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Author Martine Vrijheid

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Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies.

Joan Forns, Marc-Andre Verner, Nina Iszatt, Nikola Nowack, Cathrine Carlsen Bach, Martine Vrijheid, Olga Costa, Ainara Andiarena, Eva Sovcikova, Birgit Bjerre Høyer, Jürgen Wittsiepe, Maria-Jose Lopez-Espinosa, Jesus Ibarluzea, Irva Hertz-Picciotto, Gunnar Toft, Hein Stigum, Mònica Guxens, Zeyan Liew, Merete Eggesbø,

INTRODUCTION:To date, the evidence for an association between perfluoroalkyl substances (PFAS) exposure and attention deficit and hyperactivity disorder (ADHD) is inconclusive. OBJECTIVE:We investigated the association between early life exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), and ADHD in a collaborative study including nine European population-based studies, encompassing 4,826 ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2020, 128(5):57002]

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Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders-An Introduction to the OBERON Project.

Karine Audouze, Denis Sarigiannis, Paloma Alonso-Magdalena, Celine Brochot, Maribel Casas, Martine Vrijheid, Patrick J Babin, Spyros Karakitsios, Xavier Coumoul, Robert Barouki,

Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union (EU) to reduce the levels of endocrine disruptors (EDs) for consumers, new and effective methods for ED testing are ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(8):]

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Applying the exposome concept in birth cohort research: a review of statistical approaches.

Susana Santos, Léa Maitre, Charline Warembourg, Lydiane Agier, Lorenzo Richiardi, Xavier Basagaña, Martine Vrijheid,

The exposome represents the totality of life course environmental exposures (including lifestyle and other non-genetic factors), from the prenatal period onwards. This holistic concept of exposure provides a new framework to advance the understanding of complex and multifactorial diseases. Prospective pregnancy and birth cohort studies provide a unique opportunity for ... Read more >>

Eur. J. Epidemiol. (European journal of epidemiology)
[2020, 35(3):193-204]

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High adherence to a mediterranean diet at age 4 reduces overweight, obesity and abdominal obesity incidence in children at the age of 8.

Leyre Notario-Barandiaran, Desirée Valera-Gran, Sandra Gonzalez-Palacios, Manuela Garcia-de-la-Hera, Silvia Fernández-Barrés, Eva Pereda-Pereda, Ana Fernández-Somoano, Mònica Guxens, Carmen Iñiguez, Dora Romaguera, Martine Vrijheid, Adonina Tardón, Loreto Santa-Marina, Jesús Vioque, Eva Mª Navarrete-Muñoz, ,

BACKGROUND/OBJECTIVES:A higher adherence to a Mediterranean diet has been shown to be protective against obesity in adults, but the evidence is still inconclusive in children at early ages. Our objective was to explore the association between adherence to Mediterranean Diet at the age of 4 and the prevalence of overweight, ... Read more >>

Int J Obes (Lond) (International journal of obesity (2005))
[2020, :]

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Time Trends and Sociodemographic Factors Associated With Overweight and Obesity in Children and Adolescents in Spain.

Jeroen de Bont, Yesika Díaz, Maribel Casas, Maria García-Gil, Martine Vrijheid, Talita Duarte-Salles,

Importance:Time-trend studies of overweight and obesity in childhood by sociodemographic factors are important for prioritizing public health initiatives. However, little is known about these trends in Spain, where high levels of obesity are found and where important demographic changes have occurred during the last 2 decades. Objective:To examine how time ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e201171]

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Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.

