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Urinary thioredoxin as a biomarker of renal redox dysregulation and a companion diagnostic to identify responders to redox-modulating therapeutics.

Kenji Kasuno, Junji Yodoi, Masayuki Iwano,

<h4>Significance</h4>The development and progression of renal diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), are the result of heterogeneous pathophysiology that reflects a range of environmental factors and, in a lesser extent, genetic mutations. The pathophysiology specific to most kidney diseases is not currently identified, therefore, these ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, :]

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Role of fibroblast specific protein 1 expression in the progression of adriamycin-induced glomerulosclerosis.

Kimihiko Nakatani, Osamu Asai, Noboru Konishi, Masayuki Iwano,

Focal segmental glomerulosclerosis (FSGS) is a commonly occurring cause of steroid-resistant nephrotic syndrome and frequently progresses to renal failure. Podocyte epithelial-mesenchymal transition (EMT) is thought to induce podocyte detachment in glomerular diseases, and severe degeneration and shedding of glomerular podocytes plays a major role in the progression of FSGS. We ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 567:148-153]

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Development of Myeloperoxidase Anti-neutrophil Cytoplasmic Antibody-positive Necrotizing Crescentic Glomerulonephritis in an Elderly Patient with Immunological Kidney Disease.

Haruyoshi Yoshida, Naoki Takahashi, Takayasu Horiguchi, Hiroki Yasuhara, Tokuharu Tanaka, Yuhao Chen, Toshikazu Takasaki, Hitokazu Tsukao, Michiko Yoshida, Satoshi Kawakami, Makoto Ohta, Hironobu Naiki, Satoshi Konishi, Isao Ito, Masayuki Iwano,

A 78-year-old man presented with hypercalcemia and renal disease with high serum IgG4 and positive myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA), exhibiting sarcoidosis-like chest findings. A renal biopsy revealed tubulointerstitial nephritis, membranous nephropathy (MN), and sub-capsular lymphoid aggregates without fulfilling the diagnostic criteria of IgG4-related disease or sarcoidosis. Steroid therapy ameliorated ... Read more >>

Intern Med (Internal medicine (Tokyo, Japan))
[2021, :]

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Combined changes in albuminuria and kidney function and subsequent risk for kidney failure in type 2 diabetes.

Megumi Oshima, Tadashi Toyama, Akinori Hara, Miho Shimizu, Shinji Kitajima, Yasunori Iwata, Norihiko Sakai, Kengo Furuichi, Masakazu Haneda, Tetsuya Babazono, Hiroki Yokoyama, Kunitoshi Iseki, Shin-Ichi Araki, Toshiharu Ninomiya, Shigeko Hara, Yoshiki Suzuki, Masayuki Iwano, Eiji Kusano, Tatsumi Moriya, Hiroaki Satoh, Hiroyuki Nakamura, Hirofumi Makino, Takashi Wada,

<h4>Introduction</h4>Changes in albuminuria or estimated glomerular filtration rate (eGFR) can be used as a surrogate endpoint of end-stage kidney disease (ESKD) in people with type 2 diabetes. We investigated whether the combined changes in albuminuria and eGFR are more strongly associated with future risk of ESKD.<h4>Research design and methods</h4>Using data ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2021, 9(1):]

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Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR).

Maki Urushihara, Hiroshi Sato, Akira Shimizu, Hitoshi Sugiyama, Hitoshi Yokoyama, Hiroshi Hataya, Kentaro Matsuoka, Takayuki Okamoto, Daisuke Ogino, Kenichiro Miura, Riku Hamada, Satoshi Hibino, Yuko Shima, Tomohiko Yamamura, Koichi Kitamoto, Masayuki Ishihara, Takao Konomoto, Motoshi Hattori, ,

<h4>Background</h4>Only a few studies have investigated epidemiological and clinicopathological information regarding pediatric and adolescent and young adult (AYA) patients with renal disease. The purpose of this study was to clarify the differences and relationship of clinicopathological findings between pediatric and AYA patients using the Japan Renal Biopsy Registry (J-RBR).<h4>Methods</h4>This cross-sectional ... Read more >>

Clin Exp Nephrol (Clinical and experimental nephrology)
[2021, 25(9):1018-1026]

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Glucocorticoid-dependent Tubulointerstitial Nephritis with IgM-positive Plasma Cells Presenting with Intracellular Crystalline Inclusions within the Rough Endoplasmic Reticulum.

