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A 15-Month-old Boy With Kawasaki Disease-like Symptoms.

Hiroshi Hayashi, Kazuhiro Uda, Keiji Akamine, Nanako Kawata, Shogo Akahoshi, Masaki Shimizu, Yuho Horikoshi, Hiroshi Hataya,

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(2):173-174]

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The Acylcarnitine Profile in Dried Blood Spots is Affected by Hematocrit: A Study of Newborn Screening Samples in Very-Low-Birth-Weight Infants.

Mitsuhiro Haga, Mitsuhisa Isobe, Ken Kawabata, Masaki Shimizu, Hiroshi Mochizuki,

<h4>Objective</h4> The acylcarnitine profile is analyzed in dried blood spots (DBS) to screen for inborn errors of metabolism. Hematocrit (Ht) is known to affect the result of quantitative analyses of DBS samples; however, the effects of Ht on the acylcarnitine profiles in DBS have not been studied in actual samples from ... Read more >>

Am J Perinatol (American journal of perinatology)
[2020, :]

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Comparison of serum cytokine profiles in macrophage activation syndrome complicating different background rheumatic diseases in children.

Mao Mizuta, Masaki Shimizu, Hitoshi Irabu, Masaaki Usami, Natsumi Inoue, Yasuo Nakagishi, Taizo Wada, Akihiro Yachie,

<h4>Objectives</h4>To compare the cytokines involved in the development of macrophage activation syndrome (MAS) in different background rheumatic diseases and to identify serum biomarkers for MAS diagnosis.<h4>Methods</h4>Serum neopterin, IL-6, IL-18 and soluble TNF receptor (sTNFR) type I (sTNFR-I) and type II (sTNFR-II) levels were determined using ELISA in 12 patients with ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, 60(1):231-238]

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Childhood-onset Systemic Lupus Erythematosus With Trisomy X and the Increased Risk for Bone Complications: A Case Report

Susumu Yamazaki, Yuko Akutsu, Asami Shimbo, Masaki Shimizu, Yuko Segawa, Masaaki Mori,

<h4>Background: </h4> Childhood-onset systemic lupus erythematosus is a multi-organ inflammatory autoimmune disease mediated by immune complexes with the age of onset before 18 years. Trisomy X is the most common female chromosomal abnormality and the role of an additional X chromosome in the development of systemic lupus erythematosus is well ... Read more >>

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[Hydromorphone in Cancer Patients-A Retrospective Study].

Naoko Sato, Eriko Satomi, Tetsuhiko Yoshida, Masaki Shimizu, Daisuke Kiuchi, Hiroto Ishiki,

We retrospectively investigated the use of oral hydromorphone for cancer pain. Nineteen patients treated for cancer pain with oral hydromorphone were reviewed in this study. Cancers had occurred in the gastrointestinal (n=4), lung(n=3), breast(n=2), bone and soft tissue(n=2), hematological(n=2), and others(n=6). The administered opioids before switching to hydromorphone were morphine, ... Read more >>

Gan To Kagaku Ryoho (Gan to kagaku ryoho. Cancer & chemotherapy)
[2020, 47(12):1687-1690]

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PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages.

Hiroki Sakamoto, Yu-Ichiro Koma, Nobuhide Higashino, Takayuki Kodama, Kohei Tanigawa, Masaki Shimizu, Masataka Fujikawa, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki,

Cancer-associated fibroblasts (CAFs) contribute to the progression of various cancers. Previously, we reported the significance of CAFs in esophageal squamous cell carcinoma (ESCC); however, the functions of CAFs in the ESCC microenvironment remain unknown. To investigate CAFs' function, we established an indirect coculture assay between human bone marrow-derived mesenchymal stem ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2020, :]

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Dysregulation of angiopoietin-1 and angiopoietin-2 in an infant with fatal Clarkson disease.

Sohsaku Yamanouchi, Mitsuru Yamagishi, Shuya Kaneko, Masaki Shimizu, Kazunari Kaneko,

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, 62(12):1400-1401]

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Transitional Channel Flow: A Minimal Stochastic Model.

