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Author Mathieu Roumiguie

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Managing Discordant Findings Between Multiparametric Magnetic Resonance Imaging and Transrectal Magnetic Resonance Imaging-directed Prostate Biopsy-The Key Role of Magnetic Resonance Imaging-directed Transperineal Biopsy.

Anne-Sophie Bajeot, Bertrand Covin, Oliver Meyrignac, Sarah Pericart, Richard Aziza, Daniel Portalez, Pierre Graff-Cailleaud, Guillaume Ploussard, Mathieu Roumiguié, Bernard Malavaud,

<h4>Background</h4>Discordant findings between multiparametric magnetic resonance imaging (mpMRI) and transrectal image-guided biopsies of the prostate (TRUS-P) may result in inadequate risk stratification of localized prostate cancer.<h4>Objective</h4>To assess transperineal image-guided biopsies of the index target (TPER-IT) in terms of disease reclassification and treatment recommendations.<h4>Design, setting, and participants</h4>Cases referred for suspicion or ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

Cited: 1 time

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Pembrolizumab monotherapy for the treatment of high-risk non-muscle-invasive bladder cancer unresponsive to BCG (KEYNOTE-057): an open-label, single-arm, multicentre, phase 2 study.

Arjun V Balar, Ashish M Kamat, Girish S Kulkarni, Edward M Uchio, Joost L Boormans, Mathieu Roumiguié, Laurence E M Krieger, Eric A Singer, Dean F Bajorin, Petros Grivas, Ho Kyung Seo, Hiroyuki Nishiyama, Badrinath R Konety, Haojie Li, Kijoeng Nam, Ekta Kapadia, Tara Frenkl, Ronald de Wit,

<h4>Background</h4>Standard treatment for high-risk non-muscle-invasive bladder cancer is transurethral resection of bladder tumour followed by intravesical BCG immunotherapy. However, despite high initial responses rates, up to 50% of patients have recurrence or become BCG-unresponsive. PD-1 pathway activation is implicated in BCG resistance. In the KEYNOTE-057 study, we evaluated pembrolizumab, a ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2021, 22(7):919-930]

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Predicting Complications After Robotic Partial Nephrectomy: Back to Simplicity.

Zine-Eddine Khene, Clément Mazouin, Alessandro Larcher, Benoit Peyronnet, Anis Gasmi, Mathieu Roumiguié, Grégory Verhoest, Umberto Capitanio, Romain Mathieu, Nicolas Doumerc, Francesco Montorsi, Karim Bensalah,

<h4>Background</h4>Robotic partial nephrectomy (RPN) has a significant morbidity. Nephrometry scores have been described to predict the occurrence of complications. Their usefulness is debated.<h4>Objective</h4>To evaluate the clinical utility of three nephrometry scores (radius, exophytic/endophytic, nearness, anterior/posterior, location [RENAL], preoperative aspects and dimensions used for an anatomical [PADUA], and simplified PADUA Renal ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Immunotherapy in genitourinary cancers: achievements and perspectives.

Evanguelos Xylinas, Mathieu Roumiguié, Paul Sargos,

World J Urol (World journal of urology)
[2021, 39(5):1317]

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Intra-database validation of case-identifying algorithms using reconstituted electronic health records from healthcare claims data.

Nicolas H Thurin, Pauline Bosco-Levy, Patrick Blin, Magali Rouyer, Jérémy Jové, Stéphanie Lamarque, Séverine Lignot, Régis Lassalle, Abdelilah Abouelfath, Emmanuelle Bignon, Pauline Diez, Marine Gross-Goupil, Michel Soulié, Mathieu Roumiguié, Sylvestre Le Moulec, Marc Debouverie, Bruno Brochet, Francis Guillemin, Céline Louapre, Elisabeth Maillart, Olivier Heinzlef, Nicholas Moore, Cécile Droz-Perroteau,

<h4>Background</h4>Diagnosis performances of case-identifying algorithms developed in healthcare database are usually assessed by comparing identified cases with an external data source. When this is not feasible, intra-database validation can present an appropriate alternative.<h4>Objectives</h4>To illustrate through two practical examples how to perform intra-database validations of case-identifying algorithms using reconstituted Electronic Health ... Read more >>

BMC Med Res Methodol (BMC medical research methodology)
[2021, 21(1):95]

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Re: Ming Yuen Teo, Jose Mauricio Mota, Karissa A. Whiting, et al. Fibroblast Growth Factor Receptor 3 Alteration Status is Associated with Differential Sensitivity to Platinum-based Chemotherapy in Locally Advanced and Metastatic Urothelial Carcinoma. Eur Urol 2020;78:907-15: Linking FGFR3 Mutation Status and Luminal Papillary Subtype to Response to Cisplatin-based Chemotherapy in Bladder Cancer.

