Full Text Journal Articles by
Author Megan J Fitzpatrick

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JAK2 Rearrangements Are a Recurrent Alteration in CD30+ Systemic T-Cell Lymphomas With Anaplastic Morphology.

Megan J Fitzpatrick, Lucas R Massoth, Chelsea Marcus, Jo-Anne Vergilio, Eric Severson, Daniel Duncan, Shakti H Ramkissoon, Robert P Hasserjian, Annette S Kim, Aliyah R Sohani, Erik A Williams, Valentina Nardi,

Peripheral T-cell lymphoma (PTCL) comprises a heterogenous group of rare mature T-cell neoplasms. While some PTCL subtypes are well-characterized by histology, immunophenotype, and recurrent molecular alterations, others remain incompletely defined. In particular, the distinction between CD30+ PTCL, not otherwise specified and anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma can ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):895-904]

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Impact of initial biopsy type on the time to final diagnostic biopsy in patients with follicular lymphoma and suspected histologic transformation.

Eric Mou, Lorenzo Falchi, Vandana Sundaram, Jeremy S Abramson, Ronald Balassanian, Sara Beygi, Megan J Fitzpatrick, Annabel Kate Frank, Srishti Gupta, Oscar Lin, Steven R Long, Joshua R Menke, Daniel R Reed, Roberto Ruiz-Cordero, Ashley K Volaric, Yi Xie, Linlin Wang, Kwun Wah Wen, Sara L Zadeh, Yasodha Natkunam, Matthew C Cheung, Dita Gratzinger, ,

Diagnosis of histologic transformation (HT) of follicular lymphoma (FL) requires tissue biopsy. While surgical biopsy represents the gold standard, less invasive procedures such as fine-needle aspiration biopsy (FNAB) and core needle biopsy (CNB) are frequently performed. In this retrospective multi-institutional study including 269 patients with FL and suspected HT, the ... Read more >>

Leuk Lymphoma (Leukemia & lymphoma)
[2021, :1-9]

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Clinicopathologic Features of Peripheral T-Cell Lymphoma in Sub-Saharan Africa.

Megan J Fitzpatrick, Shahin Sayed, Zahir Moloo, Mukendi K A Kayembe, Drucilla J Roberts, Thu-Anh Pham, Liqiang Xi, Mark Raffeld, Abner Louissaint, Aliyah R Sohani,

<h4>Objectives</h4>Peripheral T-cell lymphomas (PTCLs) are heterogeneous, clinically aggressive, and rare. Subtype distribution varies by geographic location; however, data from sub-Saharan Africa (SSA) are lacking. We sought to elucidate clinicopathologic features of PTCL in SSA.<h4>Methods</h4>We reviewed PTCL consultation cases from three SSA countries. PTCL subtype was determined per 2017 World Health ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2021, 156(1):42-55]

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Plasma cell myeloma: role of histopathology, immunophenotyping, and genetic testing.

Megan J Fitzpatrick, Valentina Nardi, Aliyah R Sohani,

Myeloma is a malignant neoplasm of plasma cells with complex pathogenesis. Diagnosis and risk stratification require the integration of histology, radiology, serology, and genetic data. Bone marrow biopsies are essential for myeloma diagnosis by providing material for histologic and cytologic assessment as well as immunophenotypic and genetic studies. Flow cytometry ... Read more >>

Skeletal Radiol (Skeletal radiology)
[2021, :]

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Malignant peritoneal mesothelioma presenting as a splenic mass.

Mark Podberezin, Megan J Fitzpatrick, Lida P Hariri, Lynette Sholl,

Pathol Res Pract (Pathology, research and practice)
[2020, 216(12):153273]

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Future winters present a complex energetic landscape of decreased costs and reduced risk for a freeze‐tolerant amphibian, the Wood Frog (Lithobates sylvaticus)

Megan J Fitzpatrick, Warren P Porter, Jonathan N Pauli, Michael R Kearney, Michael Notaro, Benjamin Zuckerberg,

Winter climate warming is rapidly leading to changes in snow depth and soil temperatures across mid‐ and high‐latitude ecosystems, with important implications for survival and distribution of species that overwinter beneath the snow. Amphibians are a particularly vulnerable group to winter climate change because of the tight coupling between their ... Read more >>

(Global change biology.)
[2020, 26(11):6350-6362]

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Future winters present a complex energetic landscape of decreased costs and reduced risk for a freeze-tolerant amphibian, the Wood Frog (Lithobates sylvaticus).

Megan J Fitzpatrick, Warren P Porter, Jonathan N Pauli, Michael R Kearney, Michael Notaro, Benjamin Zuckerberg,

Winter climate warming is rapidly leading to changes in snow depth and soil temperatures across mid- and high-latitude ecosystems, with important implications for survival and distribution of species that overwinter beneath the snow. Amphibians are a particularly vulnerable group to winter climate change because of the tight coupling between their ... Read more >>

Glob Chang Biol (Global change biology)
[2020, 26(11):6350-6362]

Cited: 1 time

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Clinical sensitivity and interpretation of PCR and serological COVID-19 diagnostics for patients presenting to the hospital.

