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Author Martine van Grotel

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Daily life participation in childhood chronic disease: a qualitative study on the child's and parent's perspective.

Merel M Nap-van der Vlist, Emma E Berkelbach van der Sprenkel, Linde N Nijhof, Martha A Grootenhuis, Cornelis K van der Ent, Joost F Swart, Annet van Royen-Kerkhof, Martine van Grotel, Elise M van de Putte, Sanne L Nijhof, Marijke C Kars,

<h4>Objective</h4>To understand how a child with a stable chronic disease and his/her parents shape his/her daily life participation, we assessed: (1) the parents' goals regarding the child's daily life participation, (2) parental strategies regarding the child's participation and () how children and their parents interrelate when their goals regarding participation ... Read more >>

BMJ Paediatr Open (BMJ paediatrics open)
[2021, 5(1):e001057]

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Internet and smartphone-based ecological momentary assessment and personalized advice (PROfeel) in adolescents with chronic conditions: A feasibility study.

Merel M Nap-van der Vlist, Jan Houtveen, Geertje W Dalmeijer, Martha A Grootenhuis, Cornelis K van der Ent, Martine van Grotel, Joost F Swart, Joris M van Montfrans, Elise M van de Putte, Sanne L Nijhof,

<h4>Objective</h4>Growing up with a chronic disease comes with challenges, such as coping with fatigue. Many adolescents are severely fatigued, though its associated factors exhibit considerable interpersonal and longitudinal variation. We assessed whether PROfeel, a combination of a smartphone-based ecological momentary assessment (EMA) method using the internet, followed by a face-to-face ... Read more >>

Internet Interv (Internet interventions)
[2021, 25:100395]

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Association of Chemotherapy Timing in Pregnancy With Congenital Malformation.

Mathilde van Gerwen, Charlotte Maggen, Elyce Cardonick, Emma J Verwaaijen, Marry van den Heuvel-Eibrink, Roman G Shmakov, Ingrid Boere, Mina M Gziri, Petronella B Ottevanger, Christianne A R Lok, Michael Halaska, Long Ting Shao, Ilana Struys, Elisabeth M van Dijk-Lokkart, Kristel Van Calsteren, Robert Fruscio, Paolo Zola, Giovanna Scarfone, Frédéric Amant, ,

<h4>Importance</h4>Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear.<h4>Objective</h4>To assess congenital malformation rates associated with gestational age at initiation of chemotherapy among pregnant women with cancer.<h4>Design, setting, and ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(6):e2113180]

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Role of parents in fatigue of children with a chronic disease: a cross-sectional study.

Niels Kramer, Sanne L Nijhof, Elise M van de Putte, Marjolijn Ketelaar, Martha A Grootenhuis, Kors van der Ent, Joost F Swart, Martine van Grotel, Geertje W Dalmeijer, Merel M Nap-van der Vlist,

<h4>Objective</h4>As parents majorly impact their child's well-being, and as fatigue is a highly prevalent threat to the well-being of children with a chronic disease, we aimed to explore the association between parental factors and fatigue in children with a chronic disease.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>Two Dutch children's hospitals.<h4>Population</h4>Children 2-18 years of age with ... Read more >>

BMJ Paediatr Open (BMJ paediatrics open)
[2021, 5(1):e001055]

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Clinical Characteristics of Invasive Fungal Infections in Pediatric Oncology Patients With Solid Tumors.

Veerle J Ruijters, Natanja Oosterom, Madeleine E M van der Perk, Tom F W Wolfs, Annelot J M Meijer, Marry M van den Heuvel-Eibrink, Martine van Grotel,

Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in children with cancer. Studies on the clinical characteristics of IFI in children with solid tumors are limited. This Dutch retrospective cohort study reviewed the medical records of 61 children with solid tumors to analyze the clinical characteristics ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(3):e408-e413]

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Estimated clinical benefit of combining highly conformal target volumes with Volumetric-Modulated Arc Therapy (VMAT) versus conventional flank irradiation in pediatric renal tumors.

Joeri Mul, Enrica Seravalli, Mirjam E Bosman, Cornelis P van de Ven, Annemieke S Littooij, Martine van Grotel, Marry M van den Heuvel-Eibrink, Geert O Janssens,

<h4>Background</h4>For decades, Anterior-Posterior/Posterior-Anterior (AP/PA) photon beams were standard-of-care for flank irradiation in children with renal cancer. Recently, highly conformal flank target volumes were defined correcting for postoperative organ shift and intra-fraction motion.By radiotherapy treatment plan comparison, this study aims to estimate the clinical benefits and potential risks of combining highly ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2021, 29:20-26]

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Presence of viremia during febrile neutropenic episodes in patients undergoing chemotherapy for malignant neoplasms.

