Full Text Journal Articles by
Author Matthew E Griffin

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Sulfated glycans engage the Ang-Tie pathway to regulate vascular development.

Matthew E Griffin, Alexander W Sorum, Gregory M Miller, William A Goddard, Linda C Hsieh-Wilson,

The angiopoietin (Ang)-Tie pathway is essential for the proper maturation and remodeling of the vasculature. Despite its importance in disease, the mechanisms that control signal transduction through this pathway are poorly understood. Here, we demonstrate that heparan sulfate glycosaminoglycans (HS GAGs) regulate Ang-Tie signaling through direct interactions with both Ang ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

Cited: 0 times

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Translation of peptidoglycan metabolites into immunotherapeutics.

Matthew E Griffin, Charles W Hespen, Yen-Chih Wang, Howard C Hang,

The discovery of defined peptidoglycan metabolites that activate host immunity and their specific receptors has revealed fundamental insights into host-microbe recognition and afforded new opportunities for therapeutic development against infection and cancer. In this review, we summarise the discovery of two key peptidoglycan metabolites, γ-d-glutamyl-meso-diaminopimelic acid (iE-DAP) and muramyl dipeptide ... Read more >>

Clin Transl Immunology (Clinical & translational immunology)
[2019, 8(12):e1095]

Cited: 2 times

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Peptidoglycan Metabolite Photoaffinity Reporters Reveal Direct Binding to Intracellular Pattern Recognition Receptors and Arf GTPases.

Yen-Chih Wang, Nathan P Westcott, Matthew E Griffin, Howard C Hang,

The peptidoglycan fragments γ-d-glutamyl- meso-diaminopimelic acid (iE-DAP) and muramyl-dipeptide (MDP) are microbial-specific metabolites that activate intracellular pattern recognition receptors and stimulate immune signaling pathways. While extensive structure-activity studies have demonstrated that these bacterial cell wall metabolites trigger NOD1- and NOD2-dependent signaling, their direct binding to these innate immune receptors or ... Read more >>

ACS Chem Biol (ACS chemical biology)
[2019, 14(3):405-414]

Cited: 1 time

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Glycan Engineering for Cell and Developmental Biology.

Matthew E Griffin, Linda C Hsieh-Wilson,

Cell-surface glycans are a diverse class of macromolecules that participate in many key biological processes, including cell-cell communication, development, and disease progression. Thus, the ability to modulate the structures of glycans on cell surfaces provides a powerful means not only to understand fundamental processes but also to direct activity and ... Read more >>

Cell Chem Biol (Cell chemical biology)
[2016, 23(1):108-121]

Cited: 16 times

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Long-lived engineering of glycans to direct stem cell fate.

Abigail Pulsipher, Matthew E Griffin, Shannon E Stone, Linda C Hsieh-Wilson,

Glycans mediate many critical, long-term biological processes, such as stem cell differentiation. However, few methods are available for the sustained remodeling of cells with specific glycan structures. A new strategy that enables the long-lived presentation of defined glycosaminoglycans on cell surfaces using HaloTag proteins (HTPs) as anchors is reported. By ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2015, 54(5):1466-1470]

Cited: 9 times

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Directing neuronal signaling through cell-surface glycan engineering.

Abigail Pulsipher, Matthew E Griffin, Shannon E Stone, Joshua M Brown, Linda C Hsieh-Wilson,

The ability to tailor plasma membranes with specific glycans may enable the control of signaling events that are critical for proper development and function. We report a method to modify cell surfaces with specific sulfated chondroitin sulfate (CS) glycosaminoglycans using chemically modified liposomes. Neurons engineered to display CS-E-enriched polysaccharides exhibited ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2014, 136(19):6794-6797]

Cited: 27 times

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Chemistry. Improving biologic drugs via total chemical synthesis.

Linda C Hsieh-Wilson, Matthew E Griffin,

Science (Science (New York, N.Y.))
[2013, 342(6164):1332-1333]

Cited: 3 times

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Synthetic probes of glycosaminoglycan function.

Matthew E Griffin, Linda C Hsieh-Wilson,

Glycosaminoglycans (GAGs) participate in many critical biological processes by modulating the activities of a wide range of proteins, including growth factors, chemokines, and viral receptors. Recent studies using synthetic oligosaccharides and glycomimetic polymers have established the importance of specific structural determinants in controlling GAG function. These findings illustrate the power ... Read more >>

Curr Opin Chem Biol (Current opinion in chemical biology)
[2013, 17(6):1014-1022]

Cited: 7 times

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Molecular recognition and enhancement of aqueous solubility and bioactivity of CD437 by β-cyclodextrin.

Robert J Mishur, Matthew E Griffin, Cooper H Battle, Bin Shan, Janarthanan Jayawickramarajah,

CD437 (6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid) is a novel synthetic retinoic acid derivative that has been shown to selectively induce apoptosis in human lung cancer cells. This compound, however, is limited in its application due to its low solubility in aqueous solutions. One technique for increasing the solubility and bioavailability of a ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2011, 21(2):857-860]

Cited: 6 times

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