Masanori Minato, Taichi Murakami, Naoki Takahashi, Hiroyuki Ono, Kenji Nishimura, Masanori Tamaki, Kojiro Nagai, Hideharu Abe, Masayuki Iwano, Kensuke Joh, Toshio Doi,

Tubulointerstitial nephritis (TIN) with IgM-positive plasma cells (IgMPC-TIN) is an autoimmune kidney disease characterized by IgM/CD138-double-positive plasma cell infiltration in the tubulointerstitium. A 50-year-old man developed IgMPC-TIN and presented with crystalline inclusions in the rough endoplasmic reticulum. Intracellular crystal formation is a rare finding in paraprotein-related kidney diseases, but this ... Read more >>

Intern Med (Internal medicine (Tokyo, Japan))
[2021, 60(19):3129-3136]

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PPAR-δ activation reduces cisplatin-induced apoptosis via inhibiting p53/Bax/caspase-3 pathway without modulating autophagy in murine renal proximal tubular cells.

Juanping Shan, Hideki Kimura, Seiji Yokoi, Kazuko Kamiyama, Toru Imamoto, Izumi Takeda, Mamiko Kobayashi, Daisuke Mikami, Naoki Takahashi, Kenji Kasuno, Takeshi Sugaya, Masayuki Iwano,

<h4>Background</h4>Cisplatin-induced injury of renal proximal tubular cells results basically from increased apoptosis via mitochondrial damage, and is mitigated by appropriate enhancement of autophagy. Peroxisome proliferator-activated receptor-delta (PPAR-δ) reportedly protects against not only mitochondrial damages but also enhances autophagy. Thus, PPAR-δ may protect against cisplatin-induced kidney injury.<h4>Methods</h4>We examined the protective effects ... Read more >>

Clin Exp Nephrol (Clinical and experimental nephrology)
[2021, 25(6):598-607]

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Development and evaluation of a novel quenching probe PCR (GENECUBE) assay for rapidly detecting and distinguishing between Chlamydia pneumoniae and Chlamydia psittaci.

Kyoko Hisada, Yukio Hida, Naoki Kawabata, Yosuke Kawashima, Yoshihiro Soya, Akihiro Shimada, Masayuki Iwano, Hideki Kimura,

Early detection of the family Chlamydiaceae as pathogens is essential worldwide for the rapid and sufficient management of atypical pneumonia. GENECUBE (TOYOBO) is a novel fully automated gene analyzer capable of amplifying and detecting target DNAs within 50 min. In this study, we developed a new PCR assay with a specific ... Read more >>

J Microbiol Methods (Journal of microbiological methods)
[2021, 184:106212]

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Usefulness of tissue inhibitor of metalloproteinase 1 as a predictor of sustained remission in patients with antineutrophil cytoplasmic antibody-associated vasculitis.

Jun Ishizaki, Ayako Takemori, Kenta Horie, Daisuke Hiraoka, Koichiro Suemori, Takuya Matsumoto, Ken-Ei Sada, Koichi Amano, Masayoshi Harigai, Yoshihiro Arimura, Hirofumi Makino, Katsuto Takenaka, Nobuaki Takemori, Hitoshi Hasegawa, ,

<h4>Background</h4>We previously identified tissue inhibitor of metalloproteinase 1 (TIMP-1) as a biomarker of disease activity that distinguished mildly or highly active antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) from remission 6 months after the initiation of remission-induction therapy. In the present study, we investigated whether TIMP-1 is clinically useful as a predictor ... Read more >>

Arthritis Res Ther (Arthritis research & therapy)
[2021, 23(1):91]

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Preemptive HLA Antibody Screening Prior to Episodic Transplant Renal Biopsy Enables Early Diagnosis and Therapeutic Response in Asymptomatic Chronically Active Antibody-Related Rejection: A Case Report.

Kenji Kasuno, Kazuhisa Nishimori, Seiji Yokoi, Yuki Shimamoto, Sayumi Sakashita, Sayu Morita, Sho Nishikawa, Yudai Nishikawa, Mamiko Kobayashi, Sachiko Fukushima, Daisuke Mikami, Naoki Takahashi, Yumiko Oota, Hideki Kimura, Masayuki Iwano,

Common management of renal transplant recipients includes episodic renal biopsy based on clinical findings such as an increase in proteinuria or serum creatinine. When antibody-related rejection is suspected from the renal biopsy, subsequent testing for donor-specific antibodies (DSAs) is performed. We instead performed preemptive screening of asymptomatic post-renal transplant recipients ... Read more >>

Transplant Proc (Transplantation proceedings)
[2020, 52(9):2750-2753]

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Treatment-related damage in elderly-onset ANCA-associated vasculitis: safety outcome analysis of two nationwide prospective cohort studies.

