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Brief Report: Differences in Types of Myocardial Infarctions Among People Aging With HIV.

Heidi M Crane, Robin M Nance, Bridget M Whitney, Susan R Heckbert, Matthew Budoff, Kevin High, Alan Landay, Matthew Feinstein, Richard D Moore, William Christopher Mathews, Katerina Christopoulos, Michael S Saag, Amanda Willig, Joseph J Eron, Mari M Kitahata, Joseph A C Delaney, ,

<h4>Background</h4>Type 1 myocardial infarctions (T1MIs) result from atherosclerotic plaque instability, rupture, and/or erosion. Type 2 MIs (T2MIs) are secondary to causes such as sepsis and cocaine-induced vasospasm resulting in an oxygen demand-supply mismatch and are associated with higher mortality than T1MIs. T2MIs account for a higher proportion of MIs among ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):208-212]

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Coronary artery calcium score: pivotal role as a predictor for detecting coronary artery disease in symptomatic patients.

Lavanya Cherukuri, Divya Birudaraju, Matthew J Budoff,

Chest pain and dyspnea are common presentations for symptomatic individuals with suspected coronary artery disease (CAD) in the primary care office and cardiology clinics. However, it is imperative to properly diagnose who should undergo further evaluation for cardiac etiologies of chest pain, with either noninvasive or invasive imaging tests. The ... Read more >>

Coron Artery Dis (Coronary artery disease)
[2021, :]

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Spatially Weighted Coronary Artery Calcium Score and Coronary Heart Disease Events in the Multi-Ethnic Study of Atherosclerosis.

Steven Shea, Ana Navas-Acien, Daichi Shimbo, Elizabeth R Brown, Matthew Budoff, Michael P Bancks, R Graham Barr, Richard Kronmal,

<h4>Background</h4>A limitation of the Agatston coronary artery calcium (CAC) score is that it does not use all of the calcium density information in the computed tomography scan such that many individuals have a score of zero. We examined the predictive validity for incident coronary heart disease (CHD) events of the ... Read more >>

Circ Cardiovasc Imaging (Circulation. Cardiovascular imaging)
[2021, :CIRCIMAGING120011981]

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Topological Data Analysis of Coronary Plaques Demonstrates the Natural History of Coronary Atherosclerosis.

Doyeon Hwang, Haneol J Kim, Seung-Pyo Lee, Seonhee Lim, Bon-Kwon Koo, Yong-Jin Kim, Woong Kook, Daniele Andreini, Mouaz H Al-Mallah, Matthew J Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Edoardo Conte, Hugo Marques, Pedro de Araújo Gonçalves, Ilan Gottlieb, Martin Hadamitzky, Jonathon A Leipsic, Erica Maffei, Gianluca Pontone, Gilbert L Raff, Sanghoon Shin, Byoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Sang-Eun Lee, Daniel S Berman, Fay Y Lin, Renu Virmani, Habib Samady, Peter H Stone, Jagat Narula, Jeroen J Bax, Leslee J Shaw, James K Min, Hyuk-Jae Chang,

<h4>Objectives</h4>This study sought to identify distinct patient groups and their association with outcome based on the patient similarity network using quantitative coronary plaque characteristics from coronary computed tomography angiography (CTA).<h4>Background</h4>Coronary CTA can noninvasively assess coronary plaques quantitatively.<h4>Methods</h4>Patients who underwent 2 coronary CTAs at a minimum of 24 months' interval were analyzed ... Read more >>

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2021, :]

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Prevalence of normal coronary arteries by coronary computed tomography angiography (CCTA) in patients with type 2 diabetes mellitus from Semaglutide Treatment on Coronary Plaque Progression (STOP) trial.

