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Outcomes of clinical utility in amyloid-PET studies: state of art and future perspectives.

Matteo Cotta Ramusino, Giulia Perini, Daniele Altomare, Paola Barbarino, Wendy Weidner, Gabriella Salvini Porro, Frederik Barkhof, Gil D Rabinovici, Wiesje M van der Flier, Giovanni B Frisoni, Valentina Garibotto, Stefan Teipel, Marina Boccardi,

<h4>Purpose</h4>To review how outcomes of clinical utility are operationalized in current amyloid-PET validation studies, to prepare for formal assessment of clinical utility of amyloid-PET-based diagnosis.<h4>Methods</h4>Systematic review of amyloid-PET research studies published up to April 2020 that included outcomes of clinical utility. We extracted and analyzed (a) outcome categories, (b) their ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, :]

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Correlation of Frontal Atrophy and CSF Tau Levels With Neuropsychiatric Symptoms in Patients With Cognitive Impairment: A Memory Clinic Experience.

Matteo Cotta Ramusino, Giulia Perini, Gloria Vaghi, Beatrice Dal Fabbro, Marco Capelli, Marta Picascia, Diego Franciotta, Lisa Farina, Elena Ballante, Alfredo Costa,

<b>Background</b>: Behavioral and psychological symptoms of dementia (BPSD) are a distressful condition. We aimed to investigate the BPSD distribution in subjects with cognitive impairment, and the potential correlations between BPSD and neurodegeneration in terms of cerebrospinal fluid (CSF) tau and brain atrophy. <b>Methods</b>: One-hundred patients with mild cognitive impairment (MCI) ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2021, 13:595758]

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Effects of Oral Administration of Alprazolam and Lorazepam as Hypnotics on Cardiovascular Parameters in Hypertensive Patients.

Alfredo Costa, Angela D'Angelo, Matteo Cotta Ramusino, Giulia Perini, Daniele Bosone, Giuseppe Derosa, Roberto Fogari,

<h4>Background</h4>Previous studies have suggested that evening intake of benzodiazepine affects blood pressure (BP) and/or heart rate (HR) in healthy and hypertensive subjects. The aim of this study was to compare the effect of chronic oral administration of alprazolam and lorazepam as hypnotics on ambulatory BP and HR in patients with ... Read more >>

J Clin Psychopharmacol (Journal of clinical psychopharmacology)
[2021, 41(2):191-195]

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Different miRNA Profiles in Plasma Derived Small and Large Extracellular Vesicles from Patients with Neurodegenerative Diseases.

Daisy Sproviero, Stella Gagliardi, Susanna Zucca, Maddalena Arigoni, Marta Giannini, Maria Garofalo, Martina Olivero, Michela Dell'Orco, Orietta Pansarasa, Stefano Bernuzzi, Micol Avenali, Matteo Cotta Ramusino, Luca Diamanti, Brigida Minafra, Giulia Perini, Roberta Zangaglia, Alfredo Costa, Mauro Ceroni, Nora I Perrone-Bizzozero, Raffaele A Calogero, Cristina Cereda,

Identifying biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological functions transported in blood and they may be valid biomarkers for NDs. The aim of our study was to investigate common and different ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(5):]

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Different RNA profiles in plasma derived small and large extracellular vesicles of Neurodegenerative diseases patients

Daisy Sproviero, Stella Gagliardi, Susanna Zucca, Maddalena Arigoni, Marta Giannini, Maria Garofalo, Martina Olivero, Michela Dell’Orco, Orietta Pansarasa, Stefano Bernuzzi, Micol Avenali, Matteo Cotta Ramusino, Luca Diamanti, Brigida Minafra, Giulia Perini, Roberta Zangaglia, Alfredo Costa, Mauro Ceroni, Nora Perrone-Bizzozero, Raffaele Calogero, Cristina Cereda,

<h4>Background</h4> Identifying robust biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological functions transported in blood and they may be valid biomarkers for NDs. The aim of our study was to investigate common ... Read more >>

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Frontal and Cerebellar Atrophy Supports FTSD-ALS Clinical Continuum.

