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Author Matthew Voas

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Synaptic vesicle fusion along axons is driven by myelination and subsequently accelerates sheath growth in an activity-regulated manner

Rafael Almeida, Jill Williamson, Megan Madden, Jason Early, Matthew Voas, William Talbot, Isaac Bianco, David Lyons,

To study activity-regulated myelination, we imaged synaptic vesicle fusion along single axons in living zebrafish, and found, surprisingly, that axonal synaptic vesicle fusion is driven by myelination. This myelin-induced axonal vesicle fusion was enriched along the unmyelinated domains into which newly-formed sheaths grew, and was promoted by neuronal activity, which ... Read more >>

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Adenosine receptor expression in the adult zebrafish retina.

Stephanie L Grillo, Dillon S McDevitt, Matthew G Voas, Amanda S Khan, Michael A Grillo, Salvatore L Stella,

Adenosine is an endogenous nucleoside in the central nervous system that acts on adenosine receptors. These are G protein-coupled receptors that have four known subtypes: A1, A2A, A2B, and A3 receptors. In the present study, we aimed to map the location of the adenosine receptor subtypes in adult wild-type zebrafish ... Read more >>

Purinergic Signal. (Purinergic signalling)
[2019, 15(3):327-342]

Cited: 1 time

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Parallel control of mechanosensory hair cell orientation by the PCP and Wnt pathways

Joaquin Navajas Acedo, Matthew Voas, Richard Alexander, Thomas Woolley, Jay Unruh, Hua Li, Cecilia Moens, Tatjana Piotrowski,

ABSTRACT Cell polarity plays a crucial role during development of vertebrates and invertebrates. Planar Cell Polarity (PCP) is defined as the coordinated polarity of cells within a tissue axis and is essential for processes such as gastrulation, neural tube closure or hearing. Wnt ligands can be instructive or permissive during ... Read more >>

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Individual Neuronal Subtypes Exhibit Diversity in CNS Myelination Mediated by Synaptic Vesicle Release.

Sigrid Koudelka, Matthew G Voas, Rafael G Almeida, Marion Baraban, Jan Soetaert, Martin P Meyer, William S Talbot, David A Lyons,

Regulation of myelination by oligodendrocytes in the CNS has important consequences for higher-order nervous system function (e.g., [1-4]), and there is growing consensus that neuronal activity regulates CNS myelination (e.g., [5-9]) through local axon-oligodendrocyte synaptic-vesicle-release-mediated signaling [10-12]. Recent analyses have indicated that myelination along axons of distinct neuronal subtypes can ... Read more >>

Curr. Biol. (Current biology : CB)
[2016, 26(11):1447-1455]

Cited: 54 times

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Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology.

Kelly R Monk, Matthew G Voas, Clara Franzini-Armstrong, Ian S Hakkinen, William S Talbot,

Mutations in SEC63 cause polycystic liver disease in humans. Sec63 is a member of the endoplasmic reticulum (ER) translocon machinery, although it is unclear how mutations in SEC63 lead to liver cyst formation in humans. Here, we report the identification and characterization of a zebrafish sec63 mutant, which was discovered ... Read more >>

Dis Model Mech (Disease models & mechanisms)
[2013, 6(1):135-145]

Cited: 17 times

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DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC.

Kunal Rai, Sharmistha Sarkar, Talmage J Broadbent, Matthew Voas, Kenneth F Grossmann, Lincoln D Nadauld, Somaye Dehghanizadeh, Fanuel T Hagos, Yumei Li, Rachel K Toth, Stephanie Chidester, Timothy M Bahr, W Evan Johnson, Brad Sklow, Randall Burt, Bradley R Cairns, David A Jones,

Although genome-wide hypomethylation is a hallmark of many cancers, roles for active DNA demethylation during tumorigenesis are unknown. Here, loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system and the concomitant hypomethylation of key intestinal cell fating genes. Notably, this hypomethylation maintained zebrafish intestinal cells ... Read more >>

Cell (Cell)
[2010, 142(6):930-942]

Cited: 49 times

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Schwann cells inhibit ectopic clustering of axonal sodium channels.

