Full Text Journal Articles by
Author Mary E Winn

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Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats.

Kathy Steece-Collier, Timothy J Collier, Jack W Lipton, Jennifer A Stancati, Mary E Winn, Allyson Cole-Strauss, Rhyomi Sellnow, Melissa M Conti, Natosha M Mercado, Eduardo A Nillni, Caryl E Sortwell, Fredric P Manfredsson, Christopher Bishop,

Numerous genes, and alterations in their expression, have been identified as risk factors for developing levodopa-induced dyskinesia (LID). However, our understanding of the complexities of molecular changes remains insufficient for development of clinical treatment. In the current study we used gene array, in situ hybridization, immunohistochemistry, and microdialysis to provide ... Read more >>

Exp. Neurol. (Experimental neurology)
[2020, 330:113327]

Cited: 0 times

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Time-course RNA-seq analysis provides an improved understanding of gene regulation during the formation of nodule-like structures in rice.

Jacklyn Thomas, Ryan Hiltenbrand, Megan J Bowman, Ha Ram Kim, Mary E Winn, Arijit Mukherjee,

KEY MESSAGE:Using a time-course RNA-seq analysis we identified transcriptomic changes during formation of nodule-like structures (NLS) in rice and compared rice RNA-seq dataset with a nodule transcriptome dataset in Medicago truncatula. Plant hormones can induce the formation of nodule-like structures (NLS) in plant roots even in the absence of bacteria. ... Read more >>

Plant Mol. Biol. (Plant molecular biology)
[2020, 103(1-2):113-128]

Cited: 0 times

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Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia.

Erin C McKay, John S Beck, Sok Kean Khoo, Karl J Dykema, Sandra L Cottingham, Mary E Winn, Henry L Paulson, Andrew P Lieberman, Scott E Counts,

Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options to protect cognitive function following cerebrovascular accidents. The purpose of this study was to profile gene expression changes unique to VaD to identify and characterize disease relevant changes that could offer clues ... Read more >>

J. Neuropathol. Exp. Neurol. (Journal of neuropathology and experimental neurology)
[2019, 78(5):436-452]

Cited: 1 time

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Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors.

Jacqueline D Peacock, Matthew G Pridgeon, Elizabeth A Tovar, Curt J Essenburg, Megan Bowman, Zachary Madaj, Julie Koeman, Elissa A Boguslawski, Jamie Grit, Rebecca D Dodd, Vadim Khachaturov, Diana M Cardona, Mark Chen, David G Kirsch, Flavio Maina, Rosanna Dono, Mary E Winn, Carrie R Graveel, Matthew R Steensma,

Malignant peripheral nerve sheath tumors (MPNST) are highly resistant sarcomas that occur in up to 13% of individuals with neurofibromatosis type I (NF1). Genomic analysis of longitudinally collected tumor samples in a case of MPNST disease progression revealed early hemizygous microdeletions in NF1 and TP53, with progressive amplifications of MET, ... Read more >>

Cancer Res. (Cancer research)
[2018, 78(13):3672-3687]

Cited: 2 times

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Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.

Megan M Senchuk, Dylan J Dues, Claire E Schaar, Benjamin K Johnson, Zachary B Madaj, Megan J Bowman, Mary E Winn, Jeremy M Van Raamsdonk,

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (clk-1, isp-1 and nuo-6) to identify overlapping genetic pathways that contribute to their longevity. We find that genes regulated by the FOXO transcription ... Read more >>

PLoS Genet. (PLoS genetics)
[2018, 14(3):e1007268]

Cited: 8 times

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Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.

Randal J Westrick, Kärt Tomberg, Amy E Siebert, Guojing Zhu, Mary E Winn, Sarah L Dobies, Sara L Manning, Marisa A Brake, Audrey C Cleuren, Linzi M Hobbs, Lena M Mishack, Alexander J Johnston, Emilee Kotnik, David R Siemieniak, Jishu Xu, Jun Z Li, Thomas L Saunders, David Ginsburg,

Factor V Leiden (F5L ) is a common genetic risk factor for venous thromboembolism in humans. We conducted a sensitized N-ethyl-N-nitrosourea (ENU) mutagenesis screen for dominant thrombosuppressor genes based on perinatal lethal thrombosis in mice homozygous for F5L (F5L/L ) and haploinsufficient for tissue factor pathway inhibitor (Tfpi+/- ). F8 ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2017, 114(36):9659-9664]

Cited: 3 times

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The genomic landscape of tuberous sclerosis complex.

