Full Text Journal Articles by
Author Maurizio Baldassarre

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Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications.

Maurizio Baldassarre, Marina Naldi, Giacomo Zaccherini, Michele Bartoletti, Agnese Antognoli, Maristella Laggetta, Martina Gagliardi, Manuel Tufoni, Marco Domenicali, Katja Waterstradt, Paola Paterini, Anna Baldan, Simona Leoni, Manuela Bartolini, Pierluigi Viale, Franco Trevisani, Mauro Bernardi, Paolo Caraceni,

<h4>Background and aims</h4>Circulating albumin in cirrhosis can be dysfunctional because of accumulating structural damages, leading to the concept of effective albumin concentration (eAlb), referring to the albumin portion presenting structural and functional integrity. We aimed to estimate eAlb in patients with decompensated cirrhosis and analyze its relationships with albumin function ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, 74(4):2058-2073]

Cited: 3 times

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Insight into the internal structure of amyloid-β oligomers by isotope-edited Fourier transform infrared spectroscopy.

Cesare M Baronio, Maurizio Baldassarre, Andreas Barth,

The internal structure of amyloid-β (Aβ) oligomers was investigated with isotope-edited Fourier transform infrared spectroscopy. Homo-oligomers of Aβ40 and Aβ42 were prepared from unlabeled and 13C, 15N-labeled monomeric Aβ and from mixtures of these. For the unlabeled peptides, two main bands were observed in 2H2O at 1685 and 1622 cm-1 ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(16):8587-8597]

Cited: 7 times

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Knowledge of genito-urinary syndrome of menopause among Italian gynecologists: the DIADEM survey.

Stefania Alvisi, Maurizio Baldassarre, Giulia Gava, Ilaria Mancini, Angelo Cagnacci, Renato Seracchioli, Maria Cristina Meriggiola,

<h4>Objective</h4>The objective of this study was to present an updated picture of the knowledge and attitudes of Italian gynecologists with regard to the genitourinary syndrome of menopause (GSM).<h4>Study design</h4>An anonymous survey was sent via electronic mail to 3892 gynecologists. The survey consisted of 32 multiple-choice questions divided into four different ... Read more >>

Maturitas (Maturitas)
[2021, 143:89-95]

Cited: 0 times

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PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.

Jonel Trebicka, Javier Fernandez, Maria Papp, Paolo Caraceni, Wim Laleman, Carmine Gambino, Ilaria Giovo, Frank Erhard Uschner, Christian Jansen, Cesar Jimenez, Rajeshwar Mookerjee, Thierry Gustot, Agustin Albillos, Rafael Bañares, Peter Jarcuska, Christian Steib, Thomas Reiberger, Juan Acevedo, Pietro Gatti, Debbie L Shawcross, Stefan Zeuzem, Alexander Zipprich, Salvatore Piano, Thomas Berg, Tony Bruns, Karen Vagner Danielsen, Minneke Coenraad, Manuela Merli, Rudolf Stauber, Heinz Zoller, José Presa Ramos, Cristina Solé, Germán Soriano, Andrea de Gottardi, Henning Gronbaek, Faouzi Saliba, Christian Trautwein, Haluk Tarik Kani, Sven Francque, Stephen Ryder, Pierre Nahon, Manuel Romero-Gomez, Hans Van Vlierberghe, Claire Francoz, Michael Manns, Elisabet Garcia-Lopez, Manuel Tufoni, Alex Amoros, Marco Pavesi, Cristina Sanchez, Michael Praktiknjo, Anna Curto, Carla Pitarch, Antonella Putignano, Esau Moreno, William Bernal, Ferran Aguilar, Joan Clària, Paola Ponzo, Zsuzsanna Vitalis, Giacomo Zaccherini, Boglarka Balogh, Alexander Gerbes, Victor Vargas, Carlo Alessandria, Mauro Bernardi, Pere Ginès, Richard Moreau, Paolo Angeli, Rajiv Jalan, Vicente Arroyo, ,

<h4>Background & aims</h4>Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading to both of these AD phenotypes.<h4>Methods</h4>The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized ... Read more >>

J Hepatol (Journal of hepatology)
[2021, 74(5):1097-1108]

Cited: 17 times

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Author Correction: Hypothermic Oxygenated New Machine Perfusion System in Liver and Kidney Transplantation of Extended Criteria Donors: First Italian Clinical Trial.

