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Author Mattia Barbareschi

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Atypical Endometrial Hyperplasia, Low-grade: "Much ADO About Nothing".

Emanuela D'Angelo, Iñigo Espinosa, Valentina Cipriani, Justyna Szafranska, Mattia Barbareschi, Jaime Prat,

Atypical endometrial hyperplasia (AEH) is considered a precursor of endometrioid carcinoma. The 2020 World Health Organization (WHO) classification divides endometrial hyperplasia into 2 categories: hyperplasia without atypia and atypical hyperplasia/endometrioid intraepithelial neoplasia (EIN); however, this classification does not consider the degree of nuclear atypia. We graded nuclear atypia for estimating ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):988-996]

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TRPM8 protein expression in hormone naïve local and lymph node metastatic prostate cancer.

Andrea Lunardi, Mattia Barbareschi, Francesco Giuseppe Carbone, Luca Morelli, Matteo Brunelli, Nicolò Fortuna, Sacha Genovesi, Alessandro Alaimo,

<h4>Objective</h4>Prostate cancer (PCa) is the second most common malignancy in men. Radiotherapy and surgery successfully control organ-confined tumors, although, locally advanced/high-risk PCa frequently progress to the metastatic stage of the disease, which is uncurable. Identification of novel strategies to improve the efficacy of standard clinical protocols is a primary need. ... Read more >>

Pathologica (Pathologica)
[2021, 113(2):95-101]

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Lockdown Measures Negatively Impacted Cancer Care.

Sarita Kumari, Ranjeet Singh Mahla, Lucia Mangone, Paolo Giorgi Rossi, Roberto Grilli, Carmine Pinto, Gerardo Ferrara, Ludovica De Vincentiis, Filippo Crivelli, Elda Feyles, Enrico Orvieto, Ezio Venturino, Luca Saragoni, Mattia Barbareschi,

Am J Clin Pathol (American journal of clinical pathology)
[2021, 155(4):615-616]

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Intra-epithelial non-canonical Activin A signalling safeguards prostate progenitor quiescence

Francesco Cambuli, Veronica Foletto, Alessandro Alaimo, Dario De Felice, Francesco Gandolfi, Maria Dilia Palumbieri, Michela Zaffagni, Sacha Genovesi, Marco Lorenzoni, Martina Celotti, Emiliana Bertossio, Giosuè Mazzero, Arianna Bertossi, Alessandra Bisio, Francesco Berardinelli, Antonio Antoccia, Marco Gaspari, Mattia Barbareschi, Michelangelo Fiorentino, Michael Shen, Massimo Loda, Alessandro Romanel, Andrea Lunardi,

The healthy prostate is a relatively quiescent tissue. Yet, prostate epithelium overgrowth is a common condition during ageing, associated with urinary dysfunction and tumorigenesis. For over thirty years, TGF-β ligands have been known to induce cytostasis in a large variety of epithelia, but the intracellular pathway mediating this signal in ... Read more >>

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Wilms' Tumor 1 (WT1): A Novel Immunomarker of Dermatofibrosarcoma Protuberans-An Immunohistochemical Study on a Series of 114 Cases of Bland-Looking Mesenchymal Spindle Cell Lesions of the Dermis/Subcutaneous Tissues.

Eliana Piombino, Giuseppe Broggi, Mattia Barbareschi, Sergio Castorina, Rosalba Parenti, Giovanni Bartoloni, Lucia Salvatorelli, Gaetano Magro,

<h4>Purpose</h4>to investigate the immunohistochemical expression and distribution of Wilms' tumor 1 (WT1) (transcription factor produced by the tumor suppressor gene of the same name) in a series of 114 cases of bland-looking mesenchymal spindle cell lesions of the dermis/subcutaneous tissues to establish whether this immunomarker is differentially expressed in dermatofibrosarcoma ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(2):]

Cited: 2 times

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Unusual osteolitic intraosseous ganglion cyst of the medial tibial condyle in a patient affected by mild osteoarthritis of the knee.

Piero Giardini, Carlo Raimondo Menna, Mattia Barbareschi, Marco Molinari,

Bone lesion of the proximal tibia are common findings; depending on the site, age of the patient and symptoms a carefull differential diagnosis must be carried out. We present the case of  a 60 years old active patient presenting at our clinic with atraumatic  knee pain. X-Rays performed revealed an ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2020, 91(14-S):e2020027]

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Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors.

