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HPV E6/E7 mRNA in situ hybridization in endocervical adenocarcinoma: implications for prognosis and diagnosis.

Rong-Zhen Luo, Shu-Lin Chen, Mei Li, Yue Li, Xia Yang, Li-Li Liu,

Human papillomavirus (HPV) E6/E7 mRNA in situ hybridization (HPV E6/E7 RNAscope) appears to be a sensitive and specific technique in detecting transcriptionally active HPV. We aimed to examine the diagnostic utility of this technique in endocervical adenocarcinoma (ECA), to explore the prognostic factors for ECA patients and develop a clinically ... Read more >>

Cancer Cell Int (Cancer cell international)
[2021, 21(1):643]

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Mycoplasma ovipneumoniae induces caspase-8-dependent extrinsic apoptosis and p53- and ROS-dependent intrinsic apoptosis in murine alveolar macrophages.

Jing Chen, Yi Zhou, Erpeng Zhu, Peng Yang, Mei Li, Shuangxiang Zhang, Jun Yue, Ming Wen, Kaigong Wang, Zhentao Cheng,

<i>Mycoplasma ovipneumoniae (MO)</i> is a principle causative agent of chronic respiratory disease in ruminants, including sheep, goats, and deer, posing a great threat to the ruminant industry worldwide. However, the pathogenesis of <i>MO</i> infection still remains not well understood and needs further clarification. Here we report a time-dependent apoptosis in ... Read more >>

Virulence (Virulence)
[2021, 12(1):2703-2720]

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Prevalence and associated factors for iron deficiency anemia among pregnant women in Fuyang, China.

Ningzhi Zhang, Li Mei, Min Li, Yanjun Zhang, Jinliang Xu, Miaomiao Li, Yeqing Gu,

Iron deficiency anemia (IDA) in pregnant women was associated with increased risks of both maternal and neonatal adverse outcomes. This study aimed to investigate the prevalence of IDA and identify the associated factors of IDA among pregnancy woman in Fuyang, China. The cross-sectional study was carried out in 789 pregnant ... Read more >>

Women Health (Women & health)
[2021, :1-10]

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Efficiency and safety of laser-assisted hatching on vitrified-warmed blastocyst transfer cycles: a prospective control trial.

Changjian Yin, Lian-Jie Li, Shuiying Ma, Hui Zhao, Lihong Xu, Cheng Li, Haibin Zhao, Qing Li, Kai Xu, Mei Li,

To clarify the efficiency and safety of laser-assisted hatching (LAH) application on vitrified-warmed blastocyst transfer (VBT) cycles, we designed the non-randomized concurrent control trial included 4039 VBT cycles in the Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, during the even days from November 2014 to December 2015. ... Read more >>

Lasers Med Sci (Lasers in medical science)
[2021, :]

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Genome-wide identification and characterization of circular RNA m6A modification in pancreatic cancer.

Ying Ye, Weiyi Feng, Jialiang Zhang, Kaiyu Zhu, Xudong Huang, Ling Pan, Jiachun Su, Yanfen Zheng, Rui Li, Shuang Deng, Ruihong Bai, Lisha Zhuang, Lusheng Wei, Junge Deng, Mei Li, Rufu Chen, Dongxin Lin, Zhixiang Zuo, Jian Zheng,

<h4>Background</h4>N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most abundant modification of RNA in eukaryotic cells and play critical roles in cancer. While most related studies focus on m<sup>6</sup>A modifications in linear RNA, transcriptome-wide profiling and exploration of m<sup>6</sup>A modification in circular RNAs in cancer is still lacking.<h4>Methods</h4>For the detection of m<sup>6</sup>A modification in ... Read more >>

Genome Med (Genome medicine)
[2021, 13(1):183]

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Cu/base co-catalyzed [3+3] cycloaddition for the synthesis of highly functionalized 4-fluoropyridines.

Jinhuan Dong, Wanzhong Feng, Lei Wang, Mei Li, Zhe Chen, Xianxiu Xu,

An efficient, straightforward and general method for the <i>de novo</i> synthesis of highly functionalized 4-fluoropyridines was developed <i>via</i> a cooperative copper- and base-catalyzed [3+3] cycloaddition of active methylene isocyanides with difluorocyclopropenes. The resulting 4-fluoropyridines can be readily diversified by various nucleophiles. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(94):12635-12638]

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Maximizing Metal-Support Interactions in Pt/Co3O4 Nanocages to Simultaneously Boost Hydrogen Production Activity and Durability.

