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Author Mel Krajden

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Women's acceptability of and experience with primary human papillomavirus testing for cervix screening: HPV FOCAL trial cross-sectional online survey results.

Laurie W Smith, C Sarai Racey, Lovedeep Gondara, Mel Krajden, Marette Lee, Ruth Elwood Martin, Gavin Stuart, Stuart Peacock, Andrew J Coldman, Eduardo L Franco, Dirk van Niekerk, Gina S Ogilvie,

<h4>Objective</h4>To study participant's acceptability of and attitudes towards human papillomavirus (HPV) testing compared with cytology for cervical cancer screening and what impact having an HPV positive result may have in future acceptability of screening.<h4>Design</h4>Cross-sectional online survey of clinical trial participants.<h4>Setting</h4>Primary care, population-based Cervix Screening Program, British Columbia, Canada.<h4>Participants</h4>A total of ... Read more >>

BMJ Open (BMJ open)
[2021, 11(10):e052084]

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Impact of COVID-19-related public health measures on HCV testing in British Columbia, Canada: An interrupted time series analysis.

Mawuena Binka, Sofia Bartlett, Héctor A Velásquez García, Maryam Darvishian, Dahn Jeong, Prince Adu, Maria Alvarez, Stanley Wong, Amanda Yu, Hasina Samji, Mel Krajden, Jason Wong, Naveed Z Janjua,

<h4>Background & aims</h4>Public health measures introduced to limit transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), also disrupted various healthcare services in many regions worldwide, including British Columbia (BC), Canada. We assessed the impact of these measures, first introduced in BC in March ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, :]

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Evaluation of commercially available high-throughput SARS-CoV-2 serological assays for serosurveillance and related applications

Mars Stone, Eduard Grebe, Hasan Sulaeman, Clara Di Germanio, Honey Dave, Kathleen Kelly, Brad Biggerstaff, Bridgit Crews, Nam Tran, Keith Jerome, Thomas Denny, Boris Hogema, Mark Destree, Jefferson Jones, Natalie Thornburg, Graham Simmons, Mel Krajden, Steve Kleinman, Larry Dumont, Michael Busch,

SARS-CoV-2 serosurveys can estimate cumulative incidence for monitoring epidemics but require characterization of employed serological assays performance to inform testing algorithm development and interpretation of results. We conducted a multi-laboratory evaluation of 21 commercial high-throughput SARS-CoV-2 serological assays using blinded panels of 1,000 highly-characterized blood-donor specimens. Assays demonstrated a range ... Read more >>

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Comparative single-dose mRNA and ChAdOx1 vaccine effectiveness against SARS-CoV-2, including early variants of concern: a test-negative design, British Columbia, Canada

Danuta Skowronski, Solmaz Setayeshgar, Macy Zou, Natalie Prystajecky, John Tyson, Hind Sbihi, Chris Fjell, Eleni Galanis, Monika Naus, David Patrick, Shiraz El Adam, May Ahmed, Shinhye Kim, Bonnie Henry, Linda Hoang, Manish Sadarangani, Agatha Jassem, Mel Krajden,

<h4>ABSTRACT</h4> <h4>Introduction</h4> In randomized controlled trials, single-dose efficacy against SARS-CoV-2 illness exceeded 90% for mRNA vaccines (BNT162b2 and mRNA-1273), and 75% for ChAdOx1. In British Columbia (BC), Canada second doses were deferred up to 16 weeks and ChAdOx1 was only initially recommended for adults 55 years of age and older. ... Read more >>

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Women in the 2019 hepatitis C cascade of care: findings from the British Columbia Hepatitis Testers cohort study.

