Full Text Journal Articles by
Author Matcheri Keshavan

Advertisement

Find full text journal articles






Multivariate relationships between peripheral inflammatory marker subtypes and cognitive and brain structural measures in psychosis.

Paulo Lizano, Olivia Lutz, Yanxun Xu, Leah H Rubin, Lyle Paskowitz, Adam M Lee, Seenae Eum, Sarah K Keedy, S Kristian Hill, James L Reilly, Baolin Wu, Carol A Tamminga, Brett A Clementz, Godfrey D Pearlson, Elliot S Gershon, Matcheri S Keshavan, John A Sweeney, Jeffrey R Bishop,

Elevations in peripheral inflammatory markers have been reported in patients with psychosis. Whether this represents an inflammatory process defined by individual or subgroups of markers is unclear. Further, relationships between peripheral inflammatory marker elevations and brain structure, cognition, and clinical features of psychosis remain unclear. We hypothesized that a pattern ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Smartphone relapse prediction in serious mental illness: a pathway towards personalized preventive care.

John Torous, Tanzeem Choudhury, Ian Barnett, Matcheri Keshavan, John Kane,

World Psychiatry (World psychiatry : official journal of the World Psychiatric Association (WPA))
[2020, 19(3):308-309]

Cited: 0 times

View full text PDF listing >>



Advertisement

Neurocognitive and social cognitive training for youth at clinical high risk (CHR) for psychosis: A randomized controlled feasibility trial.

Michelle S Friedman-Yakoobian, Emma M Parrish, Shaun M Eack, Matcheri S Keshavan,

BACKGROUND:Cognitive deficits are present in individuals at clinical high risk for psychosis (CHRP). We developed Cognition for Learning and for Understanding Everyday Social Situations (CLUES), an integrated social- and neurocognitive remediation intervention for CHRP, and examined its feasibility and efficacy compared to an active control intervention in a pilot randomized ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Baseline Cortical Thickness Reductions in Clinical High Risk for Psychosis: Brain Regions Associated with Conversion to Psychosis Versus Non-Conversion as Assessed at One-Year Follow-Up in the Shanghai-At-Risk-for-Psychosis (SHARP) Study.

Elisabetta C Del Re, William S Stone, Sylvain Bouix, Johanna Seitz, Victor Zeng, Anthony Guliano, Nathaniel Somes, Tianhong Zhang, Benjamin Reid, Amanda Lyall, Monica Lyons, Huijun Li, Susan Whitfield-Gabrieli, Matcheri Keshavan, Larry J Seidman, Robert W McCarley, Jijun Wang, Martha E Shenton, Margaret A Niznikiewicz,

OBJECTIVE:To assess cortical thickness (CT) and surface area (SA) of frontal, temporal, and parietal brain regions in a large clinical high risk for psychosis (CHR) sample, and to identify cortical brain abnormalities in CHR who convert to psychosis and in the whole CHR sample, compared with the healthy controls (HC). ... Read more >>

(Schizophrenia bulletin)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Concordance and factor structure of subthreshold positive symptoms in youth at clinical high risk for psychosis.

Monica E Calkins, Scott W Woods, Carrie E Bearden, Lu Liu, Tyler M Moore, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Daniel H Mathalon, Matcheri Keshavan, William S Stone, Jean Addington,

Prevailing models of psychosis risk incorporate positive subthreshold symptoms as defining features of risk or transition to psychotic disorders. Despite this, relatively few studies have focused on characterizing longitudinal symptom features, such as prevalence, concordance and structure, which may aid in refining methods and enhancing classification and prediction efforts. The ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Systematic Review of Digital Phenotyping and Machine Learning in Psychosis Spectrum Illnesses.

James Benoit, Henry Onyeaka, Matcheri Keshavan, John Torous,

BACKGROUND:Digital phenotyping is the use of data from smartphones and wearables collected in situ for capturing a digital expression of human behaviors. Digital phenotyping techniques can be used to analyze both passively (e.g., sensor) and actively (e.g., survey) collected data. Machine learning offers a possible predictive bridge between digital phenotyping ... Read more >>

Harv Rev Psychiatry (Harvard review of psychiatry)
[2020, 28(5):296-304]

Cited: 0 times

View full text PDF listing >>



Impact of dynamic greenspace exposure on symptomatology in individuals with schizophrenia.