Matteo Ravaioli, Vanessa De Pace, Andrea Angeletti, Giorgia Comai, Francesco Vasuri, Maurizio Baldassarre, Lorenzo Maroni, Federica Odaldi, Guido Fallani, Paolo Caraceni, Giuliana Germinario, Chiara Donadei, Deborah Malvi, Massimo Del Gaudio, Valentina Rosa Bertuzzo, Antonio Siniscalchi, Vito Marco Ranieri, Antonietta D'Errico, Gianandrea Pasquinelli, Maria Cristina Morelli, Antonio Daniele Pinna, Matteo Cescon, Gaetano La Manna,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):14658]

Cited: 0 times

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On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites.

Paolo Caraceni, Manuel Tufoni, Giacomo Zaccherini, Oliviero Riggio, Paolo Angeli, Carlo Alessandria, Sergio Neri, Francesco G Foschi, Fabio Levantesi, Aldo Airoldi, Loredana Simone, Gianluca Svegliati-Baroni, Stefano Fagiuoli, Giacomo Laffi, Raffaele Cozzolongo, Vito Di Marco, Vincenzo Sangiovanni, Filomena Morisco, Pierluigi Toniutto, Antonio Gasbarrini, Rosanna De Marco, Salvatore Piano, Silvia Nardelli, Chiara Elia, Andrea Roncadori, Maurizio Baldassarre, Mauro Bernardi, ,

<h4>Background & aims</h4>The ANSWER study reported that long-term albumin administration in patients with cirrhosis and uncomplicated ascites improves survival. During treatment, serum albumin increased within a month and remained stable thereafter. In this post hoc analysis, we aimed to determine whether on-treatment serum albumin levels could guide therapy.<h4>Methods</h4>Logistic regression was ... Read more >>

J Hepatol (Journal of hepatology)
[2021, 74(2):340-349]

Cited: 4 times

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Hemodynamic and Systemic Effects of Albumin in Patients with Advanced Liver Disease.

Manuel Tufoni, Maurizio Baldassarre, Giacomo Zaccherini, Agnese Antognoli, Paolo Caraceni,

<h4>Purpose of review</h4>Albumin administration is recommended to prevent or treat specific complications of decompensated cirrhosis based on its capacity to expand plasma volume. However, the molecule also has many other biological properties that are unrelated to the oncotic activity. The purpose of this review is to examine the hemodynamic and ... Read more >>

Curr Hepatol Rep (Current hepatology reports)
[2020, :1-12]

Cited: 2 times

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The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology.

Jonel Trebicka, Javier Fernandez, Maria Papp, Paolo Caraceni, Wim Laleman, Carmine Gambino, Ilaria Giovo, Frank Erhard Uschner, Cesar Jimenez, Rajeshwar Mookerjee, Thierry Gustot, Agustin Albillos, Rafael Bañares, Martin Janicko, Christian Steib, Thomas Reiberger, Juan Acevedo, Pietro Gatti, William Bernal, Stefan Zeuzem, Alexander Zipprich, Salvatore Piano, Thomas Berg, Tony Bruns, Flemming Bendtsen, Minneke Coenraad, Manuela Merli, Rudolf Stauber, Heinz Zoller, José Presa Ramos, Cristina Solè, Germán Soriano, Andrea de Gottardi, Henning Gronbaek, Faouzi Saliba, Christian Trautwein, Osman Cavit Özdogan, Sven Francque, Stephen Ryder, Pierre Nahon, Manuel Romero-Gomez, Hans Van Vlierberghe, Claire Francoz, Michael Manns, Elisabet Garcia, Manuel Tufoni, Alex Amoros, Marco Pavesi, Cristina Sanchez, Anna Curto, Carla Pitarch, Antonella Putignano, Esau Moreno, Debbie Shawcross, Ferran Aguilar, Joan Clària, Paola Ponzo, Christian Jansen, Zsuzsanna Vitalis, Giacomo Zaccherini, Boglarka Balogh, Victor Vargas, Sara Montagnese, Carlo Alessandria, Mauro Bernardi, Pere Ginès, Rajiv Jalan, Richard Moreau, Paolo Angeli, Vicente Arroyo, ,

<h4>Background & aims</h4>Acute decompensation (AD) of cirrhosis is defined as the acute development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof, requiring hospitalization. The presence of organ failure(s) in patients with AD defines acute-on-chronic liver failure (ACLF). The PREDICT study is a European, prospective, observational study, designed ... Read more >>

J Hepatol (Journal of hepatology)
[2020, 73(4):842-854]

Cited: 33 times

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Correction to 'Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF' [J Hepatol 2020 (72) 688-701].

