Full Text Journal Articles by
Author May J Reed


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Frailty status as a potential factor in increased postoperative opioid use in older adults.

Elizabeth D Auckley, Nathalie Bentov, Shira Zelber-Sagi, Lily Jeong, May J Reed, Itay Bentov,

<h4>Background</h4>Prescription opioids are commonly used for postoperative pain relief in older adults, but have the potential for misuse. Both opioid side effects and uncontrolled pain have detrimental impacts. Frailty syndrome (reduced reserve in response to stressors), pain, and chronic opioid consumption are all complex phenomena that impair function, nutrition, psychologic ... Read more >>

BMC Geriatr (BMC geriatrics)
[2021, 21(1):189]

Cited: 0 times

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Healthy aging and the blood-brain barrier.

William A Banks, May J Reed, Aric F Logsdon, Elizabeth M Rhea, Michelle A Erickson,

The blood-brain barrier (BBB) protects the central nervous system (CNS) from unregulated exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain-to-blood permeation of many substances, resulting in nourishment of the CNS, its homeostatic regulation and communication between the CNS and peripheral tissues. The cells ... Read more >>

Nat Aging (Nature aging)
[2021, 1(3):243-254]

Cited: 1 time

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The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice.

Elizabeth M Rhea, Aric F Logsdon, Kim M Hansen, Lindsey M Williams, May J Reed, Kristen K Baumann, Sarah J Holden, Jacob Raber, William A Banks, Michelle A Erickson,

It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein. We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood-brain barrier in ... Read more >>

Nat Neurosci (Nature neuroscience)
[2021, 24(3):368-378]

Cited: 43 times

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The microvascular extracellular matrix in brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA).

Mamatha Damodarasamy, Robert B Vernon, Jasmine L Pathan, C Dirk Keene, Anthony J Day, William A Banks, May J Reed,

<h4>Background</h4>The microvasculature (MV) of brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA), in the absence of concurrent pathologies (e.g., infarctions, Lewy bodies), is incompletely understood.<h4>Objective</h4>To analyze microvascular density, diameter and extracellular matrix (ECM) content in association with ADNC and CAA.<h4>Methods</h4>We examined samples of cerebral cortex and ... Read more >>

Fluids Barriers CNS (Fluids and barriers of the CNS)
[2020, 17(1):60]

Cited: 0 times

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Thresholds and Mortality Associations of Paraspinous Muscle Sarcopenia in Older Trauma Patients.

Stephen J Kaplan, K Lynn Zhao, Melanie Koren, Itay Bentov, May J Reed, Tam N Pham,

JAMA Surg (JAMA surgery)
[2020, 155(7):662-664]

Cited: 1 time

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A Rapid Method to Preoperatively Assess Frailty for Older Patients with Pelvic Floor Conditions.

Katherine A Amin, Wai Lee, Dena Moskowitz, Kathleen C Kobashi, Alvaro Lucioni, May J Reed, Michael Nash, Una J Lee,

PURPOSE:Assessment of frailty can help surgeons predict perioperative risk and guide preoperative counseling. However, current methods are often cumbersome in the clinical setting. We prospectively compared the effectiveness of a rapid picture based Clinical Frailty Scale (CFS-9) assessed by patient and surgeon against reference standard Fried Frailty Index in older ... Read more >>

J Urol (The Journal of urology)
[2020, 203(6):1172-1177]

Cited: 1 time

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The extracellular matrix of the blood-brain barrier: structural and functional roles in health, aging, and Alzheimer's disease.

May J Reed, Mamatha Damodarasamy, William A Banks,

There is increasing interest in defining the location, content, and role of extracellular matrix (ECM) components in brain structure and function during development, aging, injury, and neurodegeneration. Studies in vivo confirm brain ECM has a dynamic composition with constitutive and induced alterations that impact subsequent cell-cell and cell-matrix interactions. Moreover, ... Read more >>

Tissue Barriers (Tissue barriers)
[2019, 7(4):1651157]

Cited: 10 times

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Creating the Next Generation of Translational Geroscientists.

