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Drought stress induces biosynthesis of flavonoids in leaves and saikosaponins in roots of Bupleurum chinense DC.

Lin-Lin Yang, Li Yang, Xiao Yang, Tao Zhang, Yi-Ming Lan, Yu Zhao, Mei Han, Li-Min Yang,

Drought stress affects vegetative and reproductive growth processes and synthesis of secondary metabolites in plants. We assessed relevant indicators of vegetative and reproductive growth in Bupleurum chinense DC. during drought stress. Samples were collected on days 4, 8, 12, 20, and 24 of a drought treatment according to drought stress ... Read more >>

Phytochemistry (Phytochemistry)
[2020, 177:112434]

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A CRISPR-Cas12a-based specific enhancer for more sensitive detection of SARS-CoV-2 infection

Weiren Huang, Lei Yu, Donghua Wen, Dong Wei, Yangyang Sun, Huailong Zhao, Yu Ye, Wei Chen, Yongqiang Zhu, Lijun Wang, Li Wang, Wenjuan Wu, Qianqian Zhao, Yong Xu, Dayong Gu, Guohui Nie, Dongyi Zhu, Zhongliang Guo, Xiaoling Ma, Liman Niu, Yikun Huang, Yuchen Liu, Bo Peng, Renli Zhang, Xiuming Zhang, Dechang Li, Yang Liu, Guoliang Yang, Lanzheng Liu, Yunying Zhou, Yunshan Wang, Tieying Hou, Qiuping Gao, Wujiao Li, Shuo Chen, Xuejiao Hu, Mei Han, Huajun Zheng, Jianping Wen, Zhiming Cai, Xinxin Zhang, Fei Song, Guoping Zhao, Jin Wang,

High Ct-values falling in the grey zone are frequently encountered in SARS-CoV-2 detection by real-time reverse transcription PCR (rRT-PCR) and have brought urgent challenges in diagnosis of samples with low viral load. Based on the single-stranded DNA reporter trans-cleavage activity by Cas12a upon target DNA recognition, we create a Specific ... Read more >>

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Efficacy of buffered hypertonic seawater in different phenotypes of chronic rhinosinusitis with nasal polyps after endoscopic sinus surgery: a randomized double-blind study.

Jun Wang, Li Shen, Zhi-Qun Huang, Qing Luo, Meng-Yue Li, Jun-Hao Tu, Mei Han, Jing Ye,

PURPOSE:Nasal douching is commonly used as a postoperative management strategy for chronic rhinosinusitis with nasal polyps (CRSwNP). Few studies to date have compared the effectiveness of nasal douching in CRSwNP phenotypes after endoscopic sinus surgery (ESS). We evaluated the efficacy of seawater types in eosinophilic CRSwNP (ECRSwNP) and noneosinophilic CRSwNP ... Read more >>

Am J Otolaryngol (American Journal of Otolaryngology)
[2020, 41(5):102554]

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Automated abnormality classification of chest radiographs using deep convolutional neural networks.

Yu-Xing Tang, You-Bao Tang, Yifan Peng, Ke Yan, Mohammadhadi Bagheri, Bernadette A Redd, Catherine J Brandon, Zhiyong Lu, Mei Han, Jing Xiao, Ronald M Summers,

As one of the most ubiquitous diagnostic imaging tests in medical practice, chest radiography requires timely reporting of potential findings and diagnosis of diseases in the images. Automated, fast, and reliable detection of diseases based on chest radiography is a critical step in radiology workflow. In this work, we developed ... Read more >>

NPJ Digit Med (NPJ digital medicine)
[2020, 3:70]

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MiR-27b-3p exerts tumor suppressor effects in esophageal squamous cell carcinoma by targeting Nrf2.

Mei Han, Na Li, Fanzhou Li, Hua Wang, Lanying Ma,

MiR-27b-3p has been reported to function as tumor suppressor in several tumors, including breast cancer and lung cancer. Recently, miR-27b-3p has been identified to be significantly down-regulated in esophageal cancer. However, the clinical significance and biological role of miR-27b-3p in esophageal squamous cell carcinoma (ESCC) still remain unclear. In this ... Read more >>

Hum. Cell (Human cell)
[2020, 33(3):641-651]

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Anticoagulant chitosan-kappa-carrageenan composite hydrogel sorbent for simultaneous endotoxin and bacteria cleansing in septic blood.

