Full Text Journal Articles by
Author Mary Maluccio

Advertisement

Find full text journal articles






Financial Burden of Liver Transplant vs Resection for Hepatocellular Carcinoma.

Nicholas J Skill, James Butler, Daniel C O'Brien, Joshua K Kays, Chandrashekar Kubal, Suthat Liangpunsakul, Nehal Ninad, Mary A Maluccio,

BACKGROUND:Liver transplant and liver resection are surgical treatments for hepatocellular carcinoma (HCC) performed with curative intent. While liver transplant provides longer survival when compared to resection, the financial burden on patients and payors is significantly greater. With the increase in health care costs and the emergence of high deductible insurance ... Read more >>

Transplant. Proc. (Transplantation proceedings)
[2019, 51(6):1907-1912]

Cited: 0 times

View full text PDF listing >>



Metabolomic Characterization of Human Model of Liver Rejection Identifies Aberrancies Linked to Cyclooxygenase (COX) and Nitric Oxide Synthase (NOS).

Nicholas J Skill, Campbell M Elliott, Brian Ceballos, Romil Saxena, Robert Pepin, Lisa Bettcher, Matthew Ellensberg, Daniel Raftery, Mary A Malucio, Burcin Ekser, Richard S Mangus, Chandrashekhar A Kubal,

BACKGROUND Acute liver rejection (ALR), a significant complication of liver transplantation, burdens patients, healthcare payers, and the healthcare providers due to an increase in morbidity, cost, and resources. Despite clinical resolution, ALR is associated with an increased risk of graft loss. A unique protocol of delayed immunosuppression used in our ... Read more >>

Ann. Transplant. (Annals of transplantation)
[2019, 24:341-349]

Cited: 0 times

View full text PDF listing >>



Advertisement

Contemporary paradigm for the evaluation and treatment of hereditary gastric cancer.

Nicholas Skill, Mary Maluccio,

Gastric cancer is the third leading cause of cancer mortality worldwide. Survival is linked to stage at diagnosis and tolerance to surgery and adjuvant therapy. The emergence of sophisticated methods to identify patients at high risk for the development of gastric cancer has given us an opportunity to eliminate a ... Read more >>

Transl Gastroenterol Hepatol (Translational gastroenterology and hepatology)
[2019, 4:14]

Cited: 0 times

View full text PDF listing >>



Functional liver image guided hepatic therapy (FLIGHT) with hepatobiliary iminodiacetic acid (HIDA) scans.

David E Long, Mark Tann, Ke Colin Huang, Gregory Bartlett, James O Galle, Yukie Furukawa, Mary Maluccio, John A Cox, Feng-Ming Spring Kong, Susannah G Ellsworth,

PURPOSE:Hepatobiliary iminodiacetic acid (HIDA) scans provide global and regional assessments of liver function that can serve as a road map for functional avoidance in stereotactic body radiation therapy (SBRT) planning. Functional liver image guided hepatic therapy (FLIGHT), an innovative planning technique, is described and compared with standard planning using functional ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2018, 8(6):429-436]

Cited: 0 times

View full text PDF listing >>



Role of Stereotactic Body Radiation Therapy Before Orthotopic Liver Transplantation: Retrospective Evaluation of Pathologic Response and Outcomes.

Edward Michael Mannina, Higinia Rosa Cardenes, Foster D Lasley, Benjamin Goodman, Jennifer Zook, Sandra Althouse, John Alvin Cox, Romil Saxena, Joseph Tector, Mary Maluccio,

To analyze the results of stereotactic body radiation therapy (SBRT) in patients with early-stage, localized hepatocellular carcinoma who underwent definitive orthotopic liver transplantation (OLT).The subjects of this retrospective report are 38 patients diagnosed with hepatocellular carcinoma who underwent SBRT per institutional phase 1 to 2 eligibility criteria, before definitive OLT. Pre-OLT ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2017, 97(5):931-938]

Cited: 6 times

View full text PDF listing >>



Decreased PCSK9 expression in human hepatocellular carcinoma.

Mamatha Bhat, Nicolas Skill, Victoria Marcus, Marc Deschenes, Xianming Tan, Jeanne Bouteaud, Sarita Negi, Zuhier Awan, Reid Aikin, Janet Kwan, Ramila Amre, Sebastien Tabaries, Mazen Hassanain, Nabil G Seidah, Mary Maluccio, Peter Siegel, Peter Metrakos,

The management of hepatocellular carcinoma (HCC) is limited by the lack of adequate screening biomarkers and chemotherapy. In response, there has been much interest in tumor metabolism as a therapeutic target. PCSK9 stimulates internalization of the LDL-receptor, decreases cholesterol uptake into hepatocytes and affects liver regeneration. Thus, we investigated whether ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2015, 15:176]

Cited: 7 times

View full text PDF listing >>



Prognosis after recurrence of hepatocellular carcinoma in liver transplantation: predictors for successful treatment and survival.

Shunji Nagai, Richard S Mangus, Chandrashekhar A Kubal, Burcin Ekser, Jonathan A Fridell, Kendell R Klingler, Mary A Maluccio, A Joseph Tector,

There are no established prognostic factors or standardized therapies for hepatocellular carcinoma (HCC) recurrence in liver transplantation (LT). The aim of this study was to investigate impact of underlying patient condition on treatment and outcomes of recurrence of HCC after LT. The medical records of 268 LT patients with HCC ... Read more >>

Clin Transplant (Clinical transplantation)
[2015, 29(12):1156-1163]

Cited: 3 times

View full text PDF listing >>



Long-term safety and efficacy of stereotactic body radiation therapy for hepatic oligometastases.

Benjamin D Goodman, Edward M Mannina, Sandra K Althouse, Mary A Maluccio, Higinia R Cárdenes,

To evaluate long-term outcome and toxicity of stereotactic body radiation therapy (SBRT) for hepatic oligometastases from solid tumors.Eligible patients had 1 to 3 liver metastases, maximum sum diameter 6 cm, without extrahepatic progression. We treated 106 lesions in 81 patients; 67% with colorectal primaries. Median dose was 5400 cGy in ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2016, 6(2):86-95]

Cited: 12 times

View full text PDF listing >>



Treatment variables related to liver toxicity in patients with hepatocellular carcinoma, Child-Pugh class A and B enrolled in a phase 1-2 trial of stereotactic body radiation therapy.

Foster D Lasley, Edward M Mannina, Cynthia S Johnson, Susan M Perkins, Sandra Althouse, Mary Maluccio, Paul Kwo, Higinia Cárdenes,

An analysis was performed on patients enrolled in a phase 1-2 trial using stereotactic body radiation therapy for hepatocellular carcinoma evaluating variables influencing liver toxicity.Thirty-eight Child-Pugh class A (CPC-A) (39 lesions) and 21 CPC-B patients (26 lesions) were followed for ≥6 months. Six months local control using modified Response Evaluation ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2015, 5(5):e443-e449]

Cited: 31 times

View full text PDF listing >>



Expert perspectives on evidence-based treatment planning for patients with hepatocellular carcinoma.

Jorge Marrero, Mary A Maluccio, Heather McCurdy, Ghassan K Abou-Alfa,

Cancer Control (Cancer control : journal of the Moffitt Cancer Center)
[2014, 21(2 Suppl):5-16]

Cited: 1 time

View full text PDF listing >>



Long-term outcomes comparing surgery to embolization-ablation for treatment of solitary HCC<7 cm.

Eldad Elnekave, Joseph P Erinjeri, Karen T Brown, Raymond H Thornton, Elena N Petre, Majid Maybody, Mary A Maluccio, Meier Hsu, Constantinos T Sofocleous, George I Getrajdman, Lynn A Brody, Stephen B Solomon, William Alago, Yuman Fong, William R Jarnagin, Anne M Covey,

BACKGROUND:Resection has been the standard of care for patients with solitary hepatocellular carcinoma (HCC). Transarterial embolization and percutaneous ablation are alternative therapies often reserved for suboptimal surgical candidates. Here we compare long-term outcomes of patients with solitary HCC treated with resection versus combined embo-ablation. METHODS:We previously reported a retrospective comparison ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2013, 20(9):2881-2886]

Cited: 13 times

View full text PDF listing >>



Lysophosphatidic acid aberrancies and hepatocellular carcinoma: studies in the MDR2 gene knockout mouse.

Nicholas Skill, Jianmin Wu, Yan Xu, Zheng Zhao, Mary Maluccio,

Studies show that lysophosphatidic acid (LPA) reprogramming is associated with the development of hepatocellular carcinoma (HCC). This manuscript evaluates the MDR2(-/-) model of HCC as a tool to examine the role of LPA reprogramming in the initiation/progression of HCC and identify novel treatment targets. Hepatic tumors developed in MDR2(-/-) mice ... Read more >>

Cancer Invest. (Cancer investigation)
[2013, 31(2):145-155]

Cited: 3 times

View full text PDF listing >>



Lysophospholipid variants in hepatocellular carcinoma.

