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Author Massimiliano Todisco

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Isolated bulbar palsy after SARS-CoV-2 infection.

Massimiliano Todisco, Enrico Alfonsi, Sebastiano Arceri, Giulia Bertino, Carlo Robotti, Michele Albergati, Matteo Gastaldi, Cristina Tassorelli, Giuseppe Cosentino,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):169-170]

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AQP4 autoantibodies in patients with idiopathic normal pressure hydrocephalus.

Matteo Gastaldi, Massimiliano Todisco, Giorgia Carlin, Silvia Scaranzin, Elisabetta Zardini, Brigida Minafra, Roberta Zangaglia, Anna Pichiecchio, Markus Reindl, Sven Jarius, Claudio Pacchetti, Diego Franciotta,

Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder with unknown etiology. A selective depletion of aquaporin 4 (AQP4) has been shown in iNPH patients. We collected serum and cerebrospinal fluid (CSF) from 43 iNPH patients and 35 with other neurodegenerative conditions, and serum from 43 healthy subjects. All ... Read more >>

J Neuroimmunol (Journal of neuroimmunology)
[2020, 349:577407]

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Reply to: "Anodal transcranial direct current stimulation and intermittent theta burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia: A methodological issue to avoid misinterpretation".

Giuseppe Cosentino, Massimiliano Todisco, Enrico Alfonsi,

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(8):e13933]

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Striatal Dopamine Deficit and Motor Impairment in Idiopathic Normal Pressure Hydrocephalus.

Nicoló Gabriele Pozzi, Joachim Brumberg, Massimiliano Todisco, Brigida Minafra, Roberta Zangaglia, Irene Bossert, Giuseppe Trifirò, Roberto Ceravolo, Paolo Vitali, Ioannis Ugo Isaias, Alfonso Fasano, Claudio Pacchetti,

<h4>Background</h4>Idiopathic normal pressure hydrocephalus can present with parkinsonism. However, abnormalities of the striatal dopamine reuptake transporter are unclear.<h4>Objectives</h4>To explore presence and features of striatal dopaminergic deficit in subjects with idiopathic normal pressure hydrocephalus as compared to Parkinson's disease (PD) patients and healthy controls.<h4>Methods</h4>We investigated 50 subjects with idiopathic normal pressure ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2021, 36(1):124-132]

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A Rare Syndrome Causing Neurogenic Dysphagia.

Antonio Zito, Paola Bini, Massimiliano Todisco, Giuseppe Cosentino, Simone Mauramati, Matteo Paoletti, Vincenzo Marasco, Enrico Marchioni, Enrico Alfonsi,

Dysphagia (Dysphagia)
[2020, :]

Cited: 0 times

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COVID-19 and Guillain-Barré Syndrome: A Case Report and Review of Literature.

Antonio Zito, Enrico Alfonsi, Diego Franciotta, Massimiliano Todisco, Matteo Gastaldi, Matteo Cotta Ramusino, Mauro Ceroni, Alfredo Costa,

During the recent coronavirus disease 2019 (COVID-19) outbreak in Northern Italy, we observed a 57-year-old man developing acute motor-sensory axonal neuropathy, a variant of Guillain-Barré syndrome (GBS), 12 days after severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Similarly to other bacterial and viral infections, dysregulation of the immune system due to ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:909]

Cited: 5 times

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Gait initiation in progressive supranuclear palsy: brain metabolic correlates.

Chiara Palmisano, Massimiliano Todisco, Giorgio Marotta, Jens Volkmann, Claudio Pacchetti, Carlo A Frigo, Gianni Pezzoli, Ioannis U Isaias,

The initiation of gait is a highly challenging task for the balance control system, and can be used to investigate the neural control of upright posture maintenance during whole-body movement. Gait initiation is a centrally-mediated motion achieved in a principled, controlled manner, including predictive mechanisms (anticipatory postural adjustments, APA) that ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 28:102408]

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Lumboperitoneal shunt in idiopathic normal pressure hydrocephalus: a prospective controlled study.