Beatrice Pizzarotti, Fulvia Palesi, Paolo Vitali, Gloria Castellazzi, Nicoletta Anzalone, Elena Alvisi, Daniele Martinelli, Sara Bernini, Matteo Cotta Ramusino, Mauro Ceroni, Giuseppe Micieli, Elena Sinforiani, Egidio D'Angelo, Alfredo Costa, Claudia A M Gandini Wheeler-Kingshott,

<h4>Background</h4>Frontotemporal Spectrum Disorder (FTSD) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases often considered as a continuum from clinical, epidemiologic, and genetic perspectives. We used localized brain volume alterations to evaluate common and specific features of FTSD, FTSD-ALS, and ALS patients to further understand this clinical continuum.<h4>Methods</h4>We used voxel-based morphometry ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:593526]

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Medical Informatics Platform (MIP): A Pilot Study Across Clinical Italian Cohorts.

Alberto Redolfi, Silvia De Francesco, Fulvia Palesi, Samantha Galluzzi, Cristina Muscio, Gloria Castellazzi, Pietro Tiraboschi, Giovanni Savini, Anna Nigri, Gabriella Bottini, Maria Grazia Bruzzone, Matteo Cotta Ramusino, Stefania Ferraro, Claudia A M Gandini Wheeler-Kingshott, Fabrizio Tagliavini, Giovanni B Frisoni, Philippe Ryvlin, Jean-François Demonet, Ferath Kherif, Stefano F Cappa, Egidio D'Angelo,

<b>Introduction:</b> With the shift of research focus to personalized medicine in Alzheimer's Dementia (AD), there is an urgent need for tools that are capable of quantifying a patient's risk using diagnostic biomarkers. The Medical Informatics Platform (MIP) is a distributed e-infrastructure federating large amounts of data coupled with machine-learning (ML) ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:1021]

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COVID-19 and Guillain-Barré Syndrome: A Case Report and Review of Literature.

Antonio Zito, Enrico Alfonsi, Diego Franciotta, Massimiliano Todisco, Matteo Gastaldi, Matteo Cotta Ramusino, Mauro Ceroni, Alfredo Costa,

During the recent coronavirus disease 2019 (COVID-19) outbreak in Northern Italy, we observed a 57-year-old man developing acute motor-sensory axonal neuropathy, a variant of Guillain-Barré syndrome (GBS), 12 days after severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Similarly to other bacterial and viral infections, dysregulation of the immune system due to ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:909]

Cited: 8 times

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Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia.

Annachiara Cagnin, Raffaele Di Lorenzo, Camillo Marra, Laura Bonanni, Chiara Cupidi, Valentina Laganà, Elisa Rubino, Alessandro Vacca, Paolo Provero, Valeria Isella, Nicola Vanacore, Federica Agosta, Ildebrando Appollonio, Paolo Caffarra, Ilaria Pettenuzzo, Renato Sambati, Davide Quaranta, Valeria Guglielmi, Giancarlo Logroscino, Massimo Filippi, Gioacchino Tedeschi, Carlo Ferrarese, Innocenzo Rainero, Amalia C Bruni, ,

<h4>Background</h4>In March 2020, the World Health Organization declared a global pandemic due to the novel coronavirus SARS-CoV-2 and several governments planned a national quarantine in order to control the virus spread. Acute psychological effects of quarantine in frail elderly subjects with special needs, such as patients with dementia, have been ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:578015]

Cited: 7 times

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Mini Nutritional Assessment May Identify a Dual Pattern of Perturbed Plasma Amino Acids in Patients with Alzheimer's Disease: A Window to Metabolic and Physical Rehabilitation?