Alessandro Alaimo, Marco Lorenzoni, Paolo Ambrosino, Arianna Bertossi, Alessandra Bisio, Alice Macchia, Eugenio Zoni, Sacha Genovesi, Francesco Cambuli, Veronica Foletto, Dario De Felice, Maria Virginia Soldovieri, Ilaria Mosca, Francesco Gandolfi, Matteo Brunelli, Gianluca Petris, Anna Cereseto, Alvaro Villarroel, George Thalmann, Francesco Giuseppe Carbone, Marianna Kruithof-de Julio, Mattia Barbareschi, Alessandro Romanel, Maurizio Taglialatela, Andrea Lunardi,

Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer treatment. Here, we demonstrate that selective agonists of Transient Receptor Potential cation channel subfamily M member 8 ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(12):1039]

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Cancer Diagnostic Delay in Northern and Central Italy During the 2020 Lockdown Due to the Coronavirus Disease 2019 Pandemic.

Gerardo Ferrara, Ludovica De Vincentiis, Andrea Ambrosini-Spaltro, Mattia Barbareschi, Valentina Bertolini, Edgardo Contato, Filippo Crivelli, Elda Feyles, Maria Paola Mariani, Luca Morelli, Enrico Orvieto, Elena Pacella, Ezio Venturino, Luca Saragoni,

<h4>Objectives</h4>We performed data collection concerning the coronavirus disease 2019 (COVID-19) pandemic-related delay in the diagnosis of cancers to individuate proper corrective procedures.<h4>Methods</h4>A comparison was made among the number of first pathologic diagnoses of malignancy made from weeks 11 to 20 of 2018, 2019, and 2020 at seven anatomic pathology units ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2021, 155(1):64-68]

Cited: 5 times

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Determinants of p16/Ki-67 adequacy and positivity in HPV-positive women from a screening population.

Maria Benevolo, Pamela Mancuso, Elena Allia, Daniela Gustinucci, Simonetta Bulletti, Elena Cesarini, Francesca Maria Carozzi, Massimo Confortini, Simonetta Bisanzi, Teresa Rubino, Francesca Rollo, Natalina Marchi, Angelo Farruggio, Teresa Pusiol, Francesco Venturelli, Paolo Giorgi Rossi, ,

<h4>Background</h4>The objective of this study was to describe the determinants of adequacy and positivity of the p16/Ki-67 assay in a human papillomavirus (HPV)-positive screening population enrolled within the New Technologies for Cervical Cancer 2 (NTCC2) study.<h4>Methods</h4>ThinPrep slides were immunostained for p16/Ki-67; each slide had 3 reports from different laboratories. The ... Read more >>

Cancer Cytopathol (Cancer cytopathology)
[2021, 129(5):383-393]

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Two distinct immunopathological profiles in autopsy lungs of COVID-19.

Ronny Nienhold, Yari Ciani, Viktor H Koelzer, Alexandar Tzankov, Jasmin D Haslbauer, Thomas Menter, Nathalie Schwab, Maurice Henkel, Angela Frank, Veronika Zsikla, Niels Willi, Werner Kempf, Thomas Hoyler, Mattia Barbareschi, Holger Moch, Markus Tolnay, Gieri Cathomas, Francesca Demichelis, Tobias Junt, Kirsten D Mertz,

Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune mediated damage has been proposed as a pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):5086]

Cited: 37 times

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Towards a "Net" generation of Pathologists: the pathCast online remote learning platform.

Luca Cima, Rifat Mannan, Emilio Madrigal, Mattia Barbareschi,

In recent years, digital and communication technology has been changing the way to spread knowledge in Medicine. In the field of Pathology, several remote learning resources have been made available through multiple social media platforms (Facebook, Twitter and others), YouTube channels and dedicated Websites, with a growing number of freely ... Read more >>

Pathologica (Pathologica)
[2020, 112(4):160-171]

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Mixed Invasive Apocrine Papillary/Micropapillary Carcinoma of the Breast: Another Brick in the Triple-Negative Wall.

Luca Cima, Nicola Mirabassi, Chiara Sartori, Francesco Giuseppe Carbone, Luca Morelli, Gábor Cserni, Mattia Barbareschi,

Pure invasive papillary carcinoma (IPC) is a rare subtype of breast carcinoma with good prognosis compared with classical invasive breast carcinoma (IBC) of no special type. The majority of IPC are estrogen receptor and progesterone receptor (ER/PR) positive and HER2 negative (luminal A-like). We report the case of a 72-year-old ... Read more >>

Int J Surg Pathol (International journal of surgical pathology)
[2021, 29(4):420-426]

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Programmed Death-Ligand 1 (PD-L1) Is a Potential Biomarker of Disease-Free Survival in Papillary Thyroid Carcinoma: a Systematic Review and Meta-Analysis of PD-L1 Immunoexpression in Follicular Epithelial Derived Thyroid Carcinoma.

