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Author Matthew Lees

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A muscle-centric view of time-restricted feeding for older adults.

Matthew J Lees, Nathan Hodson, Daniel R Moore,

<h4>Purpose of review</h4>The practice of time-restricted feeding (TRF) has received fervent interest in recent years as a strategy to mitigate obesity and metabolic disease. We sought to review the implications of TRF for skeletal muscle health and function in aging.<h4>Recent findings</h4>TRF has high adherence and can promote body weight loss ... Read more >>

Curr Opin Clin Nutr Metab Care (Current opinion in clinical nutrition and metabolic care)
[2021, 24(6):521-527]

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LAT1 and SNAT2 Protein Expression and Membrane Localization of LAT1 Are Not Acutely Altered by Dietary Amino Acids or Resistance Exercise Nor Positively Associated with Leucine or Phenylalanine Incorporation in Human Skeletal Muscle.

Michael Mazzulla, Nathan Hodson, Matthew Lees, Paula J Scaife, Kenneth Smith, Philip J Atherton, Dinesh Kumbhare, Daniel R Moore,

The influx of essential amino acids into skeletal muscle is primarily mediated by the large neutral amino acid transporter 1 (LAT1), which is dependent on the glutamine gradient generated by the sodium-dependent neutral amino acid transporter 2 (SNAT2). The protein expression and membrane localization of LAT1 may be influenced by ... Read more >>

Nutrients (Nutrients)
[2021, 13(11):]

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Cerebral, cardiac and skeletal muscle stress associated with a series of static and dynamic apnoeas.

Antonis Elia, David R Woods, Matthew J Barlow, Matthew J Lees, John P O'Hara,

<h4>Purpose</h4>This study sought to explore, for the first time, the effects of repeated maximal static and dynamic apnoeic attempts on the physiological milieu by assessing cerebral, cardiac and striatal muscle stress-related biomarkers in a group of elite breath-hold divers (EBHD).<h4>Methods</h4>Sixteen healthy males were recruited (EBHD = 8; controls = 8). On two separate occasions, ... Read more >>

Scand J Med Sci Sports (Scandinavian journal of medicine & science in sports)
[2022, 32(1):233-241]

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Modeling 65 Years of Land Subsidence in California’s San Joaquin Valley

Matthew Lees, Rosemary Knight, Ryan Smith,

[copied directly from first paragraph of paper] Land subsidence, caused by groundwater extraction and subsequent subsurface compaction, is an issue of global concern. Since the 1920s, there have been numerous periods of subsidence in California’s San Joaquin Valley leading to widespread sinking of the land surface which has locally ... Read more >>

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Consumption of High-Leucine-Containing Protein Bar Following Breakfast Impacts Aminoacidemia and Subjective Appetite in Older Persons.

Daniel A Traylor, Michael Kamal, Everson A Nunes, Todd Prior, Stefan H M Gorissen, Matthew Lees, Fran Gesel, Changhyun Lim, Stuart M Phillips,

<h4>Background</h4>Limited data are available examining dietary interventions for optimizing protein and leucine intake to stimulate muscle protein synthesis (MPS) in older humans.<h4>Objectives</h4>We aimed to investigate the aminoacidemia and appetite responses of older adults after consuming breakfast, a meal frequently consumed with high-carbohydrate and below-par amounts of protein and leucine for ... Read more >>

Curr Dev Nutr (Current developments in nutrition)
[2021, 5(6):nzab080]

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Physiology, pathophysiology and (mal)adaptations to chronic apnoeic training: a state-of-the-art review.

Antonis Elia, M Gennser, P S Harlow, Matthew J Lees,

Breath-hold diving is an activity that humans have engaged in since antiquity to forage for resources, provide sustenance and to support military campaigns. In modern times, breath-hold diving continues to gain popularity and recognition as both a competitive and recreational sport. The continued progression of world records is somewhat remarkable, ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2021, 121(6):1543-1566]

Cited: 2 times

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A Fish-Derived Protein Hydrolysate Induces Postprandial Aminoacidaemia and Skeletal Muscle Anabolism in an In Vitro Cell Model Using Ex Vivo Human Serum.

Matthew J Lees, David Nolan, Miryam Amigo-Benavent, Conor J Raleigh, Neda Khatib, Pádraigín Harnedy-Rothwell, Richard J FitzGerald, Brendan Egan, Brian P Carson,

Fish-derived proteins, particularly fish protein hydrolysates (FPH), offer potential as high-quality sources of dietary protein, whilst enhancing economic and environmental sustainability. This study investigated the impact of a blue whiting-derived protein hydrolysate (BWPH) on aminoacidaemia in vivo and skeletal muscle anabolism in vitro compared with whey protein isolate (WPI) and ... Read more >>

Nutrients (Nutrients)
[2021, 13(2):]

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The efficacy of essential amino acid supplementation for augmenting dietary protein intake in older adults: implications for skeletal muscle mass, strength and function.

