Full Text Journal Articles by
Author Mei Chun Cai

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Urinary Molecular Pathology for Patients with Newly Diagnosed Urothelial Bladder Cancer.

Ruiyun Zhang, Jingyu Zang, Feng Xie, Yue Zhang, Yiqiu Wang, Ying Jing, Yi Zhang, Zhaoxiong Chen, Akezhouli Shahatiaili, Mei-Chun Cai, Zhixin Zhao, Pan Du, Shidong Jia, Guanglei Zhuang, Haige Chen,

<h4>Purpose</h4>Next-generation sequencing (NGS)-based profiling of both urinary tumor DNA (utDNA) and circulating tumor DNA (ctDNA) shows promise for noninvasive detection and surveillance of urothelial bladder cancer (UBC). However, the analytic performance of these assays remains undefined in the real-world setting. Here, we sought to evaluate the concordance between tumor DNA ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001878]

Cited: 0 times

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Baseline immunity and impact of chemotherapy on immune microenvironment in cervical cancer.

Yi Zhang, Minhua Yu, Ying Jing, Jiejun Cheng, Caiyan Zhang, Lin Cheng, Haijiao Lu, Mei-Chun Cai, Jie Wu, Wenjing Wang, Weihua Lou, Lihua Qiu, Li Tan, Huaiwu Lu, Xia Yin, Guanglei Zhuang, Wen Di,

<h4>Background</h4>We aimed to comprehensively evaluate the immunologic landscape at baseline and upon chemotherapy in cervical cancer. The information should aid ongoing clinical investigations of checkpoint blockade immunotherapies in this disease setting.<h4>Methods</h4>A series of 109 cervical carcinoma patients was retrospectively assayed before and after neoadjuvant chemotherapy. Tumour-infiltrating immune markers (CD3, CD4, ... Read more >>

Br J Cancer (British journal of cancer)
[2021, 124(2):414-424]

Cited: 1 time

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T-cell exhaustion interrelates with immune cytolytic activity to shape the inflamed tumor microenvironment.

Mei-Chun Cai, Xiaojing Zhao, Min Cao, Pengfei Ma, Minjiang Chen, Jie Wu, Chenqiang Jia, Chunming He, Yujie Fu, Li Tan, Xinying Xue, Zhuang Yu, Guanglei Zhuang,

Direct quantification of exhausted T cells in human cancer is lacking, and its predictive value for checkpoint-based treatment remains poorly investigated. We sought to systematically characterize the pan-cancer landscape and molecular hallmarks of T-cell dysfunction for the purpose of precision immunotherapy. Here, we defined a transcriptional signature for T-cell exhaustion ... Read more >>

J Pathol (The Journal of pathology)
[2020, 251(2):147-159]

Cited: 1 time

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Multiregion whole-genome sequencing depicts intratumour heterogeneity and punctuated evolution in ovarian clear cell carcinoma.

Xia Yin, Rui Bi, Pengfei Ma, Shengzhe Zhang, Yang Zhang, Yunheng Sun, Yi Zhang, Ying Jing, Minhua Yu, Wenjing Wang, Li Tan, Wen Di, Guanglei Zhuang, Mei-Chun Cai,

<h4>Background</h4>Ovarian clear cell carcinoma (OCCC) arises from endometriosis and represents a difficult-to-treat gynaecological malignancy, in part, because its spatial intratumour heterogeneity and temporal evolutionary trajectories have not been explicitly defined.<h4>Methods</h4>We performed whole-genome sequencing on six pathologically confirmed patients with OCCC. An R package named KataegisPortal was developed to identify and ... Read more >>

J Med Genet (Journal of medical genetics)
[2020, 57(9):605-609]

Cited: 0 times

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PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors.

Kaixuan Shi, Xia Yin, Mei-Chun Cai, Ying Yan, Chenqiang Jia, Pengfei Ma, Shengzhe Zhang, Zhenfeng Zhang, Zhenyu Gu, Meiying Zhang, Wen Di, Guanglei Zhuang,

PAX8 is a prototype lineage-survival oncogene in epithelial ovarian cancer. However, neither its underlying pro-tumorigenic mechanisms nor potential therapeutic implications have been adequately elucidated. Here, we identified an ovarian lineage-specific PAX8 regulon using modified cancer outlier profile analysis, in which PAX8-FGF18 axis was responsible for promoting cell migration in an ... Read more >>

Elife (eLife)
[2019, 8:]

Cited: 8 times

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Clinicopathological, microenvironmental and genetic determinants of molecular subtypes in KEAP1/NRF2-mutant lung cancer.