Divya Birudaraju, Lavanya Cherukuri, April Kinninger, Suraj Dahal, Suvasini Lakshmanan, Vahid Rezvanizadeh, Ahmed K Ghanem, Ferdinand Flores, Sajad Hamal, Ryan G Pozon, Nishitha Adudodla, John A Tayek, Sion K Roy, Matthew J Budoff,

<h4>Introduction</h4>Coronary artery disease (CAD) is leading cause of morbidity and mortality among type 2 diabetics (T2DM).<h4>Methods</h4>140 T2DM will be enrolled in randomized, double blind, placebo controlled Semaglutide Treatment On Coronary Plaque Progression (STOP) trial to determine effect of weekly subcutaneous semaglutide on coronary plaque progression. All participants will undergo Coronary ... Read more >>

J Diabetes Complications (Journal of diabetes and its complications)
[2020, :107840]

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New carotid plaque, but not the progression of intima-media thickness, predicts the progression of high-risk coronary plaque.

Chieh-Ju Chao, Suvasini Lakshmanan, Indrce Ceponiene, Yanting Luo, Rine Nakanishi, Negin Nezarat, Mitsuru Kanisawa, Matthew J Budoff,

<h4>Background</h4>Carotid intima-media thickness (CIMT) is regarded as a controversial risk marker for cardiovascular disease (CVD). We aimed to evaluate the role of CIMT and carotid plaque progression as predictors for the progression of coronary plaque and compositions.<h4>Methods</h4>In the Garlic 4 study, asymptomatic patients with intermediate CVD risk (Framingham risk score ... Read more >>

Coron Artery Dis (Coronary artery disease)
[2021, Publish Ahead of Print:]

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Coronary CT Angiography Followed by Invasive Angiography in Patients With Moderate or Severe Ischemia-Insights From the ISCHEMIA Trial.

G B John Mancini, Jonathan Leipsic, Matthew J Budoff, Cameron J Hague, James K Min, Susanna R Stevens, Harmony R Reynolds, Sean M O'Brien, Leslee J Shaw, Cholenahally N Manjunath, Kreton Mavromatis, Marcin Demkow, Jose Luis Lopez-Sendon, Alexander M Chernavskiy, Gilbert Gosselin, Herwig Schuchlenz, Gerard P Devlin, Anoop Chauhan, Sripal Bangalore, Judith S Hochman, David J Maron,

<h4>Objectives</h4>This study aimed to examine the concordance of coronary computed tomographic angiography (CCTA) assessment of coronary anatomy and invasive coronary angiography (ICA) as the reference standard in patients enrolled in the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA).<h4>Background</h4>Performance of CCTA compared with ICA has not ... Read more >>

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2021, :]

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Progression of whole-heart Atherosclerosis by coronary CT and major adverse cardiovascular events.

Alexander R van Rosendael, Fay Y Lin, Inge J van den Hoogen, Xiaoyue Ma, Umberto Gianni, Omar Al Hussein Alawamlh, Subhi J Al'Aref, Jessica M Peña, Daniele Andreini, Matthew J Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Edoardo Conte, Hugo Marques, Pedro de Araújo Gonçalves, Ilan Gottlieb, Martin Hadamitzky, Jonathon Leipsic, Erica Maffei, Gianluca Pontone, Gilbert L Raff, Sanghoon Shin, Yong-Jin Kim, Byoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Sang-Eun Lee, Donghee Han, Daniel S Berman, Renu Virmani, Habib Samady, Peter Stone, Jagat Narula, Jeroen J Bax, Leslee J Shaw, James K Min, Hyuk-Jae Chang,

<h4>Background</h4>The current study aimed to examine the independent prognostic value of whole-heart atherosclerosis progression by serial coronary computed tomography angiography (CCTA) for major adverse cardiovascular events (MACE).<h4>Methods</h4>The multi-center PARADIGM study includes patients undergoing serial CCTA for symptomatic reasons, ≥2 years apart. Whole-heart atherosclerosis was characterized on a segmental level, with ... Read more >>

J Cardiovasc Comput Tomogr (Journal of cardiovascular computed tomography)
[2021, :]

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Age- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results from the ICONIC study.