Roberto Aquilani, Alfredo Costa, Roberto Maestri, Matteo Cotta Ramusino, Antonia Pierobon, Maurizia Dossena, Sebastiano Bruno Solerte, Anna Maria Condino, Valeria Torlaschi, Paola Bini, Mirella Boselli, Mauro Ceroni, Daniela Buonocore, Federica Boschi, Mariella Bruni, Manuela Verri,

Conflicting results about alterations of plasma amino acid (AA) levels are reported in subjects with Alzheimer's disease (AD). The current study aimed to provide more homogeneous AA profiles and correlations between AAs and cognitive tests. Venous plasma AAs were measured in 54 fasting patients with AD (37 males, 17 females; ... Read more >>

Nutrients (Nutrients)
[2020, 12(6):]

Cited: 1 time

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A Machine Learning Approach for the Differential Diagnosis of Alzheimer and Vascular Dementia Fed by MRI Selected Features.

Gloria Castellazzi, Maria Giovanna Cuzzoni, Matteo Cotta Ramusino, Daniele Martinelli, Federica Denaro, Antonio Ricciardi, Paolo Vitali, Nicoletta Anzalone, Sara Bernini, Fulvia Palesi, Elena Sinforiani, Alfredo Costa, Giuseppe Micieli, Egidio D'Angelo, Giovanni Magenes, Claudia A M Gandini Wheeler-Kingshott,

Among dementia-like diseases, Alzheimer disease (AD) and vascular dementia (VD) are two of the most frequent. AD and VD may share multiple neurological symptoms that may lead to controversial diagnoses when using conventional clinical and MRI criteria. Therefore, other approaches are needed to overcome this issue. Machine learning (ML) combined ... Read more >>

Front Neuroinform (Frontiers in neuroinformatics)
[2020, 14:25]

Cited: 2 times

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Unsuspected Involvement of Spinal Cord in Alzheimer Disease.

Roberta Maria Lorenzi, Fulvia Palesi, Gloria Castellazzi, Paolo Vitali, Nicoletta Anzalone, Sara Bernini, Matteo Cotta Ramusino, Elena Sinforiani, Giuseppe Micieli, Alfredo Costa, Egidio D'Angelo, Claudia A M Gandini Wheeler-Kingshott,

Objective: Brain atrophy is an established biomarker for dementia, yet spinal cord involvement has not been investigated to date. As the spinal cord is relaying sensorimotor control signals from the cortex to the peripheral nervous system and vice-versa, it is indeed a very interesting question to assess whether it is ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2020, 14:6]

Cited: 1 time

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Diagnostic and Therapeutic Errors in Classical Trigeminal Neuralgia: a Multicenter Survey

Fabio Antonaci, Sebastiano Arceri, Martin Rakusa, Dimos Mitsikostas, Ivan Milanov, Vasil Todorov, Matteo Cotta Ramusino, Alfredo Costa,

<h4>Background: </h4> Classical Trigeminal neuralgia (CTN) is a severe, disabling form of painful cranial neuropathy. Even though CTN has a typical clinical picture, diagnosis it is often missed or delayed in clinical practice. This study was carried over to investigate the occurrence of diagnostic and therapeutic errors in CNT. Methods ... Read more >>

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Medical Informatics Platform (MIP): A Pilot Study Across Clinical Italian Cohorts

Alberto Redolfi, Silvia De Francesco, Fulvia Palesi, Samantha Galluzzi, Cristina Muscio, Gloria Castellazzi, Pietro Tiraboschi, Giovanni Savini, Anna Nigri, Gabriella Bottini, Maria Grazia Bruzzone, Matteo Cotta Ramusino, Stefania Ferraro, Claudia A. M. Gandini Wheeler-Kingshott, Fabrizio Tagliavini, Giovanni B. Frisoni, Philippe Ryvlin, Jean-François Demonet, Ferath Kherif, Stefano F. Cappa, Egidio D'Angelo,

Introduction: With the shift of research focus to personalized medicine in Alzheimer's Dementia (AD), there is an urgent need for tools that are capable of quantifying a patient's risk using diagnostic biomarkers. The Medical Informatics Platform (MIP) is a distributed e-infrastructure federating large amounts of data coupled with machine-learning (ML) ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:]

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The Treatment of Trigeminal Autonomic Cephalalgias: An Overview.