Nicholas J Skill, Wu Jianmin, Xu Yan, Zhenweng Zhao, Alfred J Tector, Mary A Maluccio,

The U.S. incidence of hepatocellular carcinoma (HCC) is increasing and is linked to hepatitis C (HepC) infection, alcohol toxicity, and obesity. This manuscript examines lysophosphatidic acid (LPA) variant biosynthesis as a biomarker and potential therapeutic target for HCC.Serum LPA variant levels were determined in patients with HepC ± HCC, alcoholic ... Read more >>

J. Surg. Res. (The Journal of surgical research)
[2013, 182(2):241-249]

Cited: 6 times

View full text PDF listing >>



Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma.

Mary Maluccio, Anne Covey,

Hepatocellular carcinoma (HCC) is one of the few cancers in which a continued increase in incidence has been observed over several years. As such, there has been a focus on safe and accurate diagnosis and the development of treatment algorithms that take into consideration the unique complexities of this patient ... Read more >>

CA Cancer J Clin (CA: a cancer journal for clinicians)
[2012, 62(6):394-399]

Cited: 320 times

View full text PDF listing >>



Differentiating hepatocellular carcinoma from hepatitis C using metabolite profiling.

Siwei Wei, Yuliana Suryani, G A Nagana Gowda, Nicholas Skill, Mary Maluccio, Daniel Raftery,

Hepatocellular carcinoma (HCC) accounts for most liver cancer cases worldwide. Contraction of the hepatitis C virus (HCV) is considered a major risk factor for liver cancer. In order to identify the risk of cancer, metabolic profiling of serum samples from patients with HCC (n=40) and HCV (n=22) was performed by ... Read more >>

Metabolites (Metabolites)
[2012, 2(4):701-716]

Cited: 12 times

View full text PDF listing >>



Evaluation of response after stereotactic body radiotherapy for hepatocellular carcinoma.

Tracy R Price, Susan M Perkins, Kumar Sandrasegaran, Mark A Henderson, Mary A Maluccio, Jennifer E Zook, A Joseph Tector, Rodrigo M Vianna, Peter A S Johnstone, Higinia R Cardenes,

BACKGROUND: Hepatocellular carcinoma (HCC) is increasing in incidence due to hepatitis C. Stereotactic body radiotherapy (SBRT) is a noninvasive, effective therapy in the management of liver malignancies. The authors evaluated radiological response in 26 patients with HCC treated with SBRT at Indiana University. METHODS: Between March 2005 and June 2008, ... Read more >>

Cancer (Cancer)
[2012, 118(12):3191-3198]

Cited: 67 times

View full text PDF listing >>



Stereotactic body radiotherapy for primary hepatocellular carcinoma.

David L Andolino, Cynthia S Johnson, Mary Maluccio, Paul Kwo, A Joseph Tector, Jennifer Zook, Peter A S Johnstone, Higinia R Cardenes,

PURPOSE: To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of primary hepatocellular carcinoma (HCC). METHODS AND MATERIALS: From 2005 to 2009, 60 patients with liver-confined HCC were treated with SBRT at the Indiana University Simon Cancer Center: 36 Child-Turcotte-Pugh (CTP) Class A and 24 ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2011, 81(4):e447-53]

Cited: 161 times

View full text PDF listing >>



Evidence of aberrant lipid metabolism in hepatitis C and hepatocellular carcinoma.

Jian-Min Wu, Nicholas J Skill, Mary A Maluccio,

Lipids are linked to many pathological processes including hepatic steatosis and liver malignancy. This study aimed to explore lipid metabolism in hepatitis C virus (HCV) and HCV-related hepatocellular carcinoma (HCC).Serum lipids were measured in normal, HCV and HCV-HCC patients. Whole-genome microarray was performed to identify potential signature genes involved in ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2010, 12(9):625-636]

Cited: 30 times

View full text PDF listing >>



Phase I feasibility trial of stereotactic body radiation therapy for primary hepatocellular carcinoma.

Higinia R Cárdenes, Tracy R Price, Susan M Perkins, Mary Maluccio, P Kwo, T E Breen, Mark A Henderson, Tracey E Schefter, Kathy Tudor, Jill Deluca, Peter A S Johnstone,

Hepatocellular carcinoma (HCC) is increasing in incidence and the majority of patients are not candidates for radical therapies. Therefore, interest in minimally invasive therapies in growing.A Phase I dose escalation trial was conducted at Indiana University to determine the feasibility and toxicity of stereotactic body radiation therapy (SBRT) for primary ... Read more >>

Clin Transl Oncol (Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico)
[2010, 12(3):218-225]

Cited: 114 times

View full text PDF listing >>



Tumor necrosis factor alpha signaling in the development of experimental murine pre-hepatic portal hypertension.

