Full Text Journal Articles by
Author Matteo Pallocca

Advertisement

Find full text journal articles






Efficacy of immunotherapy in lung cancer with co-occurring mutations in NOTCH and homologous repair genes.

Marco Mazzotta, Marco Filetti, Mario Occhipinti, Daniele Marinelli, Stefano Scalera, Irene Terrenato, Francesca Sperati, Matteo Pallocca, Francesco Rizzo, Alain Gelibter, Andrea Botticelli, Giorgia Scafetta, Arianna Di Napoli, Eriseld Krasniqi, Laura Pizzuti, Maddalena Barba, Silvia Carpano, Patrizia Vici, Maurizio Fanciulli, Francesca De Nicola, Ludovica Ciuffreda, Frauke Goeman, Ruggero De Maria, Andrea Vecchione, Raffaele Giusti, Gennaro Ciliberto, Paolo Marchetti, Marcello Maugeri-Saccà,

BACKGROUND:Immune checkpoint inhibitors (ICIs) provide significant survival benefits in non-small cell lung cancer (NSCLC). Nevertheless, while some patients obtain a prolonged benefit, a non-negligible fraction of patients experiences an ultrarapid disease progression. Identifying specific molecular backgrounds predicting opposite outcomes is instrumental to optimize the use of these agents in clinical ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(2):]

Cited: 0 times

View full text PDF listing >>



Corrigendum: Next-Generation Sequencing Approaches for the Identification of Pathognomonic Fusion Transcripts in Sarcomas: The Experience of the Italian ACC Sarcoma Working Group.

Dominga Racanelli, Monica Brenca, Davide Baldazzi, Frauke Goeman, Beatrice Casini, Biagio De Angelis, Marika Guercio, Giuseppe Maria Milano, Elena Tamborini, Adele Busico, Gianpaolo Dagrada, Cecilia Garofalo, Chiara Caruso, Antonella Brunello, Ymera Pignochino, Enrico Berrino, Giovanni Grignani, Katia Scotlandi, Alessandro Parra, Claudia Maria Hattinger, Toni Ibrahim, Laura Mercatali, Alessandro De Vita, Maria Vincenza Carriero, Matteo Pallocca, Rossella Loria, Renato Covello, Marta Sbaraglia, Angelo Paolo Dei Tos, Rita Falcioni, Roberta Maestro,

[This corrects the article DOI: 10.3389/fonc.2020.00489.]. ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:944]

Cited: 0 times

View full text PDF listing >>



Advertisement

Companion vaccine Bioinformatic design tool reveals limited functional genomic variability of SARS-Cov-2 Spike Receptor Binding Domain

Alice Massacci, Lorenzo D’Ambrosio, Eleonora Sperandio, Fabio Palombo, Luigi Aurisicchio, Gennaro Ciliberto, Matteo Pallocca,

Abstract Tracking the genetic variability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for several reasons, such as to identify target sequences to generate robust vaccines and neutralizing monoclonal antibodies; to track viral genetic temporal and geographic evolution; and to mine for viral variants associated with reduced or ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Next-Generation Sequencing Approaches for the Identification of Pathognomonic Fusion Transcripts in Sarcomas: The Experience of the Italian ACC Sarcoma Working Group.

Dominga Racanelli, Monica Brenca, Davide Baldazzi, Frauke Goeman, Beatrice Casini, Biagio De Angelis, Marika Guercio, Giuseppe Maria Milano, Elena Tamborini, Adele Busico, Gianpaolo Dagrada, Cecilia Garofalo, Chiara Caruso, Antonella Brunello, Ymera Pignochino, Enrico Berrino, Giovanni Grignani, Katia Scotlandi, Alessandro Parra, Claudia Maria Hattinger, Toni Ibrahim, Laura Mercatali, Alessandro De Vita, Maria Vincenza Carriero, Matteo Pallocca, Rossella Loria, Renato Covello, Marta Sbaraglia, Angelo Paolo Dei Tos, Rita Falcioni, Roberta Maestro,

This work describes the set-up of a shared platform among the laboratories of the Alleanza Contro il Cancro (ACC) Italian Research Network for the identification of fusion transcripts in sarcomas by using Next Generation Sequencing (NGS). Different NGS approaches, including anchored multiplex PCR and hybrid capture-based panels, were employed to ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:489]

Cited: 0 times

View full text PDF listing >>



Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription.

Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri,

OBJECTIVE:The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host cellular chromatin. DESIGN:We explored, in relevant cellular models of HBV replication, the functional consequences of HBx interaction with DLEU2, a long non-coding RNA ... Read more >>

Gut (Gut)
[2020, :]

Cited: 0 times

View full text PDF listing >>



B4GALT1 Is a New Candidate to Maintain the Stemness of Lung Cancer Stem Cells.

Claudia De Vitis, Giacomo Corleone, Valentina Salvati, Francesca Ascenzi, Matteo Pallocca, Francesca De Nicola, Maurizio Fanciulli, Simona di Martino, Sara Bruschini, Christian Napoli, Alberto Ricci, Massimiliano Bassi, Federico Venuta, Erino Angelo Rendina, Gennaro Ciliberto, Rita Mancini,

BACKGROUND:According to the cancer stem cells (CSCs) hypothesis, a population of cancer cells with stem cell properties is responsible for tumor propagation, drug resistance, and disease recurrence. Study of the mechanisms responsible for lung CSCs propagation is expected to provide better understanding of cancer biology and new opportunities for therapy. ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(11):]

Cited: 1 time

View full text PDF listing >>



Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma.

Frauke Goeman, Francesca De Nicola, Stefano Scalera, Francesca Sperati, Enzo Gallo, Ludovica Ciuffreda, Matteo Pallocca, Laura Pizzuti, Eriseld Krasniqi, Giacomo Barchiesi, Patrizia Vici, Maddalena Barba, Simonetta Buglioni, Beatrice Casini, Paolo Visca, Edoardo Pescarmona, Marco Mazzotta, Ruggero De Maria, Maurizio Fanciulli, Gennaro Ciliberto, Marcello Maugeri-Saccà,

INTRODUCTION:Molecular characterization studies revealed recurrent kelch like ECH associated protein 1 gene (KEAP1)/nuclear factor, erythroid 2 like 2 gene (NFE2L2) alterations in NSCLC. These genes encode two interacting proteins (a stress response pathway [SRP]) that mediate a cytoprotective response to oxidative stress and xenobiotics. Nevertheless, whether KEAP1/NFE2L2 mutations have an ... Read more >>

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2019, 14(11):1924-1934]

Cited: 1 time

View full text PDF listing >>



Combinations of immuno-checkpoint inhibitors predictive biomarkers only marginally improve their individual accuracy.

Matteo Pallocca, Davide Angeli, Fabio Palombo, Francesca Sperati, Michele Milella, Frauke Goeman, Francesca De Nicola, Maurizio Fanciulli, Paola Nisticò, Concetta Quintarelli, Gennaro Ciliberto,

BACKGROUND:There are no accepted universal biomarkers capable to accurately predict response to immuno-checkpoint inhibitors (ICI). Although recent literature has been flooded with studies on ICI predictive biomarkers, available data show that currently approved companion diagnostics either leave out many possible responders, as in the case of PD-L1 testing for first-line ... Read more >>

J Transl Med (Journal of translational medicine)
[2019, 17(1):131]

Cited: 2 times

View full text PDF listing >>



PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise?

Chiara Bazzichetto, Fabiana Conciatori, Matteo Pallocca, Italia Falcone, Maurizio Fanciulli, Francesco Cognetti, Michele Milella, Ludovica Ciuffreda,

Identifying putative biomarkers of clinical outcomes in cancer is crucial for successful enrichment, and for the selection of patients who are the most likely to benefit from a specific therapeutic approach. Indeed, current research in personalized cancer therapy focuses on the possibility of identifying biomarkers that predict prognosis, sensitivity or ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(4):]

Cited: 11 times

View full text PDF listing >>



Reverse Engineering Cancer: Inferring Transcriptional Gene Signatures from Copy Number Aberrations with ICAro.

Davide Angeli, Maurizio Fanciulli, Matteo Pallocca,

The characterization of a gene product function is a process that involves multiple laboratory techniques in order to silence the gene itself and to understand the resulting cellular phenotype via several omics profiling. When it comes to tumor cells, usually the translation process from in vitro characterization results to human ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(2):]

Cited: 1 time

View full text PDF listing >>



Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.