Mathieu Roumiguie, Alberto Contreras-Sanz, Peter C Black,

Eur Urol (European urology)
[2021, 79(6):e182-e183]

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Apalutamide, darolutamide and enzalutamide in nonmetastatic castration-resistant prostate cancer: a meta-analysis.

Mathieu Roumiguié, Xavier Paoletti, Yann Neuzillet, Romain Mathieu, Sebastien Vincendeau, François Kleinclauss, Arnaud Mejean, Laurent Guy, Marc Olivier Timsit, Thierry Lebret,

<b>Aim:</b> Comparison of the efficacy/safety/health-related quality of life of apalutamide, enzalutamide and darolutamide in Phase III clinical trials involving patients with nonmetastatic castration-resistant prostate cancer was performed. <b>Materials & methods:</b> Relevant studies were identified by searching PubMed as well as conference abstracts reporting updated overall survival. Three pivotal trials were identified, SPARTAN (apalutamide), PROSPER ... Read more >>

Future Oncol (Future oncology (London, England))
[2021, 17(14):1811-1823]

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Complete Transurethral Resection before Radical Cystectomy May Improve Oncological Outcomes.

Vivien Graffeille, Grégory Verhoest, Alexandre Gryn, Solène-Florence Kammerer-Jacquet, Quentin Alimi, Jean-Baptiste Beauval, Luc Beuzit, Benjamin Pradère, Matthieu Thoulouzan, Zine Eddine Khene, François Guille, Nathalie Rioux-Leclercq, Romain Mathieu, Xavier Gamé, Karim Bensalah, Michel Soulié, Mathieu Roumiguié, Benoit Peyronnet,

<h4>Objectives</h4>The objective of this study was to assess the impact of complete transurethral resection of bladder tumors (TURBTs) before radical cystectomy on pathological and oncological outcomes of patients with muscle-invasive bladder cancer (MIBC) and high-risk non-MIBC.<h4>Materials and methods</h4>The charts of all patients who underwent radical cystectomy for bladder cancer in ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-8]

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The prognostic value of high-grade prostate cancer pattern on MRI-targeted biopsies: predictors for downgrading and importance of concomitant systematic biopsies.

Cécile Manceau, Gaëlle Fromont-Hankard, Jean-Baptiste Beauval, Marine Lesourd, Christophe Almeras, Anne-Sophie Bajeot, Jean-Romain Gautier, Michel Soulié, Guillaume Loison, Ambroise Salin, Christophe Tollon, Bernard Malavaud, Mathieu Roumiguié, Guillaume Ploussard,

<h4>Purpose</h4>To assess the proportion and risk factors for downgrading and reclassification to favorable disease in patients having high-grade (HG) prostate cancer (PCa) pattern on magnetic resonance imaging (MRI)-targeted-biopsy (TB).<h4>Methods</h4>From a radical prostatectomy (RP) cohort, we included patients with pre-biopsy positive MRI and HG [defined by Grade Group (GG) ≥ 3] PCa on ... Read more >>

World J Urol (World journal of urology)
[2021, :]

Cited: 2 times

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External Validation of a Predictive Model to Estimate Renal Function After Living Donor Nephrectomy.

Thibaut Benoit, Thomas Prudhomme, Aurélien Adypagavane, Bernard Malavaud, Michel Soulié, Xavier Gamé, Nassim Kamar, Charles Dariane, Christophe Legendre, Arnaud Méjean, Mathieu Roumiguié, Marc Olivier Timsit,

<h4>Background</h4>Transplantation from living donor nephrectomy (LDN) is the best treatment for end-stage renal disease, but observed decrease in donor renal function is a major concern. The aim of this study was to externally validate a predictive model to estimate 1-year postdonation eGFR and risk of chronic kidney disease (CKD) in ... Read more >>

Transplantation (Transplantation)
[2021, :]

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Adherent perinephric fat affects perioperative outcomes after partial nephrectomy: a systematic review and meta-analysis.

