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Prediction model for hepatocellular carcinoma occurrence in patients with hepatitis C in the era of direct-acting anti-virals.

Yuki Tahata, Ryotaro Sakamori, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Hideki Hagiwara, Yasuharu Imai, Naoki Hiramatsu, Shinji Tamura, Keiji Yamamoto, Masahide Oshita, Kazuyoshi Ohkawa, Taizo Hijioka, Hiroyuki Fukui, Toshifumi Ito, Yoshinori Doi, Yukinori Yamada, Takayuki Yakushijin, Yuichi Yoshida, Tomohide Tatsumi, Tetsuo Takehara, ,

<h4>Background</h4>Several factors associated with hepatocellular carcinoma (HCC) occurrence after sustained virological response (SVR) in patients with hepatitis C have been reported. However, few validation studies have been performed in the era of direct-acting anti-virals (DAAs).<h4>Aims</h4>To develop a prediction model for HCC occurrence after DAA-mediated SVR and validate its usefulness.<h4>Methods</h4>We analysed ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Efficacy of Ramucirumab Versus Sorafenib as Subsequent Treatment for Hepatocellular Carcinoma.

Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Yuki Tahata, Kazuyoshi Ohkawa, Masahide Oshita, Shinji Tamura, Hideki Hagiwara, Eiji Mita, Takayuki Yakushijin, Masami Inada, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Background/aim</h4>The present study aimed to examine the therapeutic efficacy of ramucirumab compared with that of sorafenib as subsequent systemic therapy for patients with hepatocellular carcinoma (HCC) and serum α-fetoprotein (AFP) levels ≥400 ng/ml.<h4>Patients and methods</h4>In our prospectively registered, real-world cohort, 13 and 11 patients treated with ramucirumab or sorafenib, respectively, ... Read more >>

Anticancer Res (Anticancer research)
[2021, 41(4):2187-2192]

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Clinical course of hepatitis C virus-positive patients with decompensated liver cirrhosis in the era of direct-acting antiviral treatment.

Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Yuki Tahata, Masahide Oshita, Hideki Hagiwara, Mitsuru Sakakibara, Shinji Tamura, Naoki Hiramatsu, Masami Inada, Sadaharu Iio, Toshifumi Ito, Takayuki Yakushijin, Yoshinori Doi, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Aim</h4>The aim of the present study was to investigate the clinical course in hepatitis C virus (HCV)-positive patients with decompensated liver cirrhosis after direct-acting antivirals (DAAs) have been used for HCV infection.<h4>Methods</h4>This multicenter study prospectively analyzed a registered cohort composed of 73 HCV-positive patients with decompensated cirrhosis who attended our ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2021, 51(5):517-527]

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Helicobacter pylori eradication prevents secondary gastric cancer in patients with mild-to-moderate atrophic gastritis.

Minoru Kato, Yoshito Hayashi, Tsutomu Nishida, Masahide Oshita, Fumihiko Nakanishi, Shinjiro Yamaguchi, Shinji Kitamura, Akihiro Nishihara, Tomofumi Akasaka, Hideharu Ogiyama, Masanori Nakahara, Takuya Yamada, Osamu Kishida, Masashi Yamamoto, Akinori Shimayoshi, Yoshiki Tsujii, Motohiko Kato, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara,

<h4>Background and aim</h4>Whether Helicobacter pylori eradication prevents metachronous recurrence after endoscopic resection (ER) of early gastric cancer remains controversial. This multicenter retrospective study aimed to evaluate the long-term (> 5 years) effects of H. pylori eradication by stratifying patients' baseline degrees of atrophic gastritis.<h4>Methods</h4>A total of 483 H. pylori-positive patients who had undergone ER ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2021, 36(8):2083-2090]

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Water-slider method reduced colonic polyp fragmentation compared with conventional suction retrieval: A prospective randomized controlled study.

Akinori Shimayoshi, Hiroki Bessho, Yasuharu Kawamoto, Shuhei Yamamoto, Jihyun Sung, Yuji Morita, Shuji Wakamatsu, Mai Horie, Yugo Kai, Risato Takeda, Kiyoshi Iwahashi, Narihiro Shibukawa, Masanori Miyazaki, Satoshi Egawa, Masahide Oshita,

<h4>Objectives</h4>After resecting colonic polyps, retrieval through the scope channel may lead to polyp fragmentation, making pathologic evaluation challenging. An easy and reliable method for complete polyp retrieval is needed.<h4>Methods</h4>We developed the water-slider method (WSM), in which the resected polyp is surrounded by water from an auxiliary water channel during suctioning. ... Read more >>

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2021, 53(6):717-721]

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Initial treatment response to transarterial chemoembolization as a predictive factor for Child-Pugh class deterioration prior to refractoriness in hepatocellular carcinoma.

Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Yuki Tahata, Yasuharu Imai, Masahide Oshita, Kazuyoshi Ohkawa, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

AIM:Repeated transarterial chemoembolization (TACE) for intermediate-stage hepatocellular carcinoma (HCC) eventually leads to either deteriorated hepatic reserve or TACE refractoriness. Switching to molecular targeted agents after TACE requires preservation of hepatic reserve. This study aimed to investigate the predictive factors associated with early deterioration of hepatic reserve by repeated TACE prior ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(11):1275-1283]

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Therapeutic efficacy of lenvatinib in hepatocellular carcinoma patients with portal hypertension.

Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Ayako Urabe, Yuki Tahata, Masahide Oshita, Kazuyoshi Ohkawa, Eiji Mita, Hideki Hagiwara, Shinji Tamura, Toshifumi Ito, Takayuki Yakushijin, Sadaharu Iio, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Aim</h4>Preserved liver function may be an important factor affecting therapeutic efficacy in hepatocellular carcinoma patients treated with lenvatinib, but not all patients can be treated while preserving liver function. This study evaluated the therapeutic efficacy of lenvatinib in patients with poor liver function with and without portal hypertension.<h4>Methods</h4>This prospectively registered ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(9):1091-1100]

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Clinical outcomes of direct-acting antiviral treatments for patients with hepatitis C after hepatocellular carcinoma are equivalent to interferon treatment.

Yuki Tahata, Ryotaro Sakamori, Ayako Urabe, Ryoko Yamada, Kazuyoshi Ohkawa, Naoki Hiramatsu, Hideki Hagiwara, Masahide Oshita, Yasuharu Imai, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Aim</h4>It remains unclear how direct-acting antiviral (DAA) treatments influence hepatocellular carcinoma (HCC) recurrence and survival in comparison with interferon (IFN).<h4>Methods</h4>In total, 338 patients with chronic hepatitis C virus (HCV) infection and previous HCC treatments who initiated IFN (N = 88, IFN group) or DAA treatment (N = 250, DAA group) from January 2005 to ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(10):1118-1127]

Cited: 1 time

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Psychologic stress and disease activity in patients with inflammatory bowel disease: A multicenter cross-sectional study.

Manabu Araki, Shinichiro Shinzaki, Takuya Yamada, Shoko Arimitsu, Masato Komori, Narihiro Shibukawa, Akira Mukai, Sachiko Nakajima, Kazuo Kinoshita, Shinji Kitamura, Yoko Murayama, Hiroyuki Ogawa, Yuichi Yasunaga, Masahide Oshita, Hiroyuki Fukui, Eiji Masuda, Masahiko Tsujii, Shoichiro Kawai, Satoshi Hiyama, Takahiro Inoue, Hitoshi Tanimukai, Hideki Iijima, Tetsuo Takehara,

BACKGROUND AND AIMS:Psychologic stress can affect the pathogenesis of inflammatory bowel disease (IBD), but the precise contribution of psychologic stress to IBD remains unclear. We investigated the association of psychologic stress with disease activity in patients with IBD, especially in terms of mental state and sleep condition. METHODS:This was a ... Read more >>

PLoS One (PloS one)
[2020, 15(5):e0233365]

Cited: 2 times

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Lower Serum Sodium Levels Are Associated with the Therapeutic Effect of Sorafenib on Hepatocellular Carcinoma.

Tadashi Kegasawa, Ryotaro Sakamori, Kazuki Maesaka, Ryoko Yamada, Yuki Tahata, Ayako Urabe, Takahiro Kodama, Hayato Hikita, Kazuho Imanaka, Kazuyoshi Ohkawa, Naoki Hiramatsu, Masahide Oshita, Yukinori Yamada, Masami Inada, Takayuki Yakushijin, Yasuharu Imai, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Background and aim</h4>Although the serum sodium level has been reported to be a prognostic and predictive marker for the therapeutic effects of lung cancer and renal cell carcinoma treated with molecular targeted therapy, the serum sodium level has not been investigated in hepatocellular carcinoma (HCC) patients treated with sorafenib. The ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, 66(5):1720-1729]

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Hepatocellular carcinoma occurrence does not differ between interferon-based and interferon-free treatment with liver histological assessment.