Simon Kebede Merid, Alexei Novoloaca, Gemma C Sharp, Leanne K Küpers, Alvin T Kho, Ritu Roy, Lu Gao, Isabella Annesi-Maesano, Pooja Jain, Michelle Plusquin, Manolis Kogevinas, Catherine Allard, Florianne O Vehmeijer, Nabila Kazmi, Lucas A Salas, Faisal I Rezwan, Hongmei Zhang, Sylvain Sebert, Darina Czamara, Sheryl L Rifas-Shiman, Phillip E Melton, Debbie A Lawlor, Göran Pershagen, Carrie V Breton, Karen Huen, Nour Baiz, Luigi Gagliardi, Tim S Nawrot, Eva Corpeleijn, Patrice Perron, Liesbeth Duijts, Ellen Aagaard Nohr, Mariona Bustamante, Susan L Ewart, Wilfried Karmaus, Shanshan Zhao, Christian M Page, Zdenko Herceg, Marjo-Riitta Jarvelin, Jari Lahti, Andrea A Baccarelli, Denise Anderson, Priyadarshini Kachroo, Caroline L Relton, Anna Bergström, Brenda Eskenazi, Munawar Hussain Soomro, Paolo Vineis, Harold Snieder, Luigi Bouchard, Vincent W Jaddoe, Thorkild I A Sørensen, Martine Vrijheid, S Hasan Arshad, John W Holloway, Siri E Håberg, Per Magnus, Terence Dwyer, Elisabeth B Binder, Dawn L DeMeo, Judith M Vonk, John Newnham, Kelan G Tantisira, Inger Kull, Joseph L Wiemels, Barbara Heude, Jordi Sunyer, Wenche Nystad, Monica C Munthe-Kaas, Katri Räikkönen, Emily Oken, Rae-Chi Huang, Scott T Weiss, Josep Maria Antó, Jean Bousquet, Ashish Kumar, Cilla Söderhäll, Catarina Almqvist, Andres Cardenas, Olena Gruzieva, Cheng-Jian Xu, Sarah E Reese, Juha Kere, Petter Brodin, Olivia Solomon, Matthias Wielscher, Nina Holland, Akram Ghantous, Marie-France Hivert, Janine F Felix, Gerard H Koppelman, Stephanie J London, Erik Melén,

BACKGROUND:Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. METHODS:We performed meta-analysis of Illumina's HumanMethylation450-array associations between ... Read more >>

Genome Med (Genome medicine)
[2020, 12(1):25]

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Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index.

Solène Cadiou, Mariona Bustamante, Lydiane Agier, Sandra Andrusaityte, Xavier Basagaña, Angel Carracedo, Leda Chatzi, Regina Grazuleviciene, Juan R Gonzalez, Kristine B Gutzkow, Léa Maitre, Dan Mason, Frédéric Millot, Mark Nieuwenhuijsen, Eleni Papadopoulou, Gillian Santorelli, Pierre-Jean Saulnier, Marta Vives, John Wright, Martine Vrijheid, Rémy Slama,

BACKGROUND:The exposome is defined as encompassing all environmental exposures one undergoes from conception onwards. Challenges of the application of this concept to environmental-health association studies include a possibly high false-positive rate. OBJECTIVES:We aimed to reduce the dimension of the exposome using information from DNA methylation as a way to more ... Read more >>

Environ Int (Environment international)
[2020, 138:105622]

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Measuring Child Socio-Economic Position in Birth Cohort Research: The Development of a Novel Standardized Household Income Indicator.

Costanza Pizzi, Matteo Richiardi, Marie-Aline Charles, Barbara Heude, Jean-Louis Lanoe, Sandrine Lioret, Sonia Brescianini, Virgilia Toccaceli, Martine Vrijheid, Franco Merletti, Daniela Zugna, Lorenzo Richiardi,

The assessment of early life socioeconomic position (SEP) is essential to the tackling of social inequalities in health. Although different indicators capture different SEP dimensions, maternal education is often used as the only indicator in birth cohort research, especially in multi-cohort analyses. Household income, as a direct measure of material ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(5):]

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Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children.

