Full Text Journal Articles by
Author Matthew Christopher


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Autoantigen Tetramer Silences Autoreactive B Cell Populations.

Matthew A Christopher, Stephanie N Johnson, J Daniel Griffin, Cory J Berkland,

Many autoimmune therapies focus on immune suppression to reduce symptom severity and halt disease progression; however, currently approved treatments lack specificity for the autoantigen and rely on more global immune suppression. Multivalent antigen arrays can disarm pathogenic autoimmune B cell populations that specifically recognize the antigen of interest via their ... Read more >>

Mol Pharm (Molecular pharmaceutics)
[2020, :]

Cited: 0 times

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Publisher Correction: A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, Xuan Mo, Oleg Ursu, Matthew Christopher, Rafael B Fernandez, Li Zheng, Brian D Dill, Huijun Wang, Yuting Xu, Andy Liaw, Jonathan D Mortison, Nirodhini Siriwardana, Brian Andresen, Meir Glick, James R Tata, Victoria Kutilek, Ivan Cornella-Taracido, An Chi,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(10):1149]

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A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, Xuan Mo, Oleg Ursu, Matthew Christopher, Rafael B Fernandez, Li Zheng, Brian D Dill, Huijun Wang, Yuting Xu, Andy Liaw, Jonathan D Mortison, Nirodhini Siriwardana, Brian Andresen, Meir Glick, James R Tata, Victoria Kutilek, Ivan Cornella-Taracido, An Chi,

Mass spectrometry-based discovery proteomics is an essential tool for the proximal readout of cellular drug action. Here, we apply a robust proteomic workflow to rapidly profile the proteomes of five lung cancer cell lines in response to more than 50 drugs. Integration of millions of quantitative protein-drug associations substantially improved ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(10):1111-1119]

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Corrigendum to "Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow" [Bioorg. Med. Chem. Lett. 29 (2019) 2575-2580].

Xavier Fradera, Joey L Methot, Abdelghani Achab, Matthew Christopher, Michael D Altman, Hua Zhou, Meredeth A McGowan, Sam D Kattar, Kevin Wilson, Yudith Garcia, Martin A Augustin, Charles A Lesburg, Sanjiv Shah, Peter Goldenblatt, Jason D Katz,

Bioorg. Med. Chem. Lett. (Bioorganic & medicinal chemistry letters)
[2020, 30(16):127363]

Cited: 0 times

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Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors.

Hua Zhou, Meredeth A McGowan, Kathryn Lipford, Matthew Christopher, Xavier Fradera, David Witter, Charles A Lesburg, Chaomin Li, Joey L Methot, John Lampe, Abdelghani Achab, Lynsey Shaffer, Peter Goldenblatt, Sanjiv Shah, Alan Bass, Gottfried Schroeder, Dapeng Chen, Haoyu Zeng, Martin A Augustin, Jason D Katz,

A high-throughput screening (HTS) campaign identified a class of heteroaryl piperazines with excellent baseline affinity and selectivity for phosphoinositide 3-kinase δ (PI3Kδ) over closely related isoforms. Rapid evaluation and optimization of structure-activity relationships (SAR) for this class, leveraging the modular nature of this scaffold, facilitated development of this hit class ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & medicinal chemistry letters)
[2020, 30(1):126715]

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Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow.

Xavier Fradera, Joey L Methot, Abdelghani Achab, Matthew Christopher, Michael D Altman, Hua Zhou, Meredeth A McGowan, Sam D Kattar, Kevin Wilson, Yudith Garcia, Martin A Augustin, Charles A Lesburg, Sanjiv Shah, Peter Goldenblatt, Jason D Katz,

PI3Kδ mediates key immune cell signaling pathways and is a target of interest for multiple indications in immunology and oncology. Here we report a structure-based scaffold-hopping strategy for the design of chemically diverse PI3Kδ inhibitors. Using this strategy, we identified several scaffolds that can be combined to generate new PI3Kδ ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2019, 29(18):2575-2580]

Cited: 0 times

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Immune Escape of AML Cells after Transplantation. Reply.

Matthew Christopher, John F DiPersio, Timothy J Ley,

N. Engl. J. Med. (The New England journal of medicine)
[2019, 380(13):1290]

Cited: 0 times

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Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.

