Full Text Journal Articles by
Author Marwa M Abu Serie

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Acacia senegal gum attenuates systemic toxicity in CCl4-intoxicated rats via regulation of the ROS/NF-κB signaling pathway.

Marwa M Abu-Serie, Asmaa F Hamouda, Noha H Habashy,

Acacia senegal (AS) gum (Gum Arabic) is a natural emulsifier exudate from the branches and trunk of Acacia trees and it is recognized by the Food and Drug Administration (FDA) agency as a secure dietary fiber. The present research evaluated the systemic oxidative and necroinflammatory stress induced by CCl<sub>4</sub> administration ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):20316]

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Diethyldithiocarbamate/silk fibroin/polyethylene oxide nanofibrous for cancer therapy: Fabrication, characterization and in vitro evaluation.

Gomaa El Fawal, Marwa M Abu-Serie, Xiumei Mo, Hongsheng Wang,

Cancer has become a serious disease threatening human health. To tackle this issue, developing the existing potent anticancer drugs is critical to reducing the time and cost associated with creating a new drug from scratch. Diethyldithiocarbamate (DDC) - an anticancer drug- has received considerable attention due to its selectivity and ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 193(Pt A):293-299]

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Novel scaffold based graphene oxide doped electrospun iota carrageenan/polyvinyl alcohol for wound healing and pathogen reduction: in-vitro and in-vivo study.

Marwa H Gouda, Safaa M Ali, Sarah Samir Othman, Samia A Abd Al-Aziz, Marwa M Abu-Serie, Noha A Elsokary, Noha A Elessawy,

Wound healing is a complicated multicellular process that involves several kinds of cells including macrophages, fibroblasts, endothelial cells, keratinocytes and platelets that are leading to their differentiation towards an anti-inflammatory response for producing several chemokines, cytokine and growth factors. In this study, electrospun nanofiber scaffold named (MNS) is composed of ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):20456]

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Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators.

Gehad Lotfy, Yasmine M Abdel Aziz, Mohamed M Said, El Sayed H El Ashry, El Sayed H El Tamany, Marwa M Abu-Serie, Mohamed Teleb, Alexander Dömling, Assem Barakat,

Despite the achieved progress in developing efficient MDM2-p53 protein-protein interaction inhibitors (MDM2 inhibitors), the acquired resistance of tumor cells to such p53 activators posed an argument about the druggability of the pathway. Combination studies disclosed that concomitant inhibition of MDM2 and BCL2 functions can sensitize the tumor cells and synergistically ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2021, 117:105427]

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Novel nanoformulated diethyldithiocarbamate complexes with biosynthesized or green chemosynthesized copper oxide nanoparticles: An in vitro comparative anticancer study.

Marwa M Abu-Serie, Marwa Eltarahony,

Developing more soluble and stable nanoformulation for the potent anticancer complex of copper diethyldithiocarbamate (CD) is extremely desired. Herein, for the first time, CD nanoparticles (NPs) were formulated by chelating diethyldithiocarbamate to bacterially and green chemically prepared copper oxide NPs (Bio CO NPs and Chemo CO NPs, respectively). Chemo CO ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2021, 609:121149]

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Halting Tumor Progression via Novel Non-Hydroxamate Triazole-Based Mannich Bases MMP-2/9 Inhibitors; Design, Microwave-Assisted Synthesis, and Biological Evaluation.

Fawzia Faleh Albelwi, Mohamed Teleb, Marwa M Abu-Serie, Mohamed Nabil Abd Al Moaty, Mai S Alsubaie, Mohamed A Zakaria, Yeldez El Kilany, Mohamed Reda Aouad, Mohamed Hagar, Nadjet Rezki,

Matrix metalloproteinases (MMPs) are key signaling modulators in the tumor microenvironment. Among MMPs, MMP-2 and MMP-9 are receiving renewed interest as validated druggable targets for halting different tumor progression events. Over the last decades, a diverse range of MMP-2/9 inhibitors has been identified starting from the early hydroxamic acid-based peptidomimetics ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(19):]

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Engineered s-Triazine-Based Dendrimer-Honokiol Conjugates as Targeted MMP-2/9 Inhibitors for Halting Hepatocellular Carcinoma.