Matteo Cotta Ramusino, Giulia Perini, Fabio Antonaci, Alfredo Costa,

Trigeminal autonomic cephalalgias (TACs) are primary headaches that include cluster headache (CH), paroxysmal hemicrania (PH), and short-lasting unilateral neuralgiform headache attacks (SUNHAs) with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA). Hemicrania continua (HC) is another form that has been ascribed to TACs for clinical and pathophysiologic reasons. ... Read more >>

J Oral Facial Pain Headache (Journal of oral & facial pain and headache)
[2019, 33(1):89-104]

Cited: 1 time

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Frontal and cerebellar atrophy supports FTSD-ALS clinical continuum

Beatrice Pizzarotti, Fulvia Palesi, Paolo Vitali, Gloria Castellazzi, Nicoletta Anzalone, Elena Alvisi, Daniele Martinelli, Sara Bernini, Matteo Cotta Ramusino, Mauro Ceroni, Giuseppe Micieli, Elena Sinforiani, Egidio D’Angelo, Alfredo Costa, Claudia AM Gandini Wheeler-Kingshott,

<h4>Background</h4> Frontotemporal Spectrum Disorder (FTSD) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases often considered as a continuum from clinical, epidemiologic and genetic perspectives. We used localized brain volume alterations to evaluate common and specific features of FTSD, FTSD-ALS and ALS patients to further understand this clinical continuum. <h4>Methods</h4> We ... Read more >>

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Incremental value of amyloid-PET versus CSF in the diagnosis of Alzheimer's disease.

Matteo Cotta Ramusino, Valentina Garibotto, Ruggero Bacchin, Daniele Altomare, Alessandra Dodich, Frederic Assal, Aline Mendes, Alfredo Costa, Michele Tinazzi, Silvia D Morbelli, Matteo Bauckneht, Agnese Picco, Massimo E Dottorini, Cristina Tranfaglia, Lucia Farotti, Nicola Salvadori, Davide Moretti, Giordano Savelli, Anna Tarallo, Flavio Nobili, Maura Parapini, Carlo Cavaliere, Elena Salvatore, Marco Salvatore, Marina Boccardi, Giovanni B Frisoni,

<h4>Purpose</h4>To compare the incremental diagnostic value of amyloid-PET and CSF (Aβ42, tau, and phospho-tau) in AD diagnosis in patients with mild cognitive impairment (MCI) or mild dementia, in order to improve the definition of diagnostic algorithm.<h4>Methods</h4>Two independent dementia experts provided etiological diagnosis and relative diagnostic confidence in 71 patients on ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2020, 47(2):270-280]

Cited: 7 times

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Medial temporal lobe atrophy and posterior atrophy scales normative values.

Matteo Cotta Ramusino, Daniele Altomare, Ruggero Bacchin, Silvia Ingala, Claudio Bnà, Matteo Bonetti, Alfredo Costa, Frederik Barkhof, Valentina Nicolosi, Cristina Festari, Giovanni B Frisoni, Marina Boccardi,

<h4>Objectives</h4>The medial temporal lobe atrophy (MTA) and the posterior atrophy (PA) scales allow to assess the degree hippocampal and parietal atrophy from magnetic resonance imaging (MRI) scans. Despite reliable, easy and widespread employment, appropriate normative values are still missing. We aim to provide norms for the Italian population.<h4>Methods</h4>Two independent raters ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2019, 24:101936]

Cited: 1 time

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Role of Cerebrospinal Fluid Biomarkers and (18)F-florbetapir PET Imaging in the Diagnosis of Primary Progressive Aphasia: A Retrospective Analysis.

Giulia Perini, Matteo Cotta Ramusino, Elena Sinforiani, Diego Franciotta, Giusppe Trifirò, Mauro Ceroni, Alfredo Costa,

The use of biomarkers has recently supported the association between Alzheimer disease (AD) pathology and the logopenic variant of primary progressive aphasia (PPA). We aim to investigate possible differences in cerebrospinal fluid (CSF) biomarker concentrations in the three PPA variants, and to assess any agreement between CSF biomarkers and (18)F-florbetapir ... Read more >>

Alzheimer Dis Assoc Disord (Alzheimer disease and associated disorders)
[2019, 33(3):282-284]

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Impact of Medical Care on Symptomatic Drug Consumption and Quality of Life in Headache: A One-Year Population Study.

