Full Text Journal Articles by
Author Mauricio A Cuello

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FIGO staging for carcinoma of the vulva: 2021 revision.

Alexander B Olawaiye, Joseph Cotler, Mauricio A Cuello, Neerja Bhatla, Aikou Okamoto, Sarikapan Wilailak, Chittaranjan N Purandare, Gerhard Lindeque, Jonathan S Berek, Sean Kehoe,

To revise the FIGO staging for carcinoma of the vulva using a new approach that involves analyses of prospectively collected data. The FIGO Committee for Gynecologic Oncology reviewed the recent literature to gain an insight into the impact of the 2009 vulvar cancer staging revision. The Committee resolved to revise ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):43-47]

Cited: 0 times

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D-Propranolol Impairs EGFR Trafficking and Destabilizes Mutant p53 Counteracting AKT Signaling and Tumor Malignancy.

Jonathan Barra, Javier Cerda-Infante, Lisette Sandoval, Patricia Gajardo-Meneses, Jenny F Henriquez, Mariana Labarca, Claudia Metz, Jaime Venegas, Claudio Retamal, Claudia Oyanadel, Jorge Cancino, Andrea Soza, Mauricio A Cuello, Juan Carlos Roa, Viviana P Montecinos, Alfonso Gonzalez,

Cancer therapy may be improved by the simultaneous interference of two or more oncogenic pathways contributing to tumor progression and aggressiveness, such as EGFR and p53. Tumor cells expressing gain-of-function (GOF) mutants of p53 (mutp53) are usually resistant to EGFR inhibitors and display invasive migration and AKT-mediated survival associated with ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(14):]

Cited: 0 times

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Cancer of the vulva.

Linda J Rogers, Mauricio A Cuello,

Vulvar cancer is an uncommon gynecological malignancy primarily affecting postmenopausal women. There is no specific screening and the most effective strategy to reduce vulvar cancer incidence is the opportune treatment of predisposing and preneoplastic lesions associated with its development. While vulvar cancer may be asymptomatic, most women present with vulvar ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2018, 143 Suppl 2:4-13]

Cited: 14 times

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Cancer of the vagina.

Tracey S Adams, Mauricio A Cuello,

Diagnosis of a primary vaginal cancer is rare because most of these lesions will be metastatic from another primary site. Although cancer of the vagina is more common in postmenopausal women, an increase in young women being diagnosed with primary vaginal cancer has been reported, especially in countries with a ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2018, 143 Suppl 2:14-21]

Cited: 7 times

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Patient inflammatory status and CD4+/CD8+ intraepithelial tumor lymphocyte infiltration are predictors of outcomes in high-grade serous ovarian cancer.

Mauricio P Pinto, Carlos Balmaceda, Maria L Bravo, Sumie Kato, Alejandra Villarroel, Gareth I Owen, Juan Carlos Roa, Mauricio A Cuello, Carolina Ibañez,

<h4>Background</h4>High-grade serous ovarian cancer (HGSOC) is the most prevalent and aggressive histologic type of ovarian cancer. To date, there are no reliable biomarkers to effectively predict patient prognosis. Studies have demonstrated inflammation and tumor infiltrating lymphocytes (TILs) correlate with a bad and good prognosis, respectively. Here, we sought to evaluate ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2018, 151(1):10-17]

Cited: 20 times

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The value of endocervical curettage during loop electrosurgical excision procedures in predicting persistent/recurrent preinvasive cervical disease.

Mauricio A Cuello, María E Espinosa, Elisa J Orlandini, Du Y Hwang,

<h4>Objective</h4>To evaluate the usefulness of endocervical curettage (ECC) during loop electrosurgical excision procedures (LEEPs) in predicting the risk of persistence/recurrence of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) and informing clinical decision-making after LEEP.<h4>Methods</h4>The present retrospective study included women undergoing LEEP for CIN2+ at a teaching hospital in Chile ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2018, 141(3):337-343]

Cited: 0 times

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The impact on high-grade serous ovarian cancer of obesity and lipid metabolism-related gene expression patterns: the underestimated driving force affecting prognosis.