Margo E Pearce, Sofia R Bartlett, Amanda Yu, Jess Lamb, Cheryl Reitz, Stanley Wong, Maria Alvarez, Mawuena Binka, Héctor Velásquez Garcia, Dahn Jeong, Emilia Clementi, Prince Adu, Hasina Samji, Jason Wong, Jane Buxton, Eric Yoshida, Chelsea Elwood, Laura Sauve, Neora Pick, Mel Krajden, Naveed Z Janjua,

<h4>Background</h4>Women living with hepatitis C virus (HCV) are rarely addressed in research and may be overrepresented within key populations requiring additional support to access HCV care and treatment. We constructed the HCV care cascade among people diagnosed with HCV in British Columbia, Canada, as of 2019 to compare progress in ... Read more >>

BMC Womens Health (BMC women's health)
[2021, 21(1):330]

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Mental health and substance use associated with hospitalization among people with laboratory confirmed diagnosis of COVID-19 in British Columbia: a population-based cohort study

Héctor Alexander Velásquez García, James Wilton, Kate Smolina, Mei Chong, Drona Rasali, Michael Otterstatter, Caren Rose, Natalie Prystajecky, Samara David, Eleni Galanis, Geoffrey McKee, Mel Krajden, Naveed Zafar Janjua,

<h4>Background</h4> This study identified factors associated with hospital admission among people with laboratory-diagnosed COVID-19 cases in British Columbia. <h4>Methods</h4> This study was performed using the BC COVID-19 Cohort, which integrates data on all COVID-19 cases, hospitalizations, medical visits, emergency room visits, prescription drugs, chronic conditions and deaths. The analysis included ... Read more >>

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Characterization of Acute HCV Infection and Transmission Networks in People Who Currently Inject Drugs in Catalonia: Usefulness of Dried Blood Spots.

Adrián Antuori, Vincent Montoya, David Piñeyro, Lauro Sumoy, Jeffrey Joy, Mel Krajden, Sara González-Gómez, Cinta Folch, Jordi Casabona, Lurdes Matas, Joan Colom, Verónica Saludes, Elisa Martró, ,

<h4>Background and aims</h4>Accurate identification of recent HCV infections is critical for tracing the extent and mechanisms of ongoing transmission. We aimed to validate dried blood spot (DBS) samples for the assessment of Hepatitis C virus (HCV) genetic diversity and to determine epidemiological parameters including incidence, determinants of acute infection, and ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, 74(2):591-606]

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Successful Liver Transplantation in a Patient With Acute COVID-19 Infection and Acute Liver Failure: A Case Report.

Kristen M Kidson, Jeieung Park, Marthe K Charles, Mahmoud Omar, Mel Krajden, Alissa J Wright, Trana Hussaini, Peter T W Kim, Stephen W Chung, Eric M Yoshida,

Current liver transplantation societies recommend recipients with active coronavirus disease 2019 (COVID-19) be deferred from transplantation for at least 2 wks, have symptom resolution and at least 1 negative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test.<sup>1</sup> This approach does not address patients who require urgent transplantation and will otherwise ... Read more >>

Transplant Direct (Transplantation direct)
[2021, 7(10):e747]

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Nanopore Metagenomic Sequencing for Detection and Characterization of SARS-CoV-2 in Clinical Samples

Nick P.G. Gauthier, Cassidy Nelson, Michael Bonsall, Kerstin Locher, Marthe Charles, Clayton MacDonald, Mel Krajden, Samuel Chorlton, Amee Manges,

The COVID-19 pandemic has underscored the need for rapid novel diagnostic strategies to detect and characterize pathogens from clinical specimens. The MinION sequencing device allows for rapid, cost-effective, high-throughput sequencing; useful features for translation to clinical laboratory settings. Metagenomic Next-Generation Sequencing (mNGS) approaches provide the opportunity to examine the entire ... Read more >>

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Rapid Increase in SARS-CoV-2 P.1 Lineage Leading to Codominance with B.1.1.7 Lineage, British Columbia, Canada, January-April 2021.