Richard Moreau, Joan Clària, Ferran Aguilar, François Fenaille, Juan José Lozano, Christophe Junot, Benoit Colsch, Paolo Caraceni, Jonel Trebicka, Marco Pavesi, Carlo Alessandria, Frederik Nevens, Faouzi Saliba, Tania M Welzel, Agustin Albillos, Thierry Gustot, Javier Fernández, Christophe Moreno, Maurizio Baldassarre, Giacomo Zaccherini, Salvatore Piano, Sara Montagnese, Victor Vargas, Joan Genescà, Elsa Solà, William Bernal, Noémie Butin, Thaïs Hautbergue, Sophie Cholet, Florence Castelli, Christian Jansen, Christian Steib, Daniela Campion, Raj Mookerjee, Miguel Rodríguez-Gandía, German Soriano, François Durand, Daniel Benten, Rafael Bañares, Rudolf E Stauber, Henning Gronbaek, Minneke J Coenraad, Pere Ginès, Alexander Gerbes, Rajiv Jalan, Mauro Bernardi, Vicente Arroyo, Paolo Angeli, , ,

J Hepatol (Journal of hepatology)
[2020, 72(6):1218-1220]

Cited: 1 time

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Hypothermic Oxygenated Perfusion Versus Static Cold Storage for Expanded Criteria Donors in Liver and Kidney Transplantation: Protocol for a Single-Center Randomized Controlled Trial.

Matteo Ravaioli, Lorenzo Maroni, Andrea Angeletti, Guido Fallani, Vanessa De Pace, Giuliana Germinario, Federica Odaldi, Valeria Corradetti, Paolo Caraceni, Maurizio Baldassarre, Francesco Vasuri, Antonia D'Errico, Gabriela Sangiorgi, Antonio Siniscalchi, Maria Cristina Morelli, Anna Rossetto, Vito Marco Ranieri, Matteo Cescon, Massimo Del Gaudio, Chiara Zanfi, Valentina Bertuzzo, Giorgia Comai, Gaetano La Manna,

BACKGROUND:Extended criteria donors (ECD) are widely utilized due to organ shortage, but they may increase the risk of graft dysfunction and poorer outcomes. Hypothermic oxygenated perfusion (HOPE) is a recent organ preservation strategy for marginal kidney and liver grafts, allowing a redirect from anaerobic metabolism to aerobic metabolism under hypothermic ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(3):e13922]

Cited: 0 times

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Hypothermic Oxygenated New Machine Perfusion System in Liver and Kidney Transplantation of Extended Criteria Donors:First Italian Clinical Trial.

Matteo Ravaioli, Vanessa De Pace, Andrea Angeletti, Giorgia Comai, Francesco Vasuri, Maurizio Baldassarre, Lorenzo Maroni, Federica Odaldi, Guido Fallani, Paolo Caraceni, Giuliana Germinario, Chiara Donadei, Deborah Malvi, Massimo Del Gaudio, Valentina Rosa Bertuzzo, Antonio Siniscalchi, Vito Marco Ranieri, Antonietta D'Errico, Gianandrea Pasquinelli, Maria Cristina Morelli, Antonio Daniele Pinna, Matteo Cescon, Gaetano La Manna,

With the aim to explore innovative tools for organ preservation, especially in marginal organs, we hereby describe a clinical trial of ex-vivo hypothermic oxygenated perfusion (HOPE) in the field of liver (LT) and kidney transplantation (KT) from Extended Criteria Donors (ECD) after brain death. A matched-case analysis of donor and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):6063]

Cited: 10 times

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Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF.