Ludovica Grassi, Romina Alfonsi, Federica Francescangeli, Michele Signore, Maria Laura De Angelis, Antonio Addario, Manuela Costantini, Elisabetta Flex, Andrea Ciolfi, Simone Pizzi, Alessandro Bruselles, Matteo Pallocca, Giuseppe Simone, Mustapha Haoui, Mario Falchi, Michele Milella, Steno Sentinelli, Paola Di Matteo, Emilia Stellacci, Michele Gallucci, Giovanni Muto, Marco Tartaglia, Ruggero De Maria, Désirée Bonci,

The pressure towards innovation and creation of new model systems in regenerative medicine and cancer research has fostered the development of novel potential therapeutic applications. Kidney injuries provoke a high request of organ transplants making it the most demanding system in the field of regenerative medicine. Furthermore, renal cancer frequently ... Read more >>

Cell Death Dis (Cell death & disease)
[2019, 10(3):201]

Cited: 12 times

View full text PDF listing >>



Poly-specific neoantigen-targeted cancer vaccines delay patient derived tumor growth.

Luigi Aurisicchio, Erika Salvatori, Lucia Lione, Silvio Bandini, Matteo Pallocca, Roberta Maggio, Maurizio Fanciulli, Francesca De Nicola, Frauke Goeman, Gennaro Ciliberto, Antonella Conforti, Laura Luberto, Fabio Palombo,

BACKGROUND:Personalized cancer vaccines based on neoantigens have reached the clinical trial stage in melanoma. Different vaccination protocols showed efficacy in preclinical models without a clear indication of the quality and the number of neoantigens required for an effective cancer vaccine. METHODS:In an effort to develop potent and efficacious neoantigen-based vaccines, ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):78]

Cited: 4 times

View full text PDF listing >>



Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model.

Laura Belloni, Silvia Di Cocco, Francesca Guerrieri, Abigail D G Nunn, Silvia Piconese, Debora Salerno, Barbara Testoni, Claudio Pulito, Federica Mori, Matteo Pallocca, Andrea Sacconi, Elisa Vivoli, Fabio Marra, Sabrina Strano, Giovanni Blandino, Massimo Levrero, Natalia Pediconi,

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease. Although genetic predisposition and epigenetic factors contribute to the development of NAFLD, our understanding of the molecular mechanism involved in the pathogenesis of the disease is still emerging. Here we investigated a possible role of a microRNAs-STAT3 ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):13638]

Cited: 2 times

View full text PDF listing >>



Coexisting YAP expression and TP53 missense mutations delineates a molecular scenario unexpectedly associated with better survival outcomes in advanced gastric cancer.

Matteo Pallocca, Frauke Goeman, Francesca De Nicola, Elisa Melucci, Francesca Sperati, Irene Terrenato, Laura Pizzuti, Beatrice Casini, Enzo Gallo, Carla Azzurra Amoreo, Patrizia Vici, Luigi Di Lauro, Simonetta Buglioni, Maria Grazia Diodoro, Edoardo Pescarmona, Marco Mazzotta, Maddalena Barba, Maurizio Fanciulli, Ruggero De Maria, Gennaro Ciliberto, Marcello Maugeri-Saccà,

We have previously reported that nuclear expression of the Hippo transducer TAZ in association with Wnt pathway mutations negatively impacts survival outcomes in advanced gastric cancer (GC) patients. Here, we extended these previous findings by investigating another oncogenic cooperation, namely, the interplay between YAP, the TAZ paralogue, and p53. The ... Read more >>

J Transl Med (Journal of translational medicine)
[2018, 16(1):247]

Cited: 0 times

View full text PDF listing >>



Deep sequencing and pathway-focused analysis revealed multigene oncodriver signatures predicting survival outcomes in advanced colorectal cancer.

Francesca De Nicola, Frauke Goeman, Matteo Pallocca, Francesca Sperati, Laura Pizzuti, Elisa Melucci, Beatrice Casini, Carla Azzurra Amoreo, Enzo Gallo, Maria Grazia Diodoro, Simonetta Buglioni, Marco Mazzotta, Patrizia Vici, Domenico Sergi, Luigi Di Lauro, Maddalena Barba, Edoardo Pescarmona, Gennaro Ciliberto, Ruggero De Maria, Maurizio Fanciulli, Marcello Maugeri-Saccà,

Genomic technologies are reshaping the molecular landscape of colorectal cancer (CRC), revealing that oncogenic driver mutations (APC and TP53) coexist with still underappreciated genetic events. We hypothesized that mutational analysis of CRC-linked genes may provide novel information on the connection between genetically-deregulated pathways and clinical outcomes. We performed next-generation sequencing ... Read more >>

Oncogenesis (Oncogenesis)
[2018, 7(7):55]

Cited: 2 times

View full text PDF listing >>



The clinical significance of PD-L1 in advanced gastric cancer is dependent on ARID1A mutations and ATM expression.

