Full Text Journal Articles by
Author Massimo Levrero


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[Management of immune checkpoint inhibitors-induced liver toxicity in cancer].

Fanny Lebossé, Brigitte Bancel, Massimo Levrero, Philippe Merle,

Pharmacological immune checkpoint inhibitors (ICI) restore the anti-tumor properties of T-lymphocytes, but unfortunately can engender auto-immune-like disorders. Those, frequent and of variable severity, sometimes target the liver parenchyma. Liver toxicity of ICI firstly leads to alteration of liver function tests (ALFT) with a risk of clinical decompensation. The appearance of ... Read more >>

Bull Cancer (Bulletin du cancer)
[2020, :]

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Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth.

Evelina Miele, Agnese Po, Angela Mastronuzzi, Andrea Carai, Zein Mersini Besharat, Natalia Pediconi, Luana Abballe, Giuseppina Catanzaro, Claudia Sabato, Enrico De Smaele, Gianluca Canettieri, Lucia Di Marcotullio, Alessandra Vacca, Antonello Mai, Massimo Levrero, Stefan M Pfister, Marcel Kool, Felice Giangaspero, Franco Locatelli, Elisabetta Ferretti,

Persistent mortality rates of medulloblastoma (MB) and severe side effects of the current therapies require the definition of the molecular mechanisms that contribute to tumor progression. Using cultured MB cancer stem cells and xenograft tumors generated in mice, we show that low expression of miR-326 and its host gene β-arrestin1 ... Read more >>

Mol Oncol (Molecular oncology)
[2020, :]

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Structural Variations of Vaginal and Endometrial Microbiota: Hints on Female Infertility.

Lucia Riganelli, Valerio Iebba, Mariagrazia Piccioni, Isabella Illuminati, Giulia Bonfiglio, Bruna Neroni, Ludovica Calvo, Antonella Gagliardi, Massimo Levrero, Lucia Merlino, Marianna Mariani, Oriana Capri, Daniela Pietrangeli, Serena Schippa, Francesca Guerrieri,

Microbiota are microorganismal communities colonizing human tissues exposed to the external environment, including the urogenital tract. The bacterial composition of the vaginal microbiota has been established and is partially related to obstetric outcome, while the uterine microbiota, considered to be a sterile environment for years, is now the focus of ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2020, 10:350]

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Editor's Note: p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes.

Konstantinos Lefkimmiatis, Mariano Francesco Caratozzolo, Paola Merlo, Anna Maria D'Erchia, Beatriz Navarro, Massimo Levrero, Elisabetta Sbisa', Apollonia Tullo,

Cancer Res. (Cancer research)
[2020, 80(7):1611]

Cited: 0 times

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Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription.

Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri,

OBJECTIVE:The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host cellular chromatin. DESIGN:We explored, in relevant cellular models of HBV replication, the functional consequences of HBx interaction with DLEU2, a long non-coding RNA ... Read more >>

Gut (Gut)
[2020, :]

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Inducing and Characterizing Vesicular Steatosis in Differentiated HepaRG Cells.

Silvia Di Cocco, Laura Belloni, Abigail D G Nunn, Debora Salerno, Silvia Piconese, Massimo Levrero, Natalia Pediconi,

Hepatic steatosis represents a metabolic dysfunction that results from an accumulation of triglyceride-containing lipid droplets in hepatocytes. Excessive fat accumulation leads to non-alcoholic fatty liver disease (NAFLD),  which is potentially reversible and may evolve into non-alcoholic steatohepatitis (NASH) and eventually cirrhosis and hepatocellular carcinoma (HCC). The molecular mechanisms linking lipid ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2019, (149):]

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EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells.

Natalia Pediconi, Debora Salerno, Leonardo Lupacchini, Annapaola Angrisani, Giovanna Peruzzi, Enrico De Smaele, Massimo Levrero, Laura Belloni,

Modification of histones by lysine methylation plays a role in many biological processes, and it is dynamically regulated by several histone methyltransferases and demethylases. The polycomb repressive complex contains the H3K27 methyltransferase EZH2 and controls dimethylation and trimethylation of H3K27 (H3K27me2/3), which trigger gene suppression. JMJD3 and UTX have been ... Read more >>

Cell Death Dis (Cell death & disease)
[2019, 10(7):518]

Cited: 2 times

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Update of the statements on biology and clinical impact of occult hepatitis B virus infection.

