Full Text Journal Articles by
Author Massimo Ralli

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Chronic maxillary sinusitis of dental origin and oroantral fistula: The results of combined surgical approach in an Italian university hospital.

Massimo Galli, Giulia De Soccio, Fabrizio Cialente, Francesca Candelori, Francesca Romana Federici, Massimo Ralli, Marco De Vincentiis, Antonio Minni,

Unilateral chronic maxillary sinusitis is a possible complication of odontogenic disease or dental treatment and is mainly due to the development of an oroantral fistula (OAF). The management of chronic maxillary sinusitis of dental origin (CMSDO) requires a combined treatment via endoscopic sinus surgery (ESS) and intraoral surgical treatment of ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):524-530]

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Tinnitus and equilibrium disorders in COVID-19 patients: preliminary results.

Pasquale Viola, Massimo Ralli, Davide Pisani, Donatella Malanga, Domenico Sculco, Luigi Messina, Carla Laria, Teodoro Aragona, Gianluca Leopardi, Francesco Ursini, Alfonso Scarpa, Davide Topazio, Antonia Cama, Viviana Vespertini, Francesco Quintieri, Lucio Cosco, Elio Maria Cunsolo, Giuseppe Chiarella,

PURPOSE:Tinnitus and equilibrium disorders such as dizziness and vertigo have been reported by patients with COVID-19; however, they have been rarely investigated. The aim of this study was to study the prevalence of subjective tinnitus and dizziness in a sample of COVID-19 patients using an online 10-item close-ended questionnaire. METHODS:A ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2020, :]

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Sudden sensorineural hearing loss and COVID-19 : (commentary about “Could sudden sensorineural hearing loss be the sole manifestation of COVID-19? An investigation into SARS-COV-2 in the etiology of sudden sensorineural hearing loss” from Osman Kılıc, Mahmut Tayyar Kalcıoglu, Yasemin Cag, Ozan Tuysuz, Emel Pektas, Hulya Caskurlu, and Ferihan Cetın)

Pietro De Luca, Claudia Cassandro, Massimo Ralli, Federico Maria Gioacchini, Massimo Re, Ettore Cassandro, Giuseppe Chiarella, Alfonso Scarpa,

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, :]

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Alcohol as an early life stressor: Epigenetics, metabolic, neuroendocrine and neurobehavioral implications.

Stefania Ciafrè, Giampiero Ferraguti, Antonio Greco, Antonella Polimeni, Massimo Ralli, Flavio Maria Ceci, Mauro Ceccanti, Marco Fiore,

Ethanol exposure during gestation is an early life stressor that profoundly dysregulates structure and functions of the embryonal nervous system, altering the cognitive and behavioral development. Such dysregulation is also achieved by epigenetic mechanisms, which, altering the chromatin structure, redraw the entire pattern of gene expression. In parallel, an oxidative ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2020, 118:654-668]

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Montgomery Salivary Bypass Tube in Head and Neck Cancer: The Experience of Our Otolaryngology Clinic.

Antonio Minni, Massimo Ralli, Simone Di Cianni, Fabrizio Cialente, Francesca Candelori, Andrea Colizza, Francesca Cambria, Marco de Vincentiis,

INTRODUCTION:One of the most common complications in the immediate and late postoperative period following total laryngectomy or pharyngolaryngectomy is pharyngocutaneous fistulae (PCF) formation and pharyngoesophageal stenosis (PES), causing significant mortality and morbidity. Since 1978, Montgomery salivary bypass tube (MSBT) has been used to reduce the incidence of PCF and PES. ... Read more >>

Ear Nose Throat J (Ear, nose, & throat journal)
[2020, :145561320961754]

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Sudden sensorineural hearing loss and COVID-19: (commentary about "Could sudden sensorineural hearing loss be the sole manifestation of COVID-19? An investigation into SARS-COV-2 in the etiology of sudden sensorineural hearing loss" from Osman Kılıc, Mahmut Tayyar Kalcıoglu, Yasemin Cag, Ozan Tuysuz, Emel Pektas, Hulya Caskurlu, and Ferihan Cetın).

Pietro De Luca, Claudia Cassandro, Massimo Ralli, Federico Maria Gioacchini, Massimo Re, Ettore Cassandro, Giuseppe Chiarella, Alfonso Scarpa,

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, :]

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Impact of COVID-19 pandemic on Italian Otolaryngology Units: a nationwide study.

