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Author Mary Kimmel

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A Brexanolone Treatment Program at an Academic Medical Center: Patient Selection, 90-Day Posttreatment Outcomes, and Lessons Learned.

Riah Patterson, Holly Krohn, Erin Richardson, Mary Kimmel, Samantha Meltzer-Brody,

<h4>Background</h4>Brexanolone (Zulresso) is the first Federal Drug Administration-approved drug for the treatment of postpartum depression. Brexanolone is a positive allosteric modulator of the GABA<sub>A</sub> receptor and is given over 60 hours by infusion in a medical setting. This drug has been shown to be effective at significantly reducing Hamilton Rating ... Read more >>

J Acad Consult Liaison Psychiatry (Journal of the Academy of Consultation-Liaison Psychiatry)
[2021, :]

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Infant gut microbiome composition is associated with non-social fear behavior in a pilot study.

Alexander L Carlson, Kai Xia, M Andrea Azcarate-Peril, Samuel P Rosin, Jason P Fine, Wancen Mu, Jared B Zopp, Mary C Kimmel, Martin A Styner, Amanda L Thompson, Cathi B Propper, Rebecca C Knickmeyer,

Experimental manipulation of gut microbes in animal models alters fear behavior and relevant neurocircuitry. In humans, the first year of life is a key period for brain development, the emergence of fearfulness, and the establishment of the gut microbiome. Variation in the infant gut microbiome has previously been linked to ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):3294]

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Heart rate variability in late pregnancy: exploration of distinctive patterns in relation to maternal mental health.

Mary C Kimmel, Emma Fransson, Janet L Cunningham, Emma Brann, Karen Grewen, Dario Boschiero, George P Chrousos, Samantha Meltzer-Brody, Alkistis Skalkidou,

Exploration of photoplethysmography (PPG), a technique that can be translated to the clinic, has the potential to assess the autonomic nervous system (ANS) through heart rate variable (HRV) in pregnant individuals. This novel study explores the complexity of mental health of individuals in a clinical sample responding to a task ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):286]

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The Crisis of Perinatal Mental Health in the Age of Covid-19.

Lauren M Osborne, Mary C Kimmel, Pamela J Surkan,

In the US, the COVID-19 pandemic adds a new source of stress for women in the perinatal period, a time when stress and anxiety are already heightened. The closures of physical mental health care spaces and lack of support could have devastating impacts on the health of postpartum women and ... Read more >>

Matern Child Health J (Maternal and child health journal)
[2021, 25(3):349-352]

Cited: 1 time

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A Proof of Concept for a Systems Approach to Biologically Characterize the Maternal Gut Microbiome, Immune Patterns and Mental Distress During Pregnancy

Beatriz Penalver Bernabe, Janet Cunningham, Lisa Tussing-Humphreys, Ian Carroll, Samantha Meltzer-Brody, Pauline Maki, Jack Gilbert, Mary Kimmel,

<h4>ABSTRACT</h4> <h4>Importance</h4> Screening for anxiety and depression is important but especially difficult during pregnancy. Identification and quantification of the variation of maternal biologic dimensions during the dynamic pregnancy period, e.g. immune and microbiome profiles, have the potential to greatly improve mental heath screening and patient stratification. <h4>Objective</h4> To determine if ... Read more >>

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Mental health among pregnant women during the pandemic in Sweden– a mixed methods approach using data from the Mom2B mobile application for research

Emma Fransson, Maria Karalexi, Mary Kimmel, Emma Bränn, Natasa Kollia, Vera van Zoest, Eira Nordling, Fotios Papadopoulos, Alkistis Skalkidou,

Public health emergencies such as the coronavirus (SARS-CoV-2) pandemic have significant impact on mental health, and have been shown to impact on already prevalent affective disorders during and after pregnancy. The aim of this study was to utilize modern tools to assess depressive and anxiety symptoms, as well as wellbeing ... Read more >>

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The Promise of Telepsychiatry to Reduce Maternal Mortality by Increasing Access to Maternal Mental Health and Addiction Services.