Zine-Eddine Khene, Gilles Dosin, Benoit Peyronnet, Anis Gasmi, Nicolas Doumerc, Idir Ouzaid, Benjamin Pradere, Marie Brassier, Mathieu Roumiguié, Romain Mathieu, Nathalie Rioux-Leclercq, Jay D Raman, Shahrokh Shariat, Karim Bensalah,

To investigate the association of adherent perinephric fat (APF) with perioperative outcomes, we conducted a systematic review and meta-analysis of the literature to clarify the impact of APF in patients undergoing partial nephrectomy. A systematic literature search using the Medline, Scopus, and Cochrane databases was performed in April 2019 and ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, 26(4):636-646]

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Intra-database Validation of Case-identifying Algorithms Using Reconstituted Electronic Health Records From Healthcare Claims Data

Nicolas Henri Thurin, Pauline Bosco-Levy, Patrick Blin, Magali Rouyer, Jérémy Jové, Stéphanie Lamarque, Lignot Séverine, Régis Lassalle, Abdelilah Abouelfath, Bignon Emmanuelle, Diez Pauline, Marine Gross-Goupil, Michel Soulié, Mathieu Roumiguié, Sylvestre Le Moulec, Marc Debouverie, Bruno Brochet, Francis Guillemin, Céline Louapre, Elisabeth Maillart, Olivier Heinzlef, Nicholas Moore, Droz-Perroteau Cécile,

<h4>Background: </h4> Diagnosis performances of case-identifying algorithms developed in healthcare database are usually assessed by comparing identified cases with an external data source. When this is not feasible, intra-database validation can present an appropriate alternative. <h4>Objectives: </h4> To illustrate through two practical examples how to perform intra-database validations of case-identifying ... Read more >>

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MRI Characteristics Accurately Predict Biochemical Recurrence after Radical Prostatectomy.

Cécile Manceau, Jean-Baptiste Beauval, Marine Lesourd, Christophe Almeras, Richard Aziza, Jean-Romain Gautier, Guillaume Loison, Ambroise Salin, Christophe Tollon, Michel Soulié, Bernard Malavaud, Mathieu Roumiguié, Guillaume Ploussard,

<h4>Background</h4>After radical prostatectomy (RP), biochemical recurrence (BCR) is associated with an increased risk of developing distant metastasis and prostate cancer specific and overall mortality.<h4>Methods</h4>The two-centre study included 521 consecutive patients undergoing RP for positive pre-biopsy magnetic resonance imaging (MRI) and pathologically proven prostate cancer (PCa), after which a combination scheme ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(12):]

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Comparison of the prognosis of primary vs. progressive muscle invasive bladder cancer after radical cystectomy: Results from a large multicenter study.

François-Xavier Nouhaud, Marouene Chakroun, Claire Lenormand, Idir Ouzaid, Benoit Peyronnet, Alexandre Gryn, Thomas Prudhomme, Vivien Grafeille, Michel Soulié, Mathieu Roumiguié, Grégory Verhoest, Evanguelos Xylinas, Abderrazak Bouzouita, Mohamed Chebil, Christian Pfister,

<h4>Purpose</h4>To assess whether progressive and primary muscle invasive bladder cancer (MIBC) have different prognosis after radical cystectomy or not. To date only a few data are available on this topic with conflicting results. Further studies on large cohort are needed to clarify these outcomes that may influence bladder cancer management ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(3):195.e1-195.e6]

Cited: 1 time

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Epidemiology of metastatic castration-resistant prostate cancer: A first estimate of incidence and prevalence using the French nationwide healthcare database.

Nicolas H Thurin, Magali Rouyer, Marine Gross-Goupil, Xavier Rebillard, Michel Soulié, Thibaud Haaser, Mathieu Roumiguié, Sylvestre Le Moulec, Camille Capone, Marie Pierrès, Stéphanie Lamarque, Jérémy Jové, Emmanuelle Bignon, Cécile Droz-Perroteau, Nicholas Moore, Patrick Blin,

<h4>Background</h4>There is a lack of information about the burden of metastatic castration-resistant prostate cancer (mCRPC). The present work aims to estimate the incidence and prevalence of mCRPC in 2014 using the French nationwide healthcare database (SNDS).<h4>Methods</h4>Prevalence and incidence were estimated based on an SNDS extraction of men covered by the ... Read more >>

Cancer Epidemiol (Cancer epidemiology)
[2020, 69:101833]

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External Validation of a Multiparametric Magnetic Resonance Imaging-based Nomogram for the Prediction of Extracapsular Extension and Seminal Vesicle Invasion in Prostate Cancer Patients Undergoing Radical Prostatectomy.