Matthew J Christopher, Allegra A Petti, Michael P Rettig, Christopher A Miller, Ezhilarasi Chendamarai, Eric J Duncavage, Jeffery M Klco, Nicole M Helton, Michelle O'Laughlin, Catrina C Fronick, Robert S Fulton, Richard K Wilson, Lukas D Wartman, John S Welch, Sharon E Heath, Jack D Baty, Jacqueline E Payton, Timothy A Graubert, Daniel C Link, Matthew J Walter, Peter Westervelt, Timothy J Ley, John F DiPersio,

BACKGROUND:As consolidation therapy for acute myeloid leukemia (AML), allogeneic hematopoietic stem-cell transplantation provides a benefit in part by means of an immune-mediated graft-versus-leukemia effect. We hypothesized that the immune-mediated selective pressure imposed by allogeneic transplantation may cause distinct patterns of tumor evolution in relapsed disease. METHODS:We performed enhanced exome sequencing ... Read more >>

N Engl J Med (The New England journal of medicine)
[2018, 379(24):2330-2341]

Cited: 32 times

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Mutation Clearance after Transplantation for Myelodysplastic Syndrome.

Eric J Duncavage, Meagan A Jacoby, Gue Su Chang, Christopher A Miller, Natasha Edwin, Jin Shao, Kevin Elliott, Joshua Robinson, Haley Abel, Robert S Fulton, Catrina C Fronick, Michelle O'Laughlin, Sharon E Heath, Kimberly Brendel, Raya Saba, Lukas D Wartman, Matthew J Christopher, Iskra Pusic, John S Welch, Geoffrey L Uy, Daniel C Link, John F DiPersio, Peter Westervelt, Timothy J Ley, Kathryn Trinkaus, Timothy A Graubert, Matthew J Walter,

BACKGROUND:Allogeneic hematopoietic stem-cell transplantation is the only curative treatment for patients with myelodysplastic syndrome (MDS). The molecular predictors of disease progression after transplantation are unclear. METHODS:We sequenced bone marrow and skin samples from 90 adults with MDS who underwent allogeneic hematopoietic stem-cell transplantation after a myeloablative or reduced-intensity conditioning regimen. ... Read more >>

N Engl J Med (The New England journal of medicine)
[2018, 379(11):1028-1041]

Cited: 12 times

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Soluble antigen arrays disarm antigen-specific B cells to promote lasting immune tolerance in experimental autoimmune encephalomyelitis.

Brittany L Hartwell, Chad J Pickens, Martin Leon, Laura Northrup, Matthew A Christopher, J Daniel Griffin, Francisco Martinez-Becerra, Cory Berkland,

Autoreactive lymphocytes that escape central immune tolerance may be silenced via an endogenous peripheral tolerance mechanism known as anergy. Antigen-specific therapies capable of inducing anergy may restore patients with autoimmune diseases to a healthy phenotype while avoiding deleterious side effects associated with global immunosuppression. Inducing anergy in B cells may ... Read more >>

J Autoimmun (Journal of autoimmunity)
[2018, 93:76-88]

Cited: 3 times

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DNMT3AR882-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3AR882C OCI-AML3 leukemia cell line.

David Chen, Matthew Christopher, Nichole M Helton, Ian Ferguson, Timothy J Ley, David H Spencer,

Blood Cancer J (Blood cancer journal)
[2018, 8(4):38]

Cited: 2 times

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Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.

Malachi Griffith, Obi L Griffith, Kilannin Krysiak, Zachary L Skidmore, Matthew J Christopher, Jeffery M Klco, Avinash Ramu, Tamara L Lamprecht, Alex H Wagner, Katie M Campbell, Robert Lesurf, Jasreet Hundal, Jin Zhang, Nicholas C Spies, Benjamin J Ainscough, David E Larson, Sharon E Heath, Catrina Fronick, Shelly O'Laughlin, Robert S Fulton, Vincent Magrini, Sean McGrath, Scott M Smith, Christopher A Miller, Christopher A Maher, Jacqueline E Payton, Jason R Walker, James M Eldred, Matthew J Walter, Daniel C Link, Timothy A Graubert, Peter Westervelt, Shashikant Kulkarni, John F DiPersio, Elaine R Mardis, Richard K Wilson, Timothy J Ley,