Ken-Ei Sada, Keiji Ohashi, Yosuke Asano, Keigo Hayashi, Michiko Morishita, Haruki Watanabe, Yoshinori Matsumoto, Shouichi Fujimoto, Yoshinari Takasaki, Kunihiro Yamagata, Shogo Banno, Hiroaki Dobashi, Koichi Amano, Masayoshi Harigai, Yoshihiro Arimura, Hirofumi Makino, ,

<h4>Background</h4>It is not elucidated that there is treatment-related damage in elderly patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).<h4>Methods</h4>Elderly (≥ 75 years of age) patients were enrolled from two nationwide prospective inception cohort studies. The primary outcome was 12-month treatment-related Vasculitis Damage Index (VDI) score. Secondary outcomes included serious infections within 6 months, ... Read more >>

Arthritis Res Ther (Arthritis research & therapy)
[2020, 22(1):236]

Cited: 5 times

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Chronic hypoxia exacerbates diabetic glomerulosclerosis through mesangiolysis and podocyte injury in db/db mice.

Naoki Takahashi, Haruyoshi Yoshida, Hideki Kimura, Kazuko Kamiyama, Tomomi Kurose, Hidehiro Sugimoto, Toshio Imura, Seiji Yokoi, Daisuke Mikami, Kenji Kasuno, Hiroyuki Kurosawa, Yoshiaki Hirayama, Hironobu Naiki, Masanori Hara, Masayuki Iwano,

<h4>Background</h4>Chronic hypoxia may play a pivotal role in the development of diabetic nephropathy (DN). However, the precise mechanisms underlying progressive hypoxia-induced glomerular injury remain unclear.<h4>Methods</h4>We housed db/db mice in a hypoxia chamber (12% O2) for up to 16 weeks beginning at 8 weeks of age. Various urine, serum and kidney abnormalities and ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2020, 35(10):1678-1688]

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Analytical and clinical validation of rapid chemiluminescence enzyme immunoassay for urinary thioredoxin, an oxidative stress-dependent early biomarker of acute kidney injury.

Seiji Yokoi, Kenji Kasuno, Kazuhisa Nishimori, Sho Nishikawa, Yudai Nishikawa, Sayu Morita, Mamiko Kobayashi, Sachiko Fukushima, Daisuke Mikami, Naoki Takahashi, Yumiko Oota, Hideki Kimura, Yoshihiro Soya, Shinsuke Kimata, Kengo Nishimura, Takahiko Ono, Eri Muso, Haruyoshi Yoshida, Junji Yodoi, Masayuki Iwano,

<h4>Background</h4>Oxidative stress is now recognized to be an important therapeutic target in kidney diseases. However, there are currently no biomarkers that can be used clinically to diagnose renal oxidative stress.<h4>Methods</h4>A rapid assay system for urinary thioredoxin 1, an oxidative stress-dependent biomarker of acute kidney injury (AKI), was developed as a ... Read more >>

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2020, 507:271-279]

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Tubulointerstitial Nephritis Cases With IgM-Positive Plasma Cells.

Natsumi Matsuoka-Uchiyama, Kenji Tsuji, Kazuhiko Fukushima, Shinji Kitamura, Haruhito A Uchida, Hitoshi Sugiyama, Naoki Takahashi, Masayuki Iwano, Jun Wada,

Kidney Int Rep (Kidney international reports)
[2020, 5(9):1576-1580]

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AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis via HDAC inhibition.

Daisuke Mikami, Mamiko Kobayashi, Junsuke Uwada, Takashi Yazawa, Kazuko Kamiyama, Kazuhisa Nishimori, Yudai Nishikawa, Sho Nishikawa, Seiji Yokoi, Takanobu Taniguchi, Masayuki Iwano,

<h4>Background</h4>Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide and establishment of new chemotherapies for HCC is urgently needed. GPR41 [free fatty acid receptor 3 (FFA3)] is a G protein-coupled receptor for short chain fatty acids, including acetate, propionate, and butyrate. In our previous study, we showed that ... Read more >>

Ther Adv Med Oncol (Therapeutic advances in medical oncology)
[2020, 12:1758835920913432]

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Functional and anatomical changes in diabetic macular edema after hemodialysis initiation: One-year follow-up multicenter study.