Yupei Li, Jiameng Li, Zhenqiang Shi, Yilin Wang, Xin Song, Liya Wang, Mei Han, Heyue Du, Chao He, Weifeng Zhao, Baihai Su, Changsheng Zhao,

Here, we describe a green approach to fabricate genipin crosslinked chitosan-kappa-carrageenan composite hydrogels (C-K hydrogels) aiming at reducing endotoxin level and bacteria burden in septic blood synchronously. The chemical compositions and morphologies of the developed C-K hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and scanning electron ... Read more >>

Carbohydr Polym (Carbohydrate polymers)
[2020, 243:116470]

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Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: a prospective cohort study.

Auyon J Ghosh, Matthew Moll, Lystra P Hayden, Jessica Bon, Elizabeth Regan, Craig P Hersh, ,

BACKGROUND:Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the effect of vitamin D levels on imaging characteristics remains mostly unexplored. Using cross-sectional and longitudinal follow up data from the ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):123]

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Inhibition of ALAS1 activity exerts anti-tumour effects on colorectal cancer in vitro.

Yalei Zhao, Xiaoyun Zhang, Yabin Liu, Yiping Ma, Pong Kong, Tianliang Bai, Mei Han, Binghui Li,

Background/Aims:Colorectal cancer (CRC) is the third most common malignant tumour worldwide and the second leading cause of cancer-related deaths. Commonly, 5'-aminolevulinic acid synthase1 (ALAS1) is the rate-limiting enzyme for haem biosynthesis. Recent studies have shown that ALAS1 is involved in a number of cellular functions and has significant effects on ... Read more >>

Saudi J Gastroenterol (Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association)
[2020, 26(3):144-152]

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The characteristics of the frequent exacerbator with chronic bronchitis phenotype and non-exacerbator phenotype in patients with chronic obstructive pulmonary disease: a meta-analysis and system review.

Jian-Jun Wu, Hong-Ri Xu, Ying-Xue Zhang, Yi-Xuan Li, Hui-Yong Yu, Liang-Duo Jiang, Cheng-Xiang Wang, Mei Han,

BACKGROUND:Chronic obstructive pulmonary disease (COPD) patients with different phenotypes show different clinical characteristics. Therefore, we conducted a meta-analysis to explore the clinical characteristics between the non-exacerbator (NE) phenotype and the frequent exacerbator with chronic bronchitis (FE-CB) phenotype among patients with COPD. METHODS:CNKI, Wan fang, Chongqing VIP, China Biology Medicine disc, ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):103]

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Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance.

Zeribe Chike Nwosu, Weronika Piorońska, Nadia Battello, Andreas David Zimmer, Bedair Dewidar, Mei Han, Sharon Pereira, Biljana Blagojevic, Darko Castven, Verodia Charlestin, Pavlo Holenya, Julia Lochead, Carolina De La Torre, Norbert Gretz, Peter Sajjakulnukit, Li Zhang, Matthew H Ward, Jens U Marquardt, Marina Pasca di Magliano, Costas A Lyssiotis, Jonathan Sleeman, Stefan Wölfl, Matthias Philip Ebert, Christoph Meyer, Ute Hofmann, Steven Dooley,

BACKGROUND:The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways are profoundly dysregulated in HCC. Whether an altered metabolic state is linked to activated ERK pathway and drug response in HCC is unaddressed. METHODS:We deprived HCC cells ... Read more >>

EBioMedicine (EBioMedicine)
[2020, 54:102699]

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JNK Signaling Pathway Suppresses LPS-Mediated Apoptosis of HK-2 Cells by Upregulating NGAL.

Mei Han, Yuxia Pan, Mengying Gao, Junli Zhang, Fan Wang,

Objective:To explore the role of the c-Jun N-terminal kinase (JNK) signaling pathway in upregulated NGAL expression and its antiapoptotic mechanism in lipopolysaccharide (LPS)-mediated renal tubular epithelial cell injury. Methods:In vitro, HK-2 cells were divided into five groups (Con, LPS 1 h, LPS 3 h, LPS 6 h, and LPS 12 h groups) based on ... Read more >>

Int J Inflam (International journal of inflammation)
[2020, 2020:3980507]

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Effect of acupoint application on T lymphocyte subsets in patients with chronic obstructive pulmonary disease: A meta-analysis.

Jian-Jun Wu, Ying-Xue Zhang, Hong-Ri Xu, Yi-Xuan Li, Liang-Duo Jiang, Cheng-Xiang Wang, Mei Han,

BACKGROUND:The development of chronic obstructive pulmonary disease (COPD) is related to the T lymphocyte mediated inflammatory immune response and immune imbalance. The purpose of this systematic review was to evaluate the clinical efficacy and safety of acupoint application on T lymphocyte subsets in patients with COPD. METHODS:We searched CNKI, Wan ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(16):e19537]

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Evidence Base of Clinical Studies on Qi Gong: A Bibliometric Analysis.