Richard Moreau, Joan Clària, Ferran Aguilar, François Fenaille, Juan José Lozano, Christophe Junot, Benoit Colsch, Paolo Caraceni, Jonel Trebicka, Marco Pavesi, Carlo Alessandria, Frederik Nevens, Faouzi Saliba, Tania M Welzel, Agustin Albillos, Thierry Gustot, Javier Fernández, Christophe Moreno, Maurizio Baldassarre, Giacomo Zaccherini, Salvatore Piano, Sara Montagnese, Victor Vargas, Joan Genescà, Elsa Solà, William Bernal, Noémie Butin, Thaïs Hautbergue, Sophie Cholet, Florence Castelli, Christian Jansen, Christian Steib, Daniela Campion, Raj Mookerjee, Miguel Rodríguez-Gandía, German Soriano, François Durand, Daniel Benten, Rafael Bañares, Rudolf E Stauber, Henning Gronbaek, Minneke J Coenraad, Pere Ginès, Alexander Gerbes, Rajiv Jalan, Mauro Bernardi, Vicente Arroyo, Paolo Angeli, , , ,

<h4>Background & aims</h4>Acute-on-chronic liver failure (ACLF), which develops in patients with cirrhosis, is characterized by intense systemic inflammation and organ failure(s). Because systemic inflammation is energetically expensive, its metabolic costs may result in organ dysfunction/failure. Therefore, we aimed to analyze the blood metabolome in patients with cirrhosis, with and without ... Read more >>

J Hepatol (Journal of hepatology)
[2020, 72(4):688-701]

Cited: 30 times

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Vaginal Health in Menopausal Women.

Stefania Alvisi, Giulia Gava, Isabella Orsili, Giulia Giacomelli, Maurizio Baldassarre, Renato Seracchioli, Maria Cristina Meriggiola,

The aim of this review is to provide an overview of genitourinary health in peri- and postmenopause, particularly of vulvovaginal atrophy (VVA), which is part of genitourinary syndrome (GSM). This condition has a high prevalence among post-menopausal women and negatively affects a woman's quality of life. Epidemiology, signs, symptoms, diagnostic ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(10):]

Cited: 4 times

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Extended Infusion of β-Lactams for Bloodstream Infection in Patients With Liver Cirrhosis: An Observational Multicenter Study.

Michele Bartoletti, Maddalena Giannella, Russell E Lewis, Paolo Caraceni, Sara Tedeschi, Mical Paul, Christoph Schramm, Tony Bruns, Manuela Merli, Nazaret Cobos-Trigueros, Elena Seminari, Pilar Retamar, Patricia Muñoz, Mario Tumbarello, Patrizia Burra, Maria Torrani Cerenzia, Bruno Barsic, Ester Calbo, Alberto Enrico Maraolo, Nicola Petrosillo, Maria Angeles Galan-Ladero, Gianpiero D'Offizi, Yael Zak-Doron, Jesus Rodriguez-Baño, Maurizio Baldassarre, Gabriella Verucchi, Marco Domenicali, Mauro Bernardi, Pierluigi Viale, ,

<h4>Background</h4>We analyzed the impact of continuous/extended infusion (C/EI) vs intermittent infusion of piperacillin-tazobactam (TZP) and carbapenems on 30-day mortality of patients with liver cirrhosis and bloodstream infection (BSI).<h4>Methods</h4>The BICRHOME study was a prospective, multicenter study that enrolled 312 cirrhotic patients with BSI. In this secondary analysis, we selected patients receiving ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 69(10):1731-1739]

Cited: 1 time

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The Analysis of Food Intake in Patients with Cirrhosis Waiting for Liver Transplantation: A Neglected Step in the Nutritional Assessment.

Francesco Palmese, Ilaria Bolondi, Ferdinando Antonino Giannone, Giacomo Zaccherini, Manuel Tufoni, Maurizio Baldassarre, Paolo Caraceni,

Patients with cirrhosis waiting for liver transplantation (LT) frequently present a nutritional disorder, which represents an independent predictor of morbidity and mortality before and after transplantation. Thus, a proper assessment of the food intake by using different methods, such as food records, food frequency questionnaires, and 24 h recall, should ... Read more >>

Nutrients (Nutrients)
[2019, 11(10):]

Cited: 1 time

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Prediction of nosocomial acute-on-chronic liver failure in patients with cirrhosis admitted to hospital with acute decompensation.

