Full Text Journal Articles by
Author Megan M Senchuk

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Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways.

Emily Machiela, Thomas Liontis, Dylan J Dues, Paige D Rudich, Annika Traa, Leslie Wyman, Corah Kaufman, Jason F Cooper, Leira Lew, Saravanapriah Nadarajan, Megan M Senchuk, Jeremy M Van Raamsdonk,

Mitochondria are dynamic organelles that can change shape and size depending on the needs of the cell through the processes of mitochondrial fission and fusion. In this work, we investigated the role of mitochondrial dynamics in organismal stress response. By using C. elegans as a genetic model, we could visualize ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(6):8475-8492]

Cited: 0 times

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Resistance to Stress Can Be Experimentally Dissociated From Longevity.

Dylan J Dues, Emily K Andrews, Megan M Senchuk, Jeremy M Van Raamsdonk,

On the basis of multiple experiments demonstrating that high resistance to stress is associated with long lifespan, it has been proposed that stress resistance is a key determinant of longevity. However, the extent to which high resistance to stress is necessary or sufficient for long life is currently unclear. In ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2019, 74(8):1206-1214]

Cited: 4 times

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Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.

Ziyun Wu, Megan M Senchuk, Dylan J Dues, Benjamin K Johnson, Jason F Cooper, Leira Lew, Emily Machiela, Claire E Schaar, Heather DeJonge, T Keith Blackwell, Jeremy M Van Raamsdonk,

BACKGROUND:The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria. This pathway has been proposed to influence lifespan, with studies suggesting that mitoUPR activation has complex effects on longevity. RESULTS:Here, we examined the contribution of the mitoUPR to the survival and ... Read more >>

BMC Biol (BMC biology)
[2018, 16(1):147]

Cited: 6 times

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α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease.

Jason F Cooper, Katie K Spielbauer, Megan M Senchuk, Saravanapriah Nadarajan, Monica P Colaiácovo, Jeremy M Van Raamsdonk,

Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by the formation of α-synuclein-containing protein aggregates called Lewy bodies within the brain. A crucial role for α-synuclein in the pathogenesis of PD is also suggested by the fact that point mutations, increased copy number, or polymorphisms ... Read more >>

Exp Neurol (Experimental neurology)
[2018, 310:58-69]

Cited: 7 times

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Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.

Megan M Senchuk, Dylan J Dues, Claire E Schaar, Benjamin K Johnson, Zachary B Madaj, Megan J Bowman, Mary E Winn, Jeremy M Van Raamsdonk,

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (clk-1, isp-1 and nuo-6) to identify overlapping genetic pathways that contribute to their longevity. We find that genes regulated by the FOXO transcription ... Read more >>

PLoS Genet (PLoS genetics)
[2018, 14(3):e1007268]

Cited: 14 times

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Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans.

Dylan J Dues, Claire E Schaar, Benjamin K Johnson, Megan J Bowman, Mary E Winn, Megan M Senchuk, Jeremy M Van Raamsdonk,

Mutations affecting components of the mitochondrial electron transport chain have been shown to increase lifespan in multiple species including the worm Caenorhabditis elegans. While it was originally proposed that decreased generation of reactive oxygen species (ROS) resulting from lower rates of electron transport could account for the observed increase in ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2017, 108:362-373]

Cited: 12 times

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Measuring Oxidative Stress in Caenorhabditis elegans: Paraquat and Juglone Sensitivity Assays.

Megan M Senchuk, Dylan J Dues, Jeremy M Van Raamsdonk,

Oxidative stress has been proposed to be one of the main causes of aging and has been implicated in the pathogenesis of many diseases. Sensitivity to oxidative stress can be measured by quantifying survival following exposure to a reactive oxygen species (ROS)-generating compound such as paraquat or juglone. Sensitivity to ... Read more >>

Bio Protoc (Bio-protocol)
[2017, 7(1):]

Cited: 8 times

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Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways.

Dylan J Dues, Emily K Andrews, Claire E Schaar, Alexis L Bergsma, Megan M Senchuk, Jeremy M Van Raamsdonk,

In this work, we examine the relationship between stress resistance and aging. We find that resistance to multiple types of stress peaks during early adulthood and then declines with age. To dissect the underlying mechanisms, we use C. elegans transcriptional reporter strains that measure the activation of different stress responses ... Read more >>

Aging (Albany NY) (Aging)
[2016, 8(4):777-795]

Cited: 32 times

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Oxidative stress is increased in C. elegans models of Huntington's disease but does not contribute to polyglutamine toxicity phenotypes.

Emily Machiela, Dylan J Dues, Megan M Senchuk, Jeremy M Van Raamsdonk,

Huntington's disease (HD) is an adult onset neurodegenerative disorder for which there is currently no cure. While HD patients and animal models of the disease exhibit increased oxidative damage, it is currently uncertain to what extent oxidative stress contributes to disease pathogenesis. In this work, we use a genetic approach ... Read more >>

Neurobiol. Dis. (Neurobiology of disease)
[2016, 96:1-11]

Cited: 17 times

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Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models.

Jason F Cooper, Dylan J Dues, Katie K Spielbauer, Emily Machiela, Megan M Senchuk, Jeremy M Van Raamsdonk,

Aging is the greatest risk factor for the development of Parkinson's disease (PD). However, the role of aging in the pathogenesis of PD is not known and it is currently uncertain why the symptoms take many decades to develop when inherited mutations that cause the disease can be present from ... Read more >>

(NPJ Parkinson's disease)
[2015, 1:15022]

Cited: 26 times

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Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4.

Kye Won Park, Lisa D Urness, Megan M Senchuk, Carrie J Colvin, Joshua D Wythe, Chi-Bin Chien, Dean Y Li,

Netrin 1 is a diffusible factor that attracts commissural axons to the floor plate of the spinal cord. Recent evidence indicates that Netrin 1 is widely expressed and functions in the development of multiple organ systems. In mammals, there are three genes encoding Netrins, whereas in zebrafish, only the Netrin ... Read more >>

Dev Dyn (Developmental dynamics : an official publication of the American Association of Anatomists)
[2005, 234(3):726-731]

Cited: 15 times

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