The genomic events responsible for the pathogenesis of relapsed adult B-lymphoblastic leukemia (B-ALL) are not yet clear. We performed integrative analysis of whole-genome, whole-exome, custom capture, whole-transcriptome (RNA-seq), and locus-specific genomic assays across nine time points from a patient with primary de novo B-ALL. Comprehensive genome and transcriptome characterization revealed ... Read more >>

Exp Hematol (Experimental hematology)
[2016, 44(7):603-613]

Cited: 13 times

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Combining antigen and immunomodulators: Emerging trends in antigen-specific immunotherapy for autoimmunity.

Laura Northrup, Matthew A Christopher, Bradley P Sullivan, Cory Berkland,

A majority of current therapies for autoimmune diseases are general immunosuppressants, which can compromise patient response to opportunistic infection and lead to adverse events. Using antigen-specific immunotherapy (ASIT) to selectively disarm autoimmune diseases, without suppressing the global immune response, would be a transformative therapy for patients. ASIT has been used ... Read more >>

Adv. Drug Deliv. Rev. (Advanced drug delivery reviews)
[2016, 98:86-98]

Cited: 19 times

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Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.

Jeffery M Klco, Christopher A Miller, Malachi Griffith, Allegra Petti, David H Spencer, Shamika Ketkar-Kulkarni, Lukas D Wartman, Matthew Christopher, Tamara L Lamprecht, Nicole M Helton, Eric J Duncavage, Jacqueline E Payton, Jack Baty, Sharon E Heath, Obi L Griffith, Dong Shen, Jasreet Hundal, Gue Su Chang, Robert Fulton, Michelle O'Laughlin, Catrina Fronick, Vincent Magrini, Ryan T Demeter, David E Larson, Shashikant Kulkarni, Bradley A Ozenberger, John S Welch, Matthew J Walter, Timothy A Graubert, Peter Westervelt, Jerald P Radich, Daniel C Link, Elaine R Mardis, John F DiPersio, Richard K Wilson, Timothy J Ley,

Tests that predict outcomes for patients with acute myeloid leukemia (AML) are imprecise, especially for those with intermediate risk AML.To determine whether genomic approaches can provide novel prognostic information for adult patients with de novo AML.Whole-genome or exome sequencing was performed on samples obtained at disease presentation from 71 patients ... Read more >>

[2015, 314(8):811-822]

Cited: 141 times

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Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro.

S M Sarkaria, M J Christopher, J M Klco, T J Ley,

Leukemia (Leukemia)
[2014, 28(12):2403-2406]

Cited: 23 times

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G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling.

L G Schuettpelz, J N Borgerding, M J Christopher, P K Gopalan, M P Romine, A C Herman, J R Woloszynek, A M Greenbaum, D C Link,

Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells (HSCs). Granulocyte colony-stimulating factor (G-CSF) is often induced with infection and has a key role in the stress granulopoiesis response. However, its effects on HSCs are less clear. Herein, we show that treatment with G-CSF induces expansion and increased quiescence ... Read more >>

Leukemia (Leukemia)
[2014, 28(9):1851-1860]

Cited: 49 times

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CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance.

Adam Greenbaum, Yen-Michael S Hsu, Ryan B Day, Laura G Schuettpelz, Matthew J Christopher, Joshua N Borgerding, Takashi Nagasawa, Daniel C Link,

Haematopoietic stem cells (HSCs) primarily reside in the bone marrow where signals generated by stromal cells regulate their self-renewal, proliferation and trafficking. Endosteal osteoblasts and perivascular stromal cells including endothelial cells, CXCL12-abundant reticular cells, leptin-receptor-positive stromal cells, and nestin-green fluorescent protein (GFP)-positive mesenchymal progenitors have all been implicated in HSC ... Read more >>

Nature (Nature)
[2013, 495(7440):227-230]

Cited: 519 times

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Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice.