Simonetta Buglioni, Elisa Melucci, Francesca Sperati, Matteo Pallocca, Irene Terrenato, Francesca De Nicola, Frauke Goeman, Beatrice Casini, Carla Azzurra Amoreo, Enzo Gallo, Maria Grazia Diodoro, Edoardo Pescarmona, Patrizia Vici, Domenico Sergi, Laura Pizzuti, Luigi Di Lauro, Marco Mazzotta, Maddalena Barba, Maurizio Fanciulli, Ilio Vitale, Ruggero De Maria, Gennaro Ciliberto, Marcello Maugeri-Saccà,

Whether PD-L1 expression is associated with survival outcomes in gastric cancer (GC) is controversial. The inhibition of the PD-1/PD-L1 pathway is effective against genomically unstable tumors. Hypothesizing that also the clinical significance of PD-L1 might be dependent on the activation of molecular circuits ensuring genomic stability, we evaluated PD-L1 expression ... Read more >>

Oncoimmunology (Oncoimmunology)
[2018, 7(8):e1457602]

Cited: 1 time

View full text PDF listing >>



Long Non-coding MIR205HG Depletes Hsa-miR-590-3p Leading to Unrestrained Proliferation in Head and Neck Squamous Cell Carcinoma.

Silvia Di Agostino, Fabio Valenti, Andrea Sacconi, Giulia Fontemaggi, Matteo Pallocca, Claudio Pulito, Federica Ganci, Paola Muti, Sabrina Strano, Giovanni Blandino,

Over 70% of head & neck squamous cell carcinoma (HNSCC) patients carry TP53 oncogenic mutations. Here we studied the role of specific tumor-derived mutant p53 proteins in the aberrant transcription of long non-coding (lnc) MIR205HG gene in head and neck cancer cells. Methods: To understand the role of lncMIR205HG, that ... Read more >>

Theranostics (Theranostics)
[2018, 8(7):1850-1868]

Cited: 11 times

View full text PDF listing >>



BCL-XL overexpression promotes tumor progression-associated properties.

Daniela Trisciuoglio, Maria Grazia Tupone, Marianna Desideri, Marta Di Martile, Chiara Gabellini, Simonetta Buglioni, Matteo Pallocca, Gabriele Alessandrini, Simona D'Aguanno, Donatella Del Bufalo,

By using human melanoma and glioblastoma cell lines and their derivative BCL-XL overexpressing clones, we investigated the role of BCL-XL in aggressive features of these two tumor histotypes. We found that in both models, BCL-XL overexpression increased in vitro cell migration and invasion and facilitated tumor cells to form de ... Read more >>

Cell Death Dis (Cell death & disease)
[2017, 8(12):3216]

Cited: 14 times

View full text PDF listing >>



Conditionally reprogrammed cells (CRC) methodology does not allow the in vitro expansion of patient-derived primary and metastatic lung cancer cells.

Giovanni Sette, Valentina Salvati, Ilenia Giordani, Emanuela Pilozzi, Denise Quacquarini, Enrico Duranti, Francesca De Nicola, Matteo Pallocca, Maurizio Fanciulli, Mario Falchi, Roberto Pallini, Ruggero De Maria, Adriana Eramo,

Availability of tumor and non-tumor patient-derived models would promote the development of more effective therapeutics for non-small cell lung cancer (NSCLC). Recently, conditionally reprogrammed cells (CRC) methodology demonstrated exceptional potential for the expansion of epithelial cells from patient tissues. However, the possibility to expand patient-derived lung cancer cells using CRC ... Read more >>

Int. J. Cancer (International journal of cancer)
[2018, 143(1):88-99]

Cited: 2 times

View full text PDF listing >>



DNA damage repair and survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy.

Livia Ronchetti, Elisa Melucci, Francesca De Nicola, Frauke Goeman, Beatrice Casini, Francesca Sperati, Matteo Pallocca, Irene Terrenato, Laura Pizzuti, Patrizia Vici, Domenico Sergi, Luigi Di Lauro, Carla Azzurra Amoreo, Enzo Gallo, Maria Grazia Diodoro, Edoardo Pescarmona, Ilio Vitale, Maddalena Barba, Simonetta Buglioni, Marcella Mottolese, Maurizio Fanciulli, Ruggero De Maria, Marcello Maugeri-Saccà,

The DNA damage response (DDR) network is exploited by cancer cells to withstand chemotherapy. Gastric cancer (GC) carries deregulation of the DDR and harbors genetic defects that fuel its activation. The ATM-Chk2 and ATR-Chk1-Wee1 axes are deputed to initiate DNA repair. Overactivation of these pathways in cancer cells may represent ... Read more >>

Int. J. Cancer (International journal of cancer)
[2017, 140(11):2587-2595]

Cited: 11 times

View full text PDF listing >>



CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.