Nikos Stratakis, David V Conti, Eva Borras, Eduardo Sabido, Theano Roumeliotaki, Eleni Papadopoulou, Lydiane Agier, Xavier Basagana, Mariona Bustamante, Maribel Casas, Shohreh F Farzan, Serena Fossati, Juan R Gonzalez, Regina Grazuleviciene, Barbara Heude, Lea Maitre, Rosemary R C McEachan, Ioannis Theologidis, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Rob McConnell, Anne-Lise Brantsaeter, Helle-Margrete Meltzer, Martine Vrijheid, Leda Chatzi,

Importance:The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown. Objective:To assess the associations of fish intake and mercury exposure during pregnancy with metabolic syndrome in children and alterations in biomarkers of inflammation in children. Design, Setting, ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e201007]

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Impact of lifestyle behaviors in early childhood on obesity and cardiometabolic risk in children: Results from the Spanish INMA birth cohort study.

Rowaedh Ahmed Bawaked, Sílvia Fernández-Barrés, Eva Maria Navarrete-Muñoz, Sandra González-Palacios, Mònica Guxens, Amaia Irizar, Aitana Lertxundi, Jordi Sunyer, Jesus Vioque, Helmut Schröder, Martine Vrijheid, Dora Romaguera,

BACKGROUND:Identifying modifiable lifestyle behaviors linked to childhood obesity is necessary to develop preventive strategies. OBJECTIVE:To estimate the association of five lifestyle behaviors in children aged 4 years on obesity and cardiometabolic risk factors at age 4 years and on obesity and blood pressure at age 7 years. METHODS:We used child lifestyle data from ... Read more >>

Pediatr Obes (Pediatric obesity)
[2020, 15(3):e12590]

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Obesity is associated with shorter telomeres in 8 year-old children.

Diana B P Clemente, Lea Maitre, Mariona Bustamante, Leda Chatzi, Theano Roumeliotaki, Serena Fossati, Regina Grazuleviciene, Kristine B Gützkow, Johanna Lepeule, Dries S Martens, Rosie R C McEachan, Helle M Meltzer, Inga Petraviciene, Rémy Slama, Ibon Tamayo-Uria, Jose Urquiza, Marina Vafeiadi, John Wright, Tim S Nawrot, Martine Vrijheid,

Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte telomere length (LTL) in childhood, data from 1,396 mother-child pairs of the multi-centre European birth cohort study HELIX were ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):18739]

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Comprehensive study of the exposome and omic data using rexposome Bioconductor Packages.

Carles Hernandez-Ferrer, Gregory A Wellenius, Ibon Tamayo, Xavier Basagaña, Jordi Sunyer, Martine Vrijheid, Juan R Gonzalez,

SUMMARY:Genomics has dramatically improved our understanding of the molecular origins of certain human diseases. Nonetheless, our health is also influenced by the cumulative impact of exposures experienced across the life course (termed 'exposome'). The study of the high-dimensional exposome offers a new paradigm for investigating environmental contributions to disease etiology. ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2019, 35(24):5344-5345]

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Early life tobacco exposure and children's telomere length: The HELIX project.

Citlalli Osorio-Yáñez, Diana B P Clemente, Lea Maitre, Martha Vives-Usano, Mariona Bustamante, David Martinez, Maribel Casas, Jan Alexander, Cathrine Thomsen, Leda Chatzi, Kristine B Gützkow, Regina Grazuleviciene, Dries S Martens, Michelle Plusquin, Remy Slama, Rosemary C McEachan, John Wright, Tiffany C Yang, Jose Urquiza, Ibon Tamayo, Jordi Sunyer, Marina Vafeiadi, Tim S Nawrot, Martine Vrijheid,

Telomere length and mitochondrial DNA content are considered biomarkers of cellular aging, oxidative stress, and inflammation, but there is almost no information on their association with tobacco smoke exposure in fetal and early life. The aim of this study was to assess whether prenatal and childhood tobacco exposure were associated ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 711:135028]

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Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries.

