Full Text Journal Articles by
Author Mathieu Nacher

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Disseminated Histoplasmosis: Fighting a neglected killer of patients with advanced HIV disease in Latin America.

Mathieu Nacher, Pierre Couppié, Loic Epelboin, Félix Djossou, Magalie Demar, Antoine Adenis,

PLoS Pathog. (PLoS pathogens)
[2020, 16(5):e1008449]

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Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil

Emilie MOSNIER, Isabelle Dusfour, Guillaume Lacour, Raphael Saldanha, Amandine Guidez, Margarete Gomes, Alice Sanna, Yanouk Epelboin, Johana Restrepo, Damien Davy, Magalie Demar, Félix Djossou, Maylis Douine, Vanessa Ardillon, Mathieu Nacher, Lise Musset, Emmanuel Roux,

Abstract Background In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax ( Pv ). While malaria cases have steadily declined between 2005-2016 in this Amazonian region, a resurgence was observed in 2017. Methods Two investigations were performed ... Read more >>

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Aetiological and morphological spectrum of cardiomyopathies in French Guiana: a retrospective study.

Paul Leménager, Yves-Kenol Franck, Florine Corlin, Nicolas Bouscaren, Mathieu Nacher, Antoine Adenis,

INTRODUCTION:Cardiomyopathies are a heterogeneous heart diseases group in terms of morphology and aetiology. Hypothesising a tropical specificity and given an absence of data in French Guiana, the primary objective of our study was to describe morphologies and aetiologies of cardiomyopathies observed at Cayenne General Hospital. METHODS:A cross-sectional study was conducted ... Read more >>

Open Heart (Open heart)
[2020, 7(1):]

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Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil.

Emilie Mosnier, Isabelle Dusfour, Guillaume Lacour, Raphael Saldanha, Amandine Guidez, Margarete S Gomes, Alice Sanna, Yanouk Epelboin, Johana Restrepo, Damien Davy, Magalie Demar, Félix Djossou, Maylis Douine, Vanessa Ardillon, Mathieu Nacher, Lise Musset, Emmanuel Roux,

BACKGROUND:In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax (Pv). While malaria cases have steadily declined between 2005 and 2016 in this Amazonian region, a resurgence was observed in 2017. METHODS:Two investigations were performed according to different ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):373]

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Social deprivation among socio-economic contrasted french areas: Using item response theory analysis to assess differential item functioning of the EPICES questionnaire in stroke patients.

Adrien Guilloteau, Christine Binquet, Abderrahmane Bourredjem, Isabelle Fournel, Marie Laure Lalanne-Mistrih, Mathieu Nacher, Devi Rochemont, André Cabie, Emmanuelle Mimeau, Caroline Mislin-Tritsch, Julien Joux, Annie Lannuzel, Claire Bonithon-Kopp, Yannick Béjot, Hervé Devilliers, ,

BACKGROUND:Multiple approaches have been proposed to measure low socio-economic status. In France the concept of precariousness, akin to social deprivation, was developed and is widely used. EPICES is a short questionnaire that was developed to measure this concept. This study aimed to evaluate Differential Item Functioning (DIF) in the EPICES ... Read more >>

PLoS ONE (PloS one)
[2020, 15(4):e0230661]

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The Imperative of Dengue Vaccination for Children with Sickle Cell Disease.

Narcisse Elenga, Mathieu Nacher, Indi Trehan,

J. Trop. Pediatr. (Journal of tropical pediatrics)
[2020, 66(3):245-247]

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HIV patients dying on anti-tuberculosis treatment: are undiagnosed infections still a problem in French Guiana?

Mathieu Nacher, Antoine Adenis, Philippe Abboud, Felix Djossou, Magalie Demar, Loïc Epelboin, Pierre Couppié,

OBJECTIVE:Despite scaling-up testing and antiretroviral treatment in Latin America, advanced HIV remains a significant public health problem. The objective of the present study was look for historical risk factors for death in French Guiana's HIV cohort taking into account the immunological status, the main opportunistic infections, and their treatment. A ... Read more >>

BMC Res Notes (BMC research notes)
[2020, 13(1):209]

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In search for the hotspots of Disease X: A biogeographic approach to mapping the predictive risk of WHO s Blueprint Priority Diseases

Soushieta Jagadesh, Marine Combe, Mathieu Nacher, Rodolphe Ellie Gozlan,

Anthropization of natural habitats including climate change along with overpopulation and global travel have been contributing to emerging infectious diseases outbreaks. The recent COVID-19 outbreak in Wuhan, highlights such threats to human health, social stability and global trade and economy. We used species distribution modelling and environmental data from satellite ... Read more >>

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Mapping priority neighborhoods: A novel approach to cluster identification in HIV/AIDS population

Soushieta Jagadesh, Marine Combe, Pierre Couppié, Rodolphe Elie Gozlan, Mathieu Nacher,

Abstract BackgroundUrban disadvantaged neighborhoods have higher HIV risk behavior and higher levels of AIDS-related mortality. Studies demonstrate that interventions at the community level focusing on risk groups have increased success rates than individual patient-based based management in the context of HIV/AIDS. We tested a novel approach to identify population groups ... Read more >>

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HIV patients dying on anti-tuberculosis treatment: are undiagnosed infections still a problem in French Guiana?

mathieu nacher, Antoine Adenis, Philippe Abboud, Felix Djossou, Magalie Demar, Loïc Epelboin, Pierre Couppié,

Abstract Objective Despite scaling-up testing and antiretroviral treatment in Latin America, advanced HIV remains a significant public health problem. The objective of the present study was look for historical risk factors for death in French Guiana’s HIV cohort taking into account the immunological status, the main opportunistic infections, and their ... Read more >>

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The epidemiology and management of stroke in French Guiana.