Philip Henson, John F Pearson, Matcheri Keshavan, John Torous,

There are currently many tools available for capturing and defining the context of one's environment. Digital phenotyping, the use of technology and sensors to capture moment-to-moment behavior, has shown potential in quantifying the lived experience of mental illness and in the identification of individualized targets related to recovery. Environmental data ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0238498]

Cited: 0 times

View full text PDF listing >>



Investigating Sexual Dimorphism of Human White Matter in a Harmonized, Multisite Diffusion Magnetic Resonance Imaging Study.

Johanna Seitz, Suheyla Cetin-Karayumak, Amanda Lyall, Ofer Pasternak, Madhura Baxi, Mark Vangel, Godfrey Pearlson, Carol Tamminga, John Sweeney, Brett Clementz, David Schretlen, Petra Verena Viher, Katharina Stegmayer, Sebastian Walther, Jungsun Lee, Tim Crow, Anthony James, Aristotle Voineskos, Robert W Buchanan, Philip R Szeszko, Anil Malhotra, Matcheri Keshavan, Inga K Koerte, Martha E Shenton, Yogesh Rathi, Marek Kubicki,

Axonal myelination and repair, critical processes for brain development, maturation, and aging, remain controlled by sexual hormones. Whether this influence is reflected in structural brain differences between sexes, and whether it can be quantified by neuroimaging, remains controversial. Diffusion-weighted magnetic resonance imaging (dMRI) is an in vivo method that can ... Read more >>

Cereb. Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, :]

Cited: 0 times

View full text PDF listing >>



Catechol-O-methyltransferase genotype differentially contributes to the flexibility and stability of cognitive sets in patients with psychotic disorders and their first-degree relatives.

William C Hochberger, Courtney L M Eskridge, Jeffrey R Bishop, James L Reilly, Leah H Rubin, Sarah Keedy, Elliot S Gershon, Carol A Tamminga, Godfrey D Pearlson, Michael Ragozzino, Matcheri S Keshavan, John A Sweeney, S Kristian Hill,

Dopaminergic activity in prefrontal cortex is modulated by the low (Met) and high (Val) activity of the rs4680 Val158Met single nucleotide polymorphism (SNP) in the Catechol-O-Methyltransferase (COMT) gene. While this has been related to working memory maintenance in patients with schizophrenia, the familial pattern, impact across the psychosis spectrum, and ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Reproducibility in the absence of selective reporting: An illustration from large-scale brain asymmetry research.

Xiang-Zhen Kong, , Clyde Francks,

The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p-hacking. Low statistical power in individual studies is also understood to be ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Association of white matter microstructure and extracellular free-water with cognitive performance in the early course of schizophrenia.

Rachal R Hegde, Sinead Kelly, Olivia Lutz, Synthia Guimond, Suheyla Cetin Karayumak, Luke Mike, Raquelle I Mesholam-Gately, Ofer Pasternak, Marek Kubicki, Shaun M Eack, Matcheri S Keshavan,

Schizophrenia (SZ) is proposed as a disorder of dysconnectivity underlying cognitive impairments and clinical manifestations. Although previous studies have shown extracellular changes in white matter of first-episode SZ, little is known about the transition period towards chronicity and its association with cognition. Free-water (FW) imaging was applied to 79 early ... Read more >>

Psychiatry Res Neuroimaging (Psychiatry research. Neuroimaging)
[2020, 305:111159]

Cited: 0 times

View full text PDF listing >>



Regression dynamic causal modeling for resting-state fMRI

Stefan Frässle, Samuel Harrison, Jakob Heinzle, Brett Clementz, Carol Tamminga, John Sweeney, Elliot Gershon, Matcheri Keshavan, Godfrey Pearlson, Albert Powers, Klaas Stephan,

A bstract “Resting-state” functional magnetic resonance imaging (rs-fMRI) is widely used to study brain connectivity. So far, researchers have been restricted to measures of functional connectivity that are computationally efficient but undirected, or to effective connectivity estimates that are directed but limited to small networks. Here, we show that a ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



The COVID pandemic and the endemic disparities in care across race for psychotic disorders.