Matteo Cotta Ramusino, Ilaria De Cillis, Alfredo Costa, Fabio Antonaci,

Background: Chronic headache is one of the most common pain conditions, often leading to symptomatic drug overuse. The aim of this study was to provide data on symptomatic drug consumption in an Italian outpatient population and to describe how the clinical picture of headache may change after headache experts take ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:629]

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Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients.

Alfredo Costa, Daniele Bosone, Matteo Cotta Ramusino, Giulia Perini, Natascia Ghiotto, Annalisa Zoppi, Angela D Apos Angelo, Roberto Fogari,

<h4>Aim</h4>To assess the effects of chronic evening oral administration of bromazepam alone or in combination with propranolol on ambulatory blood pressure (BP) and heart rate (HR) in mild hypertensive subjects.<h4>Methods</h4>Thirty-seven mild hypertensive patients after a 2-week placebo period were randomized to bromazepam 3 mg, propranolol 40 mg, bromazepam 3 mg ... Read more >>

Pharmacology (Pharmacology)
[2019, 104(1-2):1-6]

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Cognitive impairment in depression: recent advances and novel treatments.

Giulia Perini, Matteo Cotta Ramusino, Elena Sinforiani, Sara Bernini, Roberto Petrachi, Alfredo Costa,

In the past, little or no attention was paid to cognitive disorders associated with depression (a condition sometimes termed pseudodementia). However, recent years have seen a growing interest in these changes, not only because of their high frequency in acute-stage depression, but also because they have been found to persist, ... Read more >>

Neuropsychiatr Dis Treat (Neuropsychiatric disease and treatment)
[2019, 15:1249-1258]

Cited: 6 times

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Early cortical and late striatal diffusion restriction on 3T MRI in a long-lived sporadic creutzfeldt-jakob disease case.

Paolo Vitali, Fulvia Palesi, Matteo Cotta Ramusino, Marina Pan, Alfredo Costa, Claudia Gandini Wheeler-Kingshott, Mauro Ceroni, Giuseppe Micieli, Nicoletta Anzalone, Giorgio Giaccone, Fabrizio Tagliavini, Michael Geschwind,

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2019, 50(5):1659-1662]

Cited: 1 time

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Diazepam as an oral hypnotic increases nocturnal blood pressure in the elderly.

Roberto Fogari, Alfredo Costa, Annalisa Zoppi, Angela D'Angelo, Natascia Ghiotto, Domenico Battaglia, Matteo Cotta Ramusino, Giulia Perini, Daniele Bosone,

<h4>Background</h4>No study has evaluated the cardiovascular effects of diazepam in elderly subjects that assume diazepam to induce sleep.<h4>Purpose</h4>The present study was carried out in order to evaluate the effects of chronic administration of diazepam as hypnotic drug on blood pressure (BP) and heart rate (HR) in healthy elderly subjects.<h4>Patients and ... Read more >>

Aging Clin Exp Res (Aging clinical and experimental research)
[2019, 31(4):463-468]

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Effect of flunitrazepam as an oral hypnotic on 24-hour blood pressure in healthy volunteers.

Daniele Bosone, Roberto Fogari, Annalisa Zoppi, Angela D'Angelo, Natascia Ghiotto, Giulia Perini, Matteo Cotta Ramusino, Alfredo Costa,

<h4>Purpose</h4>The present study was carried out in order to assess the effects of chronic administration of flunitrazepam (as an oral hypnotic) on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults.<h4>Materials and methods</h4>Following a 2-week placebo run-in period, 28 healthy volunteers (13 males and 15 females) between ... Read more >>

Eur J Clin Pharmacol (European journal of clinical pharmacology)
[2018, 74(8):995-1000]

Cited: 1 time

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