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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Protective effect of SARS-CoV-2 preventive measures against ESKAPE and Escherichia coli infections.

Rita Gaspari, Giorgia Spinazzola, Luciana Teofili, Alfonso W Avolio, Barbara Fiori, Gian M Maresca, Teresa Spanu, Nicola Nicolotti, Gennaro De Pascale, Massimo Antonelli,

<h4>Background/objectives</h4>We investigated whether behavioral precautions adopted during Coronavirus disease (COVID-19) pandemic also influenced the spreading and multidrug resistance (MDR) of ESKAPEEc (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii [AB], Pseudomonas aeruginosa, Enterobacter spp and Escherichia Coli, [EC]) among Intensive Care Unit (ICU) patients.<h4>Subjects/methods</h4>We performed a single-center retrospective study in ... Read more >>

Eur J Clin Invest (European journal of clinical investigation)
[2021, :e13687]

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Teaching safety - Resident anaesthetists at the forefront of COVID-19.

Nicola Magnavita, Paolo Maurizio Soave, Massimo Antonelli,

We aimed to evaluate the impact of the COVID-19pandemic on anaesthesiology residents in a COVID-19 hub hospital in Latium andascertain their level of perceived justice and work-related stress. Residentsand specialist anaesthesiologists were recruited during April-May 2020.Informational and procedural justice were measured with the OrganizationalJustice questionnaire; work-related stress was measured with ... Read more >>

Ind Health (Industrial health)
[2021, :]

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Performance of the Hypotension Prediction Index With Noninvasive Arterial Pressure Waveforms in Awake Cesarean Delivery Patients Under Spinal Anesthesia.

Luciano Frassanito, Chiara Sonnino, Alessandra Piersanti, Bruno Antonio Zanfini, Stefano Catarci, Pietro Paolo Giuri, Marco Scorzoni, Gian Luigi Gonnella, Massimo Antonelli, Gaetano Draisci,

<h4>Background</h4>Arterial hypotension is common after spinal anesthesia (SA) for cesarean delivery (CD), and to date, there is no definitive method to predict it. The hypotension prediction index (HPI) is an algorithm that uses the arterial waveform to predict early phases of intraoperative hypotension. The aims of this study were to ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, :]

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Dyspnoea and clinical outcome in critically ill patients receiving noninvasive support for COVID-19 respiratory failure: post hoc analysis of a randomised clinical trial.

Luca S Menga, Domenico Luca Grieco, Tommaso Rosà, Melania Cesarano, Luca Delle Cese, Cecilia Berardi, Gabriele Pintaudi, Eloisa Sofia Tanzarella, Salvatore L Cutuli, Gennaro De Pascale, Salvatore Maurizio Maggiore, Massimo Antonelli,

<b>In #COVID19 patients, presence of moderate-to-severe dyspnoea is a marker of disease severity correlated to clinical outcomes</b> https://bit.ly/3Bp2G1b. ... Read more >>

ERJ Open Res (ERJ open research)
[2021, 7(4):]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Synergistic Effect of Static Compliance and D-dimers to Predict Outcome of Patients with COVID-19-ARDS: A Prospective Multicenter Study.

Tommaso Tonetti, Giacomo Grasselli, Paola Rucci, Francesco Alessandri, Alessio Dell'Olio, Annalisa Boscolo, Laura Pasin, Nicolò Sella, Chiara Mega, Rita Maria Melotti, Massimo Girardis, Stefano Busani, Giacomo Bellani, Giuseppe Foti, Domenico Luca Grieco, Vittorio Scaravilli, Alessandro Protti, Thomas Langer, Luciana Mascia, Francesco Pugliese, Maurizio Cecconi, Roberto Fumagalli, Stefano Nava, Massimo Antonelli, Arthur S Slutsky, Paolo Navalesi, Antonio Pesenti, Vito Marco Ranieri,

The synergic combination of D-dimer (as proxy of thrombotic/vascular injury) and static compliance (as proxy of parenchymal injury) in predicting mortality in COVID-19-ARDS has not been systematically evaluated. The objective is to determine whether the combination of elevated D-dimer and low static compliance can predict mortality in patients with COVID-19-ARDS. ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(9):]

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A One-Year Prospective Study of Work-Related Mental Health in the Intensivists of a COVID-19 Hub Hospital.

Nicola Magnavita, Paolo Maurizio Soave, Massimo Antonelli,

The COVID-19 pandemic has severely tested the physical and mental health of health care workers (HCWs). The various stages of the epidemic have posed different problems; consequently, only a prospective study can effectively describe the changes in the workers' health. This repeated cross-sectional study is based on a one-year investigation ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(18):]

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Prediction of ventilator-associated pneumonia outcomes according to the early microbiological response: a retrospective observational study.