Matthew J Christopher, Mahil Rao, Fulu Liu, Jill R Woloszynek, Daniel C Link,

Granulocyte colony-stimulating factor (G-CSF), the prototypical mobilizing cytokine, induces hematopoietic stem and progenitor cell (HSPC) mobilization from the bone marrow in a cell-nonautonomous fashion. This process is mediated, in part, through suppression of osteoblasts and disruption of CXCR4/CXCL12 signaling. The cellular targets of G-CSF that initiate the mobilization cascade have ... Read more >>

J. Exp. Med. (The Journal of experimental medicine)
[2011, 208(2):251-260]

Cited: 162 times

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Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation.

Matthew J Christopher, Daniel C Link,

Long-term treatment of mice or humans with granulocyte colony-stimulating factor (G-CSF) is associated with a clinically significant osteopenia characterized by increased osteoclast activity and number. In addition, recent reports have observed a decrease in number of mature osteoblasts during G-CSF administration. However, neither the extent of G-CSF's suppressive effect on ... Read more >>

J. Bone Miner. Res. (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2008, 23(11):1765-1774]

Cited: 60 times

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Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization.

Matthew J Christopher, Fulu Liu, Matthew J Hilton, Fanxin Long, Daniel C Link,

Current evidence suggests that hematopoietic stem/progenitor cell (HSPC) mobilization by granulocyte colony-stimulating factor (G-CSF) is mediated by induction of bone marrow proteases, attenuation of adhesion molecule function, and disruption of CXCL12/CXCR4 signaling in the bone marrow. The relative importance and extent to which these pathways overlap or function independently are ... Read more >>

Blood (Blood)
[2009, 114(7):1331-1339]

Cited: 122 times

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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

, , Paul R Burton, David G Clayton, Lon R Cardon, Nick Craddock, Panos Deloukas, Audrey Duncanson, Dominic P Kwiatkowski, Mark I McCarthy, Willem H Ouwehand, Nilesh J Samani, John A Todd, Peter Donnelly, Jeffrey C Barrett, Dan Davison, Doug Easton, David M Evans, David M Evans, Hin-Tak Leung, Jonathan L Marchini, Andrew P Morris, Chris C A Spencer, Martin D Tobin, Antony P Attwood, James P Boorman, Barbara Cant, Ursula Everson, Judith M Hussey, Jennifer D Jolley, Alexandra S Knight, Kerstin Koch, Elizabeth Meech, Sarah Nutland, Christopher V Prowse, Helen E Stevens, Niall C Taylor, Graham R Walters, Neil M Walker, Nicholas A Watkins, Thilo Winzer, Richard W Jones, Wendy L McArdle, Susan M Ring, David P Strachan, Marcus Pembrey, Gerome Breen, David St Clair, Sian Caesar, Katharine Gordon-Smith, Lisa Jones, Christine Fraser, Elaine K Green, Detelina Grozeva, Marian L Hamshere, Peter A Holmans, Ian R Jones, George Kirov, Valentina Moskivina, Ivan Nikolov, Michael C O'Donovan, Michael J Owen, David A Collier, Amanda Elkin, Anne Farmer, Richard Williamson, Peter McGuffin, Allan H Young, I Nicol Ferrier, Stephen G Ball, Anthony J Balmforth, Jennifer H Barrett, Timothy D Bishop, Mark M Iles, Azhar Maqbool, Nadira Yuldasheva, Alistair S Hall, Peter S Braund, Richard J Dixon, Massimo Mangino, Suzanne Stevens, John R Thompson, Francesca Bredin, Mark Tremelling, Miles Parkes, Hazel Drummond, Charles W Lees, Elaine R Nimmo, Jack Satsangi, Sheila A Fisher, Alastair Forbes, Cathryn M Lewis, Clive M Onnie, Natalie J Prescott, Jeremy Sanderson, Christopher G Matthew, Jamie Barbour, M Khalid Mohiuddin, Catherine E Todhunter, John C Mansfield, Tariq Ahmad, Fraser R Cummings, Derek P Jewell, John Webster, Morris J Brown, Mark G Lathrop, John Connell, Anna Dominiczak, Carolina A Braga Marcano, Beverley Burke, Richard Dobson, Johannie Gungadoo, Kate L Lee, Patricia B Munroe, Stephen J Newhouse, Abiodun Onipinla, Chris Wallace, Mingzhan Xue, Mark Caulfield, Martin Farrall, Anne Barton, , Ian N Bruce, Hannah Donovan, Steve Eyre, Paul D Gilbert, Samantha L Hilder, Anne M Hinks, Sally L John, Catherine Potter, Alan J Silman, Deborah P M Symmons, Wendy Thomson, Jane Worthington, David B Dunger, Barry Widmer, Timothy M Frayling, Rachel M Freathy, Hana Lango, John R B Perry, Beverley M Shields, Michael N Weedon, Andrew T Hattersley, Graham A Hitman, Mark Walker, Kate S Elliott, Christopher J Groves, Cecilia M Lindgren, Nigel W Rayner, Nicolas J Timpson, Eleftheria Zeggini, Melanie Newport, Giorgio Sirugo, Emily Lyons, Fredrik Vannberg, Adrian V S Hill, Linda A Bradbury, Claire Farrar, Jennifer J Pointon, Paul Wordsworth, Matthew A Brown, Jayne A Franklyn, Joanne M Heward, Matthew J Simmonds, Stephen C L Gough, Sheila Seal, , Michael R Stratton, Nazneen Rahman, Maria Ban, An Goris, Stephen J Sawcer, Alastair Compston, David Conway, Muminatou Jallow, Melanie Newport, Giorgio Sirugo, Kirk A Rockett, Suzannah J Bumpstead, Amy Chaney, Kate Downes, Mohammed J R Ghori, Rhian Gwilliam, Sarah E Hunt, Michael Inouye, Andrew Keniry, Emma King, Ralph McGinnis, Simon Potter, Rathi Ravindrarajah, Pamela Whittaker, Claire Widden, David Withers, Niall J Cardin, Dan Davison, Teresa Ferreira, Joanne Pereira-Gale, Ingeleif B Hallgrimsdo'ttir, Bryan N Howie, Zhan Su, Yik Ying Teo, Damjan Vukcevic, David Bentley, Matthew A Brown, Alastair Compston, Martin Farrall, Alistair S Hall, Andrew T Hattersley, Adrian V S Hill, Miles Parkes, Marcus Pembrey, Michael R Stratton, Sarah L Mitchell, Paul R Newby, Oliver J Brand, Jackie Carr-Smith, Simon H S Pearce, R McGinnis, A Keniry, P Deloukas, John D Reveille, Xiaodong Zhou, Anne-Marie Sims, Alison Dowling, Jacqueline Taylor, Tracy Doan, John C Davis, Laurie Savage, Michael M Ward, Thomas L Learch, Michael H Weisman, Mathew Brown,