Edoardo Conte, Aeshita Dwivedi, Saima Mushtaq, Gianluca Pontone, Fay Y Lin, Emma J Hollenberg, Sang-Eun Lee, Jeroen Bax, Filippo Cademartiri, Kavitha Chinnaiyan, Benjamin J W Chow, Ricardo C Cury, Gudrun Feuchtner, Martin Hadamitzky, Yong-Jin Kim, Andrea Baggiano, Jonathon Leipsic, Erica Maffei, Hugo Marques, Fabian Plank, Gilbert L Raff, Alexander R van Rosendael, Todd C Villines, Harald G Weirich, Subhi J Al'Aref, Lohendran Baskaran, Iksung Cho, Ibrahim Danad, Donghee Han, Ran Heo, Ji Hyun Lee, Wijnand J Stuijfzand, Heidi Gransar, Yao Lu, Ji Min Sung, Hyung-Bok Park, Mouaz H Al-Mallah, Pedro de Araújo Gonçalves, Daniel S Berman, Matthew J Budoff, Habib Samady, Leslee J Shaw, Peter H Stone, Renu Virmani, Jagat Narula, James K Min, Hyuk-Jae Chang, Daniele Andreini,

<h4>Aims</h4>Although there is increasing evidence supporting coronary atherosclerosis evaluation by coronary computed tomography angiography (CCTA), no data are available on age and sex differences for quantitative plaque features. The aim of this study was to investigate sex and age differences in both qualitative and quantitative atherosclerotic features from CCTA prior ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal cardiovascular Imaging)
[2021, 22(1):24-33]

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Novel use of coronary artery calcium scoring.

Ilana Golub, Suraj Dahal, Francesca Calicchio, Matthew J Budoff,

Coron Artery Dis (Coronary artery disease)
[2021, 32(1):86-87]

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A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction.

Bratati Kahali, Yue Chen, Mary F Feitosa, Lawrence F Bielak, Jeffrey R O'Connell, Solomon K Musani, Yash Hegde, Yanhua Chen, L C Stetson, Xiuqing Guo, Yi-Ping Fu, Albert Vernon Smith, Kathleen A Ryan, Gudny Eiriksdottir, Ariella T Cohain, Matthew Allison, Andrew Bakshi, Donald W Bowden, Matthew J Budoff, J Jeffrey Carr, Shannon Carskadon, Yii-Der I Chen, Adolfo Correa, Breland F Crudup, Xiaomeng Du, Tamara B Harris, Jian Yang, Sharon L R Kardia, Lenore J Launer, Jiankang Liu, Thomas H Mosley, Jill M Norris, James G Terry, Nallasivam Palanisamy, Eric E Schadt, Christopher J O'Donnell, Laura M Yerges-Armstrong, Jerome I Rotter, Lynne E Wagenknecht, Samuel K Handelman, Vilmundur Gudnason, Michael A Province, Patricia A Peyser, Brian Halligan, Nicholette D Palmer, Elizabeth K Speliotes,

<h4>Context</h4>Glycogen storage diseases are rare. Increased glycogen in the liver results in increased attenuation.<h4>Objective</h4>Investigate the association and function of a noncoding region associated with liver attenuation but not histologic nonalcoholic fatty liver disease.<h4>Design</h4>Genetics of Obesity-associated Liver Disease Consortium.<h4>Setting</h4>Population-based.<h4>Main outcome</h4>Computed tomography measured liver attenuation.<h4>Results</h4>Carriers of rs4841132-A (frequency 2%-19%) do not show ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2021, 106(2):372-387]

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A genome-wide association study for nonalcoholic fatty liver disease identifies novel genetic loci and trait-relevant candidate genes in the Million Veteran Program

