Full Text Journal Articles by
Author Mary E Stemper

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Phylogenetic distribution and expression of a penicillin-binding protein homologue, Ear and its significance in virulence of Staphylococcus aureus.

Vineet K Singh, Robert P Ring, Vijay Aswani, Mary E Stemper, Jennifer Kislow, Zhan Ye, Sanjay K Shukla,

<h4>Purpose</h4>Staphylococcus aureus is an opportunistic human pathogen that can cause serious infections in humans. A plethora of known and putative virulence factors are produced by staphylococci that collectively orchestrate pathogenesis. Ear protein (Escherichia coli ampicillin resistance) in S. aureus is an exoprotein in COL strain, predicted to be a superantigen, ... Read more >>

J Med Microbiol (Journal of medical microbiology)
[2017, 66(12):1811-1821]

Cited: 2 times

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Docking into Mycobacterium tuberculosis Thioredoxin Reductase Protein Yields Pyrazolone Lead Molecules for Methicillin-Resistant Staphylococcus aureus.

Noreena L Sweeney, Lauren Lipker, Alicia M Hanson, Chris J Bohl, Katie E Engel, Kelsey S Kalous, Mary E Stemper, Daniel S Sem, William R Schwan,

The thioredoxin/thioredoxin reductase system (Trx/TrxR) is an attractive drug target because of its involvement in a number of important physiological processes, from DNA synthesis to regulating signal transduction. This study describes the finding of pyrazolone compounds that are active against <i>Staphylococcus aureus</i>. Initially, the project was focused on discovering small ... Read more >>

Antibiotics (Basel) (Antibiotics (Basel, Switzerland))
[2017, 6(1):]

Cited: 1 time

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Clinical characteristics and epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in children with cystic fibrosis from a center with a high MRSA prevalence.

Nada S Harik, Gulnur Com, Xinyu Tang, Maria Melguizo Castro, Mary E Stemper, John L Carroll,

<h4>Background</h4>We describe the clinical characteristics and epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in children with cystic fibrosis (CF) from the U.S. CF center with the highest MRSA prevalence.<h4>Methods</h4>Medical records of children with CF were retrospectively reviewed from 1997-2009. MRSA clinical isolates from 2007-2009 were analyzed by polymerase chain reaction and ... Read more >>

Am J Infect Control (American journal of infection control)
[2016, 44(4):409-415]

Cited: 9 times

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An investigation of antibiotic susceptibility to empiric therapy for community-associated methicillin-resistant Staphylococcus aureus.

Kami Harless, Gwen Borlaug, Timothy A Monson, Mary E Stemper, Jeffrey P Davis, Ann E Abing, Jared F Shelerud,

<h4>Objective</h4>To analyze antibiotic susceptibility patterns of community-associated methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained from skin and soft tissue infections among Wisconsin outpatients.<h4>Design</h4>Retrospective genotype testing.<h4>Setting</h4>Isolates were forwarded to the Wisconsin State Laboratory of Hygiene and Marshfield Labs from clinical laboratories throughout Wisconsin.<h4>Methods</h4>MRSA isolates submitted during April, 2010-February, 2012 underwent genotype analysis ... Read more >>

WMJ (WMJ : official publication of the State Medical Society of Wisconsin)
[2014, 113(2):59-63]

Cited: 0 times

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Comparative whole-genome mapping to determine Staphylococcus aureus genome size, virulence motifs, and clonality.

Sanjay K Shukla, Madhulatha Pantrangi, Buffy Stahl, Adam M Briska, Mary E Stemper, Trevor K Wagner, Emily B Zentz, Steven M Callister, Steven D Lovrich, John K Henkhaus, Colin W Dykes,

Despite being a clonal pathogen, Staphylococcus aureus continues to acquire virulence and antibiotic-resistant genes located on mobile genetic elements such as genomic islands, prophages, pathogenicity islands, and the staphylococcal chromosomal cassette mec (SCCmec) by horizontal gene transfer from other staphylococci. The potential virulence of a S. aureus strain is often ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2012, 50(11):3526-3533]