John C Newman, Julie L Sokoloski, Paul D Robbins, Laura J Niedernhofer, May J Reed, Jeanne Wei, Steven N Austad, Nir Barzilai, Harvey Jay Cohen, George A Kuchel, James L Kirkland, Robert J Pignolo,

Advances in understanding fundamental processes of aging have led to a variety of investigational therapies to delay or prevent age-related diseases and conditions. These geroscience therapeutics hold the promise of revolutionizing medical care of older adults by treating the complex syndromes of aging and preserving health and independence. A crucial ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2019, 67(9):1934-1939]

Cited: 5 times

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Association of Brain Atrophy and Masseter Sarcopenia With 1-Year Mortality in Older Trauma Patients.

Christopher Tanabe, May J Reed, Tam N Pham, Kevin Penn, Itay Bentov, Stephen J Kaplan,

<h4>Importance</h4>Older adults are disproportionately affected by trauma and accounted for 47% of trauma fatalities in 2016. In many populations and disease processes, described risk factors for poor clinical outcomes include sarcopenia and brain atrophy, but these remain to be fully characterized in older trauma patients. Sarcopenia and brain atrophy may ... Read more >>

JAMA Surg (JAMA surgery)
[2019, 154(8):716-723]

Cited: 2 times

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Frailty assessment: from clinical to radiological tools.

Itay Bentov, Stephen J Kaplan, Tam N Pham, May J Reed,

Frailty is a syndrome of cumulative decline across multiple physiological systems, which predisposes vulnerable adults to adverse events. Assessing vulnerable patients can potentially lead to interventions that improve surgical outcomes. Anaesthesiologists who care for older patients can identify frailty to improve preoperative risk stratification and subsequent perioperative planning. Numerous clinical ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2019, 123(1):37-50]

Cited: 9 times

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Trauma Providers' Perceptions of Frailty Assessment: A Mixed-Methods Analysis of Knowledge, Attitudes, and Beliefs.

Thomas H Shoultz, Megan Moore, May J Reed, Stephen J Kaplan, Itay Bentov, Catherine Hough, Lisa A Taitsman, Steven H Mitchell, Grace E So, Saman Arbabi, Herb Phelan, Tam Pham,

OBJECTIVES:Quality improvement in geriatric trauma depends on timely identification of frailty, yet little is known about providers' knowledge and beliefs about frailty assessment. This study sought to understand trauma providers' understanding, beliefs, and practices for frailty assessment. METHODS:We developed a 20-question survey using the Health Belief Model of health behavior ... Read more >>

South Med J (Southern medical journal)
[2019, 112(3):159-163]

Cited: 1 time

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Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease.

May J Reed, Mamatha Damodarasamy, Jasmine L Pathan, Christina K Chan, Charles Spiekerman, Thomas N Wight, William A Banks, Anthony J Day, Robert B Vernon, C Dirk Keene,

Little is known about the extracellular matrix (ECM) during progression of AD pathology. Brain ECM is abundant in hyaluronan (HA), a non-sulfated glycosaminoglycan synthesized by HA synthases (HAS) 1-3 in a high molecular weight (MW) form that is degraded into lower MW fragments. We hypothesized that pathologic severity of AD ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2019, 67(1):91-102]

Cited: 6 times

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The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells.

Daniella Bianchi-Frias, Mamatha Damodarasamy, Susana A Hernandez, Rui M Gil da Costa, Funda Vakar-Lopez, Ilsa M Coleman, May J Reed, Peter S Nelson,

The incidence of prostate cancer is directly linked to age, but age-associated changes that facilitate prostate cancer development and progression are poorly understood. This study investigated age-related changes in the prostate microenvironment for their influence on prostate cancer behavior. Prostate cancer cells implanted orthotopically into the prostate demonstrated accelerated tumor ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2019, 17(1):321-331]

Cited: 8 times

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Utility of Geriatric Assessment in the Projection of Early Mortality Following Hip Fracture in the Elderly Patients.