Romain Diamand, Guillaume Ploussard, Mathieu Roumiguié, Marco Oderda, Daniel Benamran, Gaelle Fiard, Thierry Quackels, Grégoire Assenmacher, Giuseppe Simone, Julien Van Damme, Bernard Malavaud, Christophe Iselin, Jean-Luc Descotes, Jean-Baptiste Roche, Alexandre Peltier, Thierry Roumeguère, Simone Albisinni,

The nomogram reported by Gandaglia et al (The key combined value of multiparametric magnetic resonance imaging, and magnetic resonance imaging-targeted and concomitant systematic biopsies for the prediction of adverse pathological features in prostate cancer patients undergoing radical prostatectomy. Eur Urol 2020;77:733-41) predicting extracapsular extension (ECE) or seminal vesicle invasion (SVI) ... Read more >>

Eur Urol (European urology)
[2021, 79(2):180-185]

Cited: 1 time

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Transvaginal minimally invasive approach: An update on safety from an anatomical, anatomopathological and clinical point of view.

Ariane Weyl, Elodie Chantalat, Gwendoline Daniel, Benoît Bordier, Patrick Chaynes, Nicolas Doumerc, Bernard Malavaud, Charlotte Vaysse, Mathieu Roumiguié,

<h4>Introduction</h4>The aim of this work was to analyze the transvaginal approach in minimally invasive surgery in terms of anatomical, histopathological and functional characteristics, to show the safety of this surgical approach.<h4>Methods</h4>Anatomical study was first conducted by dissection on fresh cadavers of adult women in order to measure the distance between ... Read more >>

J Gynecol Obstet Hum Reprod (Journal of gynecology obstetrics and human reproduction)
[2021, 50(1):101941]

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Consensus Definition and Prediction of Complexity in Transurethral Resection or Bladder Endoscopic Dissection of Bladder Tumours.

Mathieu Roumiguié, Evanguelos Xylinas, Antonin Brisuda, Maximillian Burger, Hugh Mostafid, Marc Colombel, Marek Babjuk, Joan Palou Redorta, Fred Witjes, Bernard Malavaud,

Ten senior urologists were interrogated to develop a predictive model based on factors from which they could anticipate complex transurethral resection of bladder tumours (TURBT). Complexity was defined by consensus. Panel members then used a five-point Likert scale to grade those factors that, in their opinion, drove complexity. Consensual factors ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(10):]

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Stratifying patients with intermediate-risk prostate cancer: Validation of a new model based on MRI parameters and targeted biopsy and comparison with NCCN and AUA subclassifications.

Romain Diamand, Guillaume Ploussard, Mathieu Roumiguié, Bernard Malavaud, Marco Oderda, Paolo Gontero, Alexandre Fourcade, Georges Fournier, Daniel Benamran, Christophe Iselin, Gaelle Fiard, Jean-Luc Descotes, Alexandre Peltier, Giuseppe Simone, Jean-Baptiste Roche, Thierry Roumeguère, Simone Albisinni,

<h4>Objective</h4>Intermediate-risk prostate cancer regroups heterogeneous patients with different oncologic outcomes. Aim of the study is to validate a novel intermediate-risk subclassification ("magnetic resonance imaging [MRI] subclassification") that defines favorable and unfavorable diseases based on multiparametric MRI parameters and compare it to NCCN and AUA intermediate-risk subclassifications.<h4>Methods</h4>A total of 429 patients ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(5):296.e1-296.e9]

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Non-technical skills in robotic surgery and impact on near-miss events: a multi-center study.

Anthony Manuguerra, Charles Mazeaud, Nicolas Hubert, Pascal Eschwège, Mathieu Roumiguié, Julia Salleron, Jacques Hubert,

<h4>Background</h4>Robotic surgery requires a set of non-technical skills (NTS), because of the complex environment. We aim to study relationship between NTS and near-miss events in robotic surgery.<h4>Methods</h4>This is an observational study in five French centers. Three robotic procedures were observed and filmed by one of expert trainers in NTS. They ... Read more >>

Surg Endosc (Surgical endoscopy)
[2020, :]

Cited: 1 time

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Prognostic Implications of Multiparametric Magnetic Resonance Imaging and Concomitant Systematic Biopsy in Predicting Biochemical Recurrence After Radical Prostatectomy in Prostate Cancer Patients Diagnosed with Magnetic Resonance Imaging-targeted Biopsy.