Giuditta Mannelli, Massimo Ralli, Marco Bonali, Pasquale Capasso, Pierre Guarino, Valeria Iannini, Niccolò Mevio, Gennaro Russo, Alfonso Scarpa, Giacomo Spinato, Davide Topazio, Gabriele Molteni,

Acta Otorhinolaryngol Ital (Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale)
[2020, :]

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Nerve Growth Factor, Stress and Diseases.

Flavio Maria Ceci, Giampiero Ferraguti, Carla Petrella, Antonio Greco, Paola Tirassa, Angela Iannitelli, Massimo Ralli, Mario Vitali, Mauro Ceccanti, George N Chaldakov, Paolo Versacci, Marco Fiore,

Stress is a constant threat for homeostasis and is represented by different extrinsic and intrinsic stimuli (stressors, Hans Selye's 'noxious agents'), such as aggressive behavior, fear, diseases, physical activity, drugs, surgical injury, and environmental and physiological changes. Our organism responds to stress activating the adaptive stress system to activate compensatory ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2020, :]

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Phase 2 of coronavirus disease (COVID-19) and head and neck cancer: An action plan.

Francesca De Felice, Valentino Valentini, Marco de Vincentiis, Carlo Catalano, Daniela Musio, Silvia Mezi, Daniela Messineo, Cira Rosaria Tiziana Di Gioia, Gianluca Tenore, Paolo Priore, Massimo Ralli, Francesco Vullo, Andrea Botticelli, Edoardo Brauner, Filippo Giovannetti, Antonio Greco, Umberto Romeo, Paolo Marchetti, Carlo Della Rocca, Antonella Polimeni, Vincenzo Tombolini,

Oral Dis (Oral diseases)
[2020, :]

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Facial taping as biofeedback to improve the outcomes of physical rehab in Bell's palsy: preliminary results of a randomized case-control study.

Arianna Di Stadio, Valeria Gambacorta, Massimo Ralli, Jenny Pagliari, Fabrizio Longari, Antonio Greco, Giampietro Ricci,

PURPOSE:This study aimed to investigate the efficacy of taping in association with Kabat rehabilitation to ameliorate the outcomes of Bell's palsy. METHODS:This case-control study was conducted on hospital-outbound patients. 20 patients over 18 years affected from Bell's palsy were recruited at the onset of the disease (< 5 days). Patients were simply randomized into ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2020, :]

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Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation.

Massimo Ralli, Diletta Angeletti, Marco Fiore, Vittorio D'Aguanno, Alessandro Lambiase, Marco Artico, Marco de Vincentiis, Antonio Greco,

Hashimoto's thyroiditis, characterized by thyroid-specific autoantibodies, is one of the commonest autoimmune disorders. Although the exact etiology has not been fully elucidated, Hashimoto's thyroiditis is related to an interaction among genetic elements, environmental factors and epigenetic influences. Cellular and humoral immunity play a key role in the development of the ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2020, 19(10):102649]

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The role of endogenous Antisecretory Factor (AF) in the treatment of Ménière's Disease: A two-year follow-up study. Preliminary results.

Pasquale Viola, Davide Pisani, Alfonso Scarpa, Claudia Cassandro, Carla Laria, Teodoro Aragona, Marco Ciriolo, Lucrezia Spadera, Massimo Ralli, Michele Cavaliere, Maurizio Iengo, Giuseppe Chiarella,

PURPOSE:To evaluate the effects of increased endogenous Antisecretory Factor (AF) synthesis using specially processed cereals (SPC) in a sample of patients with defined unilateral Meniere's disease (MD), compared to the results of a treatment protocol of intravenous glycerol and dexamethasone. MATERIALS AND METHODS:Twenty-six patients with unilateral MD were divided in ... Read more >>

Am J Otolaryngol (American journal of otolaryngology)
[2020, 41(6):102673]

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Audiovestibular symptoms in patients with multiple sclerosis: A correlation between self-reported symptomatology and MRI findings to monitor disease progression.