Samantha Meltzer-Brody, Mary Kimmel,

Obstet Gynecol (Obstetrics and gynecology)
[2020, 136(4):643-644]

Cited: 0 times

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Effects of psychological stress on adverse pregnancy outcomes and nonpharmacologic approaches for reduction: an expert review.

Claire S Traylor, Jasmine D Johnson, Mary C Kimmel, Tracy A Manuck,

Both acute and chronic stress can cause allostatic overload, or long-term imbalance in mediators of homeostasis, that results in disruptions in the maternal-placental-fetal endocrine and immune system responses. During pregnancy, disruptions in homeostasis may increase the likelihood of preterm birth and preeclampsia. Expectant mothers traditionally have high rates of anxiety ... Read more >>

Am J Obstet Gynecol MFM (American journal of obstetrics & gynecology MFM)
[2020, 2(4):100229]

Cited: 4 times

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Access to Care During a Global Health Crisis.

Debra Furr-Holden, Olivia Carter-Pokras, Mary Kimmel, Charles Mouton,

Health Equity (Health equity)
[2020, 4(1):150-157]

Cited: 0 times

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Maternal Mental Health MATTERS.

Mary Kimmel,

Depression and anxiety during pregnancy and the postpartum period are common and have significant negative impacts on mother and child. Suicide is a leading cause of maternal mortality. Evidence-based efforts for screening, assessment, and treatment improve maternal and infant mental health, as well as overall family health, throughout the lives ... Read more >>

N C Med J (North Carolina medical journal)
[2020, 81(1):45-50]

Cited: 1 time

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Improving Mental Health for the Mother-Infant Dyad by Nutrition and the Maternal Gut Microbiome.

Beatriz Peñalver Bernabé, Lisa Tussing-Humphreys, Hannah S Rackers, Lauren Welke, Alina Mantha, Mary C Kimmel,

Perinatal mood and anxiety disorders (PMAD) have significant negative impacts on mother and child, yet treatments are limited. Adequate nutrition during the perinatal period is essential to maternal and infant health, including maternal mental health and the child's neurologic and neuropsychiatric development. Nutrition holds promise to improve prevention and treatment ... Read more >>

Gastroenterol Clin North Am (Gastroenterology clinics of North America)
[2019, 48(3):433-445]

Cited: 2 times

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Can social support during pregnancy affect maternal DNA methylation? Findings from a cohort of African-Americans.

Pamela J Surkan, Xiumei Hong, Boyang Zhang, Nobutoshi Nawa, Hongkai Ji, Wan-Yee Tang, Yuelong Ji, Mary C Kimmel, Guoying Wang, Colleen Pearson, Xiaobin Wang,

<h4>Background</h4>While stress and the absence of social support during pregnancy have been linked to poor health outcomes, the underlying biological mechanisms are unclear.<h4>Methods</h4>We examined whether adverse experiences during pregnancy alter DNA methylation (DNAm) in maternal epigenomes. Analyses included 250 African-American mothers from the Boston Birth Cohort. Genome-wide DNAm profiling was ... Read more >>

Pediatr Res (Pediatric research)
[2020, 88(1):131-138]

Cited: 2 times

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The Relationship Between Perinatal Mental Health and Stress: a Review of the Microbiome.

Nusiebeh Redpath, Hannah S Rackers, Mary C Kimmel,

PURPOSE OF REVIEW:Our current understanding of the underlying mechanisms and etiologies of perinatal mood and anxiety disorders (PMADs) is not clearly identified. The relationship of stress-induced adaptations (i.e., the hypothalamic-pituitary-adrenal (HPA) axis, the autonomic nervous system (ANS), the immune system) and the microbiota are potential contributors to psychopathology exhibited in ... Read more >>

Curr Psychiatry Rep (Current psychiatry reports)
[2019, 21(3):18]

Cited: 1 time

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Toward a framework for best practices and research guidelines for perinatal depression research.