Cited: 15 times

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Genetic characterization of antimicrobial resistance in Salmonella enterica serovars isolated from dairy cattle in Wisconsin

Roberto Marrero-Ortiz, Jing Han, Aaron M Lynne, Donna E David, Mary E Stemper, Doris Farmer, William III Burkhardt, Rajesh Nayak, Steven L Foley,

Salmonella enterica is a pathogen of humans and animals, and is one of the most frequent causes of bacterial foodborne illness worldwide. People consuming contaminated foods or working with infected livestock have the potential to become infected with Salmonella and may require antimicrobial therapy. Antimicrobial resistance in Salmonella has become ... Read more >>

Food Res Int (Food research international (Ottawa, Ont.))
[2012, 45(2):962-967]

Cited: 9 times

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Native valve endocarditis due to a novel strain of Legionella.

Meghan M Pearce, Nicole Theodoropoulos, Gary A Noskin, John P Flaherty, Mary E Stemper, Teresa Aspeslet, Nicholas P Cianciotto, Kurt D Reed,

Legionellae are Gram-negative bacteria which are capable of causing disease, most commonly in the form of pneumonia. We describe a case of native valve endocarditis caused by a Legionella strain which by genotypic (16S rRNA and mip gene sequencing) and phenotypic analyses is unlike previously described strains of Legionella. ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2011, 49(9):3340-3342]

Cited: 8 times

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Evidence of multiple virulence subtypes in nosocomial and community-associated MRSA genotypes in companion animals from the upper midwestern and northeastern United States.

Yihan Lin, Emily Barker, Jennifer Kislow, Pravin Kaldhone, Mary E Stemper, Madhulatha Pantrangi, Frances M Moore, Matthew Hall, Thomas R Fritsche, Thomas Novicki, Steven L Foley, Sanjay K Shukla,

<h4>Objective</h4>Not much is known about the zoonotic transmission of methicillin-resistant Staphylococcus aureus (MRSA) in companion animals in the United States. We report the rate of prevalence of S. aureus and MRSA recovered from clinical samples of animals requiring treatment at veterinary clinics throughout the upper midwestern and northeastern United States.<h4>Design</h4>We ... Read more >>

Clin Med Res (Clinical medicine & research)
[2011, 9(1):7-16]

Cited: 40 times

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Virulence genes and genotypic associations in nasal carriage, community-associated methicillin-susceptible and methicillin-resistant USA400 Staphylococcus aureus isolates.

Sanjay K Shukla, Mary E Karow, Jennifer M Brady, Mary E Stemper, Jennifer Kislow, Natalie Moore, Katherine Wroblewski, Po-Huang Chyou, David M Warshauer, Kurt D Reed, Ruth Lynfield, William R Schwan,

It is not well understood why strains of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), a major cause of skin and soft tissue infections, became successful so quickly, overtaking the place of methicillin-sensitive S. aureus (MSSA) in many communities. To evaluate the genetic basis of differences in their virulence traits, 293 S. ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2010, 48(10):3582-3592]

Cited: 48 times

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Distribution of virulence factors and molecular fingerprinting of Aeromonas species isolates from water and clinical samples: suggestive evidence of water-to-human transmission.

Bijay K Khajanchi, Amin A Fadl, Mark A Borchardt, Richard L Berg, Amy J Horneman, Mary E Stemper, Sam W Joseph, Nelson P Moyer, Jian Sha, Ashok K Chopra,

A total of 227 isolates of Aeromonas obtained from different geographical locations in the United States and different parts of the world, including 28 reference strains, were analyzed to determine the presence of various virulence factors. These isolates were also fingerprinted using biochemical identification and pulse-field gel electrophoresis (PFGE). Of ... Read more >>

Appl Environ Microbiol (Applied and environmental microbiology)
[2010, 76(7):2313-2325]

Cited: 70 times

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New classes of Gram-positive selective antibacterials: inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis.