Catherine A Hogan, Agatha N Jassem, Hind Sbihi, Yayuk Joffres, John R Tyson, Kyle Noftall, Marsha Taylor, Tracy Lee, Chris Fjell, Amanda Wilmer, John Galbraith, Marc G Romney, Bonnie Henry, Mel Krajden, Eleni Galanis, Natalie Prystajecky, Linda M N Hoang,

Several severe acute respiratory syndrome coronavirus 2 variants of concern (VoCs) emerged in late 2020; lineage B.1.1.7 initially dominated globally. However, lineages B.1.351 and P.1 represent potentially greater risk for transmission and immune escape. In British Columbia, Canada, B.1.1.7 and B.1.351 were first identified in December 2020 and P.1 in ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(11):]

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Evaluation of a high volume antigen test for detection of SARS-CoV-2.

Paul N Levett, Branco Cheung, Jesse Kustra, Tamara Pidduck, Annie Mak, Frankie Tsang, Martin Petric, Mel Krajden,

Increasing transmission of SARS-CoV-2 infection in successive waves may strain the capacity of laboratories performing molecular diagnostic testing. Alternative testing approaches may offer additional diagnostic capacity. A high throughput chemiluminescent antigen assay (Ortho VITROS SARS-CoV-2 antigen test) was evaluated using both an inactivated virus preparation and prospective clinical samples (nasopharyngeal ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2021, 142:104938]

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High-risk HPV prevalence among women undergoing cervical cancer screening: Findings a decade after HPV vaccine implementation in British Columbia, Canada.

Charles Litwin, Laurie Smith, Robine Donken, Mel Krajden, Dirk van Niekerk, Monika Naus, Darrel Cook, Arianne Albert, Gina Ogilvie,

<h4>Background</h4>British Columbia (BC) introduced a publicly funded, school-based human papillomavirus (HPV) immunization program in 2008 with the quadrivalent vaccine. In 2010/2011, a baseline evaluation of HPV prevalence was conducted among women undergoing cervical cancer screening. After 10 years of publicly funded HPV vaccination, HPV-type prevalence was re-evaluated.<h4>Methods</h4>From August 2017 to March ... Read more >>

Vaccine (Vaccine)
[2021, 39(36):5198-5204]

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SARS-CoV-2 serology: Validation of high-throughput chemiluminescent immunoassay (CLIA) platforms and a field study in British Columbia.

Inna Sekirov, Vilte E Barakauskas, Janet Simons, Darrel Cook, Brandon Bates, Laura Burns, Shazia Masud, Marthe Charles, Meghan McLennan, Annie Mak, Navdeep Chahil, Rohit Vijh, Althea Hayden, David Goldfarb, Paul N Levett, Mel Krajden, Muhammad Morshed,

<h4>Background</h4>SARS-CoV-2 antibody testing is required for estimating population seroprevalence and vaccine response studies. It may also increase case identification when used as an adjunct to routine molecular testing. We performed a validation study and evaluated the use of automated high-throughput assays in a field study of COVID-19-affected care facilities.<h4>Methods</h4>Six automated ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2021, 142:104914]

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Single-dose mRNA vaccine effectiveness against SARS-CoV-2, including Alpha and Gamma variants: a test-negative design in adults 70 years and older in British Columbia, Canada.

Danuta M Skowronski, Solmaz Setayeshgar, Macy Zou, Natalie Prystajecky, John R Tyson, Eleni Galanis, Monika Naus, David M Patrick, Hind Sbihi, Shiraz El Adam, Bonnie Henry, Linda M N Hoang, Manish Sadarangani, Agatha N Jassem, Mel Krajden,

<h4>Introduction</h4>Randomized-controlled trials of mRNA vaccine protection against SARS-CoV-2 included few elderly participants. We assess single-dose mRNA vaccine effectiveness (VE) in adults ≥70-years-old in British Columbia (BC), Canada where second doses were deferred by up to 16 weeks and where a spring 2021 wave uniquely included co-dominant circulation of Alpha (B.1.1.7) ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

Cited: 7 times

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Impact of direct-acting antivirals for HCV on mortality in a large population-based cohort study.