Fabio Ferrarelli, Matcheri S Keshavan,

Schizophr. Res. (Schizophrenia research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



The Convergence of Neurology and Psychiatry: The Importance of Cross-Disciplinary Education.

Matcheri S Keshavan, Bruce H Price, Joseph B Martin,

JAMA (JAMA)
[2020, 324(6):554-555]

Cited: 0 times

View full text PDF listing >>



Resting state auditory-language cortex connectivity is associated with hallucinations in clinical and biological subtypes of psychotic disorders.

Victoria T Okuneye, Shashwath Meda, Godfrey D Pearlson, Brett A Clementz, Matcheri S Keshavan, Carol A Tamminga, Elena Ivleva, John A Sweeney, Elliot S Gershon, Sarah K Keedy,

BACKGROUND:Auditory hallucinations are prevalent across the major psychotic disorders, but their underlying mechanism is poorly understood. Limited prior work supports a hypothesis of altered auditory/language brain systems. To more definitively assess this, we examined whether alterations in resting state connectivity of auditory and language cortices are associated with hallucination severity ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 27:102358]

Cited: 0 times

View full text PDF listing >>



Cognitive dysfunction in a psychotropic medication-naïve, clinical high-risk sample from the ShangHai-At-Risk-for-Psychosis (SHARP) study: Associations with clinical outcomes.

Huiru Cui, Anthony J Giuliano, Tianhong Zhang, Lihua Xu, Yanyan Wei, Yingying Tang, Zhenying Qian, Lena M Stone, Huijun Li, Susan Whitfield-Gabrieli, Margaret Niznikiewicz, Matcheri S Keshavan, Martha E Shenton, Jijun Wang, William S Stone,

OBJECTIVES:1) to assess generalizability of neurocognitive deficits reported in previous Western clinical high-risk (CHR) for psychosis studies in a prodromal program in Shanghai, China; and 2) to investigate neurocognition in CHR subjects in relation to a broader range of clinical outcomes (e.g. remission) than presence or absence of psychosis. METHOD:Baseline ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Cognition, negative symptoms, and functional outcome in psychosis.

Shaun M Eack, Matcheri S Keshavan,

Schizophr. Res. (Schizophrenia research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Distinguishing patterns of impairment on inhibitory control and general cognitive ability among bipolar with and without psychosis, schizophrenia, and schizoaffective disorder.

Milena Y Gotra, Scot K Hill, Elliot S Gershon, Carol A Tamminga, Elena I Ivleva, Godfrey D Pearlson, Matcheri S Keshavan, Brett A Clementz, Jennifer E McDowell, Peter F Buckley, John A Sweeney, Sarah K Keedy,

BACKGROUND:Deficits in inhibitory control on a Stop Signal Task (SST) were previously observed to be of similar magnitude across schizophrenia, schizoaffective, and bipolar disorder with psychosis, despite variation in general cognitive ability. Understanding different patterns of performance on the SST may elucidate different pathways to the impaired inhibitory control each ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Individual Variation in Functional Brain Network Topography is Linked to Schizophrenia Symptomatology.

Uzma Nawaz, Ivy Lee, Adam Beermann, Shaun Eack, Matcheri Keshavan, Roscoe Brady,

Resting-state fMRI (rsfMRI) demonstrates that the brain is organized into distributed networks. Numerous studies have examined links between psychiatric symptomatology and network functional connectivity. Traditional rsfMRI analyses assume that the spatial organization of networks is invariant between individuals. This dogma has recently been overturned by the demonstration that networks show ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Association Between the Duration of Untreated Psychosis and Selective Cognitive Performance in Community-Dwelling Individuals With Chronic Untreated Schizophrenia in Rural China.