M Shahjahan Kabir, Kathleen Engelbrecht, Rebecca Polanowski, Sarah M Krueger, Rachel Ignasiak, Marc Rott, William R Schwan, Mary E Stemper, Kurt D Reed, David Sherman, James M Cook, Aaron Monte,

An antimicrobial phenolic stilbene, (E)-3-hydroxy-5-methoxystilbene, 1 was recently isolated from the leaves of Comptonia peregrina (L.) Coulter and shown to possess inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillusanthracis (Sterne strain), among others. These results prompted the design and ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2008, 18(21):5745-5749]

Cited: 11 times

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Fatal brain abscess due to community-associated methicillin-resistant Staphylococcus aureus strain USA300.

Costi D Sifri, Jennifer Park, Gregory A Helm, Mary E Stemper, Sanjay K Shukla,

We report a fatal case of brain abscess caused by infection due to a community-associated methicillin-resistant Staphylococcus aureus strain (USA300) in a 37-year-old incarcerated woman with a history of furunculosis and injection drug use. Community-onset pyogenic brain abscess should be added to the growing list of life-threatening invasive infections caused ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2007, 45(9):e113-7]

Cited: 30 times

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Sporadic "transitional" community-associated methicillin-resistant Staphylococcus aureus strains from health care facilities in the United States.

Jennifer M Brady, Mary E Stemper, Ashley Weigel, Po-Huang Chyou, Kurt D Reed, Sanjay K Shukla,

We describe phenotypic and genotypic traits of a group of methicillin-resistant Staphylococcus aureus (MRSA) clones that are either remnants of unsuccessful community-associated MRSA (CA-MRSA) clones or represent a transitional state with some yet-to-be-acquired characteristics of CA-MRSA. These rare strains (n = 20) were identified during a 10-year period (1990-1999) from ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2007, 45(8):2654-2661]

Cited: 16 times

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Pulsed-field gel electrophoresis of MRSA.

Kurt D Reed, Mary E Stemper, Sanjay K Shukla,

Pulsed-field gel electrophoresis (PFGE) is a genetic typing method that is widely used as a molecular epidemiological tool for studying the genetic diversity of Staphylococcus aureus and numerous other bacterial pathogens. For PFGE, intact bacterial cells are embedded in soft agarose plugs followed by lysis of the cell wall in ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2007, 391:59-69]

Cited: 5 times

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MRSA case studies.

Kurt D Reed, Mary E Stemper, Sanjay K Shukla,

Staphylococcus aureus is a versatile pathogen associated with diverse clinical presentations. Only recently have the genetic factors underlying the virulence of this bacterial species become understood in a significant way. Methicillin-resistant S. aureus (MRSA) strains have been extremely important as nosocomial pathogens in health care facilities for more than three ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2007, 391:21-28]

Cited: 0 times

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Significant pathogens isolated from surgical site infections at a community hospital in the Midwest.

Carol A Cantlon, Mary E Stemper, William R Schwan, Michael A Hoffman, Salah S Qutaishat,

<h4>Background</h4>Studies examining the incidence of microorganisms isolated from surgical site infections (SSIs) have been conducted primarily at large academic health care centers. Results from these studies have revealed that methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a significant pathogen in SSIs. Minimal data are available from smaller, community hospitals on ... Read more >>

Am J Infect Control (American journal of infection control)
[2006, 34(8):526-529]

Cited: 18 times

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Necrotizing fasciitis due to a methicillin-sensitive Staphylococcus aureus isolate harboring an enterotoxin gene cluster.

William R Morgan, Michael D Caldwell, Jennifer M Brady, Mary E Stemper, Kurt D Reed, Sanjay K Shukla,

Benign papular eruption on the left leg of a 72-year-old diabetic man developed into rapidly spreading necrotizing fasciitis despite antimicrobial therapy and surgical debridements. This led to eventual amputation to control the infection. The etiological agent was a Staphylococcus aureus isolate harboring the enterotoxin gene cluster seg, sei, sem, sen, ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2007, 45(2):668-671]

Cited: 16 times

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Shift in Staphylococcus aureus clone linked to an infected tattoo.