Hosam H Khalil, Heba A Osman, Mohamed Teleb, A I Darwish, Marwa M Abu-Serie, Sherine N Khattab, Nesreen S Haiba,

Despite the advances in developing MMP-2/9 inhibitors, off-target side effects and pharmacokinetics problems remain major challenges hindering their clinical success in cancer therapy. However, recent targeting strategies have clearly revitalized MMP research. Herein, we introduce new s-triazine-based dendrimers endowed with intrinsic MMP-2/9 inhibitory potential and tetherable to hepatocellular carcinoma-specific targeting ... Read more >>

ChemMedChem (ChemMedChem)
[2021, :]

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Targeting ROS/NF-κB sigaling pathway by the seedless black Vitis vinifera polyphenols in CCl4-intoxicated kidney, lung, brain, and spleen in rats.

Noha H Habashy, Ahmad S Kodous, Marwa M Abu-Serie,

Carbon tetrachloride (CCl<sub>4</sub>) is an abundant environmental pollutant that can generate free radicals and induce oxidative stress in different human and animal organs like the kidney, lung, brain, and spleen, causing toxicity. The present study evaluated the alleviative mechanism of the isolated polyphenolic fraction from seedless (pulp and skin) black ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):16575]

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Structural optimization, synthesis and in vitro synergistic anticancer activities of combinations of new N3-substituted dihydropyrimidine calcium channel blockers with cisplatin and etoposide.

Marwa H El-Wakil, Mohamed Teleb, Marwa M Abu-Serie, Sun Huang, Gerald W Zamponi, Hesham Fahmy,

T-type calcium channels are considered potential drug targets to combat cancer. Combining T-type calcium channel blockers with conventional chemotherapy drugs represents a promising strategy towards successful cancer treatment. From this perspective, we report in this study the design and synthesis of a novel series of N3-sustituted dihydropyrimidines (DHPMs) as anticancer ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2021, 115:105262]

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Vitamin D3/phospholipid complex decorated caseinate nanomicelles for targeted delivery of synergistic combination therapy in breast cancer.

Mona M Agwa, Marwa M Abu-Serie, Doaa A Abdelmonsif, Nermine Moussa, Hassan Elsayed, Sherine N Khattab, Sally Sabra,

Targeted delivery of cytotoxic drugs has shown great potential in cancer therapy. In this light, vitamin D3 (vit.D3)-coated micelles were fabricated to encapsulate the cytotoxic drug; etoposide (ETP). Sodium caseinate micelles were first utilized to encapsulate vit.D3 and ETP within their hydrophobic core, then drug-loaded micelles were further decorated with ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2021, 607:120965]

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Discovery of small molecule acting as multitarget inhibitor of colorectal cancer by simultaneous blocking of the key COX-2, 5-LOX and PIM-1 kinase enzymes.

Mostafa M M El-Miligy, Ahmed K Al-Kubeisi, Saad R El-Zemity, Rasha A Nassra, Marwa M Abu-Serie, Aly A Hazzaa,

Colorectal cancer (CRC) is the second cause of cancer death worldwide. Inhibitors of COX-2, 5-LOX and PIM-1 kinase were very effective in the treatment and prevention of CRC in mouse models in vivo. Furthermore, thymol was confirmed to inhibit CRC cell proliferation in cancer cell lines and inhibitory activity against ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2021, 115:105171]

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Halting colorectal cancer metastasis via novel dual nanomolar MMP-9/MAO-A quinoxaline-based inhibitors; design, synthesis, and evaluation.

Mohammed Salah Ayoup, Marwa M Abu-Serie, Laila F Awad, Mohamed Teleb, Hanan M Ragab, Adel Amer,

Matrix metalloproteinase-9 (MMP-9) and monoamine oxidase-A (MAO-A) are central signaling nodes in CRC and promotors of distant metastasis associated with high mortality rates. Novel series of quinoxaline-based dual MMP-9/MAO-A inhibitors were synthesized to suppress CRC progression. The design rationale combines the thematic pharmacophoric features of MMP-9 and MAO-A inhibitors in ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2021, 222:113558]

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Nitrofurazone repurposing towards design and synthesis of novel apoptotic-dependent anticancer and antimicrobial agents: Biological evaluation, kinetic studies and molecular modeling.