Katie R Martin, Wanding Zhou, Megan J Bowman, Juliann Shih, Kit Sing Au, Kristin E Dittenhafer-Reed, Kellie A Sisson, Julie Koeman, Daniel J Weisenberger, Sandra L Cottingham, Steven T DeRoos, Orrin Devinsky, Mary E Winn, Andrew D Cherniack, Hui Shen, Hope Northrup, Darcy A Krueger, Jeffrey P MacKeigan,

Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem growth of benign tumours and other hamartomatous lesions, which leads to diverse and debilitating clinical symptoms. Patients are born with TSC1 or TSC2 mutations, and somatic inactivation of wild-type alleles drives MTOR activation; however, second hits to TSC1/TSC2 are ... Read more >>

Nat Commun (Nature communications)
[2017, 8:15816]

Cited: 25 times

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Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans.

Dylan J Dues, Claire E Schaar, Benjamin K Johnson, Megan J Bowman, Mary E Winn, Megan M Senchuk, Jeremy M Van Raamsdonk,

Mutations affecting components of the mitochondrial electron transport chain have been shown to increase lifespan in multiple species including the worm Caenorhabditis elegans. While it was originally proposed that decreased generation of reactive oxygen species (ROS) resulting from lower rates of electron transport could account for the observed increase in ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2017, 108:362-373]

Cited: 10 times

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A Developmental and Molecular View of Formation of Auxin-Induced Nodule-Like Structures in Land Plants.

Ryan Hiltenbrand, Jacklyn Thomas, Hannah McCarthy, Karl J Dykema, Ashley Spurr, Hamilton Newhart, Mary E Winn, Arijit Mukherjee,

Several studies have shown that plant hormones play important roles during legume-rhizobia symbiosis. For instance, auxins induce the formation of nodule-like structures (NLSs) on legume roots in the absence of rhizobia. Furthermore, these NLS can be colonized by nitrogen-fixing bacteria, which favor nitrogen fixation compared to regular roots and subsequently ... Read more >>

Front Plant Sci (Frontiers in Plant Science)
[2016, 7:1692]

Cited: 6 times

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18F-FLT Positron Emission Tomography (PET) is a Pharmacodynamic Marker for EWS-FLI1 Activity and Ewing Sarcoma.

Christy L Osgood, Mohammed N Tantawy, Nichole Maloney, Zachary B Madaj, Anderson Peck, Elissa Boguslawski, Jennifer Jess, Jason Buck, Mary E Winn, H Charles Manning, Patrick J Grohar,

Ewing sarcoma is a bone and soft-tissue tumor that depends on the activity of the EWS-FLI1 transcription factor for cell survival. Although a number of compounds have been shown to inhibit EWS-FLI1 in vitro, a clinical EWS-FLI1-directed therapy has not been achieved. One problem plaguing drug development efforts is the ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:33926]

Cited: 6 times

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Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers.

Erik S Linklater, Elizabeth A Tovar, Curt J Essenburg, Lisa Turner, Zachary Madaj, Mary E Winn, Marianne K Melnik, Hasan Korkaya, Christiane R Maroun, James G Christensen, Matthew R Steensma, Julie L Boerner, Carrie R Graveel,

There is a vital need for improved therapeutic strategies that are effective in both primary and metastatic triple-negative breast cancer (TNBC). Current treatment options for TNBC patients are restricted to chemotherapy; however tyrosine kinases are promising druggable targets due to their high expression in multiple TNBC subtypes. Since coexpression of ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(43):69903-69915]

Cited: 19 times

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Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus.

Matt L Harlow, Nichole Maloney, Joseph Roland, Maria Jose Guillen Navarro, Matthew K Easton, Susan M Kitchen-Goosen, Elissa A Boguslawski, Zachary B Madaj, Ben K Johnson, Megan J Bowman, Maurizio D'Incalci, Mary E Winn, Lisa Turner, Galen Hostetter, Carlos María Galmarini, Pablo M Aviles, Patrick J Grohar,

There is a great need to develop novel approaches to target oncogenic transcription factors with small molecules. Ewing sarcoma is emblematic of this need, as it depends on the continued activity of the EWS-FLI1 transcription factor to maintain the malignant phenotype. We have previously shown that the small molecule trabectedin ... Read more >>

Cancer Res. (Cancer research)
[2016, 76(22):6657-6668]

Cited: 13 times

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High type I error and misrepresentations in search for transgenerational epigenetic inheritance: response to Guerrero-Bosagna.

Khursheed Iqbal, Diana A Tran, Arthur X Li, Charles Warden, Angela Y Bai, Purnima Singh, Zach B Madaj, Mary E Winn, Xiwei Wu, Gerd P Pfeifer, Piroska E Szabó,

In a recent paper, we described our efforts in search for evidence supporting epigenetic transgenerational inheritance caused by endocrine disrupter chemicals. One aspect of our study was to compare genome-wide DNA methylation changes in the vinclozolin-exposed fetal male germ cells (n = 3) to control samples (n = 3), their counterparts in the next, ... Read more >>

Genome Biol. (Genome biology)
[2016, 17(1):154]

Cited: 0 times

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Miz1, a Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation.