Yuki Tahata, Ryotaro Sakamori, Ayako Urabe, Ryoko Yamada, Kazuyoshi Ohkawa, Naoki Hiramatsu, Hideki Hagiwara, Masahide Oshita, Taizo Hijioka, Shinji Tamura, Yasuharu Imai, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Aim</h4>Several studies have recently reported that hepatocellular carcinoma (HCC) occurrence does not differ between hepatitis C virus patients receiving interferon (IFN)-based and IFN-free treatments considering the patients' backgrounds. However, liver fibrosis was not directly considered in these studies.<h4>Methods</h4>In total, 3972 patients without a history of HCC who started IFN-based or IFN-free ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(3):313-320]

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Barium granuloma of the transverse colon.

Akinori Shimayoshi, Mai Horie, Yugo Kai, Kiyoshi Iwahashi, Masahide Oshita,

Gastrointest Endosc (Gastrointestinal endoscopy)
[2019, 90(6):993-994]

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Incidence and risk factors of hepatocellular carcinoma change over time in patients with hepatitis C virus infection who achieved sustained virologic response.

Ryoko Yamada, Naoki Hiramatsu, Tsugiko Oze, Ayako Urabe, Yuki Tahata, Naoki Morishita, Takahiro Kodama, Hayato Hikita, Ryotaro Sakamori, Takayuki Yakushijin, Akira Yamada, Hideki Hagiwara, Eiji Mita, Masahide Oshita, Toshifumi Itoh, Hiroyuki Fukui, Yoshiaki Inui, Taizo Hijioka, Masami Inada, Kazuhiro Katayama, Shinji Tamura, Atsuo Inoue, Yasuharu Imai, Tomohide Tatsumi, Toshimitsu Hamasaki, Norio Hayashi, Tetsuo Takehara,

<h4>Aim</h4>In patients with chronic hepatitis C, hepatocellular carcinoma (HCC) occurs at a certain frequency, even if a sustained virologic response (SVR) is achieved by antiviral treatment. Old age, liver fibrosis, and high post-treatment α-fetoprotein (AFP) level are typical risk factors of post-SVR HCC. We examined whether the frequencies and factors ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2019, 49(5):570-578]

Cited: 7 times

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Seven days triple therapy for eradication of Helicobacter pylori does not alter the disease activity of patients with inflammatory bowel disease.

Shinichiro Shinzaki, Toshimitsu Fujii, Shigeki Bamba, Maiko Ogawa, Taku Kobayashi, Masahide Oshita, Hiroki Tanaka, Keiji Ozeki, Sakuma Takahashi, Hiroki Kitamoto, Kazuhito Kani, Sohachi Nanjo, Takeshi Sugaya, Yuko Sakakibara, Toshihiro Inokuchi, Kazuki Kakimoto, Akihiro Yamada, Hisae Yasuhara, Yoko Yokoyama, Takuya Yoshino, Akira Matsui, Misaki Nakamura, Taku Tomizawa, Ryosuke Sakemi, Noriko Kamata, Toshifumi Hibi,

<h4>Background/aims</h4>The influences of Helicobacter pylori eradication therapy on the disease course of inflammatory bowel disease (IBD) are still unclear. We therefore conducted a multicenter, retrospective cohort study to evaluate the safety of H. pylori eradication therapy for IBD patients.<h4>Methods</h4>IBD patients with H. pylori eradication from 2005 to 2015 (eradication group) ... Read more >>

Intest Res (Intestinal research)
[2018, 16(4):609-618]

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Clinical use of molecular targeted agents for primary small bowel adenocarcinoma: A multicenter retrospective cohort study by the Osaka Gut Forum.

Motohiro Hirao, Masato Komori, Tsutomu Nishida, Hideki Iijima, Shinjiro Yamaguchi, Ryu Ishihara, Yuichi Yasunaga, Ichizo Kobayashi, Osamu Kishida, Masahide Oshita, Hideki Hagiwara, Toshifumi Ito, Kunio Suzuki, Yoshito Hayashi, Takahiro Inoue, Masahiko Tsujii, Harumasa Yoshihara, Tetsuo Takehara,

Primary small bowel adenocarcinoma (SBA) is a rare cancer for which effective treatment strategies have not yet been established. The results of previous retrospective studies suggest that chemotherapy contributes to a longer survival time in patients with SBA. However, there are few case reports about the efficacy of molecular targeted ... Read more >>

Oncol Lett (Oncology letters)
[2017, 14(2):1628-1636]

Cited: 3 times

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Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease.