We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, ... Read more >>

Nat Genet (Nature genetics)
[2007, 39(11):1329-1337]

Cited: 779 times

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Regulation of neutrophil homeostasis.

Matthew J Christopher, Daniel C Link,

PURPOSE OF REVIEW:Neutrophils are an essential component of the innate immune response and a major contributor to inflammation. Consequently, neutrophil number in the blood is tightly regulated. Herein, we review recent studies that have greatly advanced our understanding of the mechanisms controlling neutrophil homeostasis. RECENT FINDINGS:Accumulating evidence shows that stromal ... Read more >>

Curr. Opin. Hematol. (Current opinion in hematology)
[2007, 14(1):3-8]

Cited: 110 times

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G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow.

Craig L Semerad, Matthew J Christopher, Fulu Liu, Brenton Short, Paul J Simmons, Ingrid Winkler, Jean-Pierre Levesque, Jean Chappel, F Patrick Ross, Daniel C Link,

Accumulating evidence indicates that interaction of stromal cell-derived factor 1 (SDF-1/CXCL12 [CXC motif, ligand 12]) with its cognate receptor, CXCR4 (CXC motif, receptor 4), generates signals that regulate hematopoietic progenitor cell (HPC) trafficking in the bone marrow. During granulocyte colony-stimulating factor (G-CSF)-induced HPC mobilization, CXCL12 protein expression in the bone ... Read more >>

Blood (Blood)
[2005, 106(9):3020-3027]

Cited: 287 times

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Theoretical analysis of the condensation of hydrogen peroxide gas and water vapour as used in surface decontamination.

David Watling, Cian Ryle, Matthew Parks, Matthew Christopher,

PDA J Pharm Sci Technol (PDA journal of pharmaceutical science and technology)
[2002, 56(6):291-299]

Cited: 7 times

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