Mei-Chun Cai, Minjiang Chen, Pengfei Ma, Jie Wu, Haijiao Lu, Shengzhe Zhang, Jin Liu, Xiaojing Zhao, Guanglei Zhuang, Zhuang Yu, Yujie Fu,

Somatic KEAP1-NRF2 pathway alterations are frequently detected in both lung adenocarcinomas and squamous cell carcinomas. However, the biological characteristics and molecular subtypes of KEAP1/NRF2-mutant lung cancer remain largely undefined. Here, we performed a stepwise, integrative analytic and experimental interrogation of primary tumors and cancer cell lines harboring KEAP1 or NFE2L2 ... Read more >>

Int J Cancer (International journal of cancer)
[2019, 144(4):788-801]

Cited: 0 times

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Hybrid sequencing-based personal full-length transcriptomic analysis implicates proteostatic stress in metastatic ovarian cancer.

Ying Jing, Yi Zhang, Hui Zhu, Ke Zhang, Mei-Chun Cai, Pengfei Ma, Peiye Shen, Zhenfeng Zhang, Minghui Shao, Jing Wang, Minhua Yu, Xia Yin, Meiying Zhang, Yuan Hu, Danni Chen, Wen Di, Xiaojie Wang, Guanglei Zhuang,

Comprehensive molecular characterization of myriad somatic alterations and aberrant gene expressions at personal level is key to precision cancer therapy, yet limited by current short-read sequencing technology, individualized catalog of complete genomic and transcriptomic features is thus far elusive. Here, we integrated second- and third-generation sequencing platforms to generate a ... Read more >>

Oncogene (Oncogene)
[2019, 38(16):3047-3060]

Cited: 1 time

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Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death.

Haijiao Lu, Shengzhe Zhang, Jie Wu, Minjiang Chen, Mei-Chun Cai, Yujie Fu, Wenfeng Li, Jing Wang, Xiaojing Zhao, Zhuang Yu, Pengfei Ma, Guanglei Zhuang,

<h4>Purpose</h4>The induced death signals following oncogene inhibition underlie clinical efficacy of molecular targeted therapies against human cancer, and defects of intact cell apoptosis machinery often lead to therapeutic failure. Despite potential importance, other forms of regulated cell death triggered by pharmacologic intervention have not been systematically characterized.<h4>Experimental design</h4>Pyroptotic cell death ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2018, 24(23):6066-6077]

Cited: 32 times

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Comprehensive genomic profiling of neuroendocrine bladder cancer pinpoints molecular origin and potential therapeutics.

Peiye Shen, Ying Jing, Ruiyun Zhang, Mei-Chun Cai, Pengfei Ma, Haige Chen, Guanglei Zhuang,

Neuroendocrine bladder cancer is a relatively rare but often lethal malignancy, with cell of origin, oncogenomic architecture and standard treatment poorly defined. Here we performed comprehensive whole-genome and transcriptome sequencing on a unique cohort of genitourinary neuroendocrine neoplasms, mainly small cell carcinomas of the urinary bladder. The mutational landscape and ... Read more >>

Oncogene (Oncogene)
[2018, 37(22):3039-3044]

Cited: 6 times

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Prevalence and clonality of synchronous primary carcinomas in the bladder and prostate.

Ying Jing, Ruiyun Zhang, Pengfei Ma, Mei-Chun Cai, Guanglei Zhuang, Haige Chen,

Incidental prostate adenocarcinoma (IPCa) has been frequently discovered during postoperative histopathological evaluation of radical cystoprostatectomy specimens in patients with bladder cancer (BCa). However, there is currently no conclusive study addressing the clinical significance of IPCa and the clonal relatedness of IPCa and BCa. Here, we performed a retrospective single-center review ... Read more >>

J Pathol (The Journal of pathology)
[2018, 244(1):5-10]

Cited: 0 times

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Clonality, Heterogeneity, and Evolution of Synchronous Bilateral Ovarian Cancer.

Xia Yin, Ying Jing, Mei-Chun Cai, Pengfei Ma, Yi Zhang, Cong Xu, Meiying Zhang, Wen Di, Guanglei Zhuang,

Synchronous bilateral ovarian cancer (SBOC) represents a relatively frequent occurrence and clinically relevant diagnostic dilemma. Delineation of its clonal architecture, genetic heterogeneity, and evolutionary trajectories may have important implications for prognosis and management of patients with SBOC. Here, we describe the results of next-generation whole-exome or whole-genome sequencing of specimens ... Read more >>

Cancer Res (Cancer research)
[2017, 77(23):6551-6561]

Cited: 10 times

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Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer.