Mary E Stemper, Jennifer M Brady, Salah S Qutaishat, Gwen Borlaug, James Reed, Kurt D Reed, Sanjay K Shukla,

A retrospective investigation of skin and soft tissue infections caused by community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains among inmates in a Wisconsin correctional facility suggested a shift in MRSA genotype. Case timeline indicated a displacement of USA400 clone by USA300 clone. The USA300 index case was associated with an infected ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2006, 12(9):1444-1446]

Cited: 18 times

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Novel polymorphisms in mec genes and a new mec complex type in methicillin-resistant Staphylococcus aureus isolates obtained in rural Wisconsin.

Sanjay K Shukla, Srinivas V Ramaswamy, Jennifer Conradt, Mary E Stemper, Robert Reich, Kurt D Reed, Edward A Graviss,

We determined allelic polymorphisms in the mec complexes of 524 methicillin-resistant Staphylococcus aureus isolates by partial or complete sequencing of three mec genes, mecA, mecI, and mecR1. The isolates had been collected over a 10-year period from patients living in rural Wisconsin, where the use of antibiotics was expected to ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2004, 48(8):3080-3085]

Cited: 16 times

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Emergence and spread of community-associated methicillin-resistant Staphylococcus aureus in rural Wisconsin, 1989 to 1999.

Mary E Stemper, Sanjay K Shukla, Kurt D Reed,

We investigated the emergence and spread of community-associated strains of methicillin-resistant Staphylococcus aureus (CA-MRSA) in central and northern Wisconsin by determining the temporal and clonal relationships and geographic expansion among 581 of 956 clinical isolates of MRSA collected between 1989 and 1999. Based on EcoRI plasmid profiles (PP), two types, ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2004, 42(12):5673-5680]

Cited: 38 times

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Clustering of multiple endemic strains of methicillin-resistant Staphylococcus aureus in a nursing home: an 8-year study.

Paul J Drinka, Mary E Stemper, Cathy D Gauerke, Janice E Miller, Brian M Goodman, Kurt D Reed,

PFGE was performed on residents' first clinical MRSA isolate (n=94) during 8 years. Sixty-one percent of the isolates were clustered in time (P < .05) and space (P < .05) (i.e., 2 separate statistically significant tests). Isolates from individual units were genetically related, with only the occasional unrelated isolate. ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2005, 26(2):215-218]

Cited: 13 times

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Molecular characteristics of nosocomial and Native American community-associated methicillin-resistant Staphylococcus aureus clones from rural Wisconsin.

Sanjay K Shukla, Mary E Stemper, Srinivas V Ramaswamy, Jennifer M Conradt, Robert Reich, Edward A Graviss, Kurt D Reed,

In central and northern Wisconsin methicillin-resistant Staphylococcus aureus (MRSA) was first detected in 1989. Over the next 10-year period, 581 MRSA isolates were collected, 17.2% of which came from patients who were treated at five Native American clinics. These isolates were typed by SmaI-macrorestricted pulsed-field gel electrophoresis (PFGE). The PFGE ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2004, 42(8):3752-3757]

Cited: 36 times

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The identification of genetically related bacterial isolates using pulsed field gel electrophoresis on nursing home units: a clinical experience.

Paul J Drinka, Mary E Stemper, Cathy D Gauerke, Janice M Miller, Kurt D Reed,

<h4>Objectives</h4>To describe a laboratory-based technique to track nursing home infections.<h4>Design</h4>Retrospective data analysis.<h4>Setting</h4>A 721-bed skilled care facility with 14 nursing units.<h4>Participants</h4>Residents in a nursing home, average age 76+/-10, 78% male.<h4>Measurements</h4>Bacterial isolates were listed for each nursing unit. Clusters of identical species and antibiotic susceptibility were identified followed by pulsed-field gel electrophoresis ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2004, 52(8):1373-1377]

Cited: 4 times

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Is methicillin-resistant Staphylococcus aureus more contagious than methicillin-susceptible S. aureus in a surgical intensive care unit?

Paul J Drinka, Mary E Stemper, Cathy D Gauerke, Janice M Miller, Kurt D Reed,

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2004, 25(5):363-364]

Cited: 2 times

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Screening for methicillin-resistant Staphylococcus aureus in a nursing home.

Paul J Drinka, Mary E Stemper, Cathy D Gauerke, Janice E Miller, Kurt D Reed,

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2004, 25(2):95-96]

Cited: 4 times

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