Yoshihiro Takamura, Takehiro Matsumura, Kishiko Ohkoshi, Tatsuhiko Takei, Kunihiro Ishikawa, Masahiko Shimura, Tetsuo Ueda, Masahiko Sugimoto, Takao Hirano, Kei Takayama, Makoto Gozawa, Yutaka Yamada, Masakazu Morioka, Masayuki Iwano, Masaru Inatani,

Diabetic nephropathy and retinopathy (DR) including diabetic macular edema (DME) are representative microvascular complications of diabetes. We conducted a retrospective multicenter study analyzing records from patients with DR (132 eyes in 70 patients) and end-stage renal diseases (ESRD) who underwent hemodialysis for the first time. We demonstrated that the central ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):7788]

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Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways.

Daisuke Mikami, Mamiko Kobayashi, Junsuke Uwada, Takashi Yazawa, Kazuko Kamiyama, Kazuhisa Nishimori, Yudai Nishikawa, Sho Nishikawa, Seiji Yokoi, Hideki Kimura, Ikuo Kimura, Takanobu Taniguchi, Masayuki Iwano,

Short-chain fatty acids (SCFAs), including acetate, butyrate, and propionate, are produced when colonic bacteria in the human gastrointestinal tract ferment undigested fibers. Free fatty acid receptor 2 (FFA2) and FFA3 are G-protein-coupled receptors recently identified as SCFA receptors that may modulate inflammation. We previously showed through in vitro experiments that ... Read more >>

Biochim Biophys Acta Mol Cell Biol Lipids (Biochimica et biophysica acta. Molecular and cell biology of lipids)
[2020, 1865(6):158666]

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β-Hydroxybutyrate enhances the cytotoxic effect of cisplatin via the inhibition of HDAC/survivin axis in human hepatocellular carcinoma cells.

Daisuke Mikami, Mamiko Kobayashi, Junsuke Uwada, Takashi Yazawa, Kazuko Kamiyama, Kazuhisa Nishimori, Yudai Nishikawa, Sho Nishikawa, Seiji Yokoi, Takanobu Taniguchi, Masayuki Iwano,

Ketone bodies, including acetoacetate and β-hydroxybutyrate (βOHB), are produced from acetyl coenzyme A in the liver and then secreted into the blood. These molecules are a source of energy for peripheral tissues during exercise or fasting. βOHB has been reported to inhibit histone deacetylases (HDACs) 1, 3, and 4 in ... Read more >>

J Pharmacol Sci (Journal of pharmacological sciences)
[2020, 142(1):1-8]

Cited: 2 times

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Association of increased renal Cyp24a1 gene expression with low plasma 1,25-dihydroxyvitamin D levels in rats with streptozotocin-induced diabetes.

Mari Tajiri, Otoki Nakahashi, Tomohiro Kagawa, Masashi Masuda, Hirokazu Ohminami, Masayuki Iwano, Eiji Takeda, Yutaka Taketani, Hironori Yamamoto,

Decreases in plasma vitamin D concentrations have been reported in diabetes, although the mechanism involved in this decrease is unclear. Here, we investigated the association between Cyp24a1, a vitamin D catabolic enzyme, and abnormalities in vitamin D metabolism in streptozotocin-induced diabetes rats, an animal model of type 1 diabetes. Plasma ... Read more >>

J Clin Biochem Nutr (Journal of clinical biochemistry and nutrition)
[2020, 66(1):49-56]

Cited: 1 time

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IgA Vasculitis Developed as an Adverse Effect of Tofacitinib Taken for Rheumatoid Arthritis.

Izumi Itoh, Kenji Kasuno, Chie Yamamoto, Naoki Takahashi, Hisanori Shimizu, Tomohiro Ojima, Seigaku Hayashi, Hideki Kimura, Masayuki Iwano,

Tofacitinib is a new small-molecule inhibitor of the JAK/STAT signaling pathway used to treat rheumatoid arthritis. We herein report a case of IgA vasculitis apparently caused by tofacitinib. A 67-year-old woman with rheumatoid arthritis developed IgA vasculitis after taking tofacitinib for 6 months. She presented with proteinuria and purpura of ... Read more >>

Intern Med (Internal medicine (Tokyo, Japan))
[2020, 59(6):817-821]

Cited: 2 times

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β-Hydroxybutyrate, a ketone body, reduces the cytotoxic effect of cisplatin via activation of HDAC5 in human renal cortical epithelial cells.