Ilaria Girolami, Liron Pantanowitz, Ozgur Mete, Matteo Brunelli, Stefano Marletta, Chiara Colato, Pierpaolo Trimboli, Anna Crescenzi, Massimo Bongiovanni, Mattia Barbareschi, Albino Eccher,

The expression of programmed death-ligand 1 (PD-L1) is an established prerequisite for the administration of checkpoint inhibitor therapy and is of prognostic value in several cancer types. Data concerning the potential effect of PD-L1 on the prognosis of thyroid carcinoma are limited. Therefore, this study aimed to provide a systematic ... Read more >>

Endocr Pathol (Endocrine pathology)
[2020, 31(3):291-300]

Cited: 3 times

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Two distinct immunopathological profiles in lungs of lethal COVID-19

Ronny Nienhold, Yari Ciani, Viktor Koelzer, Alexandar Tzankov, Jasmin Haslbauer, Thomas Menter, Nathalie Schwab, Maurice Henkel, Angela Frank, Veronika Zsikla, Niels Willi, Werner Kempf, Thomas Hoyler, Mattia Barbareschi, Holger Moch, Markus Tolnay, Gieri Cathomas, Francesca Demichelis, Tobias Junt, Kirsten Mertz,

Immune responses in lungs of Coronavirus Disease 2019 (COVID-19) are poorly characterized. We conducted transcriptomic, histologic and cellular profiling of post mortem COVID-19 and normal lung tissues. Two distinct immunopathological reaction patterns were identified. One pattern showed high expression of interferon stimulated genes (ISGs) and cytokines, high viral loads and ... Read more >>

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Two distinct immunopathological profiles in autopsy lungs of COVID-19

Ronny Nienhold, Yari Ciani, Viktor Koelzer, Alexandar Tzankov, Jasmin Haslbauer, Thomas Menter, Nathalie Schwab, Maurice Henkel, Angela Frank, Veronika Zsikla, Niels Willi, Werner Kempf, Thomas Hoyler, Mattia Barbareschi, Holger Moch, Markus Tolnay, Gieri Cathomas, Francesca Demichelis, Tobias Junt, Kirsten Mertz,

Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune mediated damage has been proposed as a pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Therefore we ... Read more >>

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Magnetic Resonance Imaging Derived Biomarkers of IDH Mutation Status and Overall Survival in Grade III Astrocytomas.

Paola Feraco, Antonella Bacci, Patrizia Ferrazza, Luc van den Hauwe, Riccardo Pertile, Salvatore Girlando, Mattia Barbareschi, Cesare Gagliardo, Alessio Giuseppe Morganti, Benedetto Petralia,

The evaluation of the isocitrate dehydrogenase (IDH) mutation status in the glioma decision-making process has diagnostic, prognostic and therapeutic implications. The aim of this study was to evaluate whether conventional magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) can noninvasively predict the most common IDH mutational status (R132H) in ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(4):]

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Effects of supra-total resection in neurocognitive and oncological outcome of high-grade gliomas comparing asleep and awake surgery.

Luca Zigiotto, Luciano Annicchiarico, Francesco Corsini, Luca Vitali, Roberta Falchi, Chiara Dalpiaz, Umberto Rozzanigo, Mattia Barbareschi, Paolo Avesani, Costanza Papagno, Hugues Duffau, Franco Chioffi, Silvio Sarubbo,

<h4>Purpose</h4>Awake surgery is an established technique for resection of low-grade gliomas, while its possible benefit for resection of high-grade gliomas (HGGs) needs further confirmations. This retrospective study aims to compare overall survival, extent of resection (EOR) and cognitive outcome in two groups of HGGs patients submitted to asleep or awake surgery.<h4>Methods</h4>Thirty-three ... Read more >>

J Neurooncol (Journal of neuro-oncology)
[2020, 148(1):97-108]

Cited: 7 times

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The autopsy debate during the COVID-19 emergency: the Italian experience.

Anna Sapino, Fabio Facchetti, Emanuela Bonoldi, Andrea Gianatti, Mattia Barbareschi, ,

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2020, 476(6):821-823]

Cited: 20 times

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miR375-3p Distinguishes Low-Grade Neuroendocrine From Non-neuroendocrine Lung Tumors in FFPE Samples.

Simone Detassis, Valerio Del Vescovo, Margherita Grasso, Stefania Masella, Chiara Cantaloni, Luca Cima, Alberto Cavazza, Paolo Graziano, Giulio Rossi, Mattia Barbareschi, Leonardo Ricci, Michela Alessandra Denti,

Lung cancer is still one of the leading cause of death worldwide. The clinical variability of lung cancer is high and drives treatment decision. In this context, correct discrimination of pulmonary neuroendocrine tumors is still of critical relevance. The spectrum of neuroendocrine tumors is various, and each type has molecular ... Read more >>

Front Mol Biosci (Frontiers in molecular biosciences)
[2020, 7:86]

Cited: 1 time

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Impact of image analysis and artificial intelligence in thyroid pathology, with particular reference to cytological aspects.

Ilaria Girolami, Stefano Marletta, Liron Pantanowitz, Evelin Torresani, Claudio Ghimenton, Mattia Barbareschi, Aldo Scarpa, Matteo Brunelli, Valeria Barresi, Pierpaolo Trimboli, Albino Eccher,

OBJECTIVE:Thyroid pathology has great potential for automated/artificial intelligence algorithm application as the incidence of thyroid nodules is increasing and the indeterminate interpretation rate of fine-needle aspiration remains relatively high. The aim of the study is to review the published literature on automated image analysis and artificial intelligence applications to thyroid ... Read more >>

Cytopathology (Cytopathology : official journal of the British Society for Clinical Cytology)
[2020, 31(5):432-444]

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What are the priorities of pathologists' activities during COVID-19 emergency?

Mattia Barbareschi, Fabio Facchetti, Filippo Fraggetta, Anna Sapino,

Pathologica (Pathologica)
[2020, 112(2):57-58]

Cited: 6 times

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Biosafety in surgical pathology in the era of SARS-Cov2 pandemia. A statement of the Italian Society of Surgical Pathology and Cytology.

Mattia Barbareschi, Valeria Ascoli, Emanuela Bonoldi, Alberto Cavazza, Romano Colombari, Ilaria Cozzi, Emanuele Dainese, Fabio Facchetti, Guido Fadda, Gerardo Ferrara, Filippo Fraggetta, Paolo Graziano, Giancarlo Murer, Esther Diana Rossi, Giulio Rossi, Giovanni Negri, Gianfranco Zannoni, Anna Sapino,

Pathologica (Pathologica)
[2020, 112(2):59-63]

Cited: 7 times

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Role of circulating tumor DNA in the detection of sensitizing and resistance to epidermal growth factor receptor mutations in metastatic lung adenocarcinoma.

Antonello Veccia, Salvatore Girlando, Mariachiara Dipasquale, Stefania Kinspergher, Mattia Barbareschi, Orazio Caffo,

<h4>Purpose</h4>The EGFR (Epidermal Growth Factor Receptor) mutations may predict sensitivity and resistance to EGFR-TKIs (Tyrosine Kinases Inhibitors) in metastatic lung adenocarcinoma. The detection of these mutations is usually performed on tumor tissue samples. However, when a biopsy is not feasible or the amount of tissue is limited, circulating tumor DNA ... Read more >>

J BUON (Journal of B.U.ON. : official journal of the Balkan Union of Oncology)
[2020, 25(2):848-854]

Cited: 0 times

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Onset of vitiligo following targeted therapy for BRAFV600E-mutated melanoma: case report.

Sonia Brugnara, Mariacristina Sicher, Elena Maria Bonandini, Mattia Barbareschi, Carlo Renè Girardelli, Orazio Caffo,

Systemic treatment for metastatic melanoma has advanced dramatically in recent years with an impressive increase in the rate of overall survival. The two main different strategies are targeted therapies (i.e. BRAF and MEK inhibitors) and immunotherapy with monoclonal antibodies against the immune checkpoint proteins programmed death-1 (PD-1) and cytotoxic T-lymphocyte ... Read more >>

Drugs Context (Drugs in context)
[2019, 8:212582]

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Idiopathic hypertrophic cranial pachymeningitis as a rare cause of status epilepticus.

Monica Margoni, Mattia Barbareschi, Umberto Rozzanigo, Silvio Sarubbo, Franco Chioffi, Raffaella Tanel,

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2019, 40(10):2193-2195]

Cited: 0 times

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