Giacomo Zaccherini, Maurizio Baldassarre, Michele Bartoletti, Manuel Tufoni, Sonia Berardi, Mariarosa Tamè, Lucia Napoli, Antonio Siniscalchi, Angela Fabbri, Lorenzo Marconi, Agnese Antognoli, Giulia Iannone, Marco Domenicali, Pierluigi Viale, Franco Trevisani, Mauro Bernardi, Paolo Caraceni,

Nosocomial acute-on-chronic liver failure (nACLF) develops in at least 10% of patients with cirrhosis hospitalized for acute decompensation (AD), greatly worsening their prognosis. In this prospective observational study, we aimed to identify rapidly obtainable predictors at admission, which allow for the early recognition and stratification of patients at risk of ... Read more >>

JHEP Rep (JHEP reports : innovation in hepatology)
[2019, 1(4):270-277]

Cited: 1 time

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A Mediterranean Diet Mix Has Chemopreventive Effects in a Murine Model of Colorectal Cancer Modulating Apoptosis and the Gut Microbiota.

Giulia Piazzi, Anna Prossomariti, Maurizio Baldassarre, Claudio Montagna, Paola Vitaglione, Vincenzo Fogliano, Elena Biagi, Marco Candela, Patrizia Brigidi, Tiziana Balbi, Alessandra Munarini, Andrea Belluzzi, Milena Pariali, Franco Bazzoli, Luigi Ricciardiello,

Objectives: Unhealthy dietary patterns have been associated with colorectal cancer (CRC) onset while Mediterranean Diet (MD) has been proposed for CRC prevention. This study evaluated the effect of a Mediterranean Diet Mix (MD-MIX) on colonic tumors development in A/J mice fed a low-fat (LFD) or a high-fat western diet (HFWD), ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:140]

Cited: 5 times

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Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.

Ivana Kurelac, Luisa Iommarini, Renaud Vatrinet, Laura Benedetta Amato, Monica De Luise, Giulia Leone, Giulia Girolimetti, Nikkitha Umesh Ganesh, Victoria Louise Bridgeman, Luigi Ombrato, Marta Columbaro, Moira Ragazzi, Lara Gibellini, Manuela Sollazzo, Rene Gunther Feichtinger, Silvia Vidali, Maurizio Baldassarre, Sarah Foriel, Michele Vidone, Andrea Cossarizza, Daniela Grifoni, Barbara Kofler, Ilaria Malanchi, Anna Maria Porcelli, Giuseppe Gasparre,

Converting carcinomas in benign oncocytomas has been suggested as a potential anti-cancer strategy. One of the oncocytoma hallmarks is the lack of respiratory complex I (CI). Here we use genetic ablation of this enzyme to induce indolence in two cancer types, and show this is reversed by allowing the stabilization ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):903]

Cited: 19 times

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Structure of Epithelial and Stromal Compartments of Vulvar and Vaginal Tissue From Women With Vulvo-Vaginal Atrophy Taking Ospemifene.

Stefania Alvisi, Maurizio Baldassarre, Giulia Gava, Ilaria Mancini, Martina Gagliardi, Renato Seracchioli, Maria Cristina Meriggiola,

<h4>Introduction</h4>Vulvo-vaginal atrophy affects the daily lives of most post-menopausal women. We know that ospemifene intake can induce vaginal epithelial improvements within a few weeks; however, direct evidence of the effects of ospemifene on the human vulva and on connective tissue of both the vagina and vulva are lacking.<h4>Aim</h4>To evaluate the ... Read more >>

J Sex Med (The journal of sexual medicine)
[2018, 15(12):1776-1784]

Cited: 3 times

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Interaction of γ-conglutin from Lupinus albus with model phospholipid membranes: Investigations on structure, thermal stability and oligomerization status.

Andrea Scirè, Maurizio Baldassarre, Fabio Tanfani, Jessica Capraro, Marcello Duranti, Alessio Scarafoni,

Interaction with model phospholipid membranes of lupin seed γ-conglutin, a glycaemia-lowering protein from Lupinus albus seeds, has been studied by means of Fourier-Transform infrared spectroscopy at p<sup>2</sup>H 7.0 and at p<sup>2</sup>H 4.5. The protein maintains the same secondary structure both at p<sup>2</sup>H 7.0 and at p<sup>2</sup>H 4.5, but at p<sup>2</sup>H ... Read more >>

Biochim Biophys Acta Proteins Proteom (Biochimica et biophysica acta. Proteins and proteomics)
[2018, 1866(12):1242-1248]

Cited: 3 times

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New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy.