Paul Manneville, Masaki Shimizu,

In line with Pomeau's conjecture about the relevance of directed percolation (DP) to turbulence onset/decay in wall-bounded flows, we propose a minimal stochastic model dedicated to the interpretation of the spatially intermittent regimes observed in channel flow before its return to laminar flow. Numerical simulations show that a regime with ... Read more >>

Entropy (Basel) (Entropy (Basel, Switzerland))
[2020, 22(12):]

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Clinical significance of interleukin-18 for the diagnosis and prediction of disease course in systemic juvenile idiopathic arthritis.

Mao Mizuta, Masaki Shimizu, Natsumi Inoue, Yasuhiro Ikawa, Yasuo Nakagishi, Ryuhei Yasuoka, Naomi Iwata, Akihiro Yachie,

<h4>Objective</h4>To investigate the clinical significance of serum IL-18 levels for the diagnosis of systemic JIA (s-JIA) and to predict the disease course of s-JIA.<h4>Methods</h4>Overall, 116 patients with s-JIA, 151 with other diseases and 20 healthy controls were analysed. Serum IL-18 levels were measured longitudinally in 41 patients with s-JIA from ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, :]

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Development and initial validation of a composite disease activity score for systemic juvenile idiopathic arthritis.

Jessica Tibaldi, Angela Pistorio, Elena Aldera, Laura Puzone, Yasser El Miedany, Priyankar Pal, Prabhas Prasun Giri, Hriday De, Raju Khubchandani, Pallavi Pimpale Chavan, Soamarat Vilaiyuk, Butsabong Lerkvaleekul, Jutamas Yamsuwan, Tapas K Sabui, Pragati Datta, Manuela Pardeo, Claudia Bracaglia, Sujata Sawhney, Sumidha Mittal, Waleed A Hassan, Ghada Farouk Elderiny, Mohammed Hassan Abu-Zaid, Mervat Eissa, Flavio Sztajnbok, Fernanda C das Neves Sztajnbok, Ricardo Russo, María Martha Katsicas, Rolando Cimaz, Edoardo Marrani, Ekaterina Alexeeva, Tatyana M Dvoryakovskaya, Motasem O Alsuweiti, Ra'ed M Alzyoud, Mikhail Kostik, Irina Chikova, Francesca Minoia, Giovanni Filocamo, Yomna Farag, Hala Lotfy, Samah Ismail Nasef, Sulaiman M Al-Mayouf, Maria Cristina Maggio, Claudia Saad Magalhaes, Romina Gallizzi, Giovanni Conti, Masaki Shimizu, Adele Civino, Enrico Felici, Gabriella Giancane, Nicolino Ruperto, Alessandro Consolaro, Angelo Ravelli,

<h4>Objective</h4>To develop a composite disease activity score for systemic JIA (sJIA) and to provide preliminary evidence of its validity.<h4>Methods</h4>The systemic Juvenile Arthritis Disease Activity Score (sJADAS) was constructed by adding to the four items of the original JADAS a fifth item that aimed to quantify the activity of systemic features. ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(11):3505-3514]

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The Relationship between Serum Total Bilirubin and Severity of Hypoxic Injury in Neonatal Hypoxic-Ischemic Encephalopathy.

Mitsuhiro Haga, Ken Kawabata, Wakako Sumiya, Saori Kurita, Toshiyuki Imanishi, Chika Kanno, Masayuki Kanno, Masami Kanno, Masaki Shimizu,

<h4>Introduction</h4> Bilirubin has been found to be a natural antioxidant protecting the body from oxidative stress. This study aims to investigate the severity of neonatal hypoxic injury on bilirubin levels to clarify the physiological role of bilirubin.<h4>Study design</h4> Using lactate as a biomarker for the severity of hypoxic injury, we retrospectively analyzed ... Read more >>

Am J Perinatol (American journal of perinatology)
[2020, :]

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Kawasaki Disease with an Initial Manifestation Mimicking Bacterial Inguinal Cellulitis.

Tsukasa Tanaka, Masaki Shimizu, Oshi Tokuda, Hiroko Yamamoto, Natsuki Matsunoshita, Kanae Takenaka, Keiichiro Kawasaki,

<h4>Background</h4>Kawasaki disease (KD) is typically characterized by fever, oral cavity erythematous changes, bilateral bulbar conjunctival injection, skin rash, erythema and edema of the hands and feet, and cervical lymphadenopathy. Some atypical patients with KD initially develop cervical and pharyngeal cellulitis; however, an initial presentation with inguinal cellulitis is extremely rare. ... Read more >>

Case Rep Pediatr (Case reports in pediatrics)
[2020, 2020:8889827]

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Clinical Significance of Serum Soluble TNF Receptor I/II Ratio for the Differential Diagnosis of Tumor Necrosis Factor Receptor-Associated Periodic Syndrome From Other Autoinflammatory Diseases.