Daisuke Mikami, Mamiko Kobayashi, Junsuke Uwada, Takashi Yazawa, Kazuko Kamiyama, Kazuhisa Nishimori, Yudai Nishikawa, Yukie Morikawa, Seiji Yokoi, Naoki Takahashi, Kenji Kasuno, Takanobu Taniguchi, Masayuki Iwano,

<h4>Aims</h4>β-Hydroxybutyrate (βOHB) is a metabolic intermediate that constitutes about 70% of ketone bodies produced in liver from oxidation of fatty acids released from adipose tissue. A recent study showed that βOHB inhibits HDAC1, 3 and 4 (classes I and IIa) in human embryonic kidney 293 (HEK293) cells. Therefore, βOHB could ... Read more >>

Life Sci (Life sciences)
[2019, 222:125-132]

Cited: 1 time

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Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis.

Yukie Morikawa, Naoki Takahashi, Kazuko Kamiyama, Kazuhisa Nishimori, Yudai Nishikawa, Sayu Morita, Mamiko Kobayashi, Sachiko Fukushima, Seiji Yokoi, Daisuke Mikami, Hideki Kimura, Kenji Kasuno, Tetsuya Yashiki, Hironobu Naiki, Masanori Hara, Masayuki Iwano,

<h4>Background/aims</h4>Extracellular vesicles (EVs), including exosomes, are present in various bodily fluids, including urine. We and others previously reported that cells expressing fibroblast-specific protein 1 (FSP1) accumulate within damaged glomeruli, and that urinary FSP1, as well as urinary soluble CD163, could potentially serve as a biomarker of ongoing glomerular injury.<h4>Methods</h4>To test ... Read more >>

Nephron (Nephron)
[2019, 141(3):177-187]

Cited: 5 times

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A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signaling pathways in HepG2 cells.

Mamiko Kobayashi, Daisuke Mikami, Junsuke Uwada, Takashi Yazawa, Kazuko Kamiyama, Hideki Kimura, Takanobu Taniguchi, Masayuki Iwano,

Short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate are generated by microbial fermentation of indigestible fiber by gut flora. SCFAs are ligands of two orphan G protein-coupled receptors, GPR41 and GPR43, that modulate cell proliferation and induce apoptosis. However, it is unclear if SCFAs enhance the effects of ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(59):31342-31354]

Cited: 7 times

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Association Between Reappearance of Myeloperoxidase-Antineutrophil Cytoplasmic Antibody and Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Subgroup Analysis of Nationwide Prospective Cohort Studies.

Haruki Watanabe, Ken-Ei Sada, Yoshinori Matsumoto, Masayoshi Harigai, Koichi Amano, Hiroaki Dobashi, Shouichi Fujimoto, Joichi Usui, Kunihiro Yamagata, Tatsuya Atsumi, Shogo Banno, Takahiko Sugihara, Yoshihiro Arimura, Seiichi Matsuo, Hirofumi Makino, ,

<h4>Objective</h4>To evaluate clinical links between levels of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA) and relapse in patients with ANCA-associated vasculitis (AAV) using a data set from 2 nationwide prospective cohort studies.<h4>Methods</h4>From the cohort studies, MPO-ANCA-positive patients who achieved remission during the 6 months after remission induction therapy were enrolled. We measured ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2018, 70(10):1626-1633]

Cited: 10 times

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Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study.

Kunihiro Yamagata, Joichi Usui, Michio Nagata, Hitoshi Sugiyama, Ken-Ei Sada, Eri Muso, Masayoshi Harigai, Koichi Amano, Tatsuya Atsumi, Shouichi Fujimoto, Yukio Yuzawa, Masaki Kobayashi, Takao Saito, Takafumi Ito, Nobuhito Hirawa, Sakae Homma, Hiroaki Dobashi, Naotaka Tsuboi, Akihiro Ishizu, Yoshihiro Arimura, Hirofumi Makino, Seiichi Matsuo, ,

<h4>Background</h4>The prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis.<h4>Methods</h4>We collected 67 renal biopsy materials ... Read more >>

Clin Exp Nephrol (Clinical and experimental nephrology)
[2019, 23(3):387-394]

Cited: 1 time

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