Anna Tramarin, Daniele Tedesco, Marina Naldi, Maurizio Baldassarre, Carlo Bertucci, Manuela Bartolini,

The ADMET profile of drugs is strongly affected by human serum albumin (HSA), due to its leading role as carrier of poorly soluble compounds in plasma; a critical assessment of the binding capacity of HSA and the evaluation of binding competition between drugs are therefore pivotal for a reliable pharmacokinetic ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2019, 162:171-178]

Cited: 1 time

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Testosterone undecanoate and testosterone enanthate injections are both effective and safe in transmen over 5 years of administration.

Giulia Gava, Ilaria Mancini, Silvia Cerpolini, Maurizio Baldassarre, Renato Seracchioli, Maria C Meriggiola,

<h4>Objective</h4>To retrospectively evaluate and compare safety and efficacy of short and long-acting testosterone (T) parenteral formulations over 5 years in transmen.<h4>Design and methods</h4>Fifty transmen between 21 and 42 years of age were enrolled. Twenty-five received T undecanoate 1000 mg IM (weeks 0 and 6 then every 12-16 weeks), and 25 received T enanthate 250 mg ... Read more >>

Clin Endocrinol (Oxf) (Clinical endocrinology)
[2018, 89(6):878-886]

Cited: 6 times

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Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial.

Paolo Caraceni, Oliviero Riggio, Paolo Angeli, Carlo Alessandria, Sergio Neri, Francesco G Foschi, Fabio Levantesi, Aldo Airoldi, Sergio Boccia, Gianluca Svegliati-Baroni, Stefano Fagiuoli, Roberto G Romanelli, Raffaele Cozzolongo, Vito Di Marco, Vincenzo Sangiovanni, Filomena Morisco, Pierluigi Toniutto, Annalisa Tortora, Rosanna De Marco, Mario Angelico, Irene Cacciola, Gianfranco Elia, Alessandro Federico, Sara Massironi, Riccardo Guarisco, Alessandra Galioto, Giorgio Ballardini, Maria Rendina, Silvia Nardelli, Salvatore Piano, Chiara Elia, Loredana Prestianni, Federica Mirici Cappa, Lucia Cesarini, Loredana Simone, Chiara Pasquale, Marta Cavallin, Alida Andrealli, Federica Fidone, Matteo Ruggeri, Andrea Roncadori, Maurizio Baldassarre, Manuel Tufoni, Giacomo Zaccherini, Mauro Bernardi, ,

<h4>Background</h4>Evidence is scarce on the efficacy of long-term human albumin (HA) administration in patients with decompensated cirrhosis. The human Albumin for the treatmeNt of aScites in patients With hEpatic ciRrhosis (ANSWER) study was designed to clarify this issue.<h4>Methods</h4>We did an investigator-initiated multicentre randomised, parallel, open-label, pragmatic trial in 33 academic ... Read more >>

Lancet (Lancet (London, England))
[2018, 391(10138):2417-2429]

Cited: 76 times

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The use of human albumin in patients with cirrhosis: a European survey.

Paolo Caraceni, Marco Pavesi, Maurizio Baldassarre, Mauro Bernardi, Vicente Arroyo,

<h4>Background</h4>The administration of human albumin (HA) in patients with decompensated cirrhosis is still debated. The European Foundation for the Study of Chronic Liver Failure (EF-CLIF) promoted an online survey to assess its use across Europe.<h4>Methods</h4>Hepatologists were invited to participate to an electronic questionnaire based on multiple-choice questions divided in 6 ... Read more >>

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2018, 12(6):625-632]

Cited: 5 times

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The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma.

Daniela Pollutri, Clarissa Patrizi, Sara Marinelli, Catia Giovannini, Elena Trombetta, Ferdinando A Giannone, Maurizio Baldassarre, Santina Quarta, Y P Vandewynckel, A Vandierendonck, H Van Vlierberghe, Laura Porretti, Massimo Negrini, Luigi Bolondi, Laura Gramantieri, Francesca Fornari,

Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality worldwide and is associated with poor prognosis, especially in patients not amenable for curative treatments. The multi-kinase inhibitor sorafenib represents the first-line treatment option for advanced HCC; nevertheless, its effectiveness is limited due to tumor heterogeneity as well as innate ... Read more >>

Cell Death Dis (Cell death & disease)
[2018, 9(1):4]

Cited: 27 times

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