Tyler E Miller, Wilfredo F Garcia Beltran, Adam Z Bard, Tasos Gogakos, Melis N Anahtar, Michael Gerino Astudillo, Diane Yang, Julia Thierauf, Adam S Fisch, Grace K Mahowald, Megan J Fitzpatrick, Valentina Nardi, Jared Feldman, Blake M Hauser, Timothy M Caradonna, Hetal D Marble, Lauren L Ritterhouse, Sara E Turbett, Julie Batten, Nicholas Zeke Georgantas, Galit Alter, Aaron G Schmidt, Jason B Harris, Jeffrey A Gelfand, Mark C Poznansky, Bradley E Bernstein, David N Louis, Anand Dighe, Richelle C Charles, Edward T Ryan, John A Branda, Virginia M Pierce, Mandakolathur R Murali, A John Iafrate, Eric S Rosenberg, Jochen K Lennerz,

The diagnosis of COVID-19 requires integration of clinical and laboratory data. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic assays play a central role in diagnosis and have fixed technical performance metrics. Interpretation becomes challenging because the clinical sensitivity changes as the virus clears and the immune response emerges. Our ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(10):13877-13884]

Cited: 25 times

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Evaluating triage protocols for endoscopic ultrasound-guided fine needle biopsies of the pancreas.

Megan J Fitzpatrick, Yasmin Genevieve Hernandez-Barco, Kumar Krishnan, Brenna Casey, Martha B Pitman,

INTRODUCTION:Pancreatic endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) acquires both direct smear and small core biopsy specimens. The triage protocols for pancreatic FNBs to cytopathology (CP) or gastrointestinal surgical pathology (GIP) are controversial and vary by institution. MATERIAL AND METHODS:Pancreatic EUS-FNBs obtained with the SharkCore FNB were reviewed from January 2014 ... Read more >>

J Am Soc Cytopathol (Journal of the American Society of Cytopathology)
[2020, 9(5):396-404]

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A 39-Year-Old Male Congenital Tricuspid Atresia Patient Who Presented with a New Axillary Lesion after an Orthotopic Heart Transplant.

Zizi Yu, Nicholas Theodosakis, Megan J Fitzpatrick, Ruth K Foreman, Bonnie Mackool,

Mucormycosis is a rare and aggressive fungal infection, most often caused by species of the Mucor, Rhizomucor, Rhizopus, Absidia, and Cunninghamella genera. The condition most commonly affects patients with uncontrolled diabetes, HIV/AIDS, malignancy, and those receiving long-term immunosuppressive therapy. We report the case of a 39-year-old male with biopsy-proven cutaneous ... Read more >>

Dermatopathology (Basel) (Dermatopathology (Basel, Switzerland))
[2019, 6(4):220-224]

Cited: 0 times

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Diagnostic yield of the SharkCore EUS-guided fine-needle biopsy.

Megan J Fitzpatrick, Yasmin Genevieve Hernandez-Barco, Kumar Krishnan, William Brugge, Brenna Casey, Martha B Pitman,

<h4>Introduction</h4>Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the standard diagnostic procedure for many intrathoracic and intra-abdominal lesions. Next-generation fine-needle biopsies (FNBs) can increase diagnostic yield by procuring tissue suitable for histological processing. We evaluate the diagnostic yield and operating characteristics of the SharkCore (SC; Medtronic Corp., Minneapolis, MN) FNB in a ... Read more >>

J Am Soc Cytopathol (Journal of the American Society of Cytopathology)
[2019, 8(4):212-219]

Cited: 2 times

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Coagulation factor abnormalities related to discordance between anti-factor Xa and activated partial thromboplastin time in patients supported with continuous-flow left ventricular assist devices.

Sirtaz Adatya, Roy Sunny, Megan J Fitzpatrick, Monica Colvin, Thennapan Thennapan, Ranjit John, Nicole Dodge Zantek, Marc Pritzker, Peter Eckman, Nir Uriel,

<h4>Background</h4>High levels of discordance between activated partial thromboplastin time (aPTT) and anti-factor Xa (anti-FXa) have been reported in patients with continuous-flow left ventricular assist devices (CF-LVADs). We sought to determine the biochemical basis for discordance by simultaneous measurement of coagulation factors with aPTT and anti-FXa.<h4>Methods</h4>Consecutive CF-LVAD patients admitted for intravenous ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2016, 35(11):1311-1320]

Cited: 5 times

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Validation of a Mechanistic Model for Non-Invasive Study of Ecological Energetics in an Endangered Wading Bird with Counter-Current Heat Exchange in its Legs.

Megan J Fitzpatrick, Paul D Mathewson, Warren P Porter,

Mechanistic models provide a powerful, minimally invasive tool for gaining a deeper understanding of the ecology of animals across geographic space and time. In this paper, we modified and validated the accuracy of the mechanistic model Niche Mapper for simulating heat exchanges of animals with counter-current heat exchange mechanisms in ... Read more >>

PLoS One (PloS one)
[2015, 10(8):e0136677]

Cited: 4 times

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