Marijana Vujkovic, Shweta Ramdas, Kimberly Lorenz, Carolin Schneider, Joseph Park, Kyung Lee, Marina Serper, Rotonya Carr, David Kaplan, Mary Haas, Matthew MacLean, Walter Witschey, Xiang Zhu, Catherine Tcheandjieu, Rachel Kember, Henry Kranzler, Anurag Verma, Ayush Giri, Derek Klarin, Yan Sun, Jie Huang, Jennifer Huffman, Kate Townsend Creasy, Nicholas Hand, Ching-Ti Liu, Michelle Long, Jerome Rotter, Xiuqing Guo, Jie Yao, Matthew Budoff, Katherine Ryan, Braxton Mitchell, Dipender Gill, Andrew Wells, Elisabetta Manduchi, Yedidya Saiman, Nadim Mahmud, Donald Miller, Peter Reaven, Laurence Phillips, Sumitra Muralidhar, Scott DuVall, Jennifer Lee, Themistocles Assimes, Saiju Pyarajan, Kelly Cho, Todd Edwards, Scott Damrauer, Peter Wilson, John Gaziano, Christopher O’Donnell, Amit Khera, Struan F.A. Grant, Christopher Brown, Philip Tsao, Danish Saleheen, James Meigs, Julie Lynch, Daniel Rader, Benjamin Voight, Kyong-Mi Chang,

Nonalcoholic fatty liver disease (NAFLD) is a prevalent, heritable trait that can progress to cancer and liver failure. Using our recently developed proxy definition for NAFLD based on chronic liver enzyme elevation without other causes of liver disease or alcohol misuse, we performed a multi-ancestry genome-wide association study in the ... Read more >>

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The quest for cardiovascular disease risk prediction models in patients with nondialysis chronic kidney disease.

Elani Streja, Keith C Norris, Matthew J Budoff, Leila Hashemi, Oguz Akbilgic, Kamyar Kalantar-Zadeh,

<h4>Purpose of review</h4>Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). However, traditional CVD risk prediction equations do not work well in patients with CKD, and inclusion of kidney disease metrics such as albuminuria and estimated glomerular filtration rate have a modest to ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2021, 30(1):38-46]

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Beta-2-glycoprotein-I IgA antibodies predict coronary plaque progression in rheumatoid arthritis.

George A Karpouzas, Sarah R Ormseth, Elizabeth Hernandez, Viet L Bui, Matthew J Budoff,

<h4>Objectives</h4>To evaluate whether anti-Beta-2-Glycoprotein-I (anti-β2GPI) IgA antibodies associate with progression of coronary atherosclerosis and cardiovascular disease (CVD) events in rheumatoid arthritis (RA).<h4>Methods</h4>One hundred-fifty patients underwent plaque evaluation (total, non-calcified, mixed and calcified) with coronary computed tomography angiography; 101 were re-imaged within 6.9±0.3 years to assess progression. The Framingham-D'Agostino score assessed ... Read more >>

Semin Arthritis Rheum (Seminars in arthritis and rheumatism)
[2020, 51(1):20-27]

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Prognostic significance of aortic valve calcium in relation to coronary artery calcification for long-term, cause-specific mortality: results from the CAC Consortium.

Donghee Han, Rhanderson Cordoso, Seamus Whelton, Alan Rozanski, Matthew J Budoff, Michael D Miedema, Khurram Nasir, Leslee J Shaw, John A Rumberger, Heidi Gransar, Zeina Dardari, Roger S Blumenthal, Michael J Blaha, Daniel S Berman,

<h4>Aims</h4>Aortic valve calcification (AVC) has been shown to be associated with increased cardiovascular disease (CVD) risk; however, whether this is independent of traditional risk factors and coronary artery calcification (CAC) remains unclear.<h4>Methods and results</h4>From the multicentre CAC Consortium database, 10 007 patients (mean 55.8±11.7 years, 64% male) with concomitant CAC and ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal cardiovascular Imaging)
[2020, :]

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Life's Simple 7 and Nonalcoholic Fatty Liver Disease: The Multiethnic Study of Atherosclerosis.