Mei Li, Shengbo Zhang, Jiankang Zhao, Hua Wang,

Catalytic hydrolysis of ammonia borane (AB) provides an effective way to generate pure H<sub>2</sub> at ambient temperature for fuel cells. Pt-based catalysts usually exhibit great initial activity toward this reaction but deactivate quickly. Here, we report that the metal-support interactions in Pt/Co<sub>3</sub>O<sub>4</sub> nanocages can simultaneously accelerate the H<sub>2</sub> generation and ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, :]

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A Comparison Among Microperimetry, Standard Automated Perimetry and Spectral Domain Optical Coherence Tomography in the Evaluation of the Macula in Glaucoma Eyes with Hemifield Defects.

Tian Tian, Yu Cai, Mei Li, Yuan Fang, Yingzi Pan,

<h4>Introduction</h4>To evaluate the correlation between macular integrity assessment (MAIA) and standard automated perimetry (SAP) in detecting macular function damage in glaucoma and to explore the relationship between macular structure and functional damage by using spectral domain optical coherence tomography (SD-OCT).<h4>Methods</h4>This was a cross-sectional study. Seventy patients with glaucoma, with hemifield ... Read more >>

Ophthalmol Ther (Ophthalmology and therapy)
[2021, :]

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Clinical, Biochemical, Radiological, and Genetic Analyses of a Patient with VCP Gene Variant-Induced Paget's Disease of Bone.

Yongze Zhang, Peng Gao, Sunjie Yan, Qian Zhang, Ou Wang, Yan Jiang, Xiaoping Xing, Weibo Xia, Mei Li,

Paget's disease of bone (PDB) is a rare metabolic bone disorder, which is extremely rare in Asian population. This study aimed to investigate the phenotypes and the pathogenic mutations of woman with early-onset PDB. The clinical features, bone mineral density, x-ray, radionuclide bone scan, and serum levels of alkaline phosphatase ... Read more >>

Calcif Tissue Int (Calcified tissue international)
[2021, :]

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Bone Impairment in a Large Cohort of Chinese Patients with Tumor-induced Osteomalacia Assessed by HR-pQCT and TBS.

Xiaolin Ni, Yiming Feng, Wenmin Guan, Yue Chi, Xiang Li, Yiyi Gong, Nan Zhao, Qianqian Pang, Wei Yu, Huanwen Wu, Li Huo, Yong Liu, Jin Jin, Xi Zhou, Wei Lv, Lian Zhou, Yu Xia, Wei Liu, Ruizhi Jiajue, Ou Wang, Mei Li, Xiaoping Xing, Seiji Fukumoto, Yan Jiang, Weibo Xia,

Tumor-induced osteomalacia TIO is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 FGF23 by a tumor. Previous studies have revealed generalized mineralization defects and low areal bone mineral density aBMD in TIO. However, data on the bone microarchitecture in TIO are limited. In this study, ... Read more >>

J Bone Miner Res (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2021, :]

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miR-1290 promotes IL-8-mediated vascular endothelial cell adhesion by targeting GSK-3β.

Hongxin Xu, Ying Cui, Xianwei Liu, Xiao Zheng, Jiaqing Liu, Xinxin Hu, Fuhua Gao, Xiaoyan Hu, Mei Li, Xiaoqing Wei, Ying Gao, Ying Zhao,

<h4>Background</h4>MicroRNA-1290 (miR-1290) has been reported to be involved in many diseases and play a key role during the development process. However, the role of miR-1290 in atherosclerosis (AS) is still unclear.<h4>Methods and results</h4>The current study showed that the expressions of miR-1290 were high in serum of patients with hyperlipidemia. The ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2021, :]

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Detecting Phytophthora cinnamomi associated with dieback disease on Carya cathayensis using loop-mediated isothermal amplification.

Xiaoqing Tong, Jiayi Wu, Li Mei, Yongjun Wang,

Chinese hickory (Carya cathayensis Sarg.) is an economically and ecologically important nut plant in China. Dieback and basal stem necrosis have been observed in the plants since 2016, and its recent spread has significantly affected plant growth and nut production. Therefore, a survey was conducted to evaluate the disease incidence ... Read more >>

PLoS One (PloS one)
[2021, 16(11):e0257785]

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Prevalence and factors associated with post-traumatic stress disorder in healthcare workers exposed to COVID-19 in Wuhan, China: a cross-sectional survey.