Massimiliano Todisco, Marta Picascia, Patrizia Pisano, Roberta Zangaglia, Brigida Minafra, Paolo Vitali, Elisa Rognone, Anna Pichiecchio, Roberto Ceravolo, Nicola Vanacore, Alfonso Fasano, Claudio Pacchetti,

OBJECTIVE:In this prospective, controlled, monocentric study, we described the clinical and neuroimaging 12-month follow-up of two parallel cohorts of subjects with idiopathic normal pressure hydrocephalus (iNPH), who did or did not undergo lumboperitoneal shunt (LPS). METHODS:We recruited 78 iNPH patients. At baseline, subjects underwent clinical and neuropsychological assessments, 3 T magnetic ... Read more >>

J Neurol (Journal of neurology)
[2020, 267(9):2556-2566]

Cited: 1 time

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KCTD17-related myoclonus-dystonia syndrome: clinical and electrophysiological findings of a patient with atypical late onset.

Massimiliano Todisco, Simone Gana, Giuseppe Cosentino, Edoardo Errichiello, Sebastiano Arceri, Micol Avenali, Enza Maria Valente, Enrico Alfonsi,

<h4>Introduction</h4>Myoclonus-dystonia is a rare syndrome typically occurring during childhood or adolescence, mainly due to SGCE pathogenic variants. Early-onset, atypical presentations of myoclonus-dystonia have recently been associated with KCTD17 variants. In these cases, laryngeal involvement was reported in the advanced stages.<h4>Methods</h4>We evaluated a 52-year-old man with myoclonus-dystonia and positive family history. ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 78:129-133]

Cited: 1 time

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Reproducibility and reaction time of swallowing as markers of dysphagia in parkinsonian syndromes.

Giuseppe Cosentino, Cristina Tassorelli, Paolo Prunetti, Massimiliano Todisco, Roberto De Icco, Micol Avenali, Brigida Minafra, Roberta Zangaglia, Francesca Valentino, Claudio Pacchetti, Giulia Bertino, Simone Mauramati, Mauro Fresia, Enrico Alfonsi,

<h4>Objective</h4>To investigate reproducibility and reaction time of oropharyngeal swallowing in patients with Parkinson's disease (PD) and atypical parkinsonisms (APs).<h4>Methods</h4>We enrolled 19 patients with PD, 30 with APs, and 20 healthy subjects. Presence and severity of dysphagia were assessed with clinical and fiberoptic endoscopic evaluations of swallowing. Reproducibility of the oral ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2020, 131(9):2200-2208]

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Anodal transcranial direct current stimulation and intermittent theta-burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia.

Giuseppe Cosentino, Cristina Tassorelli, Paolo Prunetti, Giulia Bertino, Roberto De Icco, Massimiliano Todisco, Salvatore Di Marco, Filippo Brighina, Antonio Schindler, Mariangela Rondanelli, Mauro Fresia, Luca Mainardi, Domenico A Restivo, Alberto Priori, Giorgio Sandrini, Enrico Alfonsi,

BACKGROUND:Dysphagia in the elderly, known as presbydysphagia, has become a relevant public health problem in several countries. Swallowing disorders may be a consequence of different neurological disorders (secondary presbydysphagia) or the expression of the aging process itself (primary presbydysphagia). We aimed to test the therapeutic potential of two different non-invasive ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(5):e13791]

Cited: 0 times

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Vocal cord electromyographic correlates of stridor in multiple system atrophy phenotypes.