Klára Obrová, Silke Grumaz, Marlene Remely, Stefan Czurda, Isabella Krickl, Susanne Herndlhofer, Karoline V Gleixner, Wolfgang R Sperr, Lisa Größlinger, Tijana Frank, Nuno Andrade, Teresa Egger-Matiqi, Christina Peters, Gernot Engstler, Michael Dworzak, Andishe Attarbaschi, Martine van Grotel, Marry M van den Heuvel-Eibrink, Ivan S Moiseev, Yuliya Rogacheva, Ludmilla Zubarovskaya, Natalia Zubarovskaya, Herbert Pichler, Anita Lawitschka, Elisabeth Koller, Felix Keil, Peter Valent, Kai Sohn, Thomas Lion,

The importance of viral infections as a leading cause of morbidity and mortality is well documented in severely immunosuppressed patients undergoing allogeneic stem cell transplantation. By contrast, viral infections generally receive less attention in patients with malignant disorders undergoing chemotherapy, where the onset of neutropenic fever is mostly associated with ... Read more >>

Am J Hematol (American journal of hematology)
[2021, 96(6):719-726]

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Long-term neurodevelopmental outcome after prenatal exposure to maternal hematological malignancies with or without cytotoxic treatment.

Mathilde van Gerwen, Evangeline Huis In 't Veld, Martine van Grotel, Marry M van den Heuvel-Eibrink, Kristel Van Calsteren, Charlotte Maggen, Vit Drochytek, Giovanna Scarfone, Camilla Fontana, Robert Fruscio, Elyce Cardonick, Elisabeth M van Dijk-Lokkart, Frédéric Amant,

Data on the long-term neurodevelopmental outcomes of children exposed to hematological maternal cancer with or without treatment during pregnancy are lacking. A total of 57 children, of whom 33 males and 24 females, prenatally exposed to hematological malignancies and its treatment, were invited for neuropsychological and physical examinations at 18 months, ... Read more >>

Child Neuropsychol (Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence)
[2021, :1-12]

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Clinical and Molecular Characteristics and Outcome of Cystic Partially Differentiated Nephroblastoma and Cystic Nephroma: A Narrative Review of the Literature.

Sophie E van Peer, Corine J H Pleijte, Ronald R de Krijger, Marjolijn C J Jongmans, Roland P Kuiper, Marc R Lilien, Martine van Grotel, Norbert Graf, Marry M van den Heuvel-Eibrink, Janna A Hol,

In children presenting with a predominantly cystic renal tumor, the most likely diagnoses include cystic partially differentiated nephroblastoma (CPDN) and cystic nephroma (CN). Both entities are rare and limited information on the clinical and molecular characteristics, treatment, and outcome is available since large cohort studies are lacking. We performed an ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(5):]

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Locoregional control using highly conformal flank target volumes and volumetric-modulated arc therapy in pediatric renal tumors: Results from the Dutch national cohort.

Joeri Mul, Martine van Grotel, Enrica Seravalli, Mirjam E Bosman, Harm van Tinteren, Prakriti Roy, Raquel Dávila Fajardo, Godelieve A M Tytgat, Annelies M C Mavinkurve-Groothuis, Cornelis P van de Ven, Marc H W A Wijnen, Ronald R de Krijger, Annemieke S Littooij, Marry M van den Heuvel-Eibrink, Geert O Janssens,

<h4>Background and purpose</h4>In pediatric renal tumors, conventional two opposing photon beams have been used to cover the postoperative flank target volume for decades. This single center study describes the locoregional outcome using highly conformal flank target volumes adjusted for postoperative changes and intra-fraction motion combined with Volumetric-Modulated Arc Therapy (VMAT).<h4>Materials ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 159:249-254]

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Inter-clinician delineation variation for a new highly-conformal flank target volume in children with renal tumors: A SIOP-Renal Tumor Study Group international multicenter exercise.

Joeri Mul, Patrick Melchior, Enrica Seravalli, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Kristin Gurtner, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Henry Mandeville, Tom Boterberg, Petra S Kroon, Alexis N T J Kotte, Bianca A W Hoeben, Peter S N van Rossum, Martine van Grotel, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe, Geert O Janssens,

<h4>Background and purpose</h4>Recently, the SIOP-RTSG developed a highly-conformal flank target volume definition for children with renal tumors. The aims of this study were to evaluate the inter-clinician delineation variation of this new target volume definition in an international multicenter setting and to explore the necessity of quality assurance.<h4>Materials and methods</h4>Six ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2021, 28:39-47]

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Outcome of Stage IV Completely Necrotic Wilms Tumour and Local Stage III Treated According to the SIOP 2001 Protocol.

Raquel Dávila Fajardo, Rhoikos Furtwängler, Martine van Grotel, Harm van Tinteren, Claudia Pasqualini, Kathy Pritchard-Jones, Reem Al-Saadi, Beatriz de Camargo, Gema L Ramírez Villar, Norbert Graf, Xavier Muracciole, Patrick Melchior, Daniel Saunders, Christian Rübe, Marry M van den Heuvel-Eibrink, Geert O Janssens, Arnauld C Verschuur,

<h4>Objective</h4>Wilms tumour (WT) patients with a localised completely necrotic nephroblastoma after preoperative chemotherapy are a favourable outcome group. Since the introduction of the SIOP 2001 protocol, the SIOP- Renal Tumour Study Group (SIOP-RTSG) has omitted radiotherapy for such patients with low-risk, local stage III in an attempt to reduce treatment ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(5):]

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The contribution of surgical clips for optimizing highly-conformal image-guided flank irradiation in pediatric renal tumors: A single center experience.

Joeri Mul, Cornelis P van de Ven, Enrica Seravalli, Annemieke S Littooij, Marc H W A Wijnen, Martine van Grotel, Marry M van den Heuvel-Eibrink, Geert O Janssens,

<h4>Background and aims</h4>Two-opposing photon beams are considered standard of care for flank irradiation in pediatric patients with renal tumors. Nowadays, Image-Guided Radiotherapy (IGRT) techniques allow high-precision dose delivery to complex flank target volumes taking into account postoperative organ shifts and tumor bed motion. This study examines the contribution of a ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 156:62-68]

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Executive functioning in 6 year old children exposed to chemotherapy in utero.

Mathilde van Gerwen, Tineke Vandenbroucke, An-Sofie Gorissen, Martine van Grotel, Marry van den Heuvel-Eibrink, Emma Verwaaijen, Madeleine van der Perk, Kristel Van Calsteren, Elisabeth M van Dijk-Lokkart, Frédéric Amant, ,

<h4>Background</h4>Cancer treatment during pregnancy imposes a dilemma. Maternal advantage should be weighed against the potential impact of chemotherapy on child development. Recent studies in cancer survivors have shown that exposure to chemotherapeutic agents can have late adverse effects on cognitive functioning and executive functioning (EF). It is still unclear whether ... Read more >>

Early Hum Dev (Early human development)
[2020, 151:105198]

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The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.

Geert O Janssens, Patrick Melchior, Joeri Mul, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Line Claude, Kristin Gurtner, Kees P van de Ven, Martine van Grotel, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Xavier Muracciole, Tom Boterberg, Henry Mandeville, Jan Godzinski, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe,

For decades, radiotherapy with two opposing photon beams has been the standard technique used to cover the flank target volume in paediatric patients with renal tumours. Nowadays, many institutes are implementing advanced radiotherapy techniques that spare healthy tissue. To decrease the radiotherapy dose to healthy structures while preserving oncological efficacy, ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):846-852]

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Usefulness of current candidate genetic markers to identify childhood cancer patients at risk for platinum-induced ototoxicity: Results of the European PanCareLIFE cohort study.

Thorsten Langer, Eva Clemens, Linda Broer, Lara Maier, André G Uitterlinden, Andrica C H de Vries, Martine van Grotel, Saskia F M Pluijm, Harald Binder, Benjamin Mayer, Annika von dem Knesebeck, Julianne Byrne, Eline van Dulmen-den Broeder, Marco Crocco, Desiree Grabow, Peter Kaatsch, Melanie Kaiser, Claudia Spix, Line Kenborg, Jeanette F Winther, Catherine Rechnitzer, Henrik Hasle, Tomas Kepak, Anne-Lotte F van der Kooi, Leontien C Kremer, Jarmila Kruseova, Stefan Bielack, Benjamin Sorg, Stefanie Hecker-Nolting, Claudia E Kuehni, Marc Ansari, Martin Kompis, Heleen van der Pal, Ross Parfitt, Dirk Deuster, Peter Matulat, Amelie Tillmanns, Wim J E Tissing, Jörn D Beck, Susanne Elsner, Antoinette Am Zehnhoff-Dinnesen, Marry M van den Heuvel-Eibrink, Oliver Zolk, ,

<h4>Background</h4>Irreversible sensorineural hearing loss is a common side effect of platinum treatment with the potential to significantly impair the neurocognitive, social and educational development of childhood cancer survivors. Genetic association studies suggest a genetic predisposition for cisplatin-induced ototoxicity. Among other candidate genes, thiopurine methyltransferase (TPMT) is considered a critical gene ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 138:212-224]

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Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy.