Naveed Z Janjua, Stanley Wong, Younathan Abdia, Dahn Jeong, Terri Buller-Taylor, Prince A Adu, Hasina Samji, James Wilton, Margo Pearce, Zahid A Butt, Amanda Yu, Mawuena Binka, Sofia Bartlett, Maria Alvarez, Mel Krajden,

<h4>Background & aims</h4>We evaluated the effect of direct-acting antiviral (DAA)-induced sustained virologic response (SVR) on all-cause, liver- and drug-related mortality in a population-based cohort in British Columbia, Canada.<h4>Methods</h4>We used data from the British Columbia Hepatitis Testers Cohort, which includes people tested for HCV since 1990, linked with data on medical ... Read more >>

J Hepatol (Journal of hepatology)
[2021, :]

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The impact of current opioid agonist therapy on hepatitis C virus treatment initiation among people who use drugs from in the DAA era: A population-based study.

Sofia R Bartlett, Stanley Wong, Amanda Yu, Margo Pearce, Julia MacIsaac, Susan Nouch, Prince Adu, James Wilton, Hasina Samji, Emilia Clementi, Hector Velasquez, Dahn Jeong, Mawuena Binka, Maria Alvarez, Jason Wong, Jane Buxton, Mel Krajden, Naveed Z Janjua,

<h4>Background</h4>Evidence that opioid agonist therapy (OAT) is associated with increased odds of hepatitis C virus (HCV) treatment initiation among people who use drugs (PWUD) is emerging. The objective of this study was to determine the association between current OAT and HCV treatment initiation among PWUD in a population-level linked administrative ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

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Tests de détection rapides d’antigènes pour le SRAS-CoV-2.

Michael Liu, Rahul K Arora, Mel Krajden,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2021, 193(23):E886-E887]

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Opportunities to enhance linkage to hepatitis C care among hospitalised people with recent drug dependence in New South Wales, Australia: A population-based linkage study.

Heather Valerio, Maryam Alavi, Matthew Law, Hamish McManus, Shane Tillakeratne, Sahar Bajis, Marianne Martinello, Gail V Matthews, Janaki Amin, Naveed Z Janjua, Mel Krajden, Jacob George, Louisa Degenhardt, Jason Grebely, Gregory J Dore,

<h4>Background</h4>People who inject drugs are at greater risk of hepatitis C virus (HCV) infection and hospitalisation, yet admissions are not utilised for HCV treatment initiation. We aimed to assess the extent to which people with HCV notification, including those with evidence of recent drug dependence, are hospitalised while eligible for ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

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Single-dose mRNA vaccine effectiveness against SARS-CoV-2, including P.1 and B.1.1.7 variants: a test-negative design in adults 70 years and older in British Columbia, Canada

Danuta Skowronski, Solmaz Setayeshgar, Macy Zou, Natalie Prystajecky, John Tyson, Eleni Galanis, Monika Naus, David Patrick, Hind Sbihi, Shiraz El Adam, Bonnie Henry, Linda Hoang, Manish Sadarangani, Agatha Jassem, Mel Krajden,

<h4>ABSTRACT</h4> <h4>Introduction</h4> Randomized-controlled trials of mRNA vaccine protection against SARS-CoV-2 included relatively few elderly participants. We assess singe-dose mRNA vaccine effectiveness (VE) in adults ≥70-years-old in British Columbia (BC), Canada where the second dose was deferred by up to 16 weeks and where a spring 2021 wave uniquely included co-dominant ... Read more >>

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Long-term cervical precancer outcomes after a negative DNA- or RNA-based human papillomavirus test result.

Talia H R Strang, Anna Gottschlich, Darrel A Cook, Laurie W Smith, Lovedeep Gondara, Eduardo L Franco, Dirk J van Niekerk, Gina S Ogilvie, Mel Krajden,

<h4>Background</h4>Cervical cancer, a preventable disease associated with the human papillomavirus, is responsible for significant morbidity and mortality globally. Primary human papillomavirus testing is more sensitive in detecting precancerous cervical lesions than cytologic screening and can be conducted using either DNA- or RNA-based assays. Screening programs must select the most appropriate ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, :]

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Cost-effectiveness analysis of primary human papillomavirus testing in cervical cancer screening: Results from the HPV FOCAL Trial.