Manabu Araki, Shinichiro Shinzaki, Takuya Yamada, Shoko Arimitsu, Masato Komori, Narihiro Shibukawa, Akira Mukai, Sachiko Nakajima, Kazuo Kinoshita, Shinji Kitamura, Yoko Murayama, Hiroyuki Ogawa, Yuichi Yasunaga, Masahide Oshita, Hiroyuki Fukui, Eiji Masuda, Masahiko Tsujii, Satoshi Hiyama, Takahiro Inoue, Hideki Iijima, Tetsuo Takehara,

<h4>Background</h4>Environmental factors are suggested to affect the pathogenesis of several diseases, including inflammatory bowel disease (IBD). The seasonality of disease onset and exacerbation in IBD, however, are not well established. We herein aimed to clarify the disease seasonality and to investigate the underlying characteristics in IBD patients exhibiting seasonality of ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2017, 52(11):1149-1157]

Cited: 8 times

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Impact of ribavirin dosage in chronic hepatitis C patients treated with simeprevir, pegylated interferon plus ribavirin combination therapy.

Yuki Tahata, Naoki Hiramatsu, Tsugiko Oze, Ayako Urabe, Naoki Morishita, Ryoko Yamada, Takayuki Yakushijin, Atsushi Hosui, Masahide Oshita, Akira Kaneko, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Yukinori Yamada, Masami Inada, Kazuhiro Katayama, Shinji Tamura, Yasuharu Imai, Hayato Hikita, Ryotaro Sakamori, Yuichi Yoshida, Tomohide Tatsumi, Norio Hayashi, Tetsuo Takehara,

The factors associated with sustained virologic response (SVR) in chronic hepatitis C (CH-C) genotype 1 patients treated with simeprevir (SMV), pegylated interferon (Peg-IFN) plus ribavirin (RBV) triple therapy have not been fully investigated. Two hundred and twenty-nine treatment-naïve CH-C patients treated with SMV triple therapy were enrolled in this study. ... Read more >>

J Med Virol (Journal of medical virology)
[2016, 88(10):1776-1784]

Cited: 1 time

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Impact of branched-chain amino acid supplementation on survival in patients with advanced hepatocellular carcinoma treated with sorafenib: A multicenter retrospective cohort study.

Kazuho Imanaka, Kazuyoshi Ohkawa, Tomohide Tatsumi, Kazuhiro Katayama, Atsuo Inoue, Yasuharu Imai, Masahide Oshita, Sadaharu Iio, Eiji Mita, Hiroyuki Fukui, Akira Yamada, Fumihiko Nakanishi, Masami Inada, Yoshinori Doi, Kunio Suzuki, Akira Kaneko, Shigeru Marubashi, Yuri Ito, Keisuke Fukui, Ryotaro Sakamori, Takayuki Yakushijin, Naoki Hiramatsu, Norio Hayashi, Tetsuo Takehara, ,

<h4>Aim</h4>The therapeutic efficacy of branched-chain amino acid (BCAA) when added to sorafenib has not been fully assessed in patients with advanced hepatocellular carcinoma (HCC). This multicenter study investigated whether BCAA supplementation improves prognosis in patients with advanced HCC who underwent sorafenib treatment.<h4>Methods</h4>This retrospective analysis included 256 patients with advanced HCC ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2016, 46(10):1002-1010]

Cited: 11 times

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Signet ring cell carcinoma of the ampulla of vater: Report of a case and a review of the literature.

Masaki Wakasugi, Masahiro Tanemura, Kenta Furukawa, Maiko Murata, Masanori Miyazaki, Masahide Oshita, Ken-Ichi Yoshida, Hironao Yasuoka, Hiroki Akamatsu,

<h4>Introduction</h4>Signet ring cell carcinoma (SRCC) of the ampulla of vater is a very rare tumor that is reported infrequently in the literature.<h4>Presentation of case</h4>A 59-year-old woman visited our hospital for evaluation of elevated transaminase levels. On laboratory examination of tumor marker levels, carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 ... Read more >>

Int J Surg Case Rep (International journal of surgery case reports)
[2015, 12:108-111]

Cited: 8 times

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The prospective randomized study on telaprevir at 1500 or 2250 mg with pegylated interferon plus ribavirin in Japanese patients with HCV genotype 1.

Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Ryoko Yamada, Naoki Harada, Naoki Morishita, Akira Yamada, Masahide Oshita, Akira Kaneko, Kunio Suzuki, Yoshiaki Inui, Shinji Tamura, Harumasa Yoshihara, Yasuharu Imai, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Akinori Kasahara, Norio Hayashi, Tetsuo Takehara,

<h4>Background</h4>Triple therapy with telaprevir (TVR), pegylated interferon and ribavirin has improved antiviral efficacy in patients with chronic hepatitis C (CH-C). However, the severe adverse effects caused by TVR are important to resolve. In this prospective, randomized, multicenter, open-label study, the antiviral efficacy and safety in the reduced administration of TVR ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2015, 50(3):313-322]

Cited: 2 times

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Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan.