Mauricio A Cuello, Sumie Kato, Francisca Liberona,

To investigate whether specific obesity/metabolism-related gene expression patterns affect the survival of patients with ovarian cancer. Clinical and genomic data of 590 samples from the high-grade ovarian serous carcinoma (HGOSC) study of The Cancer Genome Atlas (TCGA) and 91 samples from the Australian Ovarian Cancer Study were downloaded from the ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2018, 22(3):1805-1815]

Cited: 3 times

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Structural and functional identification of vasculogenic mimicry in vitro.

Dusan Racordon, Andrés Valdivia, Gabriel Mingo, Rafaela Erices, Raúl Aravena, Felice Santoro, Maria Loreto Bravo, Carolina Ramirez, Pamela Gonzalez, Alejandra Sandoval, Alfonso González, Claudio Retamal, Marcelo J Kogan, Sumie Kato, Mauricio A Cuello, German Osorio, Francisco Nualart, Pedro Alvares, Araceli Gago-Arias, Daniella Fabri, Ignacio Espinoza, Beatriz Sanchez, Alejandro H Corvalán, Mauricio P Pinto, Gareth I Owen,

Vasculogenic mimicry (VM) describes a process by which cancer cells establish an alternative perfusion pathway in an endothelial cell-free manner. Despite its strong correlation with reduced patient survival, controversy still surrounds the existence of an in vitro model of VM. Furthermore, many studies that claim to demonstrate VM fail to ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):6985]

Cited: 15 times

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Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression.

Rafaela Erices, Sofía Cubillos, Raúl Aravena, Felice Santoro, Monica Marquez, Renan Orellana, Carolina Ramírez, Pamela González, Patricia Fuenzalida, María Loreto Bravo, Bárbara Oliva, Sumie Kato, Carolina Ibañez, Jorge Brañes, Erasmo Bravo, Catalina Alonso, Karen García, Clemente Arab, Vicente A Torres, Alejandro S Godoy, Jaime Pereira, Galdo Bustos, Julio Cesar Cardenas, Mauricio A Cuello, Gareth I Owen,

Clinical studies have suggested a survival benefit in ovarian cancer patients with type 2 diabetes mellitus taking metformin, however the mechanism by which diabetic concentrations of metformin could deliver this effect is still poorly understood. Platelets not only represent an important reservoir of growth factors and angiogenic regulators, they are ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(13):20865-20880]

Cited: 12 times

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Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women.

Sumie Kato, Lorena Abarzua-Catalan, César Trigo, Ana Delpiano, Cristobal Sanhueza, Karen García, Carolina Ibañez, Katherine Hormazábal, Daniela Diaz, Jorge Brañes, Enrique Castellón, Erasmo Bravo, Gareth Owen, Mauricio A Cuello,

The evidence linking obesity with ovarian cancer remains controversial. Leptin is expressed at higher levels in obese women and stimulates cell migration in other epithelial cancers. Here, we explored the clinical impact of overweight/obesity on patient prognosis and leptin's effects on the metastatic potential of ovarian cancer cells. We assessed ... Read more >>

Oncotarget (Oncotarget)
[2015, 6(25):21100-21119]

Cited: 45 times

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Independent anti-angiogenic capacities of coagulation factors X and Xa.

Soledad Lange, Ibeth Gonzalez, Mauricio P Pinto, Maximiliano Arce, Rodrigo Valenzuela, Evelyn Aranda, Matias Elliot, Marjorie Alvarez, Soledad Henriquez, Ethel V Velasquez, Felipe Orge, Barbara Oliva, Pamela Gonzalez, Manuel Villalon, Kelly M Cautivo, Alexis M Kalergis, Karla Pereira, Camila Mendoza, Claudia Saez, Sumie Kato, Mauricio A Cuello, Fernanda Parborell, Griselda Irusta, Veronica Palma, Miguel L Allende, Gareth I Owen,

Knockout models have shown that the coagulation system has a role in vascular development and angiogenesis. Herein, we report for the first time that zymogen FX and its active form (FXa) possess anti-angiogenic properties. Both the recombinant FX and FXa inhibit angiogenesis in vitro using endothelial EA.hy926 and human umbilical ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2014, 229(11):1673-1680]

Cited: 7 times

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Progesterone regulation of tissue factor depends on MEK1/2 activation and requires the proline-rich site on progesterone receptor.