Dévi Rita Rochemont, Emmanuelle Mimeau, Caroline Misslin-Tritsch, Martine Papaix-Puech, Emmanuel Delmas, Yannick Bejot, Bertrand DeToffol, Isabelle Fournel, Mathieu Nacher,

BACKGROUND:French Guiana has the highest incidence of ischemic and hemorrhagic stroke of all French territories. However, there is no further information on the epidemiology and management of stroke in French Guiana. Our goal was to describe the characteristics of patients in French Guiana in order to generate hypotheses regarding the ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):109]

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ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk.

Edouard Hallet, Claude Flamand, Dominique Rousset, Timothée Bonifay, Camille Fritzell, Séverine Matheus, Maryvonne Dueymes, Balthazar Ntab, Mathieu Nacher,

BACKGROUND:A recent study in French Guiana suggested that populations living in precarious neighborhoods were more at risk for Chikungunya CHIKV than those living in more privileged areas. The objective of the present study was to test the hypothesis that Zika virus (ZIKV) infection was more frequent in precarious pregnant women ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2020, 14(3):e0008193]

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What is AIDS in the Amazon and the Guianas in the 90-90-90 era?

Mathieu Nacher, Antoine Adenis, Basma Guarmit, Aude Lucarelli, Denis Blanchet, Magalie Demar, Felix Djossou, Philippe Abboud, Loïc Epelboin, Pierre Couppié,

Introduction In the past decade, new diagnostic methods and strategies have appeared, HIV testing efforts and the generalization of antiretroviral therapy may have influenced the number of opportunistic diagnoses and mortality of HIV-infected patients. To test this hypothesis we compiled data on the top opportunistic infections and causes of early ... Read more >>

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Relations between influenza, dengue outbreaks, and subsequent bacterial sepsis in French Guiana: a time series analysis

Claire Cropet, Philippe Abboud, Emilie Mosnier, Loïc Epelboin, Félix Djossou, Ward Schrooten, Milko Sobesky, mathieu nacher,

Abstract Objective : Influenza has been shown to increase the risk for severe bacterial infection, in the tropics the seasonality of influenza epidemics is less marked and this may not be the case. Dengue is often followed by prolonged asthenia and some physicians hypothesized increased susceptibility to infections based on ... Read more >>

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Mycobacterium ulcerans Infection in French Guiana; Current State of Knowledge

Pierre Couppié, Romain Blaizot, Camilla J. Velvin, Maylis Douine, Marine Combe, Mathieu Nacher, Rodolphe E. Gozlan,

M. ulcerans infections (Buruli ulcer; BU) have been reported in French Guiana since the 1960s [1]. It is striking to see that French Guiana concentrates most of the cases of BU in America with only a few cases reported in Suriname, Peru, Mexico and Bolivia in the past [2, 3]. ... Read more >>

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Incidence and Trends in Immune Reconstitution Inflammatory Syndrome Associated With Histoplasma capsulatum Among People Living With Human Immunodeficiency Virus: A 20-Year Case Series and Literature Review.

Alessia Melzani, Regis de Reynal de Saint Michel, Balthazar Ntab, Felix Djossou, Loic Epelboin, Mathieu Nacher, Denis Blanchet, Magalie Demar, Pierre Couppie, Antoine Adenis,

BACKGROUND:Histoplasmosis is among the main acquired immunodeficiency syndrome (AIDS)-defining conditions in endemic areas. Although histoplasmosis has a worldwide distribution, histoplasmosis-associated immune reconstitution inflammatory syndrome (IRIS) in people living with human immunodeficiency virus (PLHIV) is rarely reported.This study aimed to describe the incidence and features of histoplasmosis-associated IRIS in a cohort ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(4):643-652]

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Risk Factors for Nontyphi Salmonella Bacteremia Over 10 Years in Fort-de-France, Martinique, West Indies.

Arnaud Buteux, Mathieu Nacher, Célia Merat, Duc Nguyen, Benoit Roze, André Cabié, Claude Olive,

Nontyphoidal Salmonella infections can result in bacteremia. This study was undertaken to determine the predictive factors for bacteremia in children aged less than 16 years. Medical data were collected for every child with positive nontyphoidal Salmonella cultures in blood or stools at the University hospital of Martinique, French West Indies, ... Read more >>

Am. J. Trop. Med. Hyg. (The American journal of tropical medicine and hygiene)
[2020, 102(1):58-62]

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Discriminating Tonate Virus from Dengue Virus Infection: A Matched Case-Control Study in French Guiana, 2003-2016.

Rémi Mutricy, Félix Djossou, Séverine Matheus, Enguerrane Lorenzi-Martinez, Franck De Laval, Magalie Demar, Mathieu Nacher, Dominique Rousset, Loïc Epelboin,

Tonate virus (TONV) is an arbovirus discovered in 1973 in French Guiana (FG) belonging to the Venezuelan equine encephalitis virus complex, Alphavirus genus. Only few publications and cases have been reported in FG. The objectives of the present study were to describe the clinical picture of TONV and to compare ... Read more >>

Am. J. Trop. Med. Hyg. (The American journal of tropical medicine and hygiene)
[2020, 102(1):195-201]

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Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana-Brazil): Associated Factors and Spatial Distribution.

Emilie Mosnier, Emmanuel Roux, Claire Cropet, Yassamine Lazrek, Olivier Moriceau, Mélanie Gaillet, Luana Mathieu, Mathieu Nacher, Magalie Demar, Guillaume Odonne, Maylis Douine, Céline Michaud, Stéphane Pelleau, Félix Djossou, Lise Musset,

To implement future malaria elimination strategies in French Guiana, a characterization of the infectious reservoir is recommended. A cross-sectional survey was conducted between October and December 2017 in the French Guianese municipality of St Georges de l'Oyapock, located along the Brazilian border. The prevalence of Plasmodium spp. was determined using ... Read more >>

Am. J. Trop. Med. Hyg. (The American journal of tropical medicine and hygiene)
[2020, 102(1):130-141]

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Histoplasmosis in Persons Living with HIV.

Mathieu Nacher,

The increase in the number of immunocompromised persons, following the HIV pandemic, has led to a dramatic amplification of the number of patients with progressive disseminated histoplasmosis [...]. ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2019, 6(1):]

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Prevalence and risk factors for micronutrient deficiencies in pregnant women at Cayenne maternity, French Guiana

Amandine Duclau, Fanny Abad, Antoine Adenis, Malika Leneuve-Dorilas, Mathieu Nacher,

Abstract Background Involved in physical and brain development, immune system functioning and various metabolic processes, micronutrients have profound health effects. The nutritional status of the pregnant woman is a major determinant of fetal health. French Guiana has the highest annual population growth rate. Social inequalities, cultural practices and parasitoses in ... Read more >>

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Emerging human infectious diseases of aquatic origin: a comparative biogeographic approach using Bayesian spatial modelling.

Soushieta Jagadesh, Marine Combe, Pierre Couppié, Paul Le Turnier, Loïc Epelboin, Mathieu Nacher, Rodolphe Elie Gozlan,

BACKGROUND:With the increase in unprecedented and unpredictable disease outbreaks due to human-driven environmental changes in recent years, we need new analytical tools to map and predict the spatial distribution of emerging infectious diseases and identify the biogeographic drivers underpinning their emergence. The aim of the study was to identify and ... Read more >>

Int J Health Geogr (International journal of health geographics)
[2019, 18(1):23]

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High prevalence of human papillomavirus infection in HIV-infected women living in French Antilles and French Guiana.

Sylvie Abel, Fatiha Najioullah, Jean-Luc Voluménie, Laetitia Accrombessi, Gabriel Carles, Dominique Catherine, Déborah Chiappetta, Cyril Clavel, Akua Codjo-Sodokine, Myriam El Guedj, Janick Jean-Marie, Vincent Molinié, Sandrine Pierre-François, Sofia Stegmann-Planchard, Vincent Vantilcke, Tania Vaz, Mathieu Nacher, André Cabié, Raymond Césaire, ,

An association between HIV infection and cervical cancer, a major public health issue worldwide, has been reported. The aim of this study was to estimate the prevalence of human papillomavirus (HPV) infection and the distribution of HPV genotypes in HIV-infected women living in French Antilles and Guiana and to determine ... Read more >>

PLoS ONE (PloS one)
[2019, 14(9):e0221334]

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Global Emergence of Buruli Ulcer.

Soushieta Jagadesh, Marine Combe, Pierre Couppié, Mathieu Nacher, Rodolphe Elie Gozlan,

Ecohealth (EcoHealth)
[2019, 16(4):591-593]

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Virulence of atypical Toxoplasma gondii strains isolated in French Guiana in a murine model.

Stéphane Simon, Benoit de Thoisy, Aurélien Mercier, Mathieu Nacher, Magalie Demar,

BACKGROUND:Toxoplasma gondii is an obligate intracellular protozoan parasite of warm-blooded vertebrates. Most infections in immunocompetent patients are asymptomatic. However, since 2000s, strains with particular genetic profiles that differ from the known clonal type (type I, II, III), have been described. In French Guiana, these strains are highly pathogenic in immunocompetent ... Read more >>

Parasite (Parasite (Paris, France))
[2019, 26:60]

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