Tsutomu Nishida, Masahiko Tsujii, Hirohisa Tanimura, Shusaku Tsutsui, Shingo Tsuji, Akira Takeda, Atsuo Inoue, Hiroyuki Fukui, Toshiyuki Yoshio, Osamu Kishida, Hiroyuki Ogawa, Masahide Oshita, Ichizo Kobayashi, Shinichiro Zushi, Makoto Ichiba, Naoto Uenoyama, Yuichi Yasunaga, Ryu Ishihara, Mamoru Yura, Masato Komori, Satoshi Egawa, Hideki Iijima, Tetsuo Takehara,

<h4>Aim</h4>To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori (H. pylori) in usual post-marketing use in Japan, where the clarithromycin (CAM) resistance rate is 30%.<h4>Methods</h4>For this multicenter, randomized, open-label, non-inferiority trial, we recruited patients (≥ 20 ... Read more >>

World J Gastroenterol (World journal of gastroenterology)
[2014, 20(15):4362-4369]

Cited: 14 times

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Post-treatment levels of α-fetoprotein predict incidence of hepatocellular carcinoma after interferon therapy.

Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Masanori Miyazaki, Akira Yamada, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Hiroyuki Fukui, Yoshiaki Inui, Taizo Hijioka, Masami Inada, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Eijiro Hayashi, Michio Kato, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Akinori Kasahara, Toshimitsu Hamasaki, Norio Hayashi, Tetsuo Takehara, ,

<h4>Background & aims</h4>In patients with chronic hepatitis C virus (HCV) infection, lack of sustained virologic response (SVR) 24 weeks after the end of interferon therapy is a significant risk factor for hepatocellular carcinoma (HCC). Although many pretreatment factors are known to affect HCC incidence, less is known about post-treatment factors-many ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2014, 12(7):1186-1195]

Cited: 47 times

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Using early viral kinetics to predict antiviral outcome in response-guided pegylated interferon plus ribavirin therapy among patients with hepatitis C virus genotype 1.

Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Masanori Miyazaki, Sadaharu Iio, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Yoshiaki Inui, Taizo Hijioka, Masami Inada, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Tatsuya Kanto, Akinori Kasahara, Norio Hayashi, Tetsuo Takehara,

<h4>Background</h4>HCV kinetics during treatment demonstrated strong association with the antiviral outcome of patients treated with pegylated interferon (Peg-IFN) plus ribavirin. However, the relationship between HCV kinetics and pre-treatment factors remains unclear.<h4>Methods</h4>Of 547 patients with HCV genotype 1 treated with Peg-IFN alfa-2b plus ribavirin, 401 completed the response-guided therapy and were ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2014, 49(4):737-747]

Cited: 3 times

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A case of collagenous gastritis resembling nodular gastritis in endoscopic appearance.

Jun Tanabe, Masakazu Yasumaru, Masahiko Tsujimoto, Hideki Iijima, Satoshi Hiyama, Akira Nishio, Yoshiaki Sasayama, Naoki Kawai, Masahide Oshita, Takashi Abe, Sunao Kawano,

A 25-year-old Japanese female was referred to our clinic for the investigation of moderate iron-deficiency anemia and epigastralgia. Endoscopic examination showed diffuse mucosal nodules in the gastric body resembling nodular gastritis, but this pattern was not observed in the antrum. Histology of the gastric biopsies taken from the gastric body ... Read more >>

Clin J Gastroenterol (Clinical journal of gastroenterology)
[2013, 6(6):442-446]

Cited: 1 time

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Incidence of hepatocellular carcinoma in HCV-infected patients with normal alanine aminotransferase levels categorized by Japanese treatment guidelines.

Naoki Harada, Naoki Hiramatsu, Tsugiko Oze, Ryoko Yamada, Mika Kurokawa, Masanori Miyazaki, Takayuki Yakushijin, Takuya Miyagi, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Masahide Oshita, Eiji Mita, Hideki Hagiwara, Yoshiaki Inui, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Yasuharu Imai, Atsuo Inoue, Norio Hayashi, Tetsuo Takehara,

<h4>Background</h4>This study was conducted to evaluate Japanese treatment guidelines for patients with chronic hepatitis C virus (HCV) infection and normal alanine aminotransferase (N-ALT) levels from the viewpoint of the incidence of hepatocellular carcinoma (HCC).<h4>Methods</h4>Four groups of patients with chronic HCV infection treated with pegylated interferon (Peg-IFN) plus ribavirin, and classified ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2013, 48(4):535-543]

Cited: 2 times

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