Ian Cromwell, Laurie W Smith, Kim van der Hoek, Lindsay Hedden, Andrew J Coldman, Darrel Cook, Eduardo L Franco, Mel Krajden, Ruth Martin, Marette H Lee, Gavin Stuart, Dirk van Niekerk, Gina Ogilvie, Stuart Peacock,

The Human Papillomavirus FOr CervicAL cancer (HPV FOCAL) trial is a large randomized controlled trial comparing the efficacy of primary HPV testing to cytology among women in the population-based Cervix Screening Program in British Columbia, Canada. We conducted a cost-effectiveness analysis based on the HPV FOCAL trial to estimate the ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(9):2996-3003]

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Dried blood spot specimens for SARS-CoV-2 antibody testing: A multi-site, multi-assay comparison

François Cholette, Christine Mesa, Angela Harris, Hannah Ellis, Karla Cachero, Philip Lacap, Yannick Galipeau, Marc-André Langlois, Anne-Claude Gingras, Cedric Yansouni, Jesse Papenburg, Matthew Cheng, Pranesh Chakraborty, Derek Stein, Paul Van Caeseele, Sofia Bartlett, Mel Krajden, David Goldfarb, Allison McGeer, Carla Osiowy, Catherine Hankins, Bruce Mazer, Michael Drebot, John Kim,

The true severity of infection due to COVID-19 is under-represented because it is based on only those who are tested. Although nucleic acid amplifications tests (NAAT) are the gold standard for COVID-19 diagnostic testing, serological assays provide better population-level SARS-CoV-2 prevalence estimates. Implementing large sero-surveys present several logistical challenges within ... Read more >>

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Contemporary syphilis is characterised by rapid global spread of pandemic Treponema pallidum lineages

Mathew Beale, Michael Marks, Michelle Cole, Min-Kuang Lee, Rachel Pitt, Christopher Ruis, Eszter Balla, Tania Crucitti, Michael Ewens, Candela Fernández-Naval, Anna Grankvist, Malcolm Guiver, Chris Kenyon, Rafil Khairulin, Ranmini Kularatne, Maider Arando, Barbara Molini, Andrey Obukhov, Emma Page, Fruzsina Petrovay, Cornelis Rietmeijer, Dominic Rowley, Sandy Shokoples, Erasmus Smit, Emma Sweeney, George Taiaroa, Jaime Vera, Christine Wennerås, David Whiley, Deborah Williamson, Gwenda Hughes, Prenilla Naidu, Magnus Unemo, Mel Krajden, Sheila Lukehart, Muhammad Morshed, Helen Fifer, Nicholas Thomson,

Syphilis is an important sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum . The last two decades have seen syphilis incidence rise in many high-income countries, yet the evolutionary and epidemiological relationships that underpin this are poorly understood, as is the global T. pallidum population structure. We ... Read more >>

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Rapid antigen tests for SARS-CoV-2.

Michael Liu, Rahul K Arora, Mel Krajden,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2021, 193(13):E447]

Cited: 1 time

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Declining rates of cervical intraepithelial neoplasia in British Columbia, Canada: An ecological analysis on the effects of the school-based human papillomavirus vaccination program.

Robine Donken, Dirk van Niekerk, Jeremy Hamm, John J Spinelli, Laurie Smith, Manish Sadarangani, Arianne Albert, Deborah Money, Simon Dobson, Dianne Miller, Marette Lee, Sheona Mitchell-Foster, Mel Krajden, Monika Naus, Gina Ogilvie,

Since 2008, girls in British Columbia (BC), Canada, have been offered HPV vaccination through a school-based, publicly funded immunization program. The oldest birth cohort eligible for the vaccination program was born in 1994 and uptake is on average 63%. To evaluate the impact of the HPV vaccine in BC, ecological ... Read more >>

Int J Cancer (International journal of cancer)
[2021, 149(1):191-199]

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