Matthew G Voas, Thomas D Glenn, Alya R Raphael, William S Talbot,

The clustering of voltage-gated sodium channels at the axon initial segment (AIS) and nodes of Ranvier is essential for the initiation and propagation of action potentials in myelinated axons. Sodium channels localize to the AIS through an axon-intrinsic mechanism driven by ankyrin G, while clustering at the nodes requires cues ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2009, 29(46):14408-14414]

Cited: 17 times

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alphaII-spectrin is essential for assembly of the nodes of Ranvier in myelinated axons.

Matthew G Voas, David A Lyons, Stephen G Naylor, Naomi Arana, Matthew N Rasband, William S Talbot,

Saltatory conduction in myelinated axons requires organization of the nodes of Ranvier, where voltage-gated sodium channels are prominently localized [1]. Previous results indicate that alphaII-spectrin, a component of the cortical cytoskeleton [2], is enriched at the paranodes [3, 4], which flank the node of Ranvier, but alphaII-spectrin's function has not ... Read more >>

Curr. Biol. (Current biology : CB)
[2007, 17(6):562-568]

Cited: 52 times

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nsf is essential for organization of myelinated axons in zebrafish.

Ian G Woods, David A Lyons, Matthew G Voas, Hans-Martin Pogoda, William S Talbot,

BACKGROUND: Myelinated axons are essential for rapid conduction of action potentials in the vertebrate nervous system. Of particular importance are the nodes of Ranvier, sites of voltage-gated sodium channel clustering that allow action potentials to be propagated along myelinated axons by saltatory conduction. Despite their critical role in the function ... Read more >>

Curr. Biol. (Current biology : CB)
[2006, 16(7):636-648]

Cited: 32 times

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erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish.

David A Lyons, Hans-Martin Pogoda, Matthew G Voas, Ian G Woods, Brianne Diamond, Rebecca Nix, Naomi Arana, Jennifer Jacobs, William S Talbot,

BACKGROUND: Myelin is critical for efficient axonal conduction in the vertebrate nervous system. Neuregulin (Nrg) ligands and their ErbB receptors are required for the development of Schwann cells, the glial cells that form myelin in the peripheral nervous system. Previous studies have not determined whether Nrg-ErbB signaling is essential in ... Read more >>

Curr. Biol. (Current biology : CB)
[2005, 15(6):513-524]

Cited: 194 times

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Signal integration during development: insights from the Drosophila eye.

Matthew G Voas, Ilaria Rebay,

The Drosophila eye is a highly ordered epithelial tissue composed of approximately 750 subunits called ommatidia arranged in a reiterated hexagonal pattern. At higher resolution, observation of the constituent photoreceptors, cone cells, and pigment cells of the eye reveals a highly ordered mosaic of amazing regularity. This relatively simple organization ... Read more >>

Dev. Dyn. (Developmental dynamics : an official publication of the American Association of Anatomists)
[2004, 229(1):162-175]

Cited: 109 times

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The novel plant homeodomain protein rhinoceros antagonizes Ras signaling in the Drosophila eye.

Matthew G Voas, Ilaria Rebay,

The sequential specification of cell fates in the Drosophila eye requires repeated activation of the epidermal growth factor receptor (EGFR)/Ras/MAP kinase (MAPK) pathway. Equally important are the multiple layers of inhibitory regulation that prevent excessive or inappropriate signaling. Here we describe the molecular and genetic analysis of a previously uncharacterized ... Read more >>

Genetics (Genetics)
[2003, 165(4):1993-2006]

Cited: 8 times

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Biological functions of the ISWI chromatin remodeling complex NURF.

Paul Badenhorst, Matthew Voas, Ilaria Rebay, Carl Wu,

The nucleosome remodeling factor (NURF) is one of several ISWI-containing protein complexes that catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin in vitro. To establish the physiological requirements of NURF, and to distinguish NURF genetically from other ISWI-containing complexes, we isolated mutations in the gene encoding the large NURF ... Read more >>

Genes Dev. (Genes & development)
[2002, 16(24):3186-3198]

Cited: 131 times

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