Marwa H El-Wakil, Marwa Ahmed Meheissen, Marwa M Abu-Serie,

Drug repurposing has gained much attention as a cost-effective strategy that plays an exquisite role in identifying undescribed biological activities in clinical drugs. In the present work, we report the repurposing of the antibacterial drug nitrofurazone (NFZ) as a potential anticancer agent against CaCo-2, MDA-MB 231 and HepG-2 cancer cell ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2021, 113:104971]

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Pluronic F127 micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer.

Marwa M Abu-Serie, Fernanda Andrade, Patricia Cámara-Sánchez, Joaquin Seras-Franzoso, Diana Rafael, Zamira V Díaz-Riascos, Petra Gener, Ibane Abasolo, Simó Schwartz,

<b>Aim:</b> Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. <b>Materials & methods:</b> Citral-loaded micelles (CLM) were obtained using Pluronic<sup>®</sup> F127 and its efficacy tested on the growth of four breast cancer cell lines. The impact of the CLM on the growth and functional ... Read more >>

Nanomedicine (Lond) (Nanomedicine (London, England))
[2021, 16(17):1471-1485]

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Lectins purified from medicinal and edible mushrooms: Insights into their antiviral activity against pathogenic viruses.

Yousra A El-Maradny, Esmail M El-Fakharany, Marwa M Abu-Serie, Mona H Hashish, Heba S Selim,

For thousands of years, fungi have been a valuable and promising source of therapeutic agents for treatment of various diseases. Mushroom is a macrofungus which has been cultivated worldwide for its nutritional value and medicinal applications. Several bioactive molecules were extracted from mushroom such as polysaccharides, lectins and terpenoids. Lectins ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 179:239-258]

Cited: 1 time

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Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.

Mohammed Salah Ayoup, Marwa M Abu-Serie, Hamida Abdel-Hamid, Mohamed Teleb,

Harnessing the antioxidant cellular machinery has sparked considerable interest as an efficient anticancer strategy. Activating Nrf2, the master switch of the cellular redox system, suppresses ROS, alleviates oxidative stress, and halts cancer progression. 1,2,4-oxadiazoles are iconic direct Nrf2 activators that disrupt Nrf2 interaction with its endogenous repressor Keap1. This study ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2021, 220:113475]

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The potential antiviral effect of major royal jelly protein2 and its isoform X1 against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Insight on their sialidase activity and molecular docking.

Noha H Habashy, Marwa M Abu-Serie,

Severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 is a newly emerging type of CoV. We evaluated the predicted anti-SARS-CoV-2 effect of major royal jelly protein (MRJP)2 and MRJP2 isoform X1, which recently showed high efficacy against other enveloped RNA-viruses (HCV and HIV). Some in-silico analyses have been performed to predict the impact ... Read more >>

J Funct Foods (Journal of functional foods)
[2020, 75:104282]

Cited: 2 times

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Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology.

El Sayed Helmy El Ashry, Laila Fathy Awad, Mohamed Teleb, Nihal Ahmed Ibrahim, Marwa M Abu-Serie, Mohamed Nabil Abd Al Moaty,

Recently, interest in matrix metalloproteinases (MMPs) -10 and -13 has been revitalized with the growing knowledge on their relevance within the MMPs network and significance of their inhibition for treatment of various diseases like arthritis, cancer, atherosclerosis and Alzheimer. Within this approach, dual MMP-10/13 inhibition was disclosed as new approach ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2020, 96:103616]

Cited: 4 times

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Vitis vinifera polyphenols from seedless black fruit act synergistically to suppress hepatotoxicity by targeting necroptosis and pro-fibrotic mediators.

Marwa M Abu-Serie, Noha H Habashy,

Human is subjected from his surrounding to various hepatotoxins, which aggravates his liver. Nowadays, natural polyphenols have attracted great interest in health improvement, especially liver health. The present research, therefore, assessed the hepatotherapeutic potency of the isolated polyphenols (VVF1) from seedless (pulp and skin) black Vitis vinifera (VV) against CCl<sub>4</sub>-induced ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2452]

Cited: 2 times

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Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis.

