Full Text Journal Articles by
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An Ex Vivo Acid Injury and Repair (AIR) Model Using Precision-Cut Lung Slices to Understand Lung Injury and Repair.

Sally Yunsun Kim, Róisín Mongey, Mark Griffiths, Matthew Hind, Charlotte H Dean,

Recent advances in cell culture models like air-liquid interface culture and ex vivo models such as organoids have advanced studies of lung biology; however, gaps exist between these models and tools that represent the complexity of the three-dimensional environment of the lung. Precision-cut lung slices (PCLS) mimic the in vivo ... Read more >>

Curr Protoc Mouse Biol (Current protocols in mouse biology)
[2020, 10(4):e85]

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The acid injury and repair (AIR) model: A novel ex-vivo tool to understand lung repair.

Sally Yunsun Kim, Róisín Mongey, Peizhu Wang, Stephen Rothery, David C A Gaboriau, Matthew Hind, Mark Griffiths, Charlotte H Dean,

Research into mechanisms underlying lung injury and subsequent repair responses is currently of paramount importance. There is a paucity of models that bridge the gap between in vitro and in vivo research. Such intermediate models are critical for researchers to decipher the mechanisms that drive repair and to test potential ... Read more >>

Biomaterials (Biomaterials)
[2020, 267:120480]

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Mechanism of lung development in the aetiology of adult congenital pulmonary airway malformations.

Bethany Taylor, Alexandra Rice, Andrew G Nicholson, Matthew Hind, Charlotte H Dean,

Congenital pulmonary airway malformations (CPAMs) are rare lung abnormalities that result in cyst formation and are associated with respiratory distress in infants and malignant potential in adults. The pathogenesis of CPAMs remains unknown but data suggest disruption of the normal proximo-distal programme of airway branching and differentiation. Here, we demonstrate ... Read more >>

Thorax (Thorax)
[2020, 75(11):1001-1003]

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Lung Development Genes and Adult Lung Function.

Laura Portas, Miguel Pereira, Seif O Shaheen, Annah B Wyss, Stephanie J London, Peter G J Burney, Matthew Hind, Charlotte H Dean, Cosetta Minelli,

Rationale: Poor lung health in adult life may occur partly through suboptimal growth and development, as suggested by epidemiological evidence pointing to early life risk factors.Objectives: To systematically investigate the effects of lung development genes on adult lung function.Methods: Using UK Biobank data, we tested the association of 391 genes ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(6):853-865]

Cited: 1 time

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Weaning by Surgical Tracheostomy and Portable Ventilators Released ICU Ventilators During Coronavirus Disease 2019 Surge in London.

Suveer Singh, Matthew Hind, Simon Jordan, Patrick Ward, Deborah Field, Michael Polkey, Jonathan Collier,

(Critical care explorations)
[2020, 2(8):e0193]

Cited: 0 times

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Bony Breathlessness: Reversible Pulmonary Hypertension in Melnick-Needles Syndrome Using Noninvasive Ventilation

Beatrice Cockbain, Laura C Price, Matthew Hind,

Circulation (Circulation)
[2019, 140(10):880-885]

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Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour.

Khondoker M Akram, Laura L Yates, Róisín Mongey, Stephen Rothery, David C A Gaboriau, Jeremy Sanderson, Matthew Hind, Mark Griffiths, Charlotte H Dean,

Damage to alveoli, the gas-exchanging region of the lungs, is a component of many chronic and acute lung diseases. In addition, insufficient generation of alveoli results in bronchopulmonary dysplasia, a disease of prematurity. Therefore visualising the process of alveolar development (alveologenesis) is critical for our understanding of lung homeostasis and ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):1178]

Cited: 3 times

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Platypnoea-orthodeoxia syndrome: beware of investigations undertaken supine.

Felicity Liew, Fatma Gargoum, Robert Potter, Stuart D Rosen, Simon Ward, Matthew Hind, Michael I Polkey,

Platypnoea-orthodeoxia syndrome (POS) is a rare disorder, manifesting as deoxygenation occurring when the patient is in the upright position. Four broad mechanisms for the condition have been described: intracardiac shunts, intrapulmonary shunts, hepatopulmonary syndrome and pulmonary ventilation-perfusion mismatch. Here, we present the first case of POS in a patient with ... Read more >>

Thorax (Thorax)
[2019, 74(9):917-919]

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Regenerative pharmacology for COPD: breathing new life into old lungs.