Arianna Di Stadio, Massimo Ralli, Marta Altieri, Antonio Greco, Daniela Messineo, Evanthia Bernitsas,

BACKGROUNDS:The interest about audiovestibular symptoms in patients with multiple sclerosis (MS) is recently growing. However, these symptoms can be often underestimated by patients. We aim to evaluate the presence of audiovestibular symptoms in patients with MS as reported by themselves and correlate these symptoms with the different phases of MS. ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 45:102431]

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Obstructive Sleep Apnoea in Patients Treated for Head and Neck Cancer: A Systematic Review of the Literature.

Massimo Ralli, Flaminia Campo, Diletta Angeletti, Eugenia Allegra, Antonio Minni, Antonella Polimeni, Antonio Greco, Marco de Vincentiis,

Background and objectives: Obstructive sleep apnoea (OSA) is clinically defined by signs of daytime sleepiness and objective measures of disordered breathing during sleep. The literature is still controversial on the incidence and aetiology of OSA secondary to head and neck cancer treatment. The aim of this systematic review is to ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(8):]

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Chloroquine and hydroxychloroquine ototoxicity; potential implications for SARS-CoV-2 treatment. A brief review of the literature

Pietro De Luca, Alfonso Scarpa, Egidio De Bonis, Matteo Cavaliere, Pasquale Viola, Federico Maria Gioacchini, Massimo Ralli, Cassandro Ettore, Cassandro Claudia,

Introduction Current clinical evidences do not support any specific treatment against SARS-CoV-2. Chloroquine (CQ) and hydroxychloroquine (HCQ) are typically used in the treatment of rheumatoid arthritis, systemic lupus erythematosus and malaria; they have been considered for off-label and compassionate use in several countries against moderate to severe cases of COVID-19 ... Read more >>

Am J Otolaryngol (American journal of otolaryngology)
[2020, :]

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Reply to "An Approach to Manage Epistaxis in the COVID-19 Pandemic in Resource-Constrained Settings".

Vittorio D' Aguanno, Massimo Ralli, Lucia Ercoli, Antonio Greco, Marco de Vincentiis,

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2020, :194599820947363]

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Laryngeal tuberculosis in renal transplant recipients: A case report and review of the literature.

Fabrizio Cialente, Michele Grasso, Massimo Ralli, Marco De Vincentiis, Antonio Minni, Griselda Agolli, Michele Dello Spedale Venti, Mara Riminucci, Alessandro Corsi, Antonio Greco,

Renal allograft recipients are at greater risk of developing tuberculosis than the general population. A woman with a kidney transplant was admitted to our emergency department with high temperature, dysphonia, odynophagia, and asthenia. The final diagnosis was laryngeal tuberculosis. Multidisciplinary collaboration enabled accurate diagnosis and successful treatment. Laryngeal tuberculosis should ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(3):411-414]

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A Prospective Randomized Trial of N-butyl-cyanoacrylate + Metacryloxysulfolane Adhesive versus Suture Alone for Grafting in Rhinoplasty: 9 year Follow-up.

Carmine Martino, Francesco Salzano, Diletta Martino, Massimo Ralli, Marco De Vincentiis, Massimo Maranzano, Antonio Greco, Giovanni Salzano, Arianna Di Stadio,

OBJECTIVE:Use of cyanoacrylate glue in facial plastic surgery is still controversial due to the absence of long-term follow up showing the results. Aim of our study is comparing the long-term outcomes of N-butyl-cyanoacrylate + Metacryloxysulfolane versus traditional sutures in rhinoplasty. METHODS:Prospective comparative study. One hundred forty-two patients affected by ptotic ... Read more >>

Ann Otol Rhinol Laryngol (The Annals of otology, rhinology, and laryngology)
[2020, :3489420943910]

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Immunotherapy in the Treatment of Metastatic Melanoma: Current Knowledge and Future Directions.

Massimo Ralli, Andrea Botticelli, Irene Claudia Visconti, Diletta Angeletti, Marco Fiore, Paolo Marchetti, Alessandro Lambiase, Marco de Vincentiis, Antonio Greco,

Melanoma is one of the most immunologic malignancies based on its higher prevalence in immune-compromised patients, the evidence of brisk lymphocytic infiltrates in both primary tumors and metastases, the documented recognition of melanoma antigens by tumor-infiltrating T lymphocytes and, most important, evidence that melanoma responds to immunotherapy. The use of ... Read more >>

J Immunol Res (Journal of immunology research)
[2020, 2020:9235638]

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Lessons Learned from COVID-19 Pandemic in Italy.