William S Stone, Bing Cai, Xinhua Liu, Margaux M-R Grivel, Gary Yu, Yangmu Xu, Xinyi Ouyang, Hanhui Chen, Fei Deng, Fang Xue, Huijun Li, Jeffrey A Lieberman, Matcheri S Keshavan, Ezra S Susser, Lawrence H Yang, Michael R Phillips,

Importance:Cognitive deficits constitute core features of schizophrenia, but the trajectories of cognitive difficulties in chronic untreated schizophrenia remain unclear. Objective:To assess the association of neuropsychological deficits with duration of untreated psychosis in individuals with chronic untreated schizophrenia. Design, Setting, and Participants:Community-dwelling individuals with chronic untreated schizophrenia (untreated patient group) and ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2020, :]

Cited: 0 times

View full text PDF listing >>



The digital clinic: Implementing technology and augmenting care for mental health.

Elena Rodriguez-Villa, Natali Rauseo-Ricupero, Erica Camacho, Hannah Wisniewski, Matcheri Keshavan, John Torous,

Increasing both access to and quality of mental healthcare is a global priority. One solution is to integrate technologies such as smartphone apps and sensors directly into care. Acknowledging many prior attempts and barriers, we introduce the Digital Clinic which is an already functioning clinic using smartphone apps to augment ... Read more >>

Gen Hosp Psychiatry (General hospital psychiatry)
[2020, 66:59-66]

Cited: 0 times

View full text PDF listing >>



No connectivity alterations for striatum, default mode, or salience network in association with self-reported antipsychotic medication dose in a large chronic patient group.

Emma N Herms, Jeffrey R Bishop, Victoria T Okuneye, Carol A Tamminga, Matcheri S Keshavan, Godfrey D Pearlson, Brett A Clementz, Jennifer E McDowell, Elena I Ivleva, Elliot S Gershon, John A Sweeney, Sarah K Keedy,

Schizophr. Res. (Schizophrenia research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Altered cerebral perfusion in bipolar disorder: A pCASL MRI study.

Victor Zeng, Paulo Lizano, Nicolas R Bolo, Olivia Lutz, Roscoe Brady, Elena I Ivleva, Weiying Dai, Brett Clementz, Carol Tamminga, Godfrey Pearlson, Matcheri Keshavan,

BACKGROUND:Neurovascular abnormalities are relevant to the pathophysiology of bipolar disorder (BD), which can be assessed using cerebral blood flow (CBF) imaging. CBF alterations have been identified in BD, but studies to date have been small and inconclusive. We aimed to determine cortical gray matter CBF (GM-CBF) differences between BD and ... Read more >>

Bipolar Disord (Bipolar disorders)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Biology and American Sociology, Part II: Developing a Unique Evolutionary Sociology.

Jonathan H Turner, Russell K Schutt, Matcheri S Keshavan,

In sociology's formative period between 1830 and 1930, evolutionary analysis organized much theorizing and research. This line of work ended abruptly in the 1920s but, over the last decades, has come back into the discipline somewhat piecemeal with the reintroduction of more sophisticated stage models of societal evolution, functional analysis, ... Read more >>

Am Sociol (The American sociologist)
[2020, :1-36]

Cited: 0 times

View full text PDF listing >>



Do neurobiological differences exist between paranoid and non-paranoid schizophrenia? Findings from the bipolar schizophrenia network on intermediate phenotypes study.

Olivia Lutz, Paulo Lizano, Suraj Sarvode Mothi, Victor Zeng, Rachal R Hegde, Dung T Hoang, Philip Henson, Roscoe Brady, Carol A Tamminga, Godfrey Pearlson, Brett A Clementz, John A Sweeney, Matcheri S Keshavan,

Subtypes of schizophrenia, constructed using clinical phenomenology to resolve illness heterogeneity, have faced criticism due to overlapping symptomatology and longitudinal instability; they were therefore dropped from the Diagnostic Statistical Manual-5. Cognitive and imaging findings comparing paranoid (P-SZ) and non-paranoid (disorganized, residual and undifferentiated; NP-SZ) schizophrenia have been limited due to ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
0.9814 s