Pengfei Ma, Yujie Fu, Mei-Chun Cai, Ying Yan, Ying Jing, Shengzhe Zhang, Minjiang Chen, Jie Wu, Ying Shen, Liang Zhu, Hong-Zhuan Chen, Wei-Qiang Gao, Mengzhao Wang, Zhenyu Gu, Trever G Bivona, Xiaojing Zhao, Guanglei Zhuang,

Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution. Here, we sequence a unique cohort of multiple synchronous lung cancers (MSLCs) to determine the relative diversity and uniformity of genetic drivers upon identical germline ... Read more >>

Nat Commun (Nature communications)
[2017, 8(1):823]

Cited: 18 times

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Preclinical Efficacy and Molecular Mechanism of Targeting CDK7-Dependent Transcriptional Addiction in Ovarian Cancer.

Zhenfeng Zhang, Huixin Peng, Xiaojie Wang, Xia Yin, Pengfei Ma, Ying Jing, Mei-Chun Cai, Jin Liu, Meiying Zhang, Shengzhe Zhang, Kaixuan Shi, Wei-Qiang Gao, Wen Di, Guanglei Zhuang,

Ovarian cancer remains a significant cause of gynecologic cancer mortality, and novel therapeutic strategies are urgently needed in clinic as new treatment options. We previously showed that BET bromodomain inhibitors displayed promising efficacy for the treatment of epithelial ovarian cancer by downregulating pivot transcription factors. However, the potential antitumor activities ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2017, 16(9):1739-1750]

Cited: 15 times

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A VEGF-dependent gene signature enriched in mesenchymal ovarian cancer predicts patient prognosis.

Xia Yin, Xiaojie Wang, Boqiang Shen, Ying Jing, Qing Li, Mei-Chun Cai, Zhuowei Gu, Qi Yang, Zhenfeng Zhang, Jin Liu, Hongxia Li, Wen Di, Guanglei Zhuang,

We have previously reported surrogate biomarkers of VEGF pathway activities with the potential to provide predictive information for anti-VEGF therapies. The aim of this study was to systematically evaluate a new VEGF-dependent gene signature (VDGs) in relation to molecular subtypes of ovarian cancer and patient prognosis. Using microarray profiling and ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:31079]

Cited: 8 times

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Phase-locked scroll waves defy turbulence induced by negative filament tension.

Teng-Chao Li, Xiang Gao, Fei-Fei Zheng, Mei-Chun Cai, Bing-Wei Li, Hong Zhang, Hans Dierckx,

Scroll waves in a three-dimensional media may develop into turbulence due to negative tension of the filament. Such negative tension-induced instability of scroll waves has been observed in the Belousov-Zhabotinsky reaction systems. Here we propose a method to restabilize scroll wave turbulence caused by negative tension in three-dimensional chemical excitable ... Read more >>

Phys Rev E (Physical review. E)
[2016, 93(1):012216]

Cited: 1 time

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BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1.

Zhenfeng Zhang, Pengfei Ma, Ying Jing, Ying Yan, Mei-Chun Cai, Meiying Zhang, Shengzhe Zhang, Huixin Peng, Zhi-Liang Ji, Wen Di, Zhenyu Gu, Wei-Qiang Gao, Guanglei Zhuang,

Ovarian cancer is responsible for the highest mortality among all gynecologic malignancies, and novel therapies are urgently needed to improve patient outcome. Here we performed an integrative genomic analysis and identified the bromodomain and extraterminal domain (BET) protein BRD4 as a potential therapeutic target in ovarian cancer. Suppression of BRD4 ... Read more >>

Theranostics (Theranostics)
[2016, 6(2):219-230]

Cited: 40 times

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ADReCS: an ontology database for aiding standardization and hierarchical classification of adverse drug reaction terms.

Mei-Chun Cai, Quan Xu, Yan-Jing Pan, Wen Pan, Nan Ji, Yin-Bo Li, Hai-Jing Jin, Ke Liu, Zhi-Liang Ji,

Adverse drug reactions (ADRs) are noxious and unexpected effects during normal drug therapy. They have caused significant clinical burden and been responsible for a large portion of new drug development failure. Molecular understanding and in silico evaluation of drug (or candidate) safety in laboratory is thus so desired, and unfortunately ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2015, 43(Database issue):D907-13]

Cited: 21 times

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Core solutions of rigidly rotating spiral waves in highly excitable media.