Antonio Minni, Massimo Ralli, Francesca Candelori, Fabrizio Cialente, Lucia Ercoli, Claudio Parlapiano, Antonio Greco, Marco De Vincentiis,

Since the COVID-19 outbreak, Italy has been one of the most affected countries in Europe and the second for number of deaths. In this commentary, we discuss some lessons that we learned as healthcare providers working in a large public hospital during the pandemic, with a special focus on the ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Alzheimer's disease: new concepts on the role of autoimmunity and of NLRP3 inflammasome in the pathogenesis of the disease.

Cinzia Severini, Christian Barbato, Maria Grazia Di Certo, Francesca Gabanella, Carla Petrella, Arianna Di Stadio, Marco de Vincentiis, Antonella Polimeni, Massimo Ralli, Antonio Greco,

Alzheimer's disease (AD), recognized as the most common neurodegenerative disorder, is clinically characterized by the presence of extracellular beta amyloid (Aβ) plaques and by intracellular neurofibrillary tau tangles, accompanied by glial activation and neuroinflammation. Increasing evidence suggests that self-misfolded proteins stimulate an immune response mediated by glial cells, inducing release ... Read more >>

Curr Neuropharmacol (Current neuropharmacology)
[2020, :]

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Alcohol binge-drinking damage on the vestibulo-oculomotor reflex.

Salvatore Martellucci, Massimo Ralli, Giuseppe Attanasio, Francesca Yoshie Russo, Vincenzo Marcelli, Antonio Greco, Andrea Gallo, Marco Fiore, Carla Petrella, Giampiero Ferraguti, Mauro Ceccanti, Marco de Vincentiis,

PURPOSE:Binge drinking is associated with several adverse effects in multiple organs. This study aimed at evaluating the effects of a binge-like-drinking on the vestibulo-oculomotor reflex (VOR) using the video Head Impulse Test (vHIT) and the functional Head Impulse Test (fHIT). METHODS:Eleven healthy men (age range 32-35 years) with moderate drinking habits ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2020, :]

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Laser Microsurgery Versus Radiotherapy Versus Open Partial Laryngectomy for T2 Laryngeal Carcinoma: A Systematic Review of Oncological Outcomes.

Flaminia Campo, Jacopo Zocchi, Massimo Ralli, Daniele De Seta, Francesca Yoshie Russo, Diletta Angeletti, Antonio Minni, Antonio Greco, Raul Pellini, Marco de Vincentiis,

INTRODUCTION:The aim of the current systematic review is to update the pooled survival outcome of patients with T2 glottic carcinoma treated with either laser surgery (CO2 transoral laser microsurgery [CO2 TOLMS]), radiotherapy (RT), or open partial laryngectomy (OPL). METHODS:A systematic search was performed using the MEDLINE database, Scopus, and Google ... Read more >>

Ear Nose Throat J (Ear, nose, & throat journal)
[2020, :145561320928198]

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Difensil Immuno Reduces Recurrence and Severity of Tonsillitis in Children: A Randomized Controlled Trial.

Arianna Di Stadio, Antonio Della Volpe, Fiammetta M Korsch, Antonietta De Lucia, Massimo Ralli, Francesco Martines, Giampietro Ricci,

Oral supplements (OS) support the immune system in fighting upper airways infection. This study aimed to analyze the effect of Difensil Immuno (DI) on the recurrence of tonsillitis and fever in children. A multicentric randomized clinical trial was conducted. One-hundred and twenty children with chronic tonsillitis were randomly assigned to ... Read more >>

Nutrients (Nutrients)
[2020, 12(6):]

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Therapeutic role of intravenous glycerol for Meniere's disease. Preliminary results.

Alfonso Scarpa, Claudia Cassandro, Pietro De Luca, Antonio Greco, Giuseppe Chiarella, Marco de Vincentiis, Ettore Cassandro, Massimo Ralli,

PURPOSE:Osmotic diuretics such as glycerol are used for diagnostic purposes in patients with a suspect of Meniere's disease (MD). Scientific evidence in the animal model and in humans has shown that glycerol can induce a reduction in endolymphatic hydrops; however, its use for therapeutic purposes in MD has never been ... Read more >>

Am J Otolaryngol (American journal of otolaryngology)
[2020, 41(4):102498]

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