John-Poul Ng-Blichfeldt, Reinoud Gosens, Charlotte Dean, Mark Griffiths, Matthew Hind,

Chronic obstructive pulmonary disease (COPD) is a major global health concern with few effective treatments. Widespread destruction of alveolar tissue contributes to impaired gas exchange in severe COPD, and recent radiological evidence suggests that destruction of small airways is a major contributor to increased peripheral airway resistance in disease. This ... Read more >>

Thorax (Thorax)
[2019, 74(9):890-897]

Cited: 4 times

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Thoracic Park: cardiac MRI reveals massive thoracic varices as consequence of inferior vena cava ligation.

Christopher J Allen, Tanya Freeman, Wayomi Perera, Simon P Padley, Matthew Hind,

Eur Heart J Cardiovasc Imaging (European heart journal cardiovascular Imaging)
[2018, 19(3):359-360]

Cited: 0 times

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London ambulance source data on choking incidence for the calendar year 2016: an observational study.

Matthew J Pavitt, Joanne Nevett, Laura L Swanton, Matthew D Hind, Michael I Polkey, Malcolm Green, Nicholas S Hopkinson,

Complete foreign body airway obstruction is a life-threatening emergency, but there are limited data on its epidemiology.We conducted a retrospective analysis of data collected routinely from London Ambulance Service calls coded as being for choking was undertaken for the calendar year of 2016.There were 1916 choking episodes of significant severity ... Read more >>

BMJ Open Respir Res (BMJ open respiratory research)
[2017, 4(1):e000215]

Cited: 1 time

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AJRCCM: 100-Year Anniversary. Homeward Bound: A Centenary of Home Mechanical Ventilation.

Matthew Hind, Michael I Polkey, Anita K Simonds,

The evolution of home mechanical ventilation is an intertwined chronicle of negative and positive pressure modes and their role in managing ventilatory failure in neuromuscular diseases and other chronic disorders. The uptake of noninvasive positive pressure ventilation has resulted in widespread growth in home ventilation internationally and fewer patients being ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2017, 195(9):1140-1149]

Cited: 2 times

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Choking on a foreign body: a physiological study of the effectiveness of abdominal thrust manoeuvres to increase thoracic pressure.

Matthew J Pavitt, Laura L Swanton, Matthew Hind, Michael Apps, Michael I Polkey, Malcolm Green, Nicholas S Hopkinson,

The Heimlich manoeuvre is a well-known intervention for the management of choking due to foreign body airway occlusion, but the evidence base for guidance on this topic is limited and guidelines differ. We measured pressures during abdominal thrusts in healthy volunteers. The angle at which thrusts were performed (upthrust vs ... Read more >>

Thorax (Thorax)
[2017, 72(6):576-578]

Cited: 1 time

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Bronchial Dieulafoy Lesion. A 20-Year History of Unexplained Hemoptysis.

Savvas Hadjiphilippou, Pallav L Shah, Alexandra Rice, Simon Padley, Matthew Hind,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2017, 195(3):397]

Cited: 4 times

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A man with progressive type II respiratory failure.

Matthew Hind, Simon Jordan, David M Hansell, Andrew G Nicholson, Guy Neild, Michael I Polkey,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2017, 5(5):456]

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Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema.

John-Poul Ng-Blichfeldt, Joana Alçada, M Angeles Montero, Charlotte H Dean, Uta Griesenbach, Mark J Griffiths, Matthew Hind,

Molecular pathways that regulate alveolar development and adult repair represent potential therapeutic targets for emphysema. Signalling via retinoic acid (RA), derived from vitamin A, is required for mammalian alveologenesis, and exogenous RA can induce alveolar regeneration in rodents. Little is known about RA signalling in the human lung and its ... Read more >>

Thorax (Thorax)
[2017, 72(6):510-521]

Cited: 7 times

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Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair.

Thanushiyan Poobalasingam, Laura L Yates, Simone A Walker, Miguel Pereira, Nina Y Gross, Akmol Ali, Maria Kolatsi-Joannou, Marjo-Riitta Jarvelin, Juha Pekkanen, Eugenia Papakrivopoulou, David A Long, Mark Griffiths, Darcy Wagner, Melanie Königshoff, Matthew Hind, Cosetta Minelli, Clare M Lloyd, Charlotte H Dean,

Lung diseases impose a huge economic and health burden worldwide. A key aspect of several adult lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), including emphysema, is aberrant tissue repair, which leads to an accumulation of damage and impaired respiratory function. Currently, there are ... Read more >>

Dis Model Mech (Disease models & mechanisms)
[2017, 10(4):409-423]

Cited: 7 times

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Endobronchial valves for patients with heterogeneous emphysema and without interlobar collateral ventilation: open label treatment following the BeLieVeR-HIFi study.