Nicholas G Theodorakis, Yining N Wang, Jianmin Wu, Mary A Maluccio, Nicholas J Skill,

The cytokine tumor necrosis factor alpha (TNFa) has previously been identified in the development of portal hypertension (PHT) by facilitating portal venous and systemic hyperemia. TNFa is reported to contribute to hyperemia via endothelial nitric oxide synthase (eNOS) induction and nitric oxide (NO) production. This study examines this hypothesis by ... Read more >>

Int J Physiol Pathophysiol Pharmacol (International journal of physiology, pathophysiology and pharmacology)
[2010, 2(2):104-110]

Cited: 1 time

View full text PDF listing >>



Hepatocellular carcinoma associated lipid metabolism reprogramming.

Nicholas James Skill, Rachael E Scott, Jianmin Wu, Mary A Maluccio,

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with a high worldwide prevalence and poor prognosis. Previous data, by Affymetrix microarray analysis, has shown a decrease in genes involved in phospholipid catabolism, fatty acid catabolism, choline metabolism, and bile acid metabolism in HCC compared with control tissue. The ... Read more >>

J. Surg. Res. (The Journal of surgical research)
[2011, 169(1):51-56]

Cited: 17 times

View full text PDF listing >>



A comparison of outcomes from treating hepatocellular carcinoma by hepatic artery embolization in patients younger or older than 70 years.

Raymond H Thornton, Anne Covey, Elena N Petre, Elyn R Riedel, Mary A Maluccio, Constantinos T Sofocleous, Lynn A Brody, George I Getrajdman, Michael D'Angelica, Yuman Fong, Karen T Brown,

: The objective of this study was to compare the morbidity, mortality, and survival of patients aged <70 years and aged > or =70 years who underwent hepatic arterial embolization (HAE) for the treatment of hepatocellular carcinoma (HCC).: Between 1997 and 2007, 386 patients underwent HAE for HCC at a ... Read more >>

Cancer (Cancer)
[2009, 115(21):5000-5006]

Cited: 9 times

View full text PDF listing >>



Role of endothelial nitric oxide synthase in the development of portal hypertension in the carbon tetrachloride-induced liver fibrosis model.

Nicholas G Theodorakis, Yining N Wang, Jian-Ming Wu, Mary A Maluccio, James V Sitzmann, Nicholas J Skill,

Portal hypertension (PHT) is a complication of liver cirrhosis and directly increases mortality and morbidity by increasing the propensity of venous hemorrhage. There are two main underlying causations for PHT, increased hepatic resistance and systemic hyperdynamic circulation. Both are related to localized aberrations in endothelial nitric oxide synthase (eNOS) function ... Read more >>

Am. J. Physiol. Gastrointest. Liver Physiol. (American journal of physiology. Gastrointestinal and liver physiology)
[2009, 297(4):G792-9]

Cited: 14 times

View full text PDF listing >>



NF-kappaB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy.

Jian-Min Wu, Hongmiao Sheng, Romil Saxena, Nicholas James Skill, Poornima Bhat-Nakshatri, Menggang Yu, Harikrishna Nakshatri, Mary A Maluccio,

Nuclear factor-kappaB (NF-kappaB) has been shown to play an important role in the development and progression of cancer. In this study, we systematically examined NF-kappaBp65 signaling pathway in both human hepatocellular carcinoma (HCC) tissue and HCC cell lines. NF-kappaBp65 signaling pathway is aberrantly expressed and activated in both human HCC ... Read more >>

Cancer Lett. (Cancer letters)
[2009, 278(2):145-155]

Cited: 32 times

View full text PDF listing >>



Bile acids conjugation in human bile is not random: new insights from (1)H-NMR spectroscopy at 800 MHz.

G A Nagana Gowda, Narasimhamurthy Shanaiah, Amanda Cooper, Mary Maluccio, Daniel Raftery,

Bile acids constitute a group of structurally closely related molecules and represent the most abundant constituents of human bile. Investigations of bile acids have garnered increased interest owing to their recently discovered additional biological functions including their role as signaling molecules that govern glucose, fat and energy metabolism. Recent NMR ... Read more >>

Lipids (Lipids)
[2009, 44(6):527-535]

Cited: 13 times

View full text PDF listing >>



Advertisement

Disclaimer
1.7915 s