Theocharis Ispoglou, Oliver C Witard, Lauren C Duckworth, Matthew J Lees,

The primary aim of this review is to evaluate the efficacy of essential amino acid (EAA) supplementation as a strategy to increase dietary protein intake and improve muscle mass, strength and function in older adults. A sufficient daily protein intake is widely recognised to be fundamental for the successful management ... Read more >>

Proc Nutr Soc (The Proceedings of the Nutrition Society)
[2021, 80(2):230-242]

Cited: 1 time

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The Potential Role of Fish-Derived Protein Hydrolysates on Metabolic Health, Skeletal Muscle Mass and Function in Ageing.

Matthew J Lees, Brian P Carson,

Fish protein represents one of the most widely consumed dietary protein sources by humans. The processing of material from the fishing industry generates substantial unexploited waste products, many of which possess high biological value. Protein hydrolysates, such as fish protein hydrolysates (FPH), containing predominantly di- and tripeptides, are more readily ... Read more >>

Nutrients (Nutrients)
[2020, 12(8):]

Cited: 5 times

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Novel Essential Amino Acid Supplements Following Resistance Exercise Induce Aminoacidemia and Enhance Anabolic Signaling Irrespective of Age: A Proof-of-Concept Trial.

Matthew J Lees, Oliver J Wilson, Erin K Webb, Daniel A Traylor, Todd Prior, Antonis Elia, Paul S Harlow, Alistair D Black, Paul J Parker, Nick Harris, Michael Cooke, Christopher Balchin, Mathew Butterworth, Stuart M Phillips, Theocharis Ispoglou,

We investigated the effects of ingesting a leucine-enriched essential amino acid (EAA) gel alone or combined with resistance exercise (RE) versus RE alone (control) on plasma aminoacidemia and intramyocellular anabolic signaling in healthy younger (28 ± 4 years) and older (71 ± 3 years) adults. Blood samples were obtained throughout ... Read more >>

Nutrients (Nutrients)
[2020, 12(7):]

Cited: 1 time

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Skeletal muscle, haematological and splenic volume characteristics of elite breath-hold divers.

Antonis Elia, Oliver J Wilson, Matthew Lees, Paul J Parker, Matthew J Barlow, Matthew Cocks, John P O'Hara,

PURPOSE:The aim of the study was to provide an evaluation of the oxygen transport, exchange and storage capacity of elite breath-hold divers (EBHD) compared with non-divers (ND). METHODS:Twenty-one healthy males' (11 EBHD; 10 ND) resting splenic volumes were assessed by ultrasound and venous blood drawn for full blood count analysis. ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2019, 119(11-12):2499-2511]

Cited: 2 times

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Response: Muscle strength and function rather than muscle mass in sarcopenia.

Matthew J Lees, Oliver J Wilson, Karen Hind, Theocharis Ispoglou,

Eur J Appl Physiol (European journal of applied physiology)
[2019, 119(7):1673-1674]

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Αcute effects of essential amino acid gel-based and whey protein supplements on appetite and energy intake in older women.

Mathew Butterworth, Matthew Lees, Paul Harlow, Karen Hind, Lauren Duckworth, Theocharis Ispoglou,

Deficiencies in protein and energy intakes are partly responsible for age-related sarcopenia. We investigated the effects of supplements matched in essential amino acid (EAA) content (7.5 g) on energy intake and appetite. Ten women aged 69.2 ± 2.7 years completed 3 trials in a randomised, crossover design. Composite appetite scores, ... Read more >>

Appl Physiol Nutr Metab (Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme)
[2019, 44(11):1141-1149]

Cited: 4 times

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Muscle quality as a complementary prognostic tool in conjunction with sarcopenia assessment in younger and older individuals.

Matthew J Lees, Oliver J Wilson, Karen Hind, Theocharis Ispoglou,

<h4>Purpose</h4>This pilot study investigated differences in lean tissue mass, muscle strength, muscle quality (strength per unit of muscle mass; MQ), and functional performance in healthy younger and older individuals. The most robust predictors of appendicular lean mass (ALM) were then determined in each group.<h4>Methods</h4>Fifty younger (18-45 years) and 50 older (60-80 years) ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2019, 119(5):1171-1181]

Cited: 7 times

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Interpretation of Dual-Energy X-Ray Absorptiometry-Derived Body Composition Change in Athletes: A Review and Recommendations for Best Practice.

Karen Hind, Gary Slater, Brian Oldroyd, Matthew Lees, Shane Thurlow, Matthew Barlow, John Shepherd,

Dual-energy X-ray absorptiometry (DXA) is a medical imaging device which has become the method of choice for the measurement of body composition in athletes. The objectives of this review were to evaluate published longitudinal DXA body composition studies in athletic populations for interpretation of "meaningful" change, and to propose a ... Read more >>

J Clin Densitom (Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry)
[2018, 21(3):429-443]

Cited: 10 times

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Novel essential amino acid supplements enriched with L-leucine facilitate increased protein and energy intakes in older women: a randomised controlled trial.