Aunaly Palmer, Lisa A Taitsman, May J Reed, Bala G Nair, Itay Bentov,

Hip fractures result in significant morbidity and mortality in elders. Indicators of frailty are associated with poor outcomes. Commonly used frailty tools rely on motor skills that cannot be performed by this population. We determined the association between the Charlson Comorbidity Score (CCS), intraoperative hypotension (IOH), and a geriatric medicine ... Read more >>

Geriatr Orthop Surg Rehabil (Geriatric orthopaedic surgery & rehabilitation)
[2018, 9:2151459318813976]

Cited: 2 times

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The Effects of Normal Aging on Regional Accumulation of Hyaluronan and Chondroitin Sulfate Proteoglycans in the Mouse Brain.

May J Reed, Mamatha Damodarasamy, Jasmine L Pathan, Michelle A Erickson, William A Banks, Robert B Vernon,

The brain changes in volume and composition with normal aging. Cellular components of the brain are supported by an extracellular matrix (ECM) comprised largely of hyaluronan (HA) and HA-associated members of the lectican family of chondroitin sulfate proteoglycans (CSPGs). We examined regional differences in microvascular density, neuronal and glial markers, ... Read more >>

J Histochem Cytochem (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society)
[2018, 66(10):697-707]

Cited: 5 times

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Corrigendum to: Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.

Evan C Hadley, George A Kuchel, Anne B Newman, Heather G Allore, Jenna M Bartley, Cindy S Bergeman, Michael L Blinov, Cathleen S Colon-Emeric, Firdaus S Dabhar, Laura L Dugan, Chhanda Dutta, Basil A Eldadah, Luigi Ferrucci, James L Kirkland, Stephen B Kritchevsky, Lewis A Lipsitz, Neelesh K Nadkarni, May J Reed, Kenneth E Schmader, Felipe Sierra, Stephanie A Studenski, Ravi Varadhan, Jeremy D Walston, Heather E Whitson, Raymond Yung,

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2018, 73(7):995]

Cited: 2 times

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Comparison of bedside screening methods for frailty assessment in older adult trauma patients in the emergency department.

Sachita P Shah, Kevin Penn, Stephen J Kaplan, Michael Vrablik, Karl Jablonowski, Tam N Pham, May J Reed,

BACKGROUND:Frailty is linked to poor outcomes in older patients. We prospectively compared the utility of the picture-based Clinical Frailty Scale (CFS9), clinical assessments, and ultrasound muscle measurements against the reference FRAIL scale in older adult trauma patients in the emergency department (ED). METHODS:We recruited a convenience sample of adults 65 yrs. ... Read more >>

Am J Emerg Med (The American journal of emergency medicine)
[2019, 37(1):12-18]

Cited: 3 times

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The Effect of Computerized Physician Order Entry Template Modifications on the Administration of High-Risk Medications in Older Adults in the Emergency Department.

Mitchell Kim, Stephen J Kaplan, Steven H Mitchell, Medley Gatewood, Itay Bentov, Katherine A Bennett, Carol A Crawford, Paul R Sutton, Diane Matsuwaka, Mamatha Damodarasamy, May J Reed,

<h4>Background</h4>Older adults are more susceptible to adverse events when administered certain medications at doses appropriate for younger adults.<h4>Objective</h4>The aim of this study was to investigate the effect of default geriatric dosing on computerized physician order entry (CPOE) templates on the subsequent administration of recommended starting doses of opioids, benzodiazepines (BZDs) ... Read more >>

Drugs Aging (Drugs & aging)
[2017, 34(10):793-801]

Cited: 3 times

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Assessment of Osteoporosis in Injured Older Women Admitted to a Safety-Net Level One Trauma Center: A Unique Opportunity to Fulfill an Unmet Need.

Elisabeth S Young, May J Reed, Tam N Pham, Joel A Gross, Lisa A Taitsman, Stephen J Kaplan,

Background:Older trauma patients often undergo computed tomography (CT) as part of the initial work-up. CT imaging can also be used opportunistically to measure bone density and assess osteoporosis. Methods:In this retrospective cohort study, osteoporosis was ascertained from admission CT scans in women aged ≥65 admitted to the ICU for traumatic ... Read more >>

Curr Gerontol Geriatr Res (Current gerontology and geriatrics research)
[2017, 2017:4658050]

Cited: 0 times

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Older adults and high-risk medication administration in the emergency department.