Lingling Pan, Qiancheng Xu, Xia Kuang, Xiancui Zhang, Fengxia Fang, Liling Gui, Mei Li, Boris Tefsen, Lei Zha, Huan Liu,

<h4>Background</h4>The COVID-19 pandemic has posed significant threats to both the physical and psychological health of healthcare workers working in the front-line combating COVID-19. However, studies regarding the medium to long term impact of COVID-19 on mental health among healthcare workers are limited. Therefore, we conducted this cross-sectional survey to investigate ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2021, 21(1):572]

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Ubiquitin-Specific Protease 29 Exacerbates Cerebral Ischemia-Reperfusion Injury in Mice.

Jia-Bao Hou, Qian-Ni Shen, Xing Wan, Xu-Ke Liu, Yuan Yu, Mei Li, Wen-Wei Gao, Bo Zhao,

Oxidative stress and apoptosis contribute to the progression of cerebral ischemia/reperfusion (I/R) injury. Ubiquitin-specific protease 29 (USP29) is abundantly expressed in the brain and plays critical roles in regulating oxidative stress and cell apoptosis. The purpose of the present study is to investigate the role and underlying mechanisms of USP29 ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2021, 2021:6955628]

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Prevalence and Associated Factors of Kidney Dysfunction in Patients with Hypertension and/or Diabetes Mellitus from a Primary Care Population in Northwest China.

Mengyue Lin, Mulalibieke Heizhati, Lin Wang, Lin Gan, Mei Li, Wenbo Yang, Ling Yao, Zhongrong Wang, Zhikang Yang, Reyila Abudoyreyimu, Zihao Wu, Nanfang Li,

<h4>Purpose</h4>The burden of kidney dysfunction (KD) is rapidly increasing in developing countries due to an ongoing epidemic of hypertension and diabetes. We aimed to evaluate the prevalence and associated factors of KD among population with hypertension and/or diabetes from primary care setting.<h4>Methods</h4>This study was part of a cross-sectional study conducted ... Read more >>

Int J Gen Med (International journal of general medicine)
[2021, 14:7567-7578]

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Electron beam irradiation enhanced extraction and antioxidant activity of active compounds in green walnut husk.

Heyu Shen, Yujie Hou, Meihua Xi, Yingying Cai, Jingfang Ao, Jun Wang, Mei Li, Anwei Luo,

Green walnut husk (GWH) contains abundant active compounds and is valued as a potential source of natural antioxidants. This study aimed at assessing the impact of electron beam irradiation (EBI) pretreatment on the extraction yield and antioxidant activity of active compounds in GWH. The ultrasonic extraction of active substances was ... Read more >>

Food Chem (Food chemistry)
[2021, :131520]

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A novel long-range deletion spanning CDC73 and upper-stream genes discovered in a kindred of familial primary hyperparathyroidism.

Yi Yang, An Song, Min Nie, Yan Jiang, Mei Li, Weibo Xia, Xiaoping Xing, Ou Wang, Ya Hu,

<h4>Purpose</h4>To confirm the exact break-point of a novel long-range deletion discovered in one female parathyroid carcinoma (PC) patient who has a strong family history suggesting familial hyperparathyroidism, and to investigate the expression of parafibromin in the patient's affected lesion.<h4>Methods</h4>Clinical information of one female patient as well as five of her ... Read more >>

Endocrine (Endocrine)
[2021, :]

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A lithium-doped surface inspires immunomodulatory functions for enhanced osteointegration through PI3K/AKT signaling axis regulation.

Feng Peng, Longhai Qiu, Mengyu Yao, Lidan Liu, Yufeng Zheng, Shuilin Wu, Qingdong Ruan, Xuanyong Liu, Yu Zhang, Mei Li, Paul K Chu,

The response of immune systems is crucial to the success of biomedical implants <i>in vivo</i> and in particular, orthopedic implants must possess appropriate immunomodulatory functions to allow sufficient osteointegration. In this work, lithium (Li) is incorporated into titanium (Ti) implants by plasma electrolytic oxidation to realize slow and sustained release ... Read more >>

Biomater Sci (Biomaterials science)
[2021, :]

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Living material assembly of bacteriogenic protocells

Can Xu, Nicolas Martin, Mei Li, Stephen Mann,

Advancing the spontaneous bottom-up construction of artificial cells with high organisational complexity and diverse functionality remains an unresolved issue at the interface between living and non-living matter. To address this challenge, a living material assembly process based on the capture and on-site processing of spatially segregated bacterial colonies within individual ... Read more >>