Penny L Berger, Mary E Winn, Cindy K Miranti,

BACKGROUND:How prostate epithelial cells differentiate and how dysregulation of this process contributes to prostate tumorigenesis remain unclear. We recently identified a Myc target and chromatin reader protein, ING4, as a necessary component of human prostate luminal epithelial cell differentiation, which is often lost in primary prostate tumors. Furthermore, loss of ... Read more >>

Prostate (The Prostate)
[2017, 77(1):49-59]

Cited: 3 times

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Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor.

Christy L Osgood, Nichole Maloney, Christopher G Kidd, Susan Kitchen-Goosen, Laura Segars, Meti Gebregiorgis, Girma M Woldemichael, Min He, Savita Sankar, Stephen L Lessnick, Min Kang, Malcolm Smith, Lisa Turner, Zachary B Madaj, Mary E Winn, Luz-Elena Núñez, Javier González-Sabín, Lee J Helman, Francisco Morís, Patrick J Grohar,

PURPOSE:The goal of this study was to identify second-generation mithramycin analogues that better target the EWS-FLI1 transcription factor for Ewing sarcoma. We previously established mithramycin as an EWS-FLI1 inhibitor, but the compound's toxicity prevented its use at effective concentrations in patients. EXPERIMENTAL DESIGN:We screened a panel of mithralogs to establish ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2016, 22(16):4105-4118]

Cited: 20 times

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Cabozantinib (XL184) Inhibits Growth and Invasion of Preclinical TNBC Models.

Mansoureh Sameni, Elizabeth A Tovar, Curt J Essenburg, Anita Chalasani, Erik S Linklater, Andrew Borgman, David M Cherba, Arulselvi Anbalagan, Mary E Winn, Carrie R Graveel, Bonnie F Sloane,

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that is associated with poor clinical outcome. There is a vital need for effective targeted therapeutics for TNBC patients, yet treatment strategies are challenged by the significant intertumoral heterogeneity within the TNBC subtype and its surrounding microenvironment. Receptor tyrosine kinases ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2016, 22(4):923-934]

Cited: 16 times

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Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations.

Jacqueline D Peacock, Karl J Dykema, Helga V Toriello, Marie R Mooney, Donald J Scholten, Mary E Winn, Andrew Borgman, Nicholas S Duesbery, Nicholas S Duesbery, Judith A Hiemenga, Cong Liu, Stacey Campbell, Brian P Nickoloff, Bart O Williams, Matthew Steensma,

Oculoectodermal syndrome (OES) is a rare disease characterized by a combination of congenital scalp lesions and ocular dermoids, with additional manifestations including non-ossifying fibromas and giant cell granulomas of the jaw occurring during the first decade of life. To identify the genetic etiology of OES, we conducted whole-genome sequencing of ... Read more >>

Am. J. Med. Genet. A (American journal of medical genetics. Part A)
[2015, 167(7):1429-1435]

Cited: 9 times

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The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes.

Nicholas M Kanaan, Timothy J Collier, Allyson Cole-Strauss, Tessa Grabinski, Zachary R Mattingly, Mary E Winn, Kathy Steece-Collier, Caryl E Sortwell, Fredric P Manfredsson, Jack W Lipton,

We hypothesized that the study of gene expression at 1, 2, 4, 6 and 16 weeks in the substantia nigra (SN) after intrastriatal 6-OHDA in the Sprague-Dawley rat (rattus norvegicus) would identify cellular responses during the degenerative process that could be axoprotective. Specifically, we hypothesized that genes expressed within the ... Read more >>

PLoS ONE (PloS one)
[2015, 10(5):e0127768]

Cited: 9 times

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Anoikis-resistant subpopulations of human osteosarcoma display significant chemoresistance and are sensitive to targeted epigenetic therapies predicted by expression profiling.

Jessica M Foley, Donald J Scholten, Noel R Monks, David Cherba, David J Monsma, Paula Davidson, Dawna Dylewski, Karl Dykema, Mary E Winn, Matthew R Steensma,

BACKGROUND: Osteosarcoma (OS) is the most common type of solid bone cancer, with latent metastasis being a typical mode of disease progression and a major contributor to poor prognosis. For this to occur, cells must resist anoikis and be able to recapitulate tumorigenesis in a foreign microenvironment. Finding novel approaches ... Read more >>

J Transl Med (Journal of translational medicine)
[2015, 13:110]

Cited: 5 times

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Melanoma patient derived xenografts acquire distinct Vemurafenib resistance mechanisms.