Giorgio Gandaglia, Guillaume Ploussard, Massimo Valerio, Giancarlo Marra, Marco Moschini, Alberto Martini, Mathieu Roumiguié, Nicola Fossati, Armando Stabile, Jean-Baptiste Beauval, Bernard Malavaud, Simone Scuderi, Francesco Barletta, Luca Afferi, Arnas Rakauskas, Paolo Gontero, Agostino Mattei, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>The prognostic role of multiparametric magnetic resonance imaging (mpMRI) and systematic biopsy in predicting biochemical recurrence (BCR) after radical prostatectomy (RP) in prostate cancer (PCa) patients has not been addressed yet.<h4>Objective</h4>To develop a risk tool predicting BCR after RP in patients diagnosed with magnetic resonance imaging (MRI)-targeted biopsy.<h4>Design, setting, and ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(6):739-747]

Cited: 1 time

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Incidence and preoperative predictors for major complications following radical nephroureterectomy.

Neil J Kocher, David Canes, Karim Bensalah, Morgan Roupret, Costas Lallas, Vitaly Margulis, Shahrokh Shariat, Pierre Colin, Surena Matin, Chad Tracy, Evanguelos Xylinas, Andrew Wagner, Mathieu Roumiguie, Wassim Kassouf, Tobias Klatte, Jay D Raman,

<h4>Background</h4>Radical nephroureterectomy (RNU) is the referent standard for managing bulky, invasive, or high grade upper-tract urothelial carcinoma (UTUC). The UTUC patient population, however, generally harbor medical comorbidities thereby placing them at risk of surgical complications. This study reviews a large international cohort of RNU patients to define the risk of ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(4):1786-1793]

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Confirmation by Early Oncologic Outcomes After Surgery of the Accuracy of Intermediate-risk Prostate Cancer Classification Based on Magnetic Resonance Imaging Staging and Targeted Biopsy.

Cécile Manceau, Jean-Baptiste Beauval, Marine Lesourd, Christophe Almeras, Jean-Romain Gautier, Michel Soulié, Guillaume Loison, Ambroise Salin, Christophe Tollon, Bernard Malavaud, Mathieu Roumiguié, Guillaume Ploussard,

Over the past decade, prostate cancer (PCa) diagnosis drastically evolved from systematic biopsies (SBs) to multiparametric magnetic resonance imaging (mpMRI) and targeted biopsy (TB), which have emerged as powerful imaging tools for diagnosis, staging, and preoperative planning. MRI and TB should now be widely adopted for assessing prognosis and be ... Read more >>

Eur Urol Open Sci (European urology open science)
[2020, 21:5-8]

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Timing and delay of radical prostatectomy do not lead to adverse oncologic outcomes: results from a large European cohort at the times of COVID-19 pandemic.

Romain Diamand, Guillaume Ploussard, Mathieu Roumiguié, Marco Oderda, Daniel Benamran, Gaelle Fiard, Alexandre Peltier, Giuseppe Simone, Julien Van Damme, Bernard Malavaud, Christophe Iselin, Jean-Luc Descotes, Jean-Baptiste Roche, Thierry Quackels, Thierry Roumeguère, Simone Albisinni,

<h4>Purpose</h4>The current COVID-19 pandemic is transforming our urologic practice and most urologic societies recommend to defer any surgical treatment for prostate cancer (PCa) patients. It is unclear whether a delay between diagnosis and surgical management (i.e., surgical delay) may have a detrimental effect on oncologic outcomes of PCa patients. The ... Read more >>

World J Urol (World journal of urology)
[2021, 39(6):1789-1796]

Cited: 1 time

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Comparison of the Comprehensive Complication Index and Clavien-Dindo systems in predicting perioperative outcomes following radical nephroureterectomy.

Scott Geiger, Neil Kocher, Dan Illinsky, Evanguelos Xylinas, Peter Chang, Lauren Dewey, Andrew A Wagner, Firas Petros, Surena F Matin, Conrad Tobert, Chad Tracy, Pierre-Marie Patard, Mathieu Roumiguie, Leonardo Lima Monteiro, Wassim Kassouf, Jay D Raman,

<h4>Background</h4>Complications can occur following radical nephroureterectomy (RNU) in 20-40% of patients. The Comprehensive Complication Index (CCI) is an alternative grading system to the Clavien-Dindo (CD) grading system that aggregates all complications experienced by a patient on a continuous (as opposed to categorical) scale. We investigate whether the cumulative nature of ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(4):1780-1785]

Cited: 1 time

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