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PGK1 Promotes NSCLC Progression by Enhancing Aerobic Glycolysis and Activating AKT/ERK Signaling Pathway

Yongqin Tang, Mei Li, Jinxuan Hei, Likun Ma, Jianyuan Pan,

Metabolic reprogramming, especially aerobic glycolysis is considered a hallmark of cancer, and is becoming a novel target for cancer therapy. Phosphoglycerate kinase I (PGK1) which is an important enzyme generating the first ATP in glycolysis pathway was already shown can promote some types of cancer development and progression, however, the ... Read more >>

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Effects of exogenous sulfate on the chromium(VI) metabolism of chromium(VI)-resistant engineered strains.

Xinglong Li, Qi Yin, Ruijia Gu, Mei Li, Jing Yan, Yuan Liu, Yanlun Qiu, Qunhua Bai, Yingli Li, Yan Ji, Jieying Gao, Hong Xiao,

<h4>Objective</h4>To explore the effects of exogenous sulfate on the efficiency of chromium(VI) metabolism of three chromium(VI)-resistant Escherichia coli strains (eChrA / eChrB / eChrAB) by adding chromium(VI)-resistance genes chrA and/or chrB, for better understanding and further application of these Cr(VI)-resistant strains in environmental and industrial chromium removal.<h4>Methods</h4>Based on three engineered ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2021, 228:112984]

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Inflammatory cytokine-regulated tRNA-derived fragment tRF-21 suppresses pancreatic ductal adenocarcinoma progression.

Ling Pan, Xudong Huang, Ze-Xian Liu, Ying Ye, Rui Li, Jialiang Zhang, Guandi Wu, Ruihong Bai, Lisha Zhuang, Lusheng Wei, Mei Li, Yanfen Zheng, Jiachun Su, Junge Deng, Shuang Deng, Lingxing Zeng, Shaoping Zhang, Chen Wu, Xu Che, Chengfeng Wang, Rufu Chen, Dongxin Lin, Jian Zheng,

The tumorigenic mechanism for pancreatic ductal adenocarcinoma (PDAC) is not clear, although chronic inflammation is implicated. Here, we identified an inflammatory cytokine-regulated transfer RNA-derived (tRNA-derived) fragment, tRF-21-VBY9PYKHD (tRF-21), as a tumor suppressor in PDAC progression. We found that the biogenesis of tRF-21 could be inhibited by leukemia inhibitory factor and ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(22):]

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Changes in Serum Calcium and Treatment of Hypoparathyroidism During Pregnancy and Lactation: A Single-center Case Series.

Jia-Jia Wang, Ou Wang, Ya-Bing Wang, Jing Yang, An Song, Yan Jiang, Mei Li, Wei-Bo Xia, Xiao-Ping Xing,

<h4>Background</h4>Hypoparathyroidism (hypo-PT) is rare, and studies on hypo-PT, especially during pregnancy and lactation, are limited.<h4>Design and setting</h4>This was a retrospective study on a relatively large case series in a single center from mainland China.<h4>Methods</h4>A total of 19 patients with 25 pregnancies, diagnosed with hypo-PT before pregnancy, were enrolled. Data on ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2021, 106(12):e5054-e5063]

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Genome Sequence Resource of Botryosphaeria dothidea CK16, a Fungal Pathogen Causing Chinese Hickory Trunk Canker Disease.

Yuxin Rao, Li Mei, Liqin Zhang, Hong Jiang, Liangjin Ma, Yongjun Wang,

<i>Botryosphaeria dothidea</i> is a latent fungal pathogen that causes cankers or diebacks on a variety of host woody plants worldwide. The symptomatic necrosis on the host plants can be triggered by abiotic stress, such as drought and soil acidification. Here we report a high-quality genome assembly and announcement of the ... Read more >>

Plant Dis (Plant disease)
[2021, :PDIS02210254A]

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Effects of exogenous melatonin on plant growth, root hormones and photosynthetic characteristics of trifoliate orange subjected to salt stress

Ceng-hong Hu, Ying Zheng, Rong-hui Sun, Jian-hao Zheng, Mei Li, dejian zhang,

Soil salinity has negative effects on crop growth and production, and melatonin (MT) plays an important role in regulating the salt stress of plants. However, it is not clear whether exogenous melatonin mitigates the negative effect on citrus plants subjected to salt stress. This study was to explore the response ... Read more >>

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