Junko Yasumura, Masaki Shimizu, Tomoko Toma, Masato Yashiro, Akihiro Yachie, Satoshi Okada,

<b>Objectives:</b> Genetic analysis of <i>TNFRSF1A</i> can confirm the diagnosis of tumor necrosis factor receptor-associated periodic syndrome (TRAPS), but interpretation of the pathogenesis of variants of unknown significance is sometimes required. The aim of this study was to evaluate the clinical significance of serum soluble tumor necrosis factor receptor type I ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:576152]

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Efficient Emission of Ultraviolet Light by Solid State Organic Fluorophores: Synthesis and Characterization of 1,4-Dialkeny-2,5-dioxybenzenes.

Masaki Shimizu, Kenta Nishimura, Rika Hirakawa, Tsuneaki Sakurai,

The design and development of organic luminophores that exhibit efficient ultraviolet (UV) fluorescence in the solid state remains underexplored. Here, we report that 1,4-dialkenyl-2,5-dialkoxybenzenes and 1,4-dialkenyl-2,5-disiloxybenzenes act as such UV-emissive fluorophores. The dialkenyldioxybenzenes were readily prepared in three steps from 2,5-dimethoxy-1,4-diacetylbenzene or 2,5-dimethoxy-1,4-diformylbenzene via two to four steps from 1,4-bis(diethoxyphosphonylmethyl)-2,5-dimethoxybenzene. ... Read more >>

Chemistry (Chemistry (Weinheim an der Bergstrasse, Germany))
[2020, :]

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Successful treatment of spondyloenchondrodysplasia with baricitinib.

Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Hitoshi Irabu, Michiko Okajima, Yoshitaka Honda, Hiroshi Nihira, Kazushi Izawa, Akihiro Yachie, Taizo Wada,

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, :]

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Efficacy and safety of canakinumab in systemic juvenile idiopathic arthritis: 48-week results from an open-label phase III study in Japanese patients.

Kenichi Nishimura, Ryoki Hara, Hiroaki Umebayashi, Syuji Takei, Naomi Iwata, Tomoyuki Imagawa, Masaki Shimizu, Minako Tomiita, Noriko Seko, Tetsuji Kitawaki, Shumpei Yokota,

<h4>Objectives</h4>To assess the efficacy and safety of canakinumab in Japanese patients with systemic juvenile idiopathic arthritis (sJIA).<h4>Methods</h4>This was an open-label, single-arm active treatment study. sJIA patients, aged ≥2 to <20 years, were administered canakinumab 4 mg/kg every 4 weeks for ≤48 weeks. The co-primary endpoints were the proportion of patients who ... Read more >>

Mod Rheumatol (Modern rheumatology)
[2021, 31(1):226-234]

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Neoadjuvant Cisplatin in BRCA Carriers With HER2-Negative Breast Cancer.

Shigemasa Takamizawa, Hiroto Ishiki, Tatsunori Shimoi, Masaki Shimizu, Eriko Satomi,

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(23):2699-2700]

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Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome.

Xiaoyuan Jia, Tomohiko Yamamura, Rasheed Gbadegesin, Michelle T McNulty, Kyuyong Song, China Nagano, Yuki Hitomi, Dongwon Lee, Yoshihiro Aiba, Seik-Soon Khor, Kazuko Ueno, Yosuke Kawai, Masao Nagasaki, Eisei Noiri, Tomoko Horinouchi, Hiroshi Kaito, Riku Hamada, Takayuki Okamoto, Koichi Kamei, Yoshitsugu Kaku, Rika Fujimaru, Ryojiro Tanaka, Yuko Shima, , Jiwon Baek, Hee Gyung Kang, Il-Soo Ha, Kyoung Hee Han, Eun Mi Yang, , Asiri Abeyagunawardena, Brandon Lane, Megan Chryst-Stangl, Christopher Esezobor, Adaobi Solarin, , Claire Dossier, Georges Deschênes, , Marina Vivarelli, Hanna Debiec, Kenji Ishikura, Masafumi Matsuo, Kandai Nozu, Pierre Ronco, Hae Il Cheong, Matthew G Sampson, Katsushi Tokunaga, Kazumoto Iijima,