Adrian Ceccato, Cristina Dominedò, Miquel Ferrer, Ignacio Martin-Loeches, Enric Barbeta, Albert Gabarrús, Catia Cillóniz, Otavio T Ranzani, Gennaro De Pascale, Stefano Nogas, Pierluigi Di Giannatale, Massimo Antonelli, Antoni Torres,

Ventilator-associated pneumonia is a leading infectious cause of morbidity in critically ill patients; yet current guidelines offer no indications for follow-up cultures.We aimed to evaluate the role of follow-up cultures and microbiological response 3 days after diagnosing ventilator-associated pneumonia as predictors of short- and long-term outcomes.We performed a retrospective analysis of ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, :]

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BMI and pneumonia outcomes in critically ill covid-19 patients: An international multicenter study.

Mikael Chetboun, Violeta Raverdy, Julien Labreuche, Arthur Simonnet, Florent Wallet, Cyrielle Caussy, Massimo Antonelli, Antonio Artigas, Gemma Goma, Ferhat Meziani, Julie Helms, Eleftherios Mylonakis, Mitchell M Levy, Markos Kalligeros, Nicola Latronico, Simone Piva, Charles Cerf, Mathilde Neuville, Kada Klouche, Romaric Larcher, Fabienne Tamion, Emilie Occhiali, Morgane Snacken, Jean-Charles Preiser, Loay Kontar, Antoine Riviere, Stein Silva, Benjamine Sarton, Raphael Krouchi, Victoria Dubar, Leonidas Palaiodimos, Dimitrios Karamanis, Juliette Perche, Erwan L'Her, Luca Busetto, Dror Dicker, Shaul Lev, Alain Duhamel, Mercè Jourdain, François Pattou,

<h4>Objective</h4>Previous studies have unveiled a relationship between the severity of coronavirus disease 2019 (COVID-19) pneumonia and obesity. The aims of this multicenter retrospective cohort study were to disentangle the association of BMI and associated metabolic risk factors (diabetes, hypertension, hyperlipidemia, and current smoking status) in critically ill patients with COVID-19.<h4>Methods</h4>Patients ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2021, 29(9):1477-1486]

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One-Year Prospective Study of Occupational Health in the Intensivists of a COVID-19 Hub Hospital

Nicola Magnavita, Paolo Maurizio Soave, Massimo Antonelli,

The COVID-19 pandemic has severely tested the physical and mental health of health care workers (HCWs). The various stages of the epidemic have posed different problems; consequently, only a prospective study can effectively describe the changes in the workers&rsquo; health. This repeated cross-sectional study is based on a one-year investigation ... Read more >>

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Compassionate use of anti-IL6 receptor antibodies in critically ill patients with acute respiratory distress syndrome due to SARS-COV-2.

Luca Montini, Gennaro DE Pascale, Giuseppe Bello, Domenico L Grieco, Giacomo Grasselli, Antonio Pesenti, Vito M Ranieri, Maurizio Cecconi, Enzo D'Arcangelo, Elisa Gremese, Massimo Antonelli, ,

<h4>Background</h4>COVID-19 patients developing the acute respiratory distress syndrome (ARDS) show increased production of pro-inflammatory cytokines, including interleukin-6 (IL-6). The use of humanized monoclonal antibody against interleukin-6 receptor (IL-6R) may represent a potential treatment strategy. We analyzed the effects of compassionate use of Tocilizumab and Sarilumab on clinical outcome of patients ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2021, :]

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In memoriam: Goran Hedenstierna.

Luciano Gattinoni, Massimo Antonelli,

Intensive Care Med (Intensive care medicine)
[2021, 47(10):1178-1179]

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Time course of risk factors associated with mortality of 1260 critically ill patients with COVID-19 admitted to 24 Italian intensive care units.