Eleni Papadopoulou, Line Småstuen Haug, Amrit Kaur Sakhi, Sandra Andrusaityte, Xavier Basagaña, Anne Lise Brantsaeter, Maribel Casas, Sílvia Fernández-Barrés, Regina Grazuleviciene, Helle Katrine Knutsen, Lea Maitre, Helle Margrete Meltzer, Rosemary R C McEachan, Theano Roumeliotaki, Remy Slama, Marina Vafeiadi, John Wright, Martine Vrijheid, Cathrine Thomsen, Leda Chatzi,

BACKGROUND:Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status. OBJECTIVES:Our objective was to study the association between diet and measured blood and urinary levels of environmental contaminants in mother-child pairs from six European birth ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2019, 127(10):107005]

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A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.

Jonathan P Bradfield, Suzanne Vogelezang, Janine F Felix, Alessandra Chesi, Øyvind Helgeland, Momoko Horikoshi, Ville Karhunen, Estelle Lowry, Diana L Cousminer, Tarunveer S Ahluwalia, Elisabeth Thiering, Eileen Tai-Hui Boh, Mohammad H Zafarmand, Natalia Vilor-Tejedor, Carol A Wang, Raimo Joro, Zhanghua Chen, William J Gauderman, Niina Pitkänen, Esteban J Parra, Lindsay Fernandez-Rhodes, Akram Alyass, Claire Monnereau, John A Curtin, Christian T Have, Shana E McCormack, Mette Hollensted, Christine Frithioff-Bøjsøe, Adan Valladares-Salgado, Jesus Peralta-Romero, Yik-Ying Teo, Marie Standl, Jaakko T Leinonen, Jens-Christian Holm, Triinu Peters, Jesus Vioque, Martine Vrijheid, Angela Simpson, Adnan Custovic, Marc Vaudel, Mickaël Canouil, Virpi Lindi, Mustafa Atalay, Mika Kähönen, Olli T Raitakari, Barbera D C van Schaik, Robert I Berkowitz, Shelley A Cole, V Saroja Voruganti, Yujie Wang, Heather M Highland, Anthony G Comuzzie, Nancy F Butte, Anne E Justice, Sheila Gahagan, Estela Blanco, Terho Lehtimäki, Timo A Lakka, Johannes Hebebrand, Amélie Bonnefond, Niels Grarup, Philippe Froguel, Leo-Pekka Lyytikäinen, Miguel Cruz, Sayuko Kobes, Robert L Hanson, Babette S Zemel, Anke Hinney, Koon K Teo, David Meyre, Kari E North, Frank D Gilliland, Hans Bisgaard, Mariona Bustamante, Klaus Bonnelykke, Craig E Pennell, Fernando Rivadeneira, André G Uitterlinden, Leslie J Baier, Tanja G M Vrijkotte, Joachim Heinrich, Thorkild I A Sørensen, Seang-Mei Saw, Oluf Pedersen, Torben Hansen, Johan Eriksson, Elisabeth Widén, Mark I McCarthy, Pål R Njølstad, Christine Power, Elina Hyppönen, Sylvain Sebert, Christopher D Brown, Marjo-Riitta Järvelin, Nicholas J Timpson, Stefan Johansson, Hakon Hakonarson, Vincent W V Jaddoe, , S F A Grant,

Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis ... Read more >>

Hum. Mol. Genet. (Human molecular genetics)
[2019, 28(19):3327-3338]

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Maternal circulating Vitamin D3 levels during pregnancy and behaviour across childhood.

Mónica López-Vicente, Jordi Sunyer, Nerea Lertxundi, Llúcia González, Cristina Rodríguez-Dehli, Mercedes Espada Sáenz-Torre, Martine Vrijheid, Adonina Tardón, Sabrina Llop, Maties Torrent, Jesús Ibarluzea, Mònica Guxens,

Vitamin D deficiency during critical periods of development could lead to persistent brain alterations. We aimed to assess the association between maternal vitamin D3, the major circulatory form of vitamin D, at pregnancy and neurodevelopmental outcomes during childhood, namely: behavioural problems, Attention Deficit and Hyperactivity Disorder (ADHD) and Autism Spectrum ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):14792]

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Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium.

