Full Text Journal Articles by
Author Meghan Delmastro Greenwood

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Treatment with a Catalytic Superoxide Dismutase (SOD) Mimetic Improves Liver Steatosis, Insulin Sensitivity, and Inflammation in Obesity-Induced Type 2 Diabetes.

Gina M Coudriet, Meghan M Delmastro-Greenwood, Dana M Previte, Meghan L Marré, Erin C O'Connor, Elizabeth A Novak, Garret Vincent, Kevin P Mollen, Sojin Lee, H Henry Dong, Jon D Piganelli,

Oxidative stress and persistent inflammation are exaggerated through chronic over-nutrition and a sedentary lifestyle, resulting in insulin resistance. In type 2 diabetes (T2D), impaired insulin signaling leads to hyperglycemia and long-term complications, including metabolic liver dysfunction, resulting in non-alcoholic fatty liver disease (NAFLD). The manganese metalloporphyrin superoxide dismustase (SOD) mimetic, ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2017, 6(4):]

Cited: 7 times

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Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Kara S Hughan, Stacy Gelhaus Wendell, Meghan Delmastro-Greenwood, Nicole Helbling, Catherine Corey, Landon Bellavia, Gopal Potti, George Grimes, Bret Goodpaster, Daniel B Kim-Shapiro, Sruti Shiva, Bruce A Freeman, Mark T Gladwin,

Dietary NO3- (nitrate) and NO2- (nitrite) support ˙NO (nitric oxide) generation and downstream vascular signaling responses. These nitrogen oxides also generate secondary nitrosating and nitrating species that react with low molecular weight thiols, heme centers, proteins, and unsaturated fatty acids. To explore the kinetics of NO3-and NO2-metabolism and the impact ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2017, 70(3):634-644]

Cited: 7 times

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Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells.

Meghan M Delmastro-Greenwood, Tatyana Votyakova, Eric Goetzman, Meghan L Marre, Dana M Previte, Artak Tovmasyan, Ines Batinic-Haberle, Massimo M Trucco, Jon D Piganelli,

The immune system is critical for protection against infections and cancer, but requires scrupulous regulation to limit self-reactivity and autoimmunity. Our group has utilized a manganese porphyrin catalytic antioxidant (MnTE-2-PyP(5+), MnP) as a potential immunoregulatory therapy for type 1 diabetes. MnP has previously been shown to modulate diabetogenic immune responses ... Read more >>

Antioxid. Redox Signal. (Antioxidants & redox signaling)
[2013, 19(16):1902-1915]

Cited: 12 times

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Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids.

Meghan Delmastro-Greenwood, Bruce A Freeman, Stacy Gelhaus Wendell,

Unsaturated fatty acids are metabolized to reactive products that can act as pro- or anti-inflammatory signaling mediators. Electrophilic fatty acid species, including nitro- and oxo-containing fatty acids, display salutary anti-inflammatory and metabolic actions. Electrophilicity can be conferred by both enzymatic and oxidative reactions, via the homolytic addition of nitrogen dioxide ... Read more >>

Annu. Rev. Physiol. (Annual review of physiology)
[2014, 76:79-105]

Cited: 39 times

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Effects of metalloporphyrins on reducing inflammation and autoimmunity.

Meghan M Delmastro-Greenwood, Hubert M Tse, Jon D Piganelli,

High levels of reactive oxygen species can facilitate DNA and protein damage beyond the control of endogenous antioxidants, resulting in oxidative stress. Oxidative stress then triggers inflammation, which can lead to pathological conditions. In genetically susceptible individuals, the conglomeration of oxidative stress and inflammation can enhance autoreactive immune cell activation, ... Read more >>

Antioxid. Redox Signal. (Antioxidants & redox signaling)
[2014, 20(15):2465-2477]

Cited: 15 times

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Changing the energy of an immune response.

Meghan M Delmastro-Greenwood, Jon D Piganelli,

The breakdown of nutrients into the critical energy source ATP is the general purpose of cellular metabolism and is essential for sustaining life. Similarly, the immune system is composed of different cell subsets that are indispensable for defending the host against pathogens and disease. The interplay between metabolic pathways and ... Read more >>

Am J Clin Exp Immunol (American journal of clinical and experimental immunology)
[2013, 2(1):30-54]

Cited: 33 times

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