Ebenezer Oni, Oluseye Ogunmoroti, Norrina Allen, Mouaz H A-Mallah, Ron Blankstein, Seth S Martin, Irfan Zeb, Mary Cushman, Parag H Joshi, Matthew J Budoff, Michael J Blaha, Roger S Blumenthal, Emir Veledar, Khurram Nasir,

<h4>Background</h4>The American Heart Association (AHA) has defined Life's Simple 7 (LS7) as a measure of overall cardiovascular health . Nonalcoholic fatty liver disease (NAFLD) has been involved as a risk factor for cardiovascular disease. We evaluated the association between LS7 and NAFLD.<h4>Methods</h4>We evaluated participants form the Multi-Ethnic Study of Atherosclerosis ... Read more >>

Am J Med (The American journal of medicine)
[2020, :]

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The National Lipid Association scientific statement on coronary artery calcium scoring to guide preventive strategies for ASCVD risk reduction.

Carl E Orringer, Michael J Blaha, Ron Blankstein, Matthew J Budoff, Ronald B Goldberg, Edward A Gill, Kevin C Maki, Laxmi Mehta, Terry A Jacobson,

An Expert Panel of the National Lipid Association reviewed the evidence related to the use of coronary artery calcium (CAC) scoring in clinical practice for adults seen for primary prevention of atherosclerotic cardiovascular disease. Recommendations for optimal use of this test in adults of various races/ethnicities, ages and multiple domains ... Read more >>

J Clin Lipidol (Journal of clinical lipidology)
[2020, :]

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Distribution of calcium volume, density, number, and type of coronary vessel with calcified plaque in South Asians in the US and other race/ethnic groups: The MASALA and MESA studies.

Mahmoud Al Rifai, Alka M Kanaya, Namratha R Kandula, Miguel Cainzos-Achirica, Jaideep Patel, Matthew Budoff, Michael H Criqui, Michael J Blaha, Salim S Virani,

<h4>Background and aims</h4>South Asians (SA) experience disproportionately higher rates of atherosclerotic cardiovascular disease (ASCVD) events than non-Hispanic whites (NHW) and several other Asian groups. The coronary artery calcium (CAC) Agatston score may not capture the unique characteristics of coronary plaque in SA. We therefore evaluated the prevalence and patterns of ... Read more >>

Atherosclerosis (Atherosclerosis)
[2021, 317:16-21]

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To stress or not to stress: a new approach for diagnosing coronary heart disease.

Kaitlyn Mikielski, Matthew Budoff,

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2020, 10(12):2392-2395]

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Brief Report: Cystatin C-Based Estimation of Glomerular Filtration Rate and Association With Atherosclerosis Imaging Markers in People Living With HIV.

Mitchell McClean, Petra Buzkova, Matthew Budoff, Michelle Estrella, Matthew Freiberg, Howard N Hodis, Frank Palella, Cecilia Shikuma, Wendy S Post, Samir Gupta,

<h4>Introduction</h4>Reduced estimated glomerular filtration rate (eGFR) is associated with increased risk of cardiovascular disease among people living with HIV (PLWH). It is unclear whether eGFR equations incorporating cystatin C (CysC) measurements are more predictive of preclinical cardiovascular disease than those using only creatinine (Cr).<h4>Objectives</h4>The study aimed to determine which of ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, 85(4):466-469]

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Evaluation of left atrium indices among high heart rate and heart rate variability patients with advancement in computed tomography technology: The CONVERGE registry.

Lavanya Cherukuri, Divya Birudaraju, April Kinninger, Bhanu T Chaganti, Sivakrishna Pidikiti, Ryan G Pozon, Anne Concepcion G Pozon, Suvasini Lakshmanan, Suraj Dahal, Sajad Hamal, Ferdinand Flores, Christopher Dialing, Daniele Andreini, Gianluca Pontone, Edoardo Conte, Rine Nakanishi, Rachael O'Rourke, Christian Hamilton-Craig, Khurram Nasir, Sion K Roy, Song Shou Mao, Matthew J Budoff,

<b>Introduction:</b> We intended to assess the ability of current generation 256-slice coronary computed tomographic angiography (CCTA) to measure LA volume (LAV) comparing patients with high heart rate (HiHR) of > 70bpm and heart rate variability such as atrial fibrillation (AFib). <b>Methods:</b> Using the prospective CONVERGE Registry of patients undergoing 256 ... Read more >>

J Nucl Med Technol (Journal of nuclear medicine technology)
[2020, :]

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Community-Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV.