Zaid Zoumot, Claire Davey, Simon Jordan, William H McNulty, Denis H Carr, Matthew D Hind, Michael I Polkey, Pallav L Shah, Nicholas S Hopkinson,

Outcomes in early trials of bronchoscopic lung volume reduction using endobronchial valves for the treatment of patients with advanced emphysema were inconsistent. However improvements in patient selection with focus on excluding those with interlobar collateral ventilation and homogeneous emphysema resulted in significant benefits in the BeLieVeR-HIFi study compared with sham ... Read more >>

Thorax (Thorax)
[2017, 72(3):277-279]

Cited: 6 times

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Association of Forced Vital Capacity with the Developmental Gene NCOR2.

Cosetta Minelli, Charlotte H Dean, Matthew Hind, Alexessander Couto Alves, André F S Amaral, Valerie Siroux, Ville Huikari, María Soler Artigas, David M Evans, Daan W Loth, Yohan Bossé, Dirkje S Postma, Don Sin, John Thompson, Florence Demenais, John Henderson, , , Emmanuelle Bouzigon, Deborah Jarvis, Marjo-Riitta Järvelin, Peter Burney,

BACKGROUND:Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly ... Read more >>

PLoS One (PloS one)
[2016, 11(2):e0147388]

Cited: 5 times

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A randomised controlled study of Bronchoscopic Lung Volume Reduction with endobronchial valves for patients with Heterogeneous emphysema and Intact interlobar Fissures: the BeLieVeR-HIFi study

Zaid Zoumot, Claire Davey, Simon Jordan, William H McNulty, Denis H Carr, Matthew D Hind, David M Hansell, Michael B Rubens, Winston Banya, Michael I Polkey, Pallav L Shah, Nicholas S Hopkinson,

BACKGROUND:Despite optimal therapy many patients with emphysema remain significantly breathless and limited. Bronchoscopic lung volume reduction (BLVR), using valves placed to allow air to leave but not enter the worst-affected areas of the lung, has been proposed as a way to improve lung function in these patients, but response is ... Read more >>

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Bronchoscopic lung volume reduction with endobronchial valves for patients with heterogeneous emphysema and intact interlobar fissures (the BeLieVeR-HIFi study): a randomised controlled trial.

Claire Davey, Zaid Zoumot, Simon Jordan, William H McNulty, Dennis H Carr, Matthew D Hind, David M Hansell, Michael B Rubens, Winston Banya, Michael I Polkey, Pallav L Shah, Nicholas S Hopkinson,

BACKGROUND:Lung volume reduction surgery improves survival in selected patients with emphysema, and has generated interest in bronchoscopic approaches that might achieve the same effect with less morbidity and mortality. Previous trials with endobronchial valves have yielded modest group benefits because when collateral ventilation is present it prevents lobar atelectasis. METHODS:We ... Read more >>

Lancet (Lancet (London, England))
[2015, 386(9998):1066-1073]

Cited: 104 times

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Sniffing out a hidden cause of breathlessness.

Alexandra Marie Nanzer, John Janssen, Matthew Hind,

A 78-year-old man presented with severe exertional dyspnoea. He suffered from mild chronic obstructive pulmonary disease, congestive cardiac failure and seropositive myasthaenia gravis. Clinical examination of his chest and heart were unremarkable but he had speech dyspnoea and was unable to count to 20 in a single breath. Consecutive sniff ... Read more >>

BMJ Case Rep (BMJ case reports)
[2014, 2014:]

Cited: 0 times

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A deadly web.

Alexandra M Nanzer, Simon Jordan, Simon Padley, Mark Griffiths, Matthew Hind,

Thorax (Thorax)
[2015, 70(1):101]

Cited: 0 times

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Delivering and phenotyping mouse models for the respiratory community: a report on the Biochemical Society Workshop.

Charlotte Dean, Colin Bingle, Matthew Hind,

The IMPC (International Mouse Phenotyping Consortium) was launched recently, and its aim is to develop and phenotype mouse knockouts of 4000 genes over the next 5 years and, ultimately, of all 20000 or so genes in the mouse genome. As part of the IMPC, the MRC (Medical Research Council) also launched ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2013, 125(10):495-500]

Cited: 1 time

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Tobacco industry lobbyists and their health-care clients.

Nicholas S Hopkinson, John Moxham, Hugh Montgomery, Robert West, Gabriel Scally, Martin McKee, Stephen Spiro, Andrew Bush, John Stradling, Athol Wells, Kian Fan Chung, Stephen R Durham, Finbarr C Martin, Jo Congleton, Elin Roddy, Mark Dayer, Patrick White, Philip W Ind, Joanna L Brown, Irem Patel, Keir Lewis, Keir Lewis, Nicholas Hart, Samuel Kemp, Jack Barker, Matthew Hind, David Nicholl, Myra Stern, Sarah Elkin,

Lancet (Lancet (London, England))
[2013, 381(9865):445]

Cited: 2 times

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