few of these cases ... Read more >>

Skeletal Radiol (Skeletal radiology)
[2019, 48(12):2015-2020]

Cited: 0 times

View full text PDF listing >>



Cellular Dissociation Grading Based on the Parameters Tumor Budding and Cell Nest Size in Pretherapeutic Biopsy Specimens Allows for Prognostic Patient Stratification in Esophageal Squamous Cell Carcinoma Independent From Clinical Staging.

Moritz Jesinghaus, Frido Brühl, Katja Steiger, Peter Klare, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Peer Kuhn, Stefan Münch, Michael Quante, Roland M Schmid, Dirk Wilhelm, Markus Feith, Helmut Friess, Stephanie E Combs, Dieter Saur, Melanie Boxberg, Wilko Weichert,

Initial treatment planning in esophageal squamous cell carcinoma mainly relies on clinical staging. Recently, a highly prognostic grading system based on the cellular dissociation parameters Tumor Budding and Cell Nest Size has been proposed for resected esophageal squamous cell carcinoma. To probe for the transferability and relevance of this established ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(5):618-627]

Cited: 6 times

View full text PDF listing >>



A humanized bone microenvironment uncovers HIF2 alpha as a latent marker for osteosarcoma.

Ferdinand Wagner, Boris M Holzapfel, Laure C Martine, Jacqui McGovern, Christoph A Lahr, Melanie Boxberg, Peter M Prodinger, Susanne Grässel, Daniela Loessner, Dietmar W Hutmacher,

The quest for predictive tumor markers for osteosarcoma (OS) has not well progressed over the last two decades due to a lack of preclinical models. The aim of this study was to investigate if microenvironmental modifications in an original humanized in vivo model alter the expression of OS tumor markers. ... Read more >>

Acta Biomater (Acta biomaterialia)
[2019, 89:372-381]

Cited: 4 times

View full text PDF listing >>



Tumor Budding and Cell Nest Size Are Highly Prognostic in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Further Evidence for a Unified Histopathologic Grading System for Squamous Cell Carcinomas of the Upper Aerodigestive Tract.

Melanie Boxberg, Peer-Hendrik Kuhn, Marianne Reiser, Anna Erb, Katja Steiger, Anja Pickhard, Ulrich Straßen, Isabelle Koob, Andreas Kolk, Arne Warth, Moritz Jesinghaus, Wilko Weichert,

Squamous cell carcinoma (SCC) is the most common cancer of the head and neck region including-among others-laryngeal (LSCC) and hypopharyngeal (HSCC) subsites. LSCC/HSCC are heterogenous diseases with respect to patient outcome. Currently, tumor stage-based patient stratification is essential to predict prognosis and thus selection of the appropriate treatment modalities. In ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(3):303-313]

Cited: 8 times

View full text PDF listing >>



A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.

Daniela Loessner, Anja Rockstroh, Ali Shokoohmand, Boris M Holzapfel, Ferdinand Wagner, Jeremy Baldwin, Melanie Boxberg, Barbara Schmalfeldt, Ernst Lengyel, Judith A Clements, Dietmar W Hutmacher,

Peritoneal invasion through the mesothelial cell layer is a hallmark of ovarian cancer metastasis. Using tissue engineering technologies, we recreated an ovarian tumor microenvironment replicating this aspect of disease progression. Ovarian cancer cell-laden hydrogels were combined with mesothelial cell-layered melt electrospun written scaffolds and characterized with proliferation and transcriptomic analyses ... Read more >>

Biomaterials (Biomaterials)
[2019, 190-191:63-75]

Cited: 9 times

View full text PDF listing >>



Composition and Clinical Impact of the Immunologic Tumor Microenvironment in Oral Squamous Cell Carcinoma.

Melanie Boxberg, Lena Leising, Katja Steiger, Moritz Jesinghaus, Aezlat Alkhamas, Marion Mielke, Nicole Pfarr, Carolin Götz, Klaus Dietrich Wolff, Wilko Weichert, Andreas Kolk,

Immunotherapy shows promising results and revolutionizes treatment of oral squamous cell carcinoma (OSCC). The immunologic microenvironment might have prognostic/predictive implications. Morphologic immunologic parameters (inflammatory infiltrate, stromal content, and budding activity [BA] [potentially indicating epithelial-mesenchymal transition]) were evaluated in 66 human primary therapy-naive OSCCs. Intraepithelial/stromal tumor-infiltrating lymphocytes (TILs; CD3<sup>+</sup>/CD4<sup>+</sup>/CD8<sup>+</sup>/CD4<sup>+</sup>FOXP3<sup>+</sup>/IL-17A<sup>+</sup>) were quantified, ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2019, 202(1):278-291]

Cited: 11 times

View full text PDF listing >>



Novel prognostic histopathological grading system in oral squamous cell carcinoma based on tumour budding and cell nest size shows high interobserver and intraobserver concordance.