Mitchell Kim, Steven H Mitchell, Medley Gatewood, Katherine A Bennett, Paul R Sutton, Carol A Crawford, Itay Bentov, Mamatha Damodarasamy, Stephen J Kaplan, May J Reed,

Background:Older adults are susceptible to adverse effects from opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and benzodiazepines (BZDs). We investigated factors associated with the administration of elevated doses of these medications of interest to older adults (≥65 years old) in the emergency department (ED). Patients and methods:ED records were queried for the ... Read more >>

Drug Healthc Patient Saf (Drug, healthcare and patient safety)
[2017, 9:105-112]

Cited: 2 times

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Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.

Evan C Hadley, George A Kuchel, Anne B Newman, ,

<h4>Background/objectives</h4>Resilience, the ability to resist or recover from adverse effects of a stressor, is of widespread interest in social, psychologic, biologic, and medical research and particularly salient as the capacity to respond to stressors becomes diminished with aging. To date, research on human resilience responses to and factors influencing these ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2017, 72(7):980-990]

Cited: 38 times

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Microvasculature of the Mouse Cerebral Cortex Exhibits Increased Accumulation and Synthesis of Hyaluronan With Aging.

May J Reed, Robert B Vernon, Mamatha Damodarasamy, Christina K Chan, Thomas N Wight, Itay Bentov, William A Banks,

The microvasculature of the aged brain is less dense and more vulnerable to dysfunction than that of the young brain. Brain microvasculature is supported by its surrounding extracellular matrix, which is comprised largely of hyaluronan (HA). HA is continually degraded into lower molecular weight forms that induce neuroinflammation. We examined ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2017, 72(6):740-746]

Cited: 8 times

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Association of Radiologic Indicators of Frailty With 1-Year Mortality in Older Trauma Patients: Opportunistic Screening for Sarcopenia and Osteopenia.

Stephen J Kaplan, Tam N Pham, Saman Arbabi, Joel A Gross, Mamatha Damodarasamy, Itay Bentov, Lisa A Taitsman, Steven H Mitchell, May J Reed,

<h4>Importance</h4>Assessment of physical frailty in older trauma patients admitted to the intensive care unit is often not feasible using traditional frailty assessment instruments. The use of opportunistic computed tomography (CT) scans to assess sarcopenia and osteopenia as indicators of underlying frailty may provide complementary prognostic information on long-term outcomes.<h4>Objective</h4>To determine ... Read more >>

JAMA Surg (JAMA surgery)
[2017, 152(2):e164604]

Cited: 25 times

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Lidocaine Impairs Proliferative and Biosynthetic Functions of Aged Human Dermal Fibroblasts.

Itay Bentov, Mamatha Damodarasamy, Charles Spiekerman, May J Reed,

<h4>Background</h4>The aged are at increased risk of postoperative wound healing complications. Because local anesthetics are infiltrated commonly into the dermis of surgical wounds, we sought to determine whether local anesthetics adversely affect proliferative and biosynthetic functions of dermal fibroblasts. We also evaluated the effect of local anesthetics on insulin-like growth ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2016, 123(3):616-623]

Cited: 2 times

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Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit.

William A Banks, Alicia M Gray, Michelle A Erickson, Therese S Salameh, Mamatha Damodarasamy, Nader Sheibani, James S Meabon, Emily E Wing, Yoichi Morofuji, David G Cook, May J Reed,

<h4>Background</h4>Disruption of the blood-brain barrier (BBB) occurs in many diseases and is often mediated by inflammatory and neuroimmune mechanisms. Inflammation is well established as a cause of BBB disruption, but many mechanistic questions remain.<h4>Methods</h4>We used lipopolysaccharide (LPS) to induce inflammation and BBB disruption in mice. BBB disruption was measured using ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2015, 12:223]

Cited: 142 times

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