Giovanni Raimondo, Stephen Locarnini, Teresa Pollicino, Massimo Levrero, Fabien Zoulim, Anna S Lok, ,

In October 2018 a large number of international experts with complementary expertise came together in Taormina to participate in a workshop on occult hepatitis B virus infection (OBI). The objectives of the workshop were to review the existing knowledge on OBI, to identify issues that require further investigation, to highlight ... Read more >>

J. Hepatol. (Journal of hepatology)
[2019, 71(2):397-408]

Cited: 16 times

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Hepatitis B.

Fabien Zoulim, Massimo Levrero, Barbara Testoni,

Nat Rev Gastroenterol Hepatol (Nature reviews. Gastroenterology & hepatology)
[2018, :]

Cited: 0 times

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Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model.

Laura Belloni, Silvia Di Cocco, Francesca Guerrieri, Abigail D G Nunn, Silvia Piconese, Debora Salerno, Barbara Testoni, Claudio Pulito, Federica Mori, Matteo Pallocca, Andrea Sacconi, Elisa Vivoli, Fabio Marra, Sabrina Strano, Giovanni Blandino, Massimo Levrero, Natalia Pediconi,

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease. Although genetic predisposition and epigenetic factors contribute to the development of NAFLD, our understanding of the molecular mechanism involved in the pathogenesis of the disease is still emerging. Here we investigated a possible role of a microRNAs-STAT3 ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):13638]

Cited: 2 times

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Combining amplicon sequencing and metabolomics in cirrhotic patients highlights distinctive microbiota features involved in bacterial translocation, systemic inflammation and hepatic encephalopathy.

Valerio Iebba, Francesca Guerrieri, Vincenza Di Gregorio, Massimo Levrero, Antonella Gagliardi, Floriana Santangelo, Anatoly P Sobolev, Simone Circi, Valerio Giannelli, Luisa Mannina, Serena Schippa, Manuela Merli,

In liver cirrhosis (LC), impaired intestinal functions lead to dysbiosis and possible bacterial translocation (BT). Bacteria or their byproducts within the bloodstream can thus play a role in systemic inflammation and hepatic encephalopathy (HE). We combined 16S sequencing, NMR metabolomics and network analysis to describe the interrelationships of members of ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):8210]

Cited: 10 times

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Safety and efficacy of ombitasvir/paritaprevir/ritonavir/dasabuvir plus ribavirin in patients over 65 years with HCV genotype 1 cirrhosis.

Antonio Ascione, Massimo De Luca, Mario Melazzini, Simona Montilla, Maria Paola Trotta, Salvatore Petta, Massimo Puoti, Vincenzo Sangiovanni, Vincenzo Messina, Savino Bruno, Antonio Izzi, Erica Villa, Alessio Aghemo, Anna Linda Zignego, Alessandra Orlandini, Luca Fontanella, Antonio Gasbarrini, Marco Marzioni, Edoardo G Giannini, Antonio Craxì, ,

PURPOSE:To analyse safety and efficacy of treatment based on ombitasvir/paritaprevir/ritonavir/dasabuvir plus ribavirin in the sub-group of GT1 patients older than 65 years. METHODS:We collected data extracted from the ABACUS compassionate-use nationwide Italian programme, in patients with cirrhosis due to hepatitis C virus (HCV) Genotype-1 (GT1) or 4 and at high risk ... Read more >>

Infection (Infection)
[2018, 46(5):607-615]

Cited: 0 times

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Direct-acting antiviral therapy decreases hepatocellular carcinoma recurrence rate in cirrhotic patients with chronic hepatitis C.

Victor Virlogeux, Pierre Pradat, Kerstin Hartig-Lavie, François Bailly, Marianne Maynard, Guillaume Ouziel, Domitille Poinsot, Fanny Lebossé, Marie Ecochard, Sylvie Radenne, Samir Benmakhlouf, Joseph Koffi, Philippe Lack, Caroline Scholtes, Anne-Claire Uhres, Christian Ducerf, Jean-Yves Mabrut, Agnès Rode, Massimo Levrero, Christophe Combet, Philippe Merle, Fabien Zoulim,

Arrival of direct-acting antiviral agents against hepatitis C virus with high-sustained virological response rates and very few side effects has drastically changed the management of hepatitis C virus infection. The impact of direct-acting antiviral exposure on hepatocellular carcinoma recurrence after a first remission in patients with advanced fibrosis remains to ... Read more >>

Liver Int. (Liver international : official journal of the International Association for the Study of the Liver)
[2017, 37(8):1122-1127]

Cited: 23 times

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Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities.