Theocharis Ispoglou, Kevin Deighton, Roderick Fgj King, Helen White, Matthew Lees,

<h4>Background</h4>Inadequate protein intake (PI), containing a sub-optimal source of essential amino acids (EAAs), and reduced appetite are contributing factors to age-related sarcopenia. The satiating effects of dietary protein per se may negatively affect energy intake (EI), thus there is a need to explore alternative strategies to facilitate PI without compromising ... Read more >>

Nutr J (Nutrition journal)
[2017, 16(1):75]

Cited: 4 times

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Bone Density and Cross-sectional Geometry of the Proximal Femur Are Bilaterally Elevated in Elite Cricket Fast Bowlers.

Matthew J Lees, Clive B Beggs, Matthew J Barlow, Zoe H Rutherford, Kunwar Bansil, Lisa Gannon, Karen Hind,

The skeleton of a cricket fast bowler is exposed to a unique combination of gravitational and torsional loading in the form of substantial ground reaction forces delivered through the front landing foot, and anterior-posterior shear forces mediated by regional muscle contractions across the lumbo-pelvic region. The objectives of this study ... Read more >>

J Clin Densitom (Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry)
[2018, 21(3):399-405]

Cited: 1 time

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Six-year body composition change in male elite senior rugby league players.

Ben Jones, Kevin Till, Gregory Roe, John O'Hara, Matthew Lees, Matthew J Barlow, Karen Hind,

This study investigated the change in body composition and bone mineral content (BMC) of senior rugby league (RL) players between 2008 and 2014. Twelve male professional RL players (age, 24.6 ± 4.0 years; stature, 183.4 ± 8.4 cm) received a dual-energy X-ray absorptiometry scan during preseason in 2008 and 2014. Between 2008 and 2014, very likely ... Read more >>

J Sports Sci (Journal of sports sciences)
[2018, 36(3):266-271]

Cited: 2 times

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Three-Compartment Body Composition Changes in Professional Rugby Union Players Over One Competitive Season: A Team and Individualized Approach.

Matthew J Lees, Brian Oldroyd, Ben Jones, Amy Brightmore, John P O'Hara, Matthew J Barlow, Kevin Till, Karen Hind,

The purpose of this study was to investigate the longitudinal body composition of professional rugby union players over one competitive season. Given the potential for variability in changes, and as the first to do so, we conducted individual analysis in addition to analysis of group means. Thirty-five professional rugby union ... Read more >>

J Clin Densitom (Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry)
[2017, 20(1):50-57]

Cited: 12 times

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Total, regional and unilateral body composition of professional English first-class cricket fast bowlers.

Matthew J Lees, Kunwar Bansil, Karen Hind,

There have been few reports of advanced body composition profiles of elite fast bowlers in the sport of cricket. Therefore, the aim of the current study was to determine total, regional and unilateral body composition characteristics of elite English first-class cricket fast bowlers in comparison with matched controls, using dual-energy ... Read more >>

J Sports Sci (Journal of sports sciences)
[2016, 34(3):252-258]

Cited: 3 times

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Three-Compartment Body Composition in Academy and Senior Rugby League Players.

Kevin Till, Ben Jones, John O'Hara, Matthew Barlow, Amy Brightmore, Matthew Lees, Karen Hind,

<h4>Purpose</h4>To compare the body size and 3-compartment body composition between academy and senior professional rugby league players using dual-energy X-ray absorptiometry (DXA).<h4>Methods</h4>Academy (age 18.1 ± 1.1 y, n = 34) and senior (age 26.2 ± 4.6 y, n = 63) rugby league players received 1 total-body DXA scan. Height, body ... Read more >>

Int J Sports Physiol Perform (International journal of sports physiology and performance)
[2016, 11(2):191-196]

Cited: 4 times

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Precision Error in Dual-Energy X-Ray Absorptiometry Body Composition Measurements in Elite Male Rugby League Players.

Matthew J Barlow, Brian Oldroyd, Debbie Smith, Matthew J Lees, Amy Brightmore, Kevin Till, Benjamin Jones, Karen Hind,

Body composition analysis using dual-energy X-ray absorptiometry (DXA) is becoming increasingly popular in both clinical and sports science settings. Obesity, characterized by high fat mass (FM), is associated with larger precision errors; however, precision error for athletic groups with high levels of lean mass (LM) are unclear. Total (TB) and ... Read more >>

J Clin Densitom (Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry)
[2015, 18(4):546-550]

Cited: 8 times

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Convective roll dynamics in liquid 4He near the onset of convection.

Matthew J Lees, Michael S Thurlow, James R T Seddon, Peter G J Lucas,

We present results of experiments on Rayleigh-Bénard convection in liquid 4He at several temperatures. We show visually that with carefully defined boundary conditions the basic convection state consists of parallel rolls which are aligned in one of two directions, the angle thus defined as being temperature dependent and we attempt ... Read more >>

Phys Rev Lett (Physical review letters)
[2004, 93(14):144502]

Cited: 0 times

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