Maria Loreto Bravo, Mauricio P Pinto, Ibeth Gonzalez, Barbara Oliva, Sumie Kato, Mauricio A Cuello, Carol A Lange, Gareth I Owen,

To characterize the molecular mechanism and map the response element used by progesterone (P) to upregulate tissue factor (TF) in breast cancer cells. TF expression and mRNA levels were analyzed in breast cancer ZR-75 and T47D cells, using Western blot and real-time PCR, respectively. Mapping of the TF promoter was ... Read more >>

Endocrine (Endocrine)
[2015, 48(1):309-320]

Cited: 4 times

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Metformin, at concentrations corresponding to the treatment of diabetes, potentiates the cytotoxic effects of carboplatin in cultures of ovarian cancer cells.

Rafaela Erices, Maria Loreto Bravo, Pamela Gonzalez, Bárbara Oliva, Dusan Racordon, Marcelo Garrido, Carolina Ibañez, Sumie Kato, Jorge Brañes, Javier Pizarro, Maria Isabel Barriga, Alejandro Barra, Erasmo Bravo, Catalina Alonso, Eva Bustamente, Mauricio A Cuello, Gareth I Owen,

The use of the type 2 diabetics drug metformin has been correlated with enhanced progression-free survival in ovarian cancer. The literature has speculated that this enhancement is due to the high concentration of metformin directly causing cancer cell death. However, this explanation does not fit with clinical data reporting that ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2013, 20(12):1433-1446]

Cited: 32 times

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Mechanical stretch increases brain natriuretic peptide production and secretion in the human fetal membranes.

Jorge A Carvajal, Ana M Delpiano, Mauricio A Cuello, José A Poblete,

Brain natriuretic peptide (BNP) is synthesized by human fetal membranes, both the amnion and chorion. This locally produced BNP inhibits the contraction of the human myometrium, contributing to the maintenance of myometrial quiescence during pregnancy. We tested the hypothesis that BNP production is increased by fetal membrane stretching, which is ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2013, 20(5):597-604]

Cited: 2 times

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Isoform α of PKC may contribute to the maintenance of pregnancy myometrial quiescence in humans.

Nicolás M Jofré, Ana M Delpiano, Mauricio A Cuello, José A Poblete, Paula A Vargas, Jorge A Carvajal,

We postulate that protein kinase C α (PKCα) may contribute to the maintenance of pregnancy myometrial quiescence in humans. We studied the changes in myometrial PKCα gene products (messenger RNA [mRNA] and protein) in 4 groups of women: preterm not in labor (PT-NL), preterm in labor (PT-L), term not in ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2013, 20(1):69-77]

Cited: 5 times

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Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1.

Jorge Diaz, Evelyn Aranda, Soledad Henriquez, Marisol Quezada, Estefanía Espinoza, Maria Loreto Bravo, Bárbara Oliva, Soledad Lange, Manuel Villalon, Marius Jones, Jan J Brosens, Sumie Kato, Mauricio A Cuello, Todd P Knutson, Carol A Lange, Lisette Leyton, Gareth I Owen,

Progesterone and progestins have been demonstrated to enhance breast cancer cell migration, although the mechanisms are still not fully understood. The protease-activated receptors (PARs) are a family of membrane receptors that are activated by serine proteases in the blood coagulation cascade. PAR1 (F2R) has been reported to be involved in ... Read more >>

J Endocrinol (The Journal of endocrinology)
[2012, 214(2):165-175]

Cited: 15 times

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Progesterone utilizes distinct membrane pools of tissue factor to increase coagulation and invasion and these effects are inhibited by TFPI.