Mary C Kimmel, Anna Bauer, Samantha Meltzer-Brody,

This review article highlights the current state of perinatal depression (PND) research including established standards of care and innovative research in progress. PND can have a significant adverse impact on mother, child, and family; however, to date, wide-scale identification, prevention, and treatment have been limited. PND is heterogenous in presentation ... Read more >>

J Neurosci Res (Journal of neuroscience research)
[2020, 98(7):1255-1267]

Cited: 4 times

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A role for the microbiome in mother-infant interaction and perinatal depression.

Amanda Sanders, Hannah Rackers, Mary Kimmel,

Perinatal depression is a significant public health problem, due to its negative impact on maternal well-being and long-term adverse effects for children. Mother-infant interaction and maternal responsiveness and sensitivity are a hypothesized mechanism by which perinatal depression effects child development, and increasing research in the microbiota-gut-brain axis may provide a ... Read more >>

Int Rev Psychiatry (International review of psychiatry (Abingdon, England))
[2019, 31(3):280-294]

Cited: 1 time

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Emerging literature in the Microbiota-Brain Axis and Perinatal Mood and Anxiety Disorders.

Hannah S Rackers, Stephanie Thomas, Kelsey Williamson, Rachael Posey, Mary C Kimmel,

Perinatal Mood and Anxiety Disorders (PMAD) are common and can cause significant morbidity and mortality for mother and child. A healthy perinatal period requires significant adaptations; however, systems can become imbalanced resulting in depressive and anxiety symptoms. The interface between the microbiome, the immune system, and the stress system may ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2018, 95:86-96]

Cited: 8 times

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Pharmacologic Treatment of Perinatal Depression.

Mary C Kimmel, Elizabeth Cox, Crystal Schiller, Edith Gettes, Samantha Meltzer-Brody,

This review provides information about medications used to treat perinatal depression, including guidance around when to use certain medications and when to consult a mental health provider. For each group of medications, including selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, mirtazapine, bupropion, lithium, atypical antipsychotics, and lamotrigine, the risks ... Read more >>

Obstet Gynecol Clin North Am (Obstetrics and gynecology clinics of North America)
[2018, 45(3):419-440]

Cited: 3 times

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Maternal smoking during pregnancy and cord blood DNA methylation: new insight on sex differences and effect modification by maternal folate levels.

Boyang Zhang, Xiumei Hong, Hongkai Ji, Wan-Yee Tang, Mary Kimmel, Yuelong Ji, Colleen Pearson, Barry Zuckerman, Pamela J Surkan, Xiaobin Wang,

Maternal smoking during pregnancy may affect newborn DNA methylation (DNAm). However, little is known about how these associations vary by a newborn's sex and/or maternal nutrition. To fill in this research gap, we investigated epigenome-wide DNAm associations with maternal smoking during pregnancy in African American mother-newborn pairs. DNAm profiling in ... Read more >>

Epigenetics (Epigenetics)
[2018, 13(5):505-518]

Cited: 8 times

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Paternal involvement and support and risk of preterm birth: findings from the Boston birth cohort.

Pamela J Surkan, Liming Dong, Yuelong Ji, Xiumei Hong, Hongkai Ji, Mary Kimmel, Wan-Yee Tang, Xiaobin Wang,

OBJECTIVE:To investigate to what extent paternal involvement and support during pregnancy were associated with preterm (PTB) and small-for-gestational age (SGA) births. METHODS:Using data from the Boston Birth Cohort (n = 7047), multiple logistic regression models were performed to estimate the log odds of either PTB or SGA birth, with paternal involvement, paternal ... Read more >>

J Psychosom Obstet Gynaecol (Journal of psychosomatic obstetrics and gynaecology)
[2019, 40(1):48-56]

Cited: 6 times

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Comprehensive Integrated Care Model to Improve Maternal Mental Health.

Elizabeth Q Cox, Christena Raines, Mary Kimmel, Erin Richardson, Alison Stuebe, Samantha Meltzer-Brody,

In this article, we describe an integrated care model in a perinatal psychiatry program to improve access to care for women who experience mood changes during the perinatal period. A nurse-practitioner trained in psychiatry and obstetrics is embedded in the obstetric clinic, and perinatal nurses, often the first professionals to ... Read more >>

J Obstet Gynecol Neonatal Nurs (Journal of obstetric, gynecologic, and neonatal nursing : JOGNN)
[2017, 46(6):923-930]

Cited: 3 times

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Integrating Maternal Mental Health Care in the Pediatric Medical Home: Treatment Engagement and Child Outcomes.

Mary C Kimmel, Rheanna E Platt, Danielle N Steinberg, Fallon Cluxton-Keller, Lauren M Osborne, Tracy Carter, Jennifer L Payne, Barry S Solomon,

Maternal depression is associated with an array of poor child health outcomes, and low-income women face many barriers to accessing treatment. In this pilot study, we assessed treatment engagement in a maternal mental health clinic staffed by a case manager and psychiatrist in an urban pediatric practice. We also examined ... Read more >>

Clin Pediatr (Phila) (Clinical pediatrics)
[2017, 56(12):1148-1156]

Cited: 2 times

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Maternal Experiences in a Parenting Group Delivered in an Urban General Pediatric Clinic.

Mary C Kimmel, Fallon Cluxton-Keller, Emily Frosch, Tracy Carter, Barry S Solomon,

Untreated perinatal mood and anxiety disorders can result in impaired maternal-infant interactions. Pediatricians have a unique opportunity to identify and support mothers with mood and anxiety disorders. A parenting intervention, Circle of Security, was delivered in a pediatric clinic targeting women with mood and anxiety disorders. A qualitative assessment of ... Read more >>

Clin Pediatr (Phila) (Clinical pediatrics)
[2017, 56(1):13-19]

Cited: 0 times

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Oxytocin receptor DNA methylation in postpartum depression.

Mary Kimmel, Makena Clive, Fiona Gispen, Jerry Guintivano, Tori Brown, Olivia Cox, Matthias W Beckmann, Johannes Kornhuber, Peter A Fasching, Lauren M Osborne, Elisabeth Binder, Jennifer L Payne, Zachary Kaminsky,

The oxytocin receptor (OXTR) is a key regulator of stress and anxiety and may be regulated by both psychosocial risk factors and gonadal hormones, making it an attractive candidate for study in postpartum depression (PPD). The objective of this study was to investigate both serum hormone and PPD specific DNA ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2016, 69:150-160]

Cited: 25 times

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Treatment of severe perinatal mood disorders on a specialized perinatal psychiatry inpatient unit.

Mary C Kimmel, S Lara-Cinisomo, K Melvin, A Di Florio, A Brandon, S Meltzer-Brody,

Perinatal patients with bipolar and psychotic mood disorder exacerbations are challenging to treat and often receive suboptimal care. We sought to examine the treatment patterns and outcomes on one of the only US-based Perinatal Psychiatry Inpatient Units (PPIU). Perinatal patients admitted to the PPIU completed self-report measures at admission and ... Read more >>

Arch Womens Ment Health (Archives of women's mental health)
[2016, 19(4):645-653]

Cited: 3 times

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Beyond screening: a review of pediatric primary care models to address maternal depression.

Nomi S Weiss-Laxer, Rheanna Platt, Lauren M Osborne, Mary Kimmel, Barry S Solomon, Tamar Mendelson, Lindsey Webb, Anne W Riley,

Depression is one of the most debilitating chronic disorders in the United States, affecting 15 million children in homes with depressed mothers, many of whom endure household chaos, inconsistent nurturing, inadequate safety practices, and harsh discipline. Depressed mothers are under diagnosed and undertreated, yet there is broad consensus about the ... Read more >>

Pediatr Res (Pediatric research)
[2016, 79(1-2):197-204]

Cited: 5 times

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