Caitlin G Howe, Bianca Cox, Ruby Fore, James Jungius, Tuomas Kvist, Samantha Lent, Harriet E Miles, Lucas A Salas, Sheryl Rifas-Shiman, Anne P Starling, Paul Yousefi, Christine Ladd-Acosta, Andrea Baccarelli, Elisabeth B Binder, Vaia Lida Chatzi, Darina Czamara, Dana Dabelea, Dawn L DeMeo, Akram Ghantous, Zdenko Herceg, Eero Kajantie, Jari M T Lahti, Debbie A Lawlor, Augusto Litonjua, Tim S Nawrot, Ellen A Nohr, Emily Oken, Costanza Pizzi, Michelle Plusquin, Katri Räikkönen, Caroline L Relton, Gemma C Sharp, Thorkild I A Sørensen, Jordi Sunyer, Martine Vrijheid, Weiming Zhang, Marie-France Hivert, Carrie V Breton,

OBJECTIVE:Maternal gestational diabetes mellitus (GDM) has been associated with adverse outcomes in the offspring. Growing evidence suggests that the epigenome may play a role, but most previous studies have been small and adjusted for few covariates. The current study meta-analyzed the association between maternal GDM and cord blood DNA methylation ... Read more >>

Diabetes Care (Diabetes care)
[2020, 43(1):98-105]

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Maternal seafood consumption during pregnancy and child attention outcomes: a cohort study with gene effect modification by PUFA-related genes.

Jordi Julvez, Sílvia Fernández-Barrés, Florence Gignac, Mónica López-Vicente, Mariona Bustamante, Raquel Garcia-Esteban, Jesús Vioque, Sabrina Llop, Ferran Ballester, Ana Fernández-Somoano, Adonina Tardón, Martine Vrijheid, Cathryn Tonne, Jesus Ibarluzea, Amaia Irazabal, Nuria Sebastian-Galles, Miguel Burgaleta, Dora Romaguera, Jordi Sunyer,

BACKGROUND:There is a need to test the fetal programming theoretical framework in nutritional epidemiology. We evaluated whether maternal seafood intake during pregnancy was associated with 8-year-old attention outcomes after adjusting for previous child seafood intake and cognitive function. We also explored effect modification by several single nucleotide polymorphisms (SNPs) related ... Read more >>

Int J Epidemiol (International journal of epidemiology)
[2019, :]

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Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.

Xueping Liu, Dorte Helenius, Line Skotte, Robin N Beaumont, Matthias Wielscher, Frank Geller, Julius Juodakis, Anubha Mahajan, Jonathan P Bradfield, Frederick T J Lin, Suzanne Vogelezang, Mariona Bustamante, Tarunveer S Ahluwalia, Niina Pitkänen, Carol A Wang, Jonas Bacelis, Maria C Borges, Ge Zhang, Bruce A Bedell, Robert M Rossi, Kristin Skogstrand, Shouneng Peng, Wesley K Thompson, Vivek Appadurai, Debbie A Lawlor, Ilkka Kalliala, Christine Power, Mark I McCarthy, Heather A Boyd, Mary L Marazita, Hakon Hakonarson, M Geoffrey Hayes, Denise M Scholtens, Fernando Rivadeneira, Vincent W V Jaddoe, Rebecca K Vinding, Hans Bisgaard, Bridget A Knight, Katja Pahkala, Olli Raitakari, Øyvind Helgeland, Stefan Johansson, Pål R Njølstad, João Fadista, Andrew J Schork, Ron Nudel, Daniel E Miller, Xiaoting Chen, Matthew T Weirauch, Preben Bo Mortensen, Anders D Børglum, Merete Nordentoft, Ole Mors, Ke Hao, Kelli K Ryckman, David M Hougaard, Leah C Kottyan, Craig E Pennell, Leo-Pekka Lyytikainen, Klaus Bønnelykke, Martine Vrijheid, Janine F Felix, William L Lowe, Struan F A Grant, Elina Hyppönen, Bo Jacobsson, Marjo-Riitta Jarvelin, Louis J Muglia, Jeffrey C Murray, Rachel M Freathy, Thomas M Werