Full Text Journal Articles by
Author Matthew Williams

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Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>Aspirin has been proposed as a treatment for COVID-19 on the basis of its anti-thrombotic properties. We aimed to evaluate the efficacy and safety of aspirin in patients admitted to hospital with COVID-19.<h4>Methods</h4>In this randomised, controlled, open-label, platform trial, several possible treatments were compared with usual care in patients hospitalised ... Read more >>

Lancet (Lancet (London, England))
[2021, :]

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Transparency, Public Reporting and a Culture of Change to Quality and Safety in Cardiac Surgery.

Michael Ibrahim, Wilson Y Szeto, Jacob Gutsche, Steve Weiss, Joseph Bavaria, Stephanie Ottemiller, Matthew Williams, Jo Fante Gallagher, Neil Fishman, Regina Cunningham, Luann Brady, Patrick J Brennan, Michael Acker,

Academic medical centers have a duty to serve as hospitals of last resort for advanced cardiac surgical care and therefore manage patients at elevated risk of post-operative morbidity and mortality. They must also meet state and professional quality targets devised to protect the public. The tension between these imperatives can ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, :]

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Mechanochemical Organocatalysis: Do High Enantioselectivites Contradict what we Might Expect?

Matthew J Williams, Louis C Morrill, Duncan L Browne,

Ball mills input energy to samples by pulverizing the contents of the jar. Each impact on the sample or wall of the jar results in an instantaneous transmission of energy in the form of a temperature and pressure increase (volume reduction). Conversely, enantioselective organocatalytic reactions proceed through perceived delicate and ... Read more >>

ChemSusChem (ChemSusChem)
[2021, :]

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Imaging Findings of COVID-19-Related Cardiovascular Complications

Eleni Nakou, Estefania De Garate, Kate Liang, Matthew Williams, Dudley J. Pennell, Chiara Bucciarelli-Ducci,

Other than respiratory disease, patients with coronavirus disease 2019 (COVID-19) commonly have cardiovascular manifestations, which are recognised as significant risk factors for increased mortality. COVID-19 patients may present with a wide spectrum of clinical presentations ranging from asymptomatic heart disease detected incidentally by cardiac investigations (troponin, BNP, imaging) to cardiogenic ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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30-Year Trends in Graft Survival After Heart Transplant: Modeled Analyses of a Transplant Registry.

Marlena E Sabatino, Matthew L Williams, Ike S Okwuosa, Ehimare Akhabue, Jung Hyun Kim, Mark J Russo, Soko Setoguchi,

<h4>Background</h4>Heart failure is an epidemic in the United States, and transplantation remains the most definitive therapy. We describe multi-decade trends in post-transplant graft survival, adjusted for concurrent changes in the population, over the 30 years antecedent to the most recent heart allocation policy change.<h4>Methods</h4>Scientific Registry of Transplant Recipients data were ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, :]

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Socioeconomic Disparities in Surveillance and Follow-Up of Patients with Thoracic Aortic Aneurysm

Michael Shang, Gabe Weininger, Makoto Mori, Arianna Kahler-Quesada, Ellelan Degife, Cornell Brooks, Matthew Williams, Roland Assi, Arnar Geirsson, Prashanth Vallabhajosyula,

<h4>Background: </h4> Thoracic aortic aneurysm is a significant risk factor for aortic dissection and rupture. Guidelines recommend referral of patients to a cardiovascular specialist for periodic surveillance imaging with surgical intervention determined primarily by aneurysm size. We investigated the association between socioeconomic status and surveillance practices in patients with ascending ... Read more >>

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Biliary ascariasis: an unexpected cause of abdominal pain in a non-endemic region.

James Hong-En Kang, Jessica Sue Yi Wong, Aamir Saleem, Matthew Williams,

Postgrad Med J (Postgraduate medical journal)
[2021, :]

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Prior Exposure to Coxsackievirus A21 Does Not Mitigate Oncolytic Therapeutic Efficacy.

William J Burnett, David M Burnett, Gennie Parkman, Andrew Ramstead, Nico Contreras, William Gravley, Sheri L Holmen, Matthew A Williams, Matthew W VanBrocklin,

Oncolytic viruses (OVs) are being developed as a type of immunotherapy and have demonstrated durable tumor responses and clinical efficacy. One such OV, Coxsackievirus A21 (CVA21), exhibited therapeutic efficacy in early phase clinical trials, demonstrating the ability to infect and kill cancer cells and stimulate anti-tumor immune responses. However, one ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(17):]

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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

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<h4>Background</h4>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.<h4>Methods</h4>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an ... Read more >>

Br J Surg (The British journal of surgery)
[2021, 108(9):1056-1063]

Cited: 17 times

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The learning curve of robotic coronary arterial bypass surgery: A report from the STS database.

William L Patrick, Amit Iyengar, Jason J Han, Jarvis C Mays, Mark Helmers, John J Kelly, Xingmei Wang, Mehrdad Ghoreishi, Bradley S Taylor, Pavan Atluri, Nimesh D Desai, Matthew L Williams,

<h4>Background</h4>There is limited data to inform minimum case requirements for training in robotically assisted coronary artery bypass grafting (RA-CABG). Current recommendations rely on nonclinical endpoints and expert opinion.<h4>Objectives</h4>To determine the minimum number of RA-CABG procedures required to achieve stable clinical outcomes.<h4>Methods</h4>We included isolated RA-CABG in the Society of Thoracic Surgeons ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2021, 36(11):4178-4186]

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Cardiovascular magnetic resonance characterisation of anthracycline cardiotoxicity in adults with normal left ventricular ejection fraction.

Iwan Harries, Bostjan Berlot, Natasha Ffrench-Constant, Matthew Williams, Kate Liang, Estefania De Garate, Anna Baritussio, Giovanni Biglino, Juan Carlos Plana, Chiara Bucciarelli-Ducci,

<h4>Background</h4>Anthracycline therapy may lead to changes in cardiac structure and function not detectable by solely evaluating left ventricular ejection fraction (LVEF).<h4>Objectives</h4>We hypothesized that cardiovascular magnetic resonance (CMR) would identify structural and functional myocardial abnormalities in anthracycline-treated cancer survivors with normal LVEF, compared to a matched control population.<h4>Methods</h4>Forty-five cancer survivors (56 ± 16 yrs., ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 343:180-186]

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SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.

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SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We ... Read more >>

Anaesthesia (Anaesthesia)
[2021, :]

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Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study.

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We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave ... Read more >>

Anaesthesia (Anaesthesia)
[2021, 76(11):1454-1464]

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Exploring definitions of radiological sarcopenia in cancer: a protocol for a scoping review.

James Wei Wang, Matthew Williams,

<h4>Introduction</h4>Sarcopenia is the loss of skeletal muscle volume or quality, a concept previously established in age-related frailty. Sarcopenia is part of the cancer cachexia syndrome and has therefore been explored as biomarker through the opportunistic measurement of skeletal muscle from routine cancer imaging. However, there is inconsistency in diagnostic landmarks ... Read more >>

BMJ Open (BMJ open)
[2021, 11(7):e053076]

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The Learning Curve of Robotic Coronary Arterial Bypass Surgery: A Report From The STS Database

William Patrick, Amit Iyengar, Jason Han, Jarvis Mays, Mark Helmers, John Kelly, Xingmei Wang, Mehrdad Ghoreishi, Bradley Taylor, Pavan Atluri, Nimesh Desai, Matthew Williams,

<h4>Background: </h4> There is limited data to inform minimum case requirements for training in robotically-assisted coronary artery bypass grafting (RA-CABG). Current recommendations rely on non-clinical endpoints and expert opinion. <h4>Objectives:</h4> To determine the minimum number of RA-CABG procedures required to achieve stable clinical outcomes. <h4>Methods:</h4> We included isolated RA-CABG in ... Read more >>

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COVID-19 and cardiothoracic surgery: Effects on training and workforce utilization in a global pandemic.

Benjamin Smood, John R Spratt, J Hunter Mehaffey, Jessica G Y Luc, Eric E Vinck, Miia L Lehtinen, Tyler J Wallen, Charles G Jenkinson, Woojung Kim, Emeka B Kesieme, Jason J Han, Mark R Helmers, Amit Iyengar, William L Patrick, John J Kelly, Ammara A Watkins, Marisa Cevasco, Matthew L Williams,

<h4>Background</h4>The COVID-19 pandemic has disrupted all aspects of healthcare, including cardiothoracic surgery (CTS). We sought to determine the pandemic's impact on CTS trainees' educational experiences.<h4>Methods</h4>A survey was developed and distributed to members of the Thoracic Surgery Residents Association and other international CTS trainees. Trainees were asked to evaluate their cumulative ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2021, 36(9):3296-3305]

Cited: 4 times

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The Functional Hallmarks of Cancer Predisposition Genes.

Alexandra Capellini, Matthew Williams, Kenan Onel, Kuan-Lin Huang,

The canonical model for hereditary cancer predisposition is a cancer predisposition gene (CPG) that drives either one or both of two fundamental hallmarks of cancer, defective genomic integrity and deregulated cell proliferation, ultimately resulting in the accumulation of mutations within cells. Thus, the genes most commonly associated with cancer-predisposing genetic ... Read more >>

Cancer Manag Res (Cancer management and research)
[2021, 13:4351-4357]

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Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.

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<h4>Background</h4>Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10289):2049-2059]

Cited: 49 times

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The Surgeon's Role in Cardiogenic Shock.

Alexandra E Sperry, Matthew Williams, Pavan Atluri, Wilson Y Szeto, Marisa Cevasco, Christian A Bermudez, Michael A Acker, Michael Ibrahim,

<h4>Purpose of review</h4>Cardiogenic shock represents a very challenging patient population due to the undifferentiated pathologies presenting as cardiogenic shock, difficult decision-making, prognostication, and ever-expanding support options. The role of cardiac surgeons on this team is evolving.<h4>Recent findings</h4>The implementation of a shock team is associated with improved outcomes in patients with ... Read more >>

Curr Heart Fail Rep (Current heart failure reports)
[2021, 18(4):240-251]

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Wisdom From Past Presidents of The Society of Thoracic Surgeons.

Jason J Han, Jarvis C Mays, Amit Iyengar, Jessica G Y Luc, William L Patrick, Mark R Helmers, Benjamin Smood, John J Kelly, Matthew L Williams, Wilson Y Szeto, Marisa Cevasco,

The Society of Thoracic Surgeons is a highly impactful professional organization in cardiothoracic surgery and an important network of mentors for trainees. Annually, presidents of The Society of Thoracic Surgeons deliver an address encapsulating their professional experiences, lessons learned, and future vision for the field. We sought to summarize these ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, 112(4):1372-1377]

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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10285):1637-1645]

Cited: 176 times

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Transient recurrent takotsubo cardiomyopathy mimicking apical hypertrophic cardiomyopathy.

Matthew G L Williams, Kate Liang, Chiara Bucciarelli-Ducci,

Eur Heart J Cardiovasc Imaging (European heart journal. Cardiovascular Imaging)
[2021, 22(6):e72]

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Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections.

Joel Hellewell, Timothy W Russell, , , , Rupert Beale, Gavin Kelly, Catherine Houlihan, Eleni Nastouli, Adam J Kucharski,

<h4>Background</h4>Routine asymptomatic testing using RT-PCR of people who interact with vulnerable populations, such as medical staff in hospitals or care workers in care homes, has been employed to help prevent outbreaks among vulnerable populations. Although the peak sensitivity of RT-PCR can be high, the probability of detecting an infection will ... Read more >>

BMC Med (BMC medicine)
[2021, 19(1):106]

Cited: 11 times

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What is your diagnosis? Blood smear from a bull.

Marjorie J Williams, Gretchen Grissett, Jennifer Beam, Ryan Taylor, Heather Cunningham, Matthew L Williams,

Vet Clin Pathol (Veterinary clinical pathology)
[2021, 50(2):293-295]

Cited: 0 times

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Multifocal nodular steatosis mimicking malignancy.

James Hong-En Kang, Jessica Sue-Yi Wong, Matthew Williams,

Postgrad Med J (Postgraduate medical journal)
[2021, :]

Cited: 0 times

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