Mohammed Salah Ayoup, Manar Ahmed Fouad, Hamida Abdel-Hamid, El Sayed Ramadan, Marwa M Abu-Serie, Ahmed Noby, Mohamed Teleb,

Matrix metalloproteinases (MMPs) are major modulators of the tumor microenvironment. They participate in extracellular matrix turnover, tumor growth, angiogenesis and metastasis. Accordingly, MMPs inhibition seems to be ideal solution to control cancer. Many MMPs inhibitors have been introduced ranging from hydroxamate-based peptidomimetics to the next generation non-hydroxamate inhibitors. Among MMPs, ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 186:111875]

Cited: 3 times

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Dual VEGFR-2/PIM-1 kinase inhibition towards surmounting the resistance to antiangiogenic agents via hybrid pyridine and thienopyridine-based scaffolds: Design, synthesis and biological evaluation.

Ola H Rizk, Mohamed Teleb, Marwa M Abu-Serie, Omaima G Shaaban,

Angiogenesis is a hallmark in cancer. Most antiangiogenic agents block the action of vascular endothelial growth factor (VEGF). In clinic, patients develop hypoxia-mediated resistance consistent with vascular responses to these agents. Recent studies underlying such resistance revealed hypoxia-inducible PIM-1 kinase upregulation which promotes cancer progression. PIM-1 kinase expression is thus ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2019, 92:103189]

Cited: 2 times

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Synthesis and biological evaluation of purine-pyrazole hybrids incorporating thiazole, thiazolidinone or rhodanine moiety as 15-LOX inhibitors endowed with anticancer and antioxidant potential.

Ola S Afifi, Omaima G Shaaban, Heba A Abd El Razik, Shams El-Dine A Shams El-Dine, Fawzia A Ashour, Alaa A El-Tombary, Marwa M Abu-Serie,

Novel purine-pyrazole hybrids combining thiazoles, thiazolidinones and rhodanines, were designed and tested as 15-LOX inhibitors, potential anticancer and antioxidant agents. All tested compounds were found to be potent 15-LOX inhibitors with IC<sub>50</sub> ranging from 1.76 to 6.12 µM. The prepared compounds were evaluated in vitro against five cancer cell lines: A549 ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2019, 87:821-837]

Cited: 4 times

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Design, synthesis and biological evaluation of novel α-acyloxy carboxamides via Passerini reaction as caspase 3/7 activators.

Mohammed Salah Ayoup, Yasmin Wahby, Hamida Abdel-Hamid, El Sayed Ramadan, Mohamed Teleb, Marwa M Abu-Serie, Ahmed Noby,

Evasion of apoptosis is a hallmark of cancer. Caspases; the key executors of apoptotic cascade are attractive targets for selective induction of apoptosis in cancer cells. Within this approach, various caspase activators were introduced as lead anticancer agents. In the current study, a new series of multifunctional Passerini products was ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2019, 168:340-356]

Cited: 3 times

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Two purified proteins from royal jelly with in vitro dual anti-hepatic damage potency: Major royal jelly protein 2 and its novel isoform X1.

Marwa M Abu-Serie, Noha H Habashy,

Liver diseases are serious life-threating conditions that should be controlled. Here, we identify a protein fraction from royal-jelly (RJ) that represents the most effective composite against CCl4-induced hepatotoxicity and HepG2 cell growth. Two closely related proteins were purified from this fraction by a new simple method and identified by MALDI-TOF ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2019, 128:782-795]

Cited: 5 times

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Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.

Ehab D AlFadly, Perihan A Elzahhar, Anna Tramarin, Salwa Elkazaz, Hossam Shaltout, Marwa M Abu-Serie, Jana Janockova, Ondrej Soukup, Doaa A Ghareeb, Ahmed F El-Yazbi, Rim W Rafeh, Nour-Mounira Z Bakkar, Firas Kobeissy, Isabel Iriepa, Ignacio Moraleda, Manal N S Saudi, Manuela Bartolini, Ahmed S F Belal,

Neuroinflammation and cholinergic deficit are key detrimental processes involved in Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the multi-target-directed ligand paradigm was applied to the rational design of two series of new hybrids endowed with anti-inflammatory and anticholinesterase activity via triple targeting properties, namely able ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2019, 167:161-186]

Cited: 7 times

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