Jerry S Zifodya, Meredith S Duncan, Kaku A So-Armah, Engi F Attia, Kathleen M Akgün, Maria C Rodriguez-Barradas, Vincent C Marconi, Matthew J Budoff, Roger J Bedimo, Charles W Alcorn, Guy W Soo Hoo, Adeel A Butt, Joon W Kim, Jason J Sico, Hilary A Tindle, Laurence Huang, Janet P Tate, Amy C Justice, Matthew S Freiberg, Kristina Crothers,

Background Hospitalization with community-acquired pneumonia (CAP) is associated with an increased risk of cardiovascular disease (CVD) events in patients uninfected with HIV. We evaluated whether people living with HIV (PLWH) have a higher risk of CVD or mortality than individuals uninfected with HIV following hospitalization with CAP. Methods and Results ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(23):e017645]

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COVID-19 IgG/IgM antibody testing in Los Angeles County, California.

Khadije Ahmad, Vahid Rezvanizadeh, Suraj Dahal, April Kinninger, Ahmed K Ghanem, Suvasini Lakshmanan, Sajad Hamal, Ferdinand Flores, Christopher Dailing, Sion K Roy, Matthew J Budoff,

Evidence suggests that asymptomatic and mild SARS-CoV-2 infections comprise > 95% of all cases. Developing a test that indicates past infection and possible immunity against the virus is important. We administered 244 antibody tests to three groups of high-risk population. The test consisted of an IgG component and an IgM ... Read more >>

Eur J Clin Microbiol Infect Dis (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2021, 40(2):457-459]

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Comparative differences in the atherosclerotic disease burden between the epicardial coronary arteries: quantitative plaque analysis on coronary computed tomography angiography.

A Maxim Bax, Alexander R van Rosendael, Xiaoyue Ma, Inge J van den Hoogen, Umberto Gianni, Sara W Tantawy, Emma J Hollenberg, Daniele Andreini, Mouaz H Al-Mallah, Matthew J Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Edoardo Conte, Hugo Marques, Pedro de Araújo Gonçalves, Ilan Gottlieb, Martin Hadamitzky, Jonathon A Leipsic, Erica Maffei, Gianluca Pontone, Sanghoon Shin, Yong-Jin Kim, Byoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Sang-Eun Lee, Renu Virmani, Habib Samady, Peter H Stone, Daniel S Berman, James K Min, Jagat Narula, Fay Y Lin, Hyuk-Jae Chang, Leslee J Shaw, ,

<h4>Aims</h4>Anatomic series commonly report the extent and severity of coronary artery disease (CAD), regardless of location. The aim of this study was to evaluate differences in atherosclerotic plaque burden and composition across the major epicardial coronary arteries.<h4>Methods and results</h4>A total of 1271 patients (age 60 ± 9 years; 57% men) with suspected CAD ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal cardiovascular Imaging)
[2020, :]

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Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure.

Deepak L Bhatt, Michael Szarek, P Gabriel Steg, Christopher P Cannon, Lawrence A Leiter, Darren K McGuire, Julia B Lewis, Matthew C Riddle, Adriaan A Voors, Marco Metra, Lars H Lund, Michel Komajda, Jeffrey M Testani, Christopher S Wilcox, Piotr Ponikowski, Renato D Lopes, Subodh Verma, Pablo Lapuerta, Bertram Pitt, ,

<h4>Background</h4>Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure or death from cardiovascular causes among patients with stable heart failure. However, the safety and efficacy of SGLT2 inhibitors when initiated soon after an episode of decompensated heart failure are unknown.<h4>Methods</h4>We performed a multicenter, double-blind trial in ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(2):117-128]

Cited: 2 times

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