Soledad Henriquez, Claudia Calderon, Marisol Quezada, Bárbara Oliva, Maria Loreto Bravo, Evelyn Aranda, Sumie Kato, Mauricio A Cuello, Jorge Gutiérrez, Andrew F G Quest, Gareth I Owen,

Tissue factor (TF) serving as the receptor for coagulation factor VII (FVII) initiates the extrinsic coagulation pathway. We previously demonstrated that progesterone increases TF, coagulation and invasion in breast cancer cell lines. Herein, we investigated if tissue factor pathway inhibitor (TFPI) could down-regulate progesterone-increased TF activity in these cells. Classically, ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2011, 226(12):3278-3285]

Cited: 6 times

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2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells.

Marisol Quezada, Jorge Diaz, Soledad Henriquez, Maria Loreto Bravo, Evelyn Aranda, Barbara Oliva, Manuel Villalon, Sumie Kato, Mauricio A Cuello, Jan J Brosens, Carol A Lange, Gareth I Owen,

2-Methoxyestradiol (2ME) is an endogenous metabolite of 17β-estradiol with antiangiogenic and antitumor properties, although its mechanisms of action remain unclear. Progestins in hormone replacement therapy increase the risk of breast cancer. Progesterone also enhances the procoagulant activity and invasive potential of progesterone receptor (PR)-positive breast cancer cell lines, an effect ... Read more >>

Horm Cancer (Hormones & cancer)
[2010, 1(3):117-126]

Cited: 5 times

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Brain natriuretic peptide (BNP) produced by the human chorioamnion may mediate pregnancy myometrial quiescence.

Jorge A Carvajal, Ana M Delpiano, Mauricio A Cuello, Jose A Poblete, Paola C Casanello, Luis A Sobrevia, Carl P Weiner,

We aim to demonstrate that Brain Natriuretic Peptide (BNP) is synthesized and released from the fetal membranes and mediates pregnancy myometrial quiescence. Myometrium and fetal membranes (FM) were obtained from term and preterm pregnancies at the time of cesarean section, either in labor or not in labor. BNP was measured ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2009, 16(1):32-42]

Cited: 9 times

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2-methoxyestradiol mediates apoptosis through caspase-dependent and independent mechanisms in ovarian cancer cells but not in normal counterparts.

Sumie Kato, Anil Sadarangani, Soledad Lange, Ana M Delpiano, Macarena Vargas, Jorge Brañes, Jorge Carvajal, Stanley Lipkowitz, Gareth I Owen, Mauricio A Cuello,

<h4>Objective</h4>The estrogen metabolite 2-methoxyestradiol has shown antitumorigenic action in some epithelial tumors. In the present work we investigate its effects in ovarian cancer used alone or in combination with other apoptotic-inducing reagents such as tumor necrosis factor-related apoptosis-inducing ligand.<h4>Methods</h4>To assess the effect of 2-methoxyestradiol, dose response and time courses in ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2008, 15(9):878-894]

Cited: 15 times

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Mechanisms of paracrine regulation by fetal membranes of human uterine quiescence.

Jorge A Carvajal, Rossana J Vidal, Mauricio A Cuello, Jose A Poblete, Carl P Weiner,

<h4>Objective</h4>To test the hypothesis that fetal membranes (chorion or amnion) release one or more factors responsible for myometrial quiescence.<h4>Methods</h4>Myometrial samples were excised from women at elective term cesarean delivery prior to the onset of labor. Fetal membranes were obtained after cesarean delivery either before or during labor, and either term ... Read more >>

J Soc Gynecol Investig (Journal of the Society for Gynecologic Investigation)
[2006, 13(5):343-349]

Cited: 9 times

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Apoptosis and the treatment of breast cancer.

Mauricio A Cuello, Marion Nau, Stan Lipkowitz,

Dysregulation of apoptosis plays a major role in cancer etiology. Cancer cells often contain genetic abnormalities which allow the cells to survive under conditions that normally would trigger their demise. The identification of these mutations has changed the models of cancer progression from a disease of excessive proliferation to one ... Read more >>

Breast Dis (Breast disease)
[2002, 15:71-82]

Cited: 1 time

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