To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls with Japanese ancestry. Beyond known associations in the HLA-DR/DQ region, common variants in NPHS1-KIRREL2 (rs56117924, P=4.94E-20, odds ratio (OR) =1.90) and TNFSF15 (rs6478109, P=2.54E-8, OR=0.72) regions achieved ... Read more >>

Kidney Int (Kidney international)
[2020, 98(5):1308-1322]

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Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schönlein purpura nephritis.

Hitoshi Irabu, Masaki Shimizu, Shuya Kaneko, Natsumi Inoue, Mao Mizuta, Yuko Tasaki, Kazuhide Ohta, Akihiro Yachie, Taizo Wada,

BACKGROUND:To evaluate the apoptosis inhibitor of macrophage (AIM) deposition patterns on the kidneys of children with IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) and to investigate the clinical usefulness of serum and/or urinary AIM levels as biomarkers for the disease activity. METHODS:Immunohistochemical study was performed in the kidneys of ... Read more >>

Pediatr Res (Pediatric research)
[2020, :]

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Successful treatment of tumor necrosis factor inhibitor-resistant cutaneous polyarteritis nodosa with tocilizumab.

Natsumi Inoue, Masaki Shimizu, Mao Mizuta, Akihiro Yachie,

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, 62(6):753-755]

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Chronic recurrent multifocal osteomyelitis with myositis: A case report and review of the literature.

Shuya Kaneko, Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Akihiro Yachie,

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, 62(5):644-645]

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Clinical Significance of Serum Galactose-Deficient IgA1 Level in Children with IgA Nephropathy.

Hitoshi Irabu, Masaki Shimizu, Shuya Kaneko, Natsumi Inoue, Mao Mizuta, Kazuhide Ohta, Akihiro Yachie,

This study was aimed at investigating the clinical significance of serum galactose-deficient IgA1 (Gd-IgA1) levels measured by a novel lectin-independent enzyme-linked immunosorbent assay (ELISA) using an anti-Gd-IgA1 monoclonal antibody (KM55) as a disease-specific biomarker for IgA nephropathy (IgAN) in children. Thirty-three children with IgAN, 40 with non-IgA glomerular diseases, and ... Read more >>

J Immunol Res (Journal of immunology research)
[2020, 2020:4284379]

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Periorbital Edema as the Initial Sign of Juvenile Dermatomyositis.

Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yasuhisa Sakakibara, Yasuhito Hamaguchi, Akihiro Yachie,

J Clin Rheumatol (Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases)
[2020, 26(3):e61]

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Comparison of serum biomarkers for the diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis during tocilizumab therapy.

Hitoshi Irabu, Masaki Shimizu, Shuya Kaneko, Natsumi Inoue, Mao Mizuta, Yasuo Nakagishi, Akihiro Yachie,

<h4>Background</h4>To compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (s-JIA) during tocilizumab therapy.<h4>Methods</h4>Serum cytokine levels of neopterin, IL-18, C-X-C motif chemokine ligand 9, soluble tumor necrosis factor receptor (sTNFR)-I, and sTNFR-II were determined by enzyme-linked immunosorbent assay in 36 ... Read more >>

Pediatr Res (Pediatric research)
[2020, 88(6):934-939]

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Dual Emission from Precious Metal-Free Luminophores Consisting of C, H, O, Si, and S/P at Room Temperature.

Masaki Shimizu, Sho Nagano, Takumi Kinoshita,

Fluorescence-phosphorescence dual-emissive compounds are valuable tools for ratiometric luminescence sensing. Herein, it is reported that 2,5-bis(phenylsulfonyl)- and 2,5-bis[bis(4-methoxyphenyl)phosphinyl]-1,4-disiloxybenzenes exhibit dual emission with emission peaks that were easily identified without performing time-gated measurement. The disiloxybenzenes in powder simultaneously fluoresced and phosphoresced at 358-374 and 457-470 nm, respectively, under vacuum. The intensity ratios ... Read more >>

Chemistry (Chemistry (Weinheim an der Bergstrasse, Germany))
[2020, 26(23):5162-5167]

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