Alberto Zanella, Gaetano Florio, Massimo Antonelli, Giacomo Bellani, Angela Berselli, Tiziana Bove, Luca Cabrini, Eleonora Carlesso, Gian Paolo Castelli, Maurizio Cecconi, Giuseppe Citerio, Irene Coloretti, Daniele Corti, Francesca Dalla Corte, Edoardo De Robertis, Giuseppe Foti, Roberto Fumagalli, Massimo Girardis, Riccardo Giudici, Lorenzo Guiotto, Thomas Langer, Lucia Mirabella, Daniela Pasero, Alessandro Protti, Marco V Ranieri, Roberto Rona, Luigia Scudeller, Paolo Severgnini, Savino Spadaro, Nino Stocchetti, Martina Viganò, Antonio Pesenti, Giacomo Grasselli, ,

<h4>Purpose</h4>To evaluate the daily values and trends over time of relevant clinical, ventilatory and laboratory parameters during the intensive care unit (ICU) stay and their association with outcome in critically ill patients with coronavirus disease 19 (COVID-19).<h4>Methods</h4>In this retrospective-prospective multicentric study, we enrolled COVID-19 patients admitted to Italian ICUs from ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(9):995-1008]

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Variations in end-of-life practices in intensive care units worldwide (Ethicus-2): a prospective observational study.

Alexander Avidan, Charles L Sprung, Joerg C Schefold, Bara Ricou, Christiane S Hartog, Joseph L Nates, Ulrich Jaschinski, Suzana M Lobo, Gavin M Joynt, Olivier Lesieur, Manfred Weiss, Massimo Antonelli, Hans-Henrik Bülow, Maria G Bocci, Annette Robertsen, Matthew H Anstey, Belén Estébanez-Montiel, Alexandre Lautrette, Anastasiia Gruber, Angel Estella, Sudakshina Mullick, Roshni Sreedharan, Andrej Michalsen, Charles Feldman, Kai Tisljar, Martin Posch, Steven Ovu, Barbara Tamowicz, Alexandre Demoule, Freda DeKeyser Ganz, Hans Pargger, Alberto Noto, Philipp Metnitz, Laszlo Zubek, Veronica de la Guardia, Christopher M Danbury, Orsolya Szűcs, Alessandro Protti, Mario Filipe, Steven Q Simpson, Cameron Green, Alberto M Giannini, Ivo W Soliman, Claudio Piras, Eliana B Caser, Manuel Hache-Marliere, Spyros D Mentzelopoulos, ,

<h4>Background</h4>End-of-life practices vary among intensive care units (ICUs) worldwide. Differences can result in variable use of disproportionate or non-beneficial life-sustaining interventions across diverse world regions. This study investigated global disparities in end-of-life practices.<h4>Methods</h4>In this prospective, multinational, observational study, consecutive adult ICU patients who died or had a limitation of life-sustaining ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(10):1101-1110]

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Lung ultrasound predicts non-invasive ventilation outcome in COVID-19 acute respiratory failure: a pilot study.

Daniele G Biasucci, Danilo Buonsenso, Alfonso Piano, Nicola Bonadia, Joel Vargas, Donatella Settanni, Maria G Bocci, Domenico L Grieco, Annamaria Carnicelli, Giancarlo Scoppettuolo, Davide Eleuteri, Gennaro DE Pascale, Mariano A Pennisi, Francesco Franceschi, Massimo Antonelli, ,

<h4>Background</h4>The aim of this study is to determine relationships between lung aeration assessed by lung ultrasound (LUS) with non-invasive ventilation (NIMV) outcome, intensive care unit (ICU) admission and mechanical ventilation (MV) needs in COVID-19 respiratory failure.<h4>Methods</h4>A cohort of adult patients with COVID-19 respiratory failure underwent LUS during initial assessment. A ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2021, 87(9):1006-1016]

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Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS.

Domenico Luca Grieco, Salvatore Maurizio Maggiore, Oriol Roca, Elena Spinelli, Bhakti K Patel, Arnaud W Thille, Carmen Sílvia V Barbas, Marina Garcia de Acilu, Salvatore Lucio Cutuli, Filippo Bongiovanni, Marcelo Amato, Jean-Pierre Frat, Tommaso Mauri, John P Kress, Jordi Mancebo, Massimo Antonelli,

The role of non-invasive respiratory support (high-flow nasal oxygen and noninvasive ventilation) in the management of acute hypoxemic respiratory failure and acute respiratory distress syndrome is debated. The oxygenation improvement coupled with lung and diaphragm protection produced by non-invasive support may help to avoid endotracheal intubation, which prevents the complications ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(8):851-866]

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Prolonged Stress Causes Depression in Frontline Workers Facing the COVID-19 Pandemic-A Repeated Cross-Sectional Study in a COVID-19 Hub-Hospital in Central Italy.

Nicola Magnavita, Paolo Maurizio Soave, Massimo Antonelli,

The COVID-19 pandemic has severely tested the mental health of frontline health care workers. A repeated cross-sectional study can provide information on how their mental health evolved during the various phases of the pandemic. The intensivists of a COVID-19 hub hospital in Rome were investigated with a baseline survey during ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(14):]

Cited: 1 time

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Diaphragm thickening fraction predicts noninvasive ventilation outcome: a preliminary physiological study.

