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Author Mary Rensel

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Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis.

Kristen M Krysko, Jennifer S Graves, Mary Rensel, Bianca Weinstock-Guttman, Alice Rutatangwa, Gregory Aaen, Anita Belman, Leslie Benson, Tanuja Chitnis, Mark Gorman, Manu S Goyal, Yolanda Harris, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

OBJECTIVE:To assess real-world effectiveness of initial treatment with newer compared to injectable disease-modifying therapies (DMTs) on disease activity in pediatric multiple sclerosis (MS) and clinically isolated syndrome (CIS). METHODS:This is a cohort study of children with MS/CIS followed at 12 clinics in the US Network of Pediatric MS Centers, who ... Read more >>

Ann. Neurol. (Annals of neurology)
[2020, :]

Cited: 0 times

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Cognitive processing speed in pediatric-onset multiple sclerosis: Baseline characteristics of impairment and prediction of decline.

Asya I Wallach, Michael Waltz, T Charles Casper, Gregory Aaen, Anita Belman, Leslie Benson, Tanuja Chitnis, Mark Gorman, Jennifer Graves, Yolanda Harris, Timothy E Lotze, Soe Mar, Manikum Moodley, Jayne M Ness, Mary Rensel, Moses Rodriguez, John W Rose, Teri Schreiner, Jan-Mendelt Tillema, Emmanuelle Waubant, Bianca Weinstock-Guttman, Leigh E Charvet, Lauren B Krupp,

BACKGROUND:Cognitive impairment occurs in approximately one-third of pediatric-onset multiple sclerosis (POMS) patients. The Symbol Digit Modalities Test (SDMT), a widely used cognitive screen in adults, has yet to be incorporated early into the standard care of POMS. OBJECTIVE:To screen for cognitive impairment early in the course of POMS and analyze ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, :1352458519891984]

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Review Of The Safety, Efficacy And Tolerability Of Fingolimod In The Treatment Of Pediatric Patients With Relapsing-Remitting Forms Of Multiple Sclerosis (RRMS).

Jenny Feng, Mary Rensel,

Pediatric-onset multiple sclerosis (POMS) is an immune-mediated, demyelinating, neurodegenerative disease that accounts for 3-5% of all multiple sclerosis (MS) cases. Although evidence suggests that it has similar risk factors and disease pathophysiology as adult-onset MS (AOMS), there are distinctive features in disease characteristics and patient demographics of POMS that require ... Read more >>

Pediatric Health Med Ther (Pediatric health, medicine and therapeutics)
[2019, 10:141-146]

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Pregnancy and multiple sclerosis: Risk of unplanned pregnancy and drug exposure in utero.

Andrew L Smith, Jeffrey A Cohen, Daniel Ontaneda, Mary Rensel,

Background:Multiple sclerosis is a central nervous system demyelinating disease that affects women of reproductive potential. It is important to identify the frequency and risk factors of unplanned or disease-modifying therapy-exposed pregnancies to create interventions to reduce these. Methods:This retrospective, single-center, observational chart review study aims to identify risk factors for ... Read more >>

Mult Scler J Exp Transl Clin (Multiple sclerosis journal - experimental, translational and clinical)
[2019, 5(4):2055217319891744]

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Newer Treatment Approaches in Pediatric-Onset Multiple Sclerosis.

Gabrielle Macaron, Jenny Feng, Manikum Moodley, Mary Rensel,

PURPOSE OF REVIEW:With the recognition that pediatric-onset multiple sclerosis (POMS) is characterized by more prominent disease activity, earlier age at onset of disability milestones, and more prominent cognitive impairment compared with physical disability earlier in the disease course compared with adult-onset multiple sclerosis (AOMS), there has been increasing interest in ... Read more >>

Curr Treat Options Neurol (Current treatment options in neurology)
[2019, 21(10):50]

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Long-Term Treatment Strategies of Pediatric Multiple Sclerosis, Including the use of Disease Modifying Therapies.

Mary Rensel,

Multiple sclerosis (MS) presenting in the pediatric years can lead to landmark disability levels younger in life than adult onset MS and so therefore early and effective treatment remains paramount for long-term outcomes. The goals of MS therapeutics in adults have widened to address multiple mechanisms: anti-inflammatory, neuroprotective, and myelin ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2019, 6(6):]

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Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.