Claudio Pulito, Federica Mori, Andrea Sacconi, Frauke Goeman, Maria Ferraiuolo, Patrizia Pasanisi, Carlo Campagnoli, Franco Berrino, Maurizio Fanciulli, Rebecca J Ford, Massimo Levrero, Natalia Pediconi, Ludovica Ciuffreda, Michele Milella, Gregory R Steinberg, Mario Cioce, Paola Muti, Sabrina Strano, Giovanni Blandino,

Metformin is a commonly prescribed type II diabetes medication that exhibits promising anticancer effects. Recently, these effects were found to be associated, at least in part, with a modulation of microRNA expression. However, the mechanisms by which single modulated microRNAs mediate the anticancer effects of metformin are not entirely clear ... Read more >>

Cell Discov (Cell discovery)
[2017, 3:17022]

Cited: 17 times

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Ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin for patients with hepatitis C virus genotype 1 or 4 infection with cirrhosis (ABACUS): a prospective observational study.

Salvatore Petta, Marco Marzioni, Pierluigi Russo, Alessio Aghemo, Alfredo Alberti, Antonio Ascione, Andrea Antinori, Raffaele Bruno, Savino Bruno, Antonio Chirianni, Giovanni Battista Gaeta, Edoardo G Giannini, Manuela Merli, Vincenzo Messina, Simona Montilla, Carlo Federico Perno, Massimo Puoti, Giovanni Raimondo, Maria Rendina, Francesca Ceccherini Silberstein, Erica Villa, Anna Linda Zignego, Luca Pani, Antonio Craxì, , ,

BACKGROUND:We ran a compassionate use nationwide programme (ABACUS) to provide access to ombitasvir, paritaprevir, and ritonavir, with dasabuvir, plus ribavirin for hepatitis C virus (HCV) genotype 1 infection and ombitasvir, paritaprevir, and ritonavir, plus ribavirin for HCV genotype 4 infection in patients with cirrhosis at high risk of decompensation while ... Read more >>

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2017, 2(6):427-434]

Cited: 9 times

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Erratum: The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells.

Abigail D G Nunn, Tullio Scopigno, Natalia Pediconi, Massimo Levrero, Henning Hagman, Juris Kiskis, Annika Enejder,

Sci Rep (Scientific reports)
[2016, 6:37204]

Cited: 0 times

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Correction: IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome.

Gianna Aurora Palumbo, Cecilia Scisciani, Natalia Pediconi, Leonardo Lupacchini, Dulce Alfaiate, Francesca Guerrieri, Ludovica Calvo, Debora Salerno, Silvia Di Cocco, Massimo Levrero, Laura Belloni,

PLoS ONE (PloS one)
[2015, 10(12):e0145555]

Cited: 0 times

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Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes.

Barbara Testoni, David Durantel, Fanny Lebossé, Judith Fresquet, François Helle, Francesco Negro, Maria Francesca Donato, Massimo Levrero, Fabien Zoulim,

Caveats in the understanding of ribavirin (RBV) mechanisms of action has somehow prevented the development of better analogues able to further improve its therapeutic contribution in interferon (IFN)-based and direct antiviral agent-based regimens for chronic HCV or other indications. Here, we describe a new mechanism by which RBV modulates IFN-stimulated ... Read more >>

Gut (Gut)
[2016, 65(4):672-682]

Cited: 4 times

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TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.

Antonio Costanzo, Natalia Pediconi, Alessandra Narcisi, Francesca Guerrieri, Francesca Guerrieri, Laura Belloni, Francesca Fausti, Elisabetta Botti, Massimo Levrero,

TP53 belongs to a small gene family that includes, in mammals, two additional paralogs, TP63 and TP73. The p63 and p73 proteins are structurally and functionally similar to p53 and their activity as transcription factors is regulated by a wide repertoire of shared and unique post-translational modifications and interactions with ... Read more >>

FEBS Lett. (FEBS letters)
[2014, 588(16):2590-2599]

Cited: 15 times

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HCV core-mediated activation of latent TGF-β via thrombospondin drives the crosstalk between hepatocytes and stromal environment.