Gwenola Manic, Michele Signore, Antonella Sistigu, Giorgio Russo, Francesca Corradi, Silvia Siteni, Martina Musella, Sara Vitale, Maria Laura De Angelis, Matteo Pallocca, Carla Azzurra Amoreo, Francesca Sperati, Simone Di Franco, Sabina Barresi, Eleonora Policicchio, Gabriele De Luca, Francesca De Nicola, Marcella Mottolese, Ann Zeuner, Maurizio Fanciulli, Giorgio Stassi, Marcello Maugeri-Saccà, Marta Baiocchi, Marco Tartaglia, Ilio Vitale, Ruggero De Maria,

Cancer stem cells (CSCs) are responsible for tumour formation and spreading, and their targeting is required for tumour eradication. There are limited therapeutic options for advanced colorectal cancer (CRC), particularly for tumours carrying RAS-activating mutations. The aim of this study was to identify novel CSC-targeting strategies.To discover potential therapeutics to ... Read more >>

Gut (Gut)
[2018, 67(5):903-917]

Cited: 13 times

View full text PDF listing >>



Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization.

Tiziana Bruno, Mariacristina Valerio, Luca Casadei, Francesca De Nicola, Frauke Goeman, Matteo Pallocca, Valeria Catena, Simona Iezzi, Cristina Sorino, Agata Desantis, Cesare Manetti, Giovanni Blandino, Aristide Floridi, Maurizio Fanciulli,

Solid tumours are less oxygenated than normal tissues. Consequently, cancer cells acquire to be adapted to a hypoxic environment. The poor oxygenation of solid tumours is also a major indicator of an adverse cancer prognosis and leads to resistance to conventional anticancer treatments. We previously showed the involvement of Che-1/AATF ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2017, 36(1):32]

Cited: 8 times

View full text PDF listing >>



Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells.

Valeria Catena, Tiziana Bruno, Francesca De Nicola, Frauke Goeman, Matteo Pallocca, Simona Iezzi, Cristina Sorino, Giovanni Cigliana, Aristide Floridi, Giovanni Blandino, Maurizio Fanciulli,

Multiple myeloma (MM) is a malignant disorder of plasma cells characterized by active production and secretion of monoclonal immunoglobulins (IgG), thus rendering cells prone to endoplasmic reticulum (ER) stress. For this reason, MM cell survival requires to maintain ER homeostasis at basal levels. Deptor is an mTOR binding protein, belonging ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(43):70546-70558]

Cited: 10 times

View full text PDF listing >>



Multitargeting activity of miR-24 inhibits long-term melatonin anticancer effects.

Federica Mori, Maria Ferraiuolo, Raffaela Santoro, Andrea Sacconi, Frauke Goeman, Matteo Pallocca, Claudio Pulito, Etleva Korita, Maurizio Fanciulli, Paola Muti, Giovanni Blandino, Sabrina Strano,

We have previously shown that melatonin exerts tumor suppressor activities by inducing the p38-p53 axis. This occurred within a few hours while no data are available on how melatonin pathway can be sustained on the long term. Here we show that miR-24, which has been demonstrated to target genes involved ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(15):20532-20548]

Cited: 20 times

View full text PDF listing >>



RAP: RNA-Seq Analysis Pipeline, a new cloud-based NGS web application.

Mattia D'Antonio, Paolo D'Onorio De Meo, Matteo Pallocca, Ernesto Picardi, Anna Maria D'Erchia, Raffaele A Calogero, Tiziana Castrignanò, Graziano Pesole,

The study of RNA has been dramatically improved by the introduction of Next Generation Sequencing platforms allowing massive and cheap sequencing of selected RNA fractions, also providing information on strand orientation (RNA-Seq). The complexity of transcriptomes and of their regulative pathways make RNA-Seq one of most complex field of NGS ... Read more >>

BMC Genomics (BMC genomics)
[2015, 16:S3]

Cited: 55 times

View full text PDF listing >>



Advertisement

Disclaimer
1.2092 s