Giovanna Mercurio, Sonia D'Arrigo, Rossana Moroni, Domenico Luca Grieco, Luca Salvatore Menga, Anna Romano, Maria Giuseppina Annetta, Maria Grazia Bocci, Davide Eleuteri, Giuseppe Bello, Luca Montini, Mariano Alberto Pennisi, Giorgio Conti, Massimo Antonelli,

<h4>Background</h4>A correlation between unsuccessful noninvasive ventilation (NIV) and poor outcome has been suggested in de-novo Acute Respiratory Failure (ARF) patients. Consequently, it is of paramount importance to identify accurate predictors of NIV outcome. The aim of our preliminary study is to evaluate the Diaphragmatic Thickening Fraction (DTF) and the respiratory ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):219]

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The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis.

Mark E Nunnally, Ricard Ferrer, Greg S Martin, Ignacio Martin-Loeches, Flavia R Machado, Daniel De Backer, Craig M Coopersmith, Clifford S Deutschman, ,

<h4>Objective</h4>To identify priorities for administrative, epidemiologic and diagnostic research in sepsis.<h4>Design</h4>As a follow-up to a previous consensus statement about sepsis research, members of the Surviving Sepsis Campaign Research Committee, representing the European Society of Intensive Care Medicine and the Society of Critical Care Medicine addressed six questions regarding care delivery, ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2021, 9(1):34]

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A Machine-learning Parsimonious Multivariable Predictive Model of Mortality Risk in Patients With Covid-19

Rita Murri, Jacopo Lenkowicz, Carlotta Masciocchi, Chiara Iacomini, Massimo Fantoni, Andrea Damiani, Antonio Marchetti, Paolo Domenico Angelo Sergi, Giovanni Arcuri, Alfredo Cesario, Stefano Patarnello, Massimo Antonelli, Rocco Bellantone, Roberto Bernabei, Stefania Boccia, Paolo Calabresi, Andrea Cambieri, Roberto Cauda, Cesare Colosimo, Filippo Crea, Ruggero De Maria, Valerio De Stefano, Francesco Franceschi, Antonio Gasbarrini, Ornella Parolini, Luca Richeldi, Maurizio Sanguinetti, Andrea Urbani, Maurizio Zega, Giovanni Scambia, Vincenzo Valentini,

<h4>Background: </h4> The COVID-19 pandemic is impressively challenging the healthcare system. Several prognostic models have been validated but few of them are implemented in daily practice. The objective of the study was to validate a machine-learning risk prediction model using easy-to-obtain parameters, potentially available at home, to help identifying patients ... Read more >>

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An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients.

Gianluigi Li Bassi, Jacky Y Suen, Heidi J Dalton, Nicole White, Sally Shrapnel, Jonathon P Fanning, Benoit Liquet, Samuel Hinton, Aapeli Vuorinen, Gareth Booth, Jonathan E Millar, Simon Forsyth, Mauro Panigada, John Laffey, Daniel Brodie, Eddy Fan, Antoni Torres, Davide Chiumello, Amanda Corley, Alyaa Elhazmi, Carol Hodgson, Shingo Ichiba, Carlos Luna, Srinivas Murthy, Alistair Nichol, Pauline Yeung Ng, Mark Ogino, Antonio Pesenti, Huynh Trung Trieu, John F Fraser, ,

<h4>Background</h4>Heterogeneous respiratory system static compliance (C<sub>RS</sub>) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous small-case series or studies conducted at a national level.<h4>Methods</h4>We designed a retrospective observational cohort study with rapid data gathering from the international COVID-19 Critical ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):199]

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COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study.

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<h4>Background</h4>The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.<h4>Methods</h4>International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression ... Read more >>

Infection (Infection)
[2021, 49(5):889-905]

Cited: 4 times

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Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study.

Tài Pham, Antonio Pesenti, Giacomo Bellani, Gordon Rubenfeld, Eddy Fan, Guillermo Bugedo, José Angel Lorente, Antero do Vale Fernandes, Frank Van Haren, Alejandro Bruhn, Fernando Rios, Andres Esteban, Luciano Gattinoni, Anders Larsson, Daniel F McAuley, Marco Ranieri, B Taylor Thompson, Hermann Wrigge, Laurent J Brochard, John G Laffey, ,

<h4>Background</h4>Current incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS).<h4>Methods</h4>An international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(6):]

Cited: 6 times

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