Melanie Boxberg, Christine Bollwein, Korinna Jöhrens, Peer-Hendrik Kuhn, Bernhard Haller, Katja Steiger, Klaus-Dietrich Wolff, Andreas Kolk, Moritz Jesinghaus, Wilko Weichert,

<h4>Aims</h4>Squamous cell carcinoma of the oral cavity (OSCC) is a common tumour entity with a variable, partially highly aggressive clinical course. Recently, we proposed a novel (three-tiered) clinically useful grading scheme strongly associated with patient outcome in OSCC, consisting of a sum score of the histomorphological patterns tumour budding and ... Read more >>

J Clin Pathol (Journal of clinical pathology)
[2019, 72(4):285-294]

Cited: 6 times

View full text PDF listing >>



Immunohistochemical expression of CD44 in oral squamous cell carcinoma in relation to histomorphological parameters and clinicopathological factors.

Melanie Boxberg, Carolin Götz, Selgai Haidari, Christiane Dorfner, Moritz Jesinghaus, Enken Drecoll, Marko Boskov, Klaus D Wolff, Wilko Weichert, Bernhard Haller, Andreas Kolk,

AIMS:Oral squamous cell carcinoma (OSCC) is characterised by its variable clinical course. In addition to the routinely used TNM and Union for International Cancer Control systems, patient-specific prognostic/predictive biomarkers are needed. Promising biomarkers include the determination of the cancer stem cell compartment, which can be identified by CD44 expression (among ... Read more >>

Histopathology (Histopathology)
[2018, 73(4):559-572]

Cited: 5 times

View full text PDF listing >>



Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma.

Ferdinand Wagner, Boris M Holzapfel, Jacqui A McGovern, Abbas Shafiee, Jeremy G Baldwin, Laure C Martine, Christoph A Lahr, Felix M Wunner, Thor Friis, Onur Bas, Melanie Boxberg, Peter M Prodinger, Ali Shokoohmand, Davide Moi, Roberta Mazzieri, Daniela Loessner, Dietmar W Hutmacher,

BACKGROUND:Existing preclinical murine models often fail to predict effects of anti-cancer drugs. In order to minimize interspecies-differences between murine hosts and human bone tumors of in vivo xenograft platforms, we tissue-engineered a novel orthotopic humanized bone model. METHODS:Orthotopic humanized tissue engineered bone constructs (ohTEBC) were fabricated by 3D printing of medical-grade ... Read more >>

Biomaterials (Biomaterials)
[2018, 171:230-246]

Cited: 11 times

View full text PDF listing >>



Introducing a novel highly prognostic grading scheme based on tumour budding and cell nest size for squamous cell carcinoma of the uterine cervix.

Moritz Jesinghaus, Johanna Strehl, Melanie Boxberg, Frido Brühl, Adrian Wenzel, Björn Konukiewitz, Anna M Schlitter, Katja Steiger, Arne Warth, Andreas Schnelzer, Marion Kiechle, Matthias W Beckmann, Aurelia Noske, Arndt Hartmann, Grit Mehlhorn, Martin C Koch, Wilko Weichert,

A novel histopathological grading system based on tumour budding and cell nest size has recently been shown to outperform conventional (WHO-based) grading algorithms in several tumour entities such as lung, oral, and oesophageal squamous cell carcinoma (SCC) in terms of prognostic patient stratification. Here, we tested the prognostic value of ... Read more >>

J Pathol Clin Res (The journal of pathology. Clinical research)
[2018, 4(2):93-102]

Cited: 9 times

View full text PDF listing >>



PD-L1 and PD-1 and characterization of tumor-infiltrating lymphocytes in high grade sarcomas of soft tissue - prognostic implications and rationale for immunotherapy.

Melanie Boxberg, Katja Steiger, Ulrich Lenze, Hans Rechl, Rüdiger von Eisenhart-Rothe, Klaus Wörtler, Wilko Weichert, Rupert Langer, Katja Specht,

Therapies targeting programmed death 1-(PD-1) or its ligand (PD-L1), promoting antitumor T-cell activity have been successfully introduced into clinical practice. Clinical response correlates with PD-L1 expression by tumor cells or immune cells within the tumor microenvironment. The PD-L1/PD-1 axis and tumor microenvironment has been rarely studied in high-grade sarcomas of ... Read more >>

Oncoimmunology (Oncoimmunology)
[2018, 7(3):e1389366]

Cited: 21 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0111 s