Tineke Vandenbroucke, Magali Verheecke, Mathilde van Gerwen, Kristel Van Calsteren, Michael J Halaska, Monica Fumagalli, Robert Fruscio, Amarendra Gandhi, Margreet Veening, Lieven Lagae, Petronella B Ottevanger, Jens-Uwe Voigt, Jorine de Haan, Mina M Gziri, Charlotte Maggen, Luc Mertens, Gunnar Naulaers, Laurence Claes, Frédéric Amant, ,

<h4>Background</h4>Data on the long-term effects of prenatal exposure to maternal cancer and its treatment on child development are scarce.<h4>Methods</h4>In a multicenter cohort study, the neurologic and cardiac outcomes of 6-year-old children born to women diagnosed with cancer during pregnancy were compared with the outcome of children born after an uncomplicated ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 138:57-67]

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Association of candidate pharmacogenetic markers with platinum-induced ototoxicity: PanCareLIFE dataset.

Thorsten Langer, Eva Clemens, Linda Broer, Lara Maier, André G Uitterlinden, Andrica C H de Vries, Martine van Grotel, Saskia F M Pluijm, Harald Binder, Benjamin Mayer, Annika von dem Knesebeck, Julianne Byrne, Eline van Dulmen-den Broeder, Marco Crocco, Desiree Grabow, Peter Kaatsch, Melanie Kaiser, Claudia Spix, Line Kenborg, Jeanette F Winther, Catherine Rechnitzer, Henrik Hasle, Tomas Kepak, Anne-Lotte F van der Kooi, Leontien C Kremer, Jarmila Kruseova, Stefan Bielack, Benjamin Sorg, Stefanie Hecker-Nolting, Claudia E Kuehni, Marc Ansari, Martin Kompis, Heleen J van der Pal, Ross Parfitt, Dirk Deuster, Peter Matulat, Amelie Tillmanns, Wim J E Tissing, Jörn D Beck, Susanne Elsner, Antoinette Am Zehnhoff-Dinnesen, Marry M van den Heuvel-Eibrink, Oliver Zolk, ,

Genetic association studies suggest a genetic predisposition for cisplatin-induced ototoxicity. Among other candidate genes, thiopurine methyltransferase (<i>TPMT</i>) is considered a critical gene for susceptibility to cisplatin-induced hearing loss in a pharmacogenetic guideline. The PanCareLIFE cross-sectional cohort study evaluated the genetic associations in a large pan-European population and assessed the diagnostic ... Read more >>

Data Brief (Data in brief)
[2020, 32:106227]

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Paediatric metanephric tumours: a clinicopathological and molecular characterisation.

Dominique V C de Jel, Janna A Hol, Ariadne H A G Ooms, Ronald R de Krijger, Marjolijn C J Jongmans, Annemieke S Littooij, Jarno Drost, Martine van Grotel, Marry M van den Heuvel-Eibrink,

To characterize metanephric tumours in children, we performed a literature review investigating paediatric metanephric adenomas (MA), metanephric stromal tumours (MST) and metanephric adenofibromas (MAF). Including two patients from our own institution (MA, MAF), 110 individual cases (41 MA, 20 MAF, 49 MST) were identified. Additionally, fifteen composite tumours were identified, ... Read more >>

Crit Rev Oncol Hematol (Critical reviews in oncology/hematology)
[2020, 150:102970]

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Risk factors associated with tinnitus in 2948 Dutch survivors of childhood cancer: a Dutch LATER questionnaire study.

Annelot J M Meijer, Marta F Fiocco, Geert O Janssens, Eva Clemens, Wim J E Tissing, Jacqueline J Loonen, Eline van Dulmen-den Broeder, Andrica C H de Vries, Dorine Bresters, Birgitta Versluys, Cécile M Ronckers, Leontien C M Kremer, Helena J van der Pal, Sebastian J C M M Neggers, Margriet van der Heiden-van der Loo, Robert J Stokroos, Alex E Hoetink, Martine van Grotel, Marry M van den Heuvel-Eibrink,

<h4>Background</h4>Tinnitus is a serious late effect of childhood cancer treatment. The aim of this study was to determine the occurrence and risk factors for tinnitus in a national cohort of childhood cancer survivors (CCS).<h4>Methods</h4>Data were collected within the national Dutch Childhood Oncology Group - Long-Term Effects after Childhood Cancer (DCOG-LATER) ... Read more >>

Neurooncol Adv (Neuro-oncology advances)
[2020, 2(1):vdaa122]

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PICU Admission Rates in Pediatric Cancer and Hematopoietic Stem Cell Transplant Patients Receiving High-flow Nasal Cannula Oxygen Therapy on the General Ward.