David J Monsma, David M Cherba, Emily E Eugster, Dawna L Dylewski, Paula T Davidson, Chelsea A Peterson, Andrew S Borgman, Mary E Winn, Karl J Dykema, Craig P Webb, Jeffrey P MacKeigan, Nicholas S Duesbery, Brian J Nickoloff, Noel R Monks,

Variable clinical responses, tumor heterogeneity, and drug resistance reduce long-term survival outcomes for metastatic melanoma patients. To guide and accelerate drug development, we characterized tumor responses for five melanoma patient derived xenograft models treated with Vemurafenib. Three BRAF(V600E) models showed acquired drug resistance, one BRAF(V600E) model had a complete and ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2015, 5(4):1507-1518]

Cited: 13 times

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Stromal expression of miR-21 identifies high-risk group in triple-negative breast cancer.

Todd A MacKenzie, Gary N Schwartz, Heather M Calderone, Carrie R Graveel, Mary E Winn, Galen Hostetter, Wendy A Wells, Lorenzo F Sempere,

Triple-negative breast cancer (TNBC) is an aggressive subtype defined by the lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. Expression of miR-21, an oncomiR, is frequently altered and may be distinctly expressed in the tumor stroma. Because tumor lesions are a complex mixture of ... Read more >>

Am. J. Pathol. (The American journal of pathology)
[2014, 184(12):3217-3225]

Cited: 21 times

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A blood-based gene expression test for obstructive coronary artery disease tested in symptomatic nondiabetic patients referred for myocardial perfusion imaging the COMPASS study.

Gregory S Thomas, Szilard Voros, John A McPherson, Alexandra J Lansky, Mary E Winn, Timothy M Bateman, Michael R Elashoff, Hsiao D Lieu, Andrea M Johnson, Susan E Daniels, Joseph A Ladapo, Charles E Phelps, Pamela S Douglas, Steven Rosenberg,

BACKGROUND- Obstructive coronary artery disease diagnosis in symptomatic patients often involves noninvasive testing before invasive coronary angiography. A blood-based gene expression score (GES) was previously validated in nondiabetic patients referred for invasive coronary angiography but not in symptomatic patients referred for myocardial perfusion imaging (MPI). METHODS AND RESULTS- This prospective, ... Read more >>

Circ Cardiovasc Genet (Circulation. Cardiovascular genetics)
[2013, 6(2):154-162]

Cited: 41 times

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Preprocessing and Quality Control Strategies for Illumina DASL Assay-Based Brain Gene Expression Studies with Semi-Degraded Samples.

Maggie L Chow, Mary E Winn, Hai-Ri Li, Craig April, Anthony Wynshaw-Boris, Jian-Bing Fan, Xiang-Dong Fu, Eric Courchesne, Nicholas J Schork,

Available statistical preprocessing or quality control analysis tools for gene expression microarray datasets are known to greatly affect downstream data analysis, especially when degraded samples, unique tissue samples, or novel expression assays are used. It is therefore important to assess the validity and impact of the assumptions built in to ... Read more >>

Front Genet (Frontiers in genetics)
[2012, 3:11]

Cited: 11 times

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Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages.

Maggie L Chow, Tiziano Pramparo, Mary E Winn, Cynthia Carter Barnes, Hai-Ri Li, Lauren Weiss, Jian-Bing Fan, Sarah Murray, Craig April, Haim Belinson, Xiang-Dong Fu, Anthony Wynshaw-Boris, Nicholas J Schork, Eric Courchesne,

Autism is a highly heritable neurodevelopmental disorder, yet the genetic underpinnings of the disorder are largely unknown. Aberrant brain overgrowth is a well-replicated observation in the autism literature; but association, linkage, and expression studies have not identified genetic factors that explain this trajectory. Few studies have had sufficient statistical power ... Read more >>

PLoS Genet. (PLoS genetics)
[2012, 8(3):e1002592]

Cited: 94 times

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Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples.

Maggie L Chow, Hai-Ri Li, Mary E Winn, Craig April, Cynthia C Barnes, Anthony Wynshaw-Boris, Jian-Bing Fan, Xiang-Dong Fu, Eric Courchesne, Nicholas J Schork,

Gene expression assays have been shown to yield high quality genome-wide data from partially degraded RNA samples. However, these methods have not yet been applied to postmortem human brain tissue, despite their potential to overcome poor RNA quality and other technical limitations inherent in many assays. We compared cDNA-mediated annealing, ... Read more >>

BMC Genomics (BMC genomics)
[2011, 12:449]

Cited: 3 times

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