Massimiliano Todisco, Enrico Alfonsi, Ioannis Ugo Isaias, Roberta Zangaglia, Brigida Minafra, Giuseppe Cosentino, Michele Terzaghi, Nicoló Gabriele Pozzi, Raffaele Manni, Claudio Pacchetti,

<h4>Introduction</h4>Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by dysautonomia in combination with parkinsonian and cerebellar signs. Stridor may also occur and it is associated with life-threatening events and poor prognosis. The pathophysiology of stridor in MSA is still debated.<h4>Objective</h4>To define correlations between diurnal electromyographic (EMG) abnormalities of vocal ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 70:31-35]

Cited: 2 times

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Pisa syndrome in Idiopathic Normal Pressure Hydrocephalus.

Massimiliano Todisco, Nicolò Gabriele Pozzi, Roberta Zangaglia, Brigida Minafra, Domenico Servello, Roberto Ceravolo, Enrico Alfonsi, Alfonso Fasano, Claudio Pacchetti,

<h4>Introduction</h4>Idiopathic Normal Pressure Hydrocephalus (iNPH) is a complex syndrome of ventriculomegaly that can include parkinsonian-like features besides the classical triad of cognitive decline, urinary incontinence, and gait/balance disturbances. Pisa syndrome (PS) is a postural abnormality often associated with parkinsonism and defined as lateral trunk flexion greater than 10° while standing ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2019, 66:40-44]

Cited: 1 time

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Monitoring subthalamic oscillations for 24 hours in a freely moving Parkinson's disease patient.

Mattia Arlotti, Chiara Palmisano, Brigida Minafra, Massimiliano Todisco, Claudio Pacchetti, Andrea Canessa, Nicoló G Pozzi, Roberto Cilia, Marco Prenassi, Sara Marceglia, Alberto Priori, Paolo Rampini, Sergio Barbieri, Domenico Servello, Jens Volkmann, Gianni Pezzoli, Ioannis U Isaias,

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2019, 34(5):757-759]

Cited: 1 time

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Effects of More-Affected vs. Less-Affected Motor Cortex tDCS in Parkinson's Disease.

Giuseppe Cosentino, Francesca Valentino, Massimiliano Todisco, Enrico Alfonsi, Rosaria Davì, Giovanni Savettieri, Brigida Fierro, Marco D'Amelio, Filippo Brighina,

<b>Objective</b>: To evaluate therapeutic potential of different montages of transcranial direct current stimulation (tDCS) in Parkinson's Disease (PD) patients with asymmetric motor symptoms. <b>Materials and Methods</b>: Fourteen patients with asymmetric PD underwent, while on treatment, seven separate sessions including electrophysiological and clinical evaluation at baseline and after anodal, cathodal and ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2017, 11:309]

Cited: 5 times

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Botulinum Toxin Is Effective in the Management of Neurogenic Dysphagia. Clinical-Electrophysiological Findings and Tips on Safety in Different Neurological Disorders.

Enrico Alfonsi, Domenico A Restivo, Giuseppe Cosentino, Roberto De Icco, Giulia Bertino, Antonio Schindler, Massimiliano Todisco, Mauro Fresia, Andrea Cortese, Paolo Prunetti, Matteo C Ramusino, Arrigo Moglia, Giorgio Sandrini, Cristina Tassorelli,

<b>Background and Aims:</b> Neurogenic dysphagia linked to failed relaxation of the upper esophageal sphincter (UES) can be treated by injecting botulinum toxin (BTX) into the cricopharyngeal (CP) muscle. We compared the effects of this treatment in different neurological disorders with dysphagia, to evaluate its efficacy over time including the response ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2017, 8:80]

Cited: 7 times

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Quasi-Lagrangian neural network for convex quadratic optimization.

Giovanni Costantini, Renzo Perfetti, Massimiliano Todisco,

A new neural network for convex quadratic optimization is presented in this brief. The proposed network can handle both equality and inequality constraints, as well as bound constraints on the optimization variables. It is based on the Lagrangian approach, but exploits a partial dual method in order to keep the ... Read more >>

IEEE Trans Neural Netw (IEEE transactions on neural networks)
[2008, 19(10):1804-1809]

Cited: 2 times

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