Mila van Dorst, Josephus P J van Gestel, Martine van Grotel, Birgitta Versluijs, Marry M van den Heuvel-Eibrink, Joppe Nijman, Roelie M Wösten-van Asperen,

The use of high-flow nasal cannula (HFNC) oxygen therapy is growing as an alternative to standard oxygen. However, its use in patients treated for malignancies, including hematopoietic stem cell transplantation (HSCT) patients, is controversial. In this retrospective cohort study, we assessed outcomes of pediatric cancer and HSCT patients (including nonmalignant ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2020, 42(1):e1-e6]

Cited: 1 time

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Daily life participation in childhood chronic disease: a qualitative study.

Merel M Nap-van der Vlist, Marijke C Kars, Emma E Berkelbach van der Sprenkel, Linde N Nijhof, Martha A Grootenhuis, Stefan M van Geelen, Cornelis K van der Ent, Joost F Swart, Annet van Royen-Kerkhof, Martine van Grotel, Elise M van de Putte, Sanne L Nijhof,

<h4>Objective</h4>Opportunities to participate in daily life have improved considerably for children with chronic disease. Nevertheless, they still face challenges associated with their ever-present illness affecting every aspect of their lives. To best help these children, we aimed to assess the child's own perspective on participation and the main considerations that ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, 105(5):463-469]

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Treatment-Related Toxicities During Anti-GD2 Immunotherapy in High-Risk Neuroblastoma Patients.

Thomas Blom, Roosmarijn Lurvink, Leonie Aleven, Maarten Mensink, Tom Wolfs, Miranda Dierselhuis, Natasha van Eijkelenburg, Kathelijne Kraal, Max van Noesel, Martine van Grotel, Godelieve Tytgat,

The introduction of immunotherapy using an anti-GD2 antibody (dinutuximab, ch14.18) has significantly improved survival rates for high-risk neuroblastoma patients. However, this improvement in survival is accompanied by a substantial immunotherapy-related toxicity burden. The primary objective of this study was to describe treatment-related toxicities during immunotherapy with dinutuximab, IL-2, GM-CSF, and ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:601076]

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Genetic variation of cisplatin-induced ototoxicity in non-cranial-irradiated pediatric patients using a candidate gene approach: The International PanCareLIFE Study.

Eva Clemens, Linda Broer, Thorsten Langer, André G Uitterlinden, Andrica C H de Vries, Martine van Grotel, Saskia F M Pluijm, Harald Binder, Julianne Byrne, Eline van Dulmen-den Broeder, Marco Crocco, Desiree Grabow, Peter Kaatsch, Melanie Kaiser, Line Kenborg, Jeanette F Winther, Catherine Rechnitzer, Henrik Hasle, Tomas Kepak, Anne-Lotte F van der Kooi, Leontien C Kremer, Jarmila Kruseova, Claudia E Kuehni, Heleen van der Pal, Ross Parfitt, Dirk Deuster, Peter Matulat, Claudia Spix, Amelie Tillmanns, Wim J E Tissing, Lara Maier, Antoinette Am Zehnhoff-Dinnesen, Oliver Zolk, Marry M van den Heuvel-Eibrink, ,

Ototoxicity is a common side effect of platinum treatment and manifests as irreversible, high-frequency sensorineural hearing loss. Genetic association studies have suggested a role for SNPs in genes related to the disposition of cisplatin or deafness. In this study, 429 pediatric patients that were treated with cisplatin were genotyped for ... Read more >>

Pharmacogenomics J (The pharmacogenomics journal)
[2020, 20(2):294-305]

Cited: 2 times

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Research priorities in pediatric onco-critical care: an international Delphi consensus study.

Marijn Soeteman, Jenny Potratz, Jeppe S Angaard Nielsen, Jef Willems, Frédéric V Valla, Joe Brierley, Roelie M Wösten-van Asperen, ,

Intensive Care Med (Intensive care medicine)
[2019, 45(11):1681-1683]

Cited: 3 times

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