Mei-Chun Cai, Jun-Ting Pan, Hong Zhang,

Analytical spiral wave solutions for reaction-diffusion equations play an important role in studying spiral wave dynamics. In this paper, we focus on such analytical solutions in the case of highly excitable media. We present numerical evidence that, for rigidly rotating spiral waves in highly excitable media, the species values in ... Read more >>

Phys Rev E Stat Nonlin Soft Matter Phys (Physical review. E, Statistical, nonlinear, and soft matter physics)
[2014, 89(2):022920]

Cited: 0 times

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Immunosuppressive effect of compound K on islet transplantation in an STZ-induced diabetic mouse model.

Peng-Fei Ma, Jie Jiang, Chang Gao, Pan-Pan Cheng, Jia-Li Li, Xin Huang, Ying-Ying Lin, Qing Li, Yuan-Zheng Peng, Mei-Chun Cai, Wei Shao, Qi Zhu, Sai Han, Qing Qin, Jun-Jie Xia, Zhong-Quan Qi,

Islet transplantation is a therapeutic option for type 1 diabetes, but its long-term success is limited by islet allograft survival. Many factors imperil islet survival, especially the adverse effects and toxicity due to clinical immunosuppressants. Compound (Cpd) K is a synthesized analog of highly unsaturated fatty acids from Isatis tinctoria ... Read more >>

Diabetes (Diabetes)
[2014, 63(10):3458-3469]

Cited: 5 times

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Chiral selection and frequency response of spiral waves in reaction-diffusion systems under a chiral electric field.

Bing-Wei Li, Mei-Chun Cai, Hong Zhang, Alexander V Panfilov, Hans Dierckx,

Chirality is one of the most fundamental properties of many physical, chemical, and biological systems. However, the mechanisms underlying the onset and control of chiral symmetry are largely understudied. We investigate possibility of chirality control in a chemical excitable system (the Belousov-Zhabotinsky reaction) by application of a chiral (rotating) electric ... Read more >>

J Chem Phys (The Journal of chemical physics)
[2014, 140(18):184901]

Cited: 7 times

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PaGenBase: a pattern gene database for the global and dynamic understanding of gene function.

Jian-Bo Pan, Shi-Chang Hu, Dan Shi, Mei-Chun Cai, Yin-Bo Li, Quan Zou, Zhi-Liang Ji,

Pattern genes are a group of genes that have a modularized expression behavior under serial physiological conditions. The identification of pattern genes will provide a path toward a global and dynamic understanding of gene functions and their roles in particular biological processes or events, such as development and pathogenesis. In ... Read more >>

PLoS One (PloS one)
[2013, 8(12):e80747]

Cited: 35 times

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Chiralities of spiral waves and their transitions.

Jun-ting Pan, Mei-chun Cai, Bing-wei Li, Hong Zhang,

The chiralities of spiral waves usually refer to their rotation directions (the turning orientations of the spiral temporal movements as time elapses) and their curl directions (the winding orientations of the spiral spatial geometrical structures themselves). Traditionally, they are the same as each other. Namely, they are both clockwise or ... Read more >>

Phys Rev E Stat Nonlin Soft Matter Phys (Physical review. E, Statistical, nonlinear, and soft matter physics)
[2013, 87(6):062907]

Cited: 2 times

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Inwardly rotating spirals in nonuniform excitable media.

Xiang Gao, Xia Feng, Mei-chun Cai, Bing-wei Li, He-ping Ying, Hong Zhang,

Inwardly rotating spirals (IRSs) have attracted great attention since their observation in an oscillatory reaction-diffusion system. However, IRSs have not yet been reported in planar excitable media. In the present work we investigate rotating waves in a nonuniform excitable medium, consisting of an inner disk part surrounded by an outer ... Read more >>

Phys Rev E Stat Nonlin Soft Matter Phys (Physical review. E, Statistical, nonlinear, and soft matter physics)
[2012, 85(1 Pt 2):016213]

Cited: 1 time

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Electric-field-sustained spiral waves in subexcitable media.

Mei-chun Cai, Jun-ting Pan, Hong Zhang,

We present numerical evidence that, in the presence of a suitable electric field, an isolated broken plane wave retracting originally in subexcitable media can propagate continuously and eventually evolve into a rotating spiral. Simulations for the FitzHugh-Nagumo, the Barkley, and the Oregonator models are carried out and the same electric-field-sustained ... Read more >>

Phys Rev E Stat Nonlin Soft Matter Phys (Physical review. E, Statistical, nonlinear, and soft matter physics)
[2012, 86(1 Pt 2):016208]

Cited: 2 times

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