Nassima Benzoubir, Charlène Lejamtel, Serena Battaglia, Barbara Testoni, Barbara Benassi, Claire Gondeau, Laure Perrin-Cocon, Christophe Desterke, Valérie Thiers, Didier Samuel, Massimo Levrero, Christian Bréchot, Marie-Françoise Bourgeade,

BACKGROUND & AIMS: The mechanisms by which fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) develop during chronic hepatitis C virus (HCV) infection are not fully understood. We previously observed that HCV core protein induced a TGF-β-dependent epithelial mesenchymal transition, a process contributing to the promotion of cell invasion and metastasis by ... Read more >>

J. Hepatol. (Journal of hepatology)
[2013, 59(6):1160-1168]

Cited: 28 times

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Mechanism of action of ribavirin in anti-HCV regimens: new insights for an age-old question?

Barbara Testoni, Massimo Levrero, David Durantel,

Gut (Gut)
[2014, 63(1):3-4]

Cited: 5 times

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Position paper of the Italian Association for the Study of the Liver (AISF): the multidisciplinary clinical approach to hepatocellular carcinoma.

, , , Luigi Bolondi, Umberto Cillo, Massimo Colombo, Antonio Craxì, Fabio Farinati, Edoardo G Giannini, Rita Golfieri, Massimo Levrero, Antonio Daniele Pinna, Fabio Piscaglia, Giovanni Raimondo, Franco Trevisani, Raffaele Bruno, Paolo Caraceni, Alessia Ciancio, Barbara Coco, Mirella Fraquelli, Maria Rendina, Giovanni Squadrito, Pierluigi Toniutto,

Patients with hepatocellular carcinoma should be managed with a multidisciplinary approach framed in a network where all the diagnostic techniques and therapeutic resources are available in order to provide the optimal level of care. Given this assumption, the Coordinating Committee of the Italian Association for the Study of the Liver ... Read more >>

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2013, 45(9):712-723]

Cited: 76 times

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Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.

Salvatore Petta, Donatella Ferraro, Calogero Cammà, Daniela Cabibi, Antonietta Di Cristina, Vito Di Marco, Rosa Di Stefano, Stefania Grimaudo, Alessandra Mazzola, Massimo Levrero, Concetta Scazzone, Antonio Craxì,

BACKGROUND:Genotype 1 (G1) chronic hepatitis C (CHC) patients achieving a rapid virological response (RVR) on pegylated interferon (PEG-IFN) plus ribavirin have a high chance of sustained virological response (SVR), influenced by IL28B status, viral load, fibrosis and insulin resistance. We assessed whether 25-hydroxyvitamin D (25[OH]D) serum levels are linked to ... Read more >>

Antivir. Ther. (Lond.) (Antiviral therapy)
[2012, 17(5):823-831]

Cited: 18 times

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The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1.

Isabella Massimi, Francesca Guerrieri, Francesca Guerrieri, Marialaura Petroni, Veronica Veschi, Silvia Truffa, Isabella Screpanti, Luigi Frati, Massimo Levrero, Alberto Gulino, Giuseppe Giannini,

Reactivation of the HMGA1 protoncogene is very frequent in human cancer, but still very little is known on the molecular mechanisms leading to this event. Prompted by the finding of putative E2F binding sites in the human HMGA1 promoter and by the frequent deregulation of the RB/E2F1 pathway in human ... Read more >>

Mol. Carcinog. (Molecular carcinogenesis)
[2013, 52(7):526-534]

Cited: 15 times

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IL28B polymorphisms influence stage of fibrosis and spontaneous or interferon-induced viral clearance in thalassemia patients with hepatitis C virus infection.

Vito Di Marco, Fabrizio Bronte, Vincenza Calvaruso, Marcello Capra, Zelia Borsellino, Aurelio Maggio, Maria Concetta Renda, Lorella Pitrolo, Maria Carmela Lo Pinto, Michele Rizzo, Flavia Fiorenza, Calogera Gerardi, Stefania Grimaudo, Antonietta Di Cristina, Massimo Levrero, Antonio Craxì,

BACKGROUND:Polymorphisms in the interleukin-28B are important determinants in the spontaneous and drug-induced control of hepatitis C virus infection. DESIGN AND METHODS:We assessed the association of rs8099917 and rs12979860 polymorphisms with spontaneous viral clearance, severity of liver fibrosis, and response to interferon-monotherapy in 245 thalassemia major patients with hepatitis C virus ... Read more >>

Haematologica (Haematologica)
[2012, 97(5):679-686]

Cited: 22 times

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