Emmanuelle Waubant, Brenda Banwell, Evangeline Wassmer, Maria-Pia Sormani, Maria-Pia Amato, Rogier Hintzen, Lauren Krupp, Kevin Rostásy, Silvia Tenembaum, Tanuja Chitnis, ,

OBJECTIVE:The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data for effective therapies for pediatric patients, in a reasonable timeframe, with a key focus on short- and long-term safety. METHODS:The International Pediatric Multiple Sclerosis Study Group convened a meeting of experts to review ... Read more >>

Neurology (Neurology)
[2019, 92(22):e2538-e2549]

Cited: 1 time

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Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry.

Calvin Chi, Xiaorong Shao, Brooke Rhead, Edlin Gonzales, Jessica B Smith, Anny H Xiang, Jennifer Graves, Amy Waldman, Timothy Lotze, Teri Schreiner, Bianca Weinstock-Guttman, Gregory Aaen, Jan-Mendelt Tillema, Jayne Ness, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Tanuja Chitnis, Soe Mar, Anita Belman, Theron Charles Casper, John Rose, Manikum Moodley, Mary Rensel, Moses Rodriguez, Benjamin Greenberg, Llana Kahn, Jennifer Rubin, Catherine Schaefer, Emmanuelle Waubant, Annette Langer-Gould, Lisa F Barcellos,

Multiple sclerosis (MS) is an autoimmune disease with high prevalence among populations of northern European ancestry. Past studies have shown that exposure to ultraviolet radiation could explain the difference in MS prevalence across the globe. In this study, we investigate whether the difference in MS prevalence could be explained by ... Read more >>

PLoS Genet. (PLoS genetics)
[2019, 15(1):e1007808]

Cited: 2 times

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Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis.

Gregory Aaen, Michael Waltz, Wendy Vargas, Naila Makhani, Jayne Ness, Yolanda Harris, T Charles Casper, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Jennifer Graves, Benjamin Greenberg, Timothy Lotze, Soe Mar, Jan-Mendelt Tillema, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Amy Waldman, Bianca Weinstock-Guttman, Anita Belman, Emmanuelle Waubant, Lauren Krupp,

Children with pediatric-onset multiple sclerosis and pediatric controls were enrolled across 16 pediatric multiple sclerosis centers in the United States and completed questionnaires that addressed time of first unaided walking and acquisition of 2-word phrases. A total of 467 (308 female) cases and 428 (209 female) controls were enrolled. Pediatric ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2019, 34(3):148-152]

Cited: 0 times

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Heterogeneity in association of remote herpesvirus infections and pediatric MS.

Bardia Nourbakhsh, Alice Rutatangwa, Michael Waltz, Mary Rensel, Manikum Moodley, Jennifer Graves, Theron Charles Casper, Amy Waldman, Anita Belman, Benjamin Greenberg, Manu Goyal, Yolanda Harris, Ilana Kahn, Timothy Lotze, Soe Mar, Teri Schreiner, Gregory Aaen, Janace Hart, Jayne Ness, Jennifer Rubin, Jan-Mendelt Tillema, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, John Rose, Meghan Candee, Bianca Weinstock-Guttman, Xiaorong Shao, Lisa Barcellos, Judith James, Emmanuelle Waubant, ,

Objective:While prior Epstein-Barr virus (EBV) infection has been consistently associated with subsequent risk of developing multiple sclerosis (MS), the association with other common herpesviruses has been more controversial. Our objectives were to determine whether remote infection with EBV and other common herpesviruses affect the susceptibility to pediatric MS and if ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(10):1222-1228]

Cited: 2 times

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Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US.

Kristen M Krysko, Jennifer Graves, Mary Rensel, Bianca Weinstock-Guttman, Gregory Aaen, Leslie Benson, Tanuja Chitnis, Mark Gorman, Manu Goyal, Lauren Krupp, Timothy Lotze, Soe Mar, Moses Rodriguez, John Rose, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

OBJECTIVE:To characterize the use and safety of newer disease-modifying therapies (DMTs) in children with multiple sclerosis (MS) and clinically isolated syndrome (CIS) treated under 18 years of age. METHODS:This is a cohort study including children with MS or CIS followed at 12 outpatient practices participating in the US Network of ... Read more >>

Neurology (Neurology)
[2018, 91(19):e1778-e1787]

Cited: 3 times

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Several household chemical exposures are associated with pediatric-onset multiple sclerosis.

Soe Mar, Shannon Liang, Michael Waltz, T Charles Casper, Manu Goyal, Benjamin Greenberg, Bianca Weinstock-Guttman, Moses Rodriguez, Gregory Aaen, Anita Belman, Lisa F Barcellos, John Rose, Mark Gorman, Leslie Benson, Meghan Candee, Tanjua Chitnis, Yolanda Harris, Ilana Kahn, Shelly Roalsted, Janace Hart, Timothy Lotze, Manikum Moodley, Jayne Ness, Mary Rensel, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Lauren Krupp, Jennifer S Graves, Emmanuelle Waubant, ,

Background:There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals. Methods:We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www.usnpmsc.org/Documents/EnvironmentalAssessment.pdf) completed ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(12):1513-1521]

Cited: 1 time

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Correction to: Impact of an electronic monitoring device and behavioural feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial.

E Ann Yeh, Stephanie A Grover, Victoria E Powell, Gulay Alper, Brenda L Banwell, Kim Edwards, Mark Gorman, Jennifer Graves, Timothy E Lotze, Jean K Mah, Lauren Mednick, Jayne Ness, Maya Obadia, Ruth Slater, Amy Waldman, Emmanuelle Waubant, Carolyn E Schwartz, ,

The clinicaltrials.gov identifying number for the article titled "Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial" is NCT02234713 (https://clinicaltrials.gov/ct2/show/NCT02234713). ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2018, 27(4):1117]

Cited: 0 times

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Pediatric-Onset Multiple Sclerosis: A Single Center Study.

Erin Yamamoto, Matthew Ginsberg, Mary Rensel, Manikum Moodley,

Pediatric-onset multiple sclerosis (POMS), once thought to be rare, is now being diagnosed in increasing numbers in children. Despite improvements to diagnostic criteria, the diagnosis and management of POMS remains challenging. The aim of this study is to retrospectively describe a growing POMS patient population seen at a single center ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2018, 33(1):98-105]

Cited: 1 time

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Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis.

Leena Suleiman, Emmanuelle Waubant, Gregory Aaen, Anita Belman, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Manu Goyal, Benjamin Greenberg, Yolanda Harris, Janace Hart, Ilana Kahn, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Bardia Nourbakhsh, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Bianca Weinstock-Guttman, T Charles Casper, Michael Waltz, Jennifer S Graves, ,

OBJECTIVE:We sought to determine if early infectious exposures such as daycare, early use of antibiotics, vaccinations and other germ exposures including pacifier use and playing on grass are associated with multiple sclerosis (MS) risk in children. METHODS:This was a case-control study of children with MS or clinically isolated syndrome (CIS) ... Read more >>

Mult Scler Relat Disord (Multiple Sclerosis and Related Disorders)
[2018, 22:103-107]

Cited: 0 times

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Wellness and the Role of Comorbidities in Multiple Sclerosis.

Brandon P Moss, Mary R Rensel, Carrie M Hersh,

Multiple sclerosis (MS) is a demyelinating and neurodegenerative disorder of the central nervous system, for which disease modifying therapies (DMTs) are the mainstay treatment approach to reduce inflammatory disease activity and slow worsening disability. In addition to conventional pharmacologic therapy, there is growing interest in the use of lifestyle strategies ... Read more >>

Neurotherapeutics (Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics)
[2017, 14(4):999-1017]

Cited: 8 times

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Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial.

E Ann Yeh, Stephanie A Grover, Victoria E Powell, Gulay Alper, Brenda L Banwell, Kim Edwards, Mark Gorman, Jennifer Graves, Timothy E Lotze, Jean K Mah, Lauren Mednick, Jayne Ness, Maya Obadia, Ruth Slater, Amy Waldman, Emmanuelle Waubant, Carolyn E Schwartz, ,

To report the results of a randomized controlled trial using an electronic monitoring device (EM) plus a motivational interviewing (MI) intervention to enhance adherence to disease-modifying therapies (DMT) in pediatric MS.Fifty-two youth with MS (16.03 ± 2.2 years) were randomized to receive either MI (n = 25) (target intervention) or a MS medication video (n = 27) ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2017, 26(9):2333-2349]

Cited: 4 times

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Risk factors for non-adherence to disease-modifying therapy in pediatric multiple sclerosis.

Carolyn E Schwartz, Stephanie A Grover, Victoria E Powell, Austin Noguera, Jean K Mah, Soe Mar, Lauren Mednick, Brenda L Banwell, Gulay Alper, Mary Rensel, Mark Gorman, Amy Waldman, Teri Schreiner, Emmanuelle Waubant, E Ann Yeh,

BACKGROUND:Adherence to disease-modifying therapies (DMTs) in pediatric multiple sclerosis (MS) is not well understood. We examined the prevalence and risk factors for poor adherence in pediatric MS. METHODS:This cross-sectional study recruited youth with MS from 12 North American pediatric MS clinics. In addition to pharmacy-refill data, patients and parents completed ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(2):175-185]

Cited: 5 times

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Management of pediatric central nervous system demyelinating disorders: consensus of United States neurologists.

Amy T Waldman, Mark P Gorman, Mary R Rensel, Tracy E Austin, Deborah P Hertz, Nancy L Kuntz, ,

Demyelinating diseases are a group of autoimmune inflammatory disorders affecting the central nervous system in adults and children; however, the diagnosis, evaluation, and treatment of these disorders are primarily based on adult data. The purpose of this study was to assess the practice patterns of US physicians who specialize in ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2011, 26(6):675-682]

Cited: 33 times

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Effects of meditation on pain and quality of life in multiple sclerosis and peripheral neuropathy: a pilot study.

Jinny Tavee, Mary Rensel, Sarah M Planchon, Robert S Butler, Lael Stone,

The objective of this study was to determine whether meditation affects pain and quality of life in people with multiple sclerosis (MS) and peripheral neuropathy (PN). A total of 22 patients (10 with MS, 12 with PN) participated in a weekly meditation class over a 2-month period. A total of ... Read more >>

Int J MS Care (International journal of MS care)
[2011, 13(4):163-168]

Cited: 22 times

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Glatiramer acetate: successful desensitization for treatment of multiple sclerosis.

Sonia N Bains, Fred H Hsieh, Mary R Rensel, Cristine Radojicic, Hary T Katz, S Rubina Inamdar, David M Lang,

BACKGROUND: Glatiramer acetate is an immunomodulatory drug that is widely prescribed for the treatment of multiple sclerosis. It is frequently associated with local injection site reactions and generalized urticaria. It is also associated with immediate postinjection systemic reactions in approximately 10% of patients. To our knowledge, no desensitization protocols for ... Read more >>

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2010, 104(4):321-325]

Cited: 3 times

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Peripheral mononeuropathy with etanercept use: case report.

Beatriz Yae Hanaoka, James Libecco, Mary Rensel, Rula A Hajj-Ali,

J. Rheumatol. (The Journal of rheumatology)
[2008, 35(1):182]

Cited: 8 times

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Differential diagnosis and evaluation in pediatric multiple sclerosis.

Jin S Hahn, Daniela Pohl, Mary Rensel, Sanjai Rao, ,

The differential diagnosis for multiple sclerosis (MS) in childhood and adolescence includes infectious, inflammatory, and neoplastic disorders as well as metabolic neurogenetic leukodystrophies, toxic leukodystrophies, and vascular conditions. The evaluation is determined by the clinical and neuroradiologic presentation. A minimal diagnostic battery is proposed. More expanded evaluations are indicated for ... Read more >>

Neurology (Neurology)
[2007, 68(16 Suppl 2):S13-22]

Cited: 21 times

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Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study.

Brenda Banwell, Lauren Krupp, Julia Kennedy, Raymond Tellier, Silvia Tenembaum, Jayne Ness, Anita Belman, Alexei Boiko, Olga Bykova, Emmanuelle Waubant, Jean K Mah, Cristina Stoian, Marcelo Kremenchutzky, Maria Rita Bardini, Martino Ruggieri, Mary Rensel, Jin Hahn, Bianca Weinstock-Guttman, E Ann Yeh, Kevin Farrell, Mark Freedman, Matti Iivanainen, Meri Sevon, Virender Bhan, Marie-Emmanuelle Dilenge, Derek Stephens, Amit Bar-Or,

BACKGROUND: The full spectrum of clinical manifestations and outcome, and the potential importance of regional or demographic features or viral triggers in paediatric multiple sclerosis (MS), has yet to be fully characterised. Our aim was to determine some of these characteristics in children with MS. METHODS: 137 children with MS ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2007, 6(9):773-781]

Cited: 143 times

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