Ya-Peng Zhang, Rui-Xue Hu, Mei Han, Bao-Yong Lai, Shi-Bing Liang, Bing-Jie Chen, Nicola Robinson, Kevin Chen, Jian-Ping Liu,

OBJECTIVE:This bibliometric study aimed to systematically and comprehensively summarize the volume, breadth and evidence for clinical research on Qigong. And this bibliometric analysis also can provide the evidence of this field. DESIGN:Bibliometric analysis. METHODS:All types of primary and secondary studies on humans were included: systematic reviews, randomized clinical trials, non-randomized ... Read more >>

Complement Ther Med (Complementary therapies in medicine)
[2020, 50:102392]

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[Analysis of Water Quality Change and Its Driving Factors of the Xiaoqing River Estuary in Recent Ten Rears].

Xin-Feng Fan, Mei Han, Lei Wang, Xiu-Ping Li, Jing Zhou,

According to the monitoring data of pollutant concentration in the Xiaoqing River estuary from 2008 to 2017, 13 pollutants affecting water quality were selected. The trends of changes in water quality were identified mainly by the pollution index method, and the driving factors affecting water quality changes were quantitatively and ... Read more >>

Huan Jing Ke Xue (Huan jing ke xue= Huanjing kexue)
[2020, 41(4):1619-1628]

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Cases Report of Cured Novel Coronavirus-infected Pneumonia Patients with Viral Nucleic Acid Test Positive in Fecal Specimens

Mei Han, Jingbo Zou, Wenguang Tian, Xiaoyu Wei, Yang Zhou, Jie Qiao, Xia Li, Jing Zhou, Tiangyuan Sun, Yiheng Ou, Zongyu Zhou, Yaokai Chen, Pingliang Pan, junjie zhang,

Abstract Background: The outbreak of the novel coronavirus in China (COVID-19) represents a significant and urgent threat to global health. We report here five cases of COVID-19 infection patients in our clinical practices who are medically stable and presumed to successfully “cleared” the virus after antiviral treatments. Case presentation: The ... Read more >>

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[Research progress on the expression and function of erythropoietin-producing hepatomocellular receptors and their receptor-interacting proteins in oral-related diseases].

Qi Wang, Yan Liu, Yun Zhao, Li-Zhong Sun, Lin-Xuan Wang, Mei Han, Fang-Lin Mi,

Erythropoietin-producing hepatomocellular receptors and their receptor-interacting proteins (Eph/ephrin) can participate in the regulation of growth and development and promote the development of diseases through short-distance signal transduction between cells. To study the mechanism of Eph/ephrin and oral-related diseases, we provided a new theoretical basis and a strategy for the treatment ... Read more >>

Hua Xi Kou Qiang Yi Xue Za Zhi (Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology)
[2020, 38(2):218-223]

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The characteristics of the frequent exacerbator with chronic bronchitis phenotype and non-exacerbator phenotype in patients with chronic obstructive pulmonary disease: a meta-analysis and system review

Jianjun Wu, Hong-ri Xu, Ying-xue Zhang, Yi-xuan Li, Hui-yong Yu, Liang-duo Jiang, Cheng-xiang Wang, Mei Han,

Abstract Objective: To investigate the clinical characteristics between the frequent exacerbator with chronic bronchitis (FE-CB) phenotype and the non-exacerbator (NE) phenotype among patients with chronic obstructive pulmonary disease (COPD). Methods: We searched CNKI, Wan fang, Chongqing VIP, China Biology Medicine disc, PubMed, Cochrane Library, and EMBASE databases for relevant studies ... Read more >>

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The psychological impact of the COVID-19 epidemic on college students in China.

Wenjun Cao, Ziwei Fang, Guoqiang Hou, Mei Han, Xinrong Xu, Jiaxin Dong, Jianzhong Zheng,

A COVID-19 epidemic has been spreading in China and other parts of the world since December 2019. The epidemic has brought not only the risk of death from infection but also unbearable psychological pressure. We sampled college students from Changzhi medical college by using cluster sampling. They responded to a ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, 287:112934]

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Study on the Changes of Chemical Constituents in Different Compatibilities of Ginseng-Prepared Rehmannia Root and Their Effects on Bone Marrow Inhibition after Chemotherapy.

Si-Qi Wang, Xiao Yang, Yong-Gang Zhang, En-Bo Cai, Xiao-Man Zheng, Yan Zhao, Ge Li, Mei Han, Li-Min Yang,

Ginseng (G) and Prepared Rehmannia Root (PRR) are commonly used in traditional Chinese medicine for blood supplementation. This study aimed to study G and PRR with different compatibility ratios changes in chemical composition and inhibition of cyclophosphamide-induced myelosuppression. HPLC was used to determine the chemical constituents of 13 ginsenosides, 5-hydroxymethylfurfural ... Read more >>

Chem. Pharm. Bull. (Chemical & pharmaceutical bulletin)
[2020, 68(5):428-435]

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Potential Factors for Prediction of Disease Severity of COVID-19 Patients

huizheng zhang, xiaoying wang, zongqiang fu, ming luo, zhen zhang, ke zhang, ying he, dongyong wan, liwen zhang, jing wang, xiaofeng yan, mei han, yaokai chen,

Abstract: Objective: Coronavirus disease 2019 (COVID-19) is an escalating global epidemic caused by SARS-CoV-2, with a high mortality in critical patients. Effective indicators for predicting disease severity in SARS-CoV-2 infected patients are urgently needed. Methods: In this study, 43 COVID-19 patients admitted in Chongqing Public Health Medical Center were involved. ... Read more >>

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A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice.

Lijuan Wang, Lei Tang, Yiming Feng, Suying Zhao, Mei Han, Chuan Zhang, Gehui Yuan, Jun Zhu, Shuyuan Cao, Qian Wu, Lei Li, Zhan Zhang,

OBJECTIVE:Gut microbiota have been linked to inflammatory bowel disease (IBD) and colorectal cancer (CRC). Akkermansia muciniphila (A. muciniphila) is a gram-negative anaerobic bacterium that is selectively decreased in the faecal microbiota of patients with IBD, but its causative role and molecular mechanism in blunting colitis-associated colorectal cancer (CAC) remain inconclusive. ... Read more >>

Gut (Gut)
[2020, :]

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Does marital status correlate with the female breast cancer risk? A systematic review and meta-analysis of observational studies.

Menglin Li, Mei Han, Zijie Chen, Yu Tang, Jie Ma, Zhiying Zhang, Zhenzhu Liu, Ning Zhang, Chongcheng Xi, Jintao Liu, Dong Tian, Xiaoxuan Wang, Xunying Huang, Jingwen Chen, Weiguang Wang, Shuangqing Zhai,

OBJECTIVE:To investigate that whether an association between marital status and the female breast cancer risk exists. METHODS:The MEDLINE, EMBASE and PsycINFO databases were searched from their inception to July 2019. The Newcastle-Ottawa Scale was used to rate the methodological quality of included studies. Study data were pooled using random-effects meta-analyses ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0229899]

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Functioning Mechanism of the Secondary Aqueous Zn-β-MnO2 Battery.

Longyan Li, Tuan K A Hoang, Jian Zhi, Mei Han, Shengkai Li, P Chen,

Rechargeable aqueous Zn-MnO2 batteries are a promising candidate for large-scale energy storage systems due to their outstanding advantages, such as high energy density, high safety, low cost, and environmental friendliness. Considering the controversies surrounding the mechanism of this battery containing a mildly acidic electrolyte, the electrochemical behavior of this type ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(11):12834-12846]

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Hepatocyte caveolin-1 modulates metabolic gene profiles and functions in non-alcoholic fatty liver disease.

Mei Han, Weronika Piorońska, Sai Wang, Zeribe Chike Nwosu, Carsten Sticht, Shanshan Wang, Yan Gao, Matthias Philip Ebert, Steven Dooley, Christoph Meyer,

Caveolin-1 (CAV1) is a crucial regulator of lipid accumulation and metabolism. Previous studies have shown that global Cav1 deficiency affects lipid metabolism and hepatic steatosis. We aimed to analyze the consequences of hepatocyte-specific Cav1 knockout under healthy conditions and upon non-alcoholic fatty liver disease (NAFLD) development. Male and female hepatocyte-specific ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(2):104]

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Author Correction: Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR-/- mice fed on high-fat diet.

Lin Liu, Chenxi Liang, Xiaowei Wang, Xiayu Ding, Yingjing Lu, Jinghui Dong, Mei Han, Hongyuan Yang, Mingming Gao, Jiawei Liao,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2181]

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