Full Text Journal Articles by
Author Mary F Achim

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Therapeutic Consequences of Omitting a Pelvic Lymph Node Dissection at Radical Prostatectomy when Grade and/or Stage Increase.

Muammer Altok, Brian F Chapin, Surena F Matin, Mary F Achim, Justin R Gregg, John W Davis,

<h4>Objective</h4>To analyze the effect on biochemical recurrence (BCR) of omitting PLND in subsequently upgraded/upstaged patients (pNx regret). Using nomograms, patients with low to intermediate-risk prostate cancer can be selected to omit a pelvic lymph node dissection (PLND) at the time of a radical prostatectomy (RP). However, some patients will experience ... Read more >>

Urology (Urology)
[2021, :]

Cited: 0 times

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Ductal Prostate Cancers Demonstrate Poor Outcomes with Conventional Therapies.

Weranja Ranasinghe, Daniel D Shapiro, Hyunsoo Hwang, Xuemei Wang, Chad A Reichard, Mohamed Elsheshtawi, Mary F Achim, Tharakeswara Bathala, Chad Tang, Ana Aparicio, Shi-Ming Tu, Nora Navone, Timothy C Thompson, Louis Pisters, Patricia Troncoso, John W Davis, Brian F Chapin,

<h4>Background</h4>Ductal prostate adenocarcinoma (DAC) is a rare, aggressive, histologic variant of prostate cancer that is treated with conventional therapies, similar to high-risk prostate adenocarcinoma (PAC).<h4>Objective</h4>To assess the outcomes of men undergoing definitive therapy for DAC or high-risk PAC and to explore the effects of androgen deprivation therapy (ADT) in improving ... Read more >>

Eur Urol (European urology)
[2021, 79(2):298-306]

Cited: 1 time

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Downgrading from Biopsy Grade Group 4 Prostate Cancer in Patients Undergoing Radical Prostatectomy for High or Very High Risk Prostate Cancer.

Weranja Ranasinghe, Chad A Reichard, Yaw A Nyame, Debasish Sundi, Jeffrey J Tosoian, Lamont Wilkins, Ridwan Alam, Mary F Achim, Xuemei Wang, Andrew J Stephenson, Eric A Klein, Ashley E Ross, Mohamad E Allaf, John W Davis, Brian F Chapin,

<h4>Purpose</h4>We examined rates of Grade Group 4 downgrading at radical prostatectomy among men diagnosed with high and very high risk prostate cancer at biopsy.<h4>Materials and methods</h4>A pooled cohort of 1,776 patients from 3 tertiary referral centers who underwent radical prostatectomy for National Comprehensive Cancer Network® high risk (prostate specific antigen ... Read more >>

J Urol (The Journal of urology)
[2020, 204(4):748-753]

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Prostate cancer upgrading or downgrading of biopsy Gleason scores at radical prostatectomy: prediction of "regression to the mean" using routine clinical features with correlating biochemical relapse rates.

Muammer Altok, Patricia Troncoso, Mary F Achim, Surena F Matin, Graciela N Gonzalez, John W Davis,

Recommendations for managing clinically localized prostate cancer are structured around clinical risk criteria, with prostate biopsy (PB) Gleason score (GS) being the most important factor. Biopsy to radical prostatectomy (RP) specimen upgrading/downgrading is well described, and is often the rationale for costly imaging or genomic studies. We present simple, no-cost ... Read more >>

Asian J Androl (Asian journal of andrology)
[2019, 21(6):598-604]

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Prediction of Organ-confined Disease in High- and Very-high-risk Prostate Cancer Patients Staged with Magnetic Resonance Imaging: Implications for Clinical Trial Design.

Chad A Reichard, Janet Kukreja, Justin R Gregg, Tharakeswala K Bathala, Mary F Achim, Xuemei Wang, John W Davis, Quynh-Nhu Nguyen, Brian F Chapin,

<h4>Background</h4>High-risk (HR) prostate cancer (PCa) is a heterogeneous disease leading to difficulties in designing appropriate inclusion criteria for clinical trials.<h4>Objective</h4>To describe clinical predictors of organ-confined disease in HR or very-high-risk (VHR) PCa patients staged with multiparametric magnetic resonance imaging with endorectal coil (mp-MRI-ER).<h4>Design, setting, and participants</h4>We reviewed 366 HR/VHR PCa ... Read more >>

Eur Urol Focus (European urology focus)
[2021, 7(1):71-77]

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Radical prostatectomy or radiotherapy for high- and very high-risk prostate cancer: a multidisciplinary prostate cancer clinic experience of patients eligible for either treatment.

Chad A Reichard, Karen E Hoffman, Chad Tang, Stephen B Williams, Pamela K Allen, Mary F Achim, Deborah A Kuban, Brian F Chapin,

<h4>Objective</h4>To compare radical prostatectomy (RP) vs radiotherapy (RT) with androgen-deprivation therapy (ADT) in the setting of patients with high-risk and very high-risk (VHR) prostate cancer who were deemed eligible for either therapy and made a treatment choice after consultation in a multidisciplinary prostate cancer clinic (MDPCC), and to compare the ... Read more >>

BJU Int (BJU international)
[2019, 124(5):811-819]

Cited: 7 times

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Does time from diagnosis to treatment of high- or very-high-risk prostate cancer affect outcome?

Chad A Reichard, Yaw A Nyame, Debasish Sundi, Jeffrey Tosoian, Lamont Wilkins, Ridwan Alam, Mary F Achim, Xuemei Wang, Andrew J Stephenson, Eric A Klein, Ashley E Ross, John W Davis, Brian F Chapin,

<h4>Objective</h4>To determine whether time from diagnosis to treatment impacted outcomes in a multicentre cohort of high- and very-high-risk (VHR) patients with prostate cancer undergoing radical prostatectomy (RP).<h4>Patients and methods</h4>In all, 1392 patients from three tertiary centres who underwent RP for either high-risk or VHR disease, from 2005 to 2015, were identified. The ... Read more >>

BJU Int (BJU international)
[2019, 124(2):282-289]

Cited: 5 times

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Radical Prostatectomy in Metastatic Castration-resistant Prostate Cancer: Feasibility, Safety, and Quality of Life Outcomes.

Chad A Reichard, Justin R Gregg, Mary F Achim, Ana M Aparicio, Curtis A Pettaway, Louis L Pisters, John F Ward, John W Davis, Brian F Chapin,

Ongoing prospective studies are evaluating treatment of the primary tumor in men with de novo metastatic prostate cancer (PCa). One potential benefit is prevention of morbidity from local progression. Thus, local therapy may be best applied selectively to men with local progression once resistance to first-line therapies has occurred. Here, ... Read more >>

Eur Urol (European urology)
[2018, 74(2):140-143]

Cited: 3 times

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Surgeon-led prostate cancer lymph node staging: pathological outcomes stratified by robot-assisted dissection templates and patient selection.

Muammer Altok, Kara Babaian, Mary F Achim, Grace C Achim, Patricia Troncoso, Surena F Matin, Brian F Chapin, John W Davis,

<h4>Objectives</h4>To evaluate the perioperative, pathological, and oncological outcomes from surgeon-led pathological staging of pelvic lymph node (LN) metastases at the time of robot-assisted radical prostatectomy (RARP).<h4>Patients and methods</h4>Over the 6-year period of 2006-2012, three distinct pelvic LN dissection (PLND) strategies were used in chronological order at a single cancer referral ... Read more >>

BJU Int (BJU international)
[2018, 122(1):66-75]

Cited: 2 times

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Positive margin length and highest Gleason grade of tumor at the margin predict for biochemical recurrence after radical prostatectomy in patients with organ-confined prostate cancer.

Brian F Chapin, Jenny N Nguyen, Mary F Achim, Neema Navai, Stephen B Williams, Ina N Prokhorova, Xuemei Wang, Elsa M Li Ning Tapia, John W Davis, Patricia Troncoso,

BACKGROUND:To evaluate the pathologic features after radical prostatectomy to determine if the length of positive surgical margin (PSM) and the highest Gleason grade within the tumor at the PSM could risk stratify patients for biochemical recurrence (BCR). METHODS:We performed a retrospective, matched, cohort study to identify patients with pathologically organ-confined ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2018, 21(2):221-227]

Cited: 2 times

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A decade of robot-assisted radical prostatectomy training: Time-based metrics and qualitative grading for fellows and residents.

Muammer Altok, Mary F Achim, Surena F Matin, Curtis A Pettaway, Brian F Chapin, John W Davis,

<h4>Objectives</h4>As modern urology residency and fellowship training in robot-assisted surgery evolves toward standardized curricula (didactics, dry/wet-laboratory exercises, and surgical assistance), additional tools are needed to evaluate on-console performance. At the start of our robotics program in 2006, we set-up a time- and quality-based evaluation program and aim to consolidate this ... Read more >>

Urol Oncol (Urologic oncology)
[2018, 36(1):13.e19-13.e25]

Cited: 0 times

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Baseline and longitudinal plasma caveolin-1 level as a biomarker in active surveillance for early-stage prostate cancer.

Spyridon P Basourakos, John W Davis, Brian F Chapin, John F Ward, Curtis A Pettaway, Louis L Pisters, Neema Navai, Mary F Achim, Xuemei Wang, Hsiang-Chun Chen, Seungtaek Choi, Deborah Kuban, Patricia Troncoso, Sam Hanash, Timothy C Thompson, Jeri Kim,

<h4>Objectives</h4>To evaluate the role of caveolin-1 (Cav-1) as a predictor of disease reclassification (DR) in men with early prostate cancer undergoing active surveillance (AS).<h4>Patients and methods</h4>We analysed archived plasma samples prospectively collected from patients with early prostate cancer in a single-institution AS study. Of 825 patients enrolled, 542 had ≥1 ... Read more >>

BJU Int (BJU international)
[2018, 121(1):69-76]

Cited: 5 times

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Neoadjuvant Systemic Therapy Before Radical Prostatectomy in High-Risk Prostate Cancer Does Not Increase Surgical Morbidity: Contemporary Results Using the Clavien System.

Stephen B Williams, John W Davis, Xuemei Wang, Mary F Achim, Amado Zurita-Saavedra, Surena F Matin, Louis L Pisters, John F Ward, Curtis A Pettaway, Brian F Chapin,

<h4>Background</h4>Multimodality therapies for men with high- and very high-risk prostate cancer, including neoadjuvant systemic therapy followed by subsequent radical prostatectomy (RP) are being increasingly explored despite the lack of adequate morbidity data.<h4>Materials and methods</h4>We analyzed the data from 215 consecutive patients with high- and very high-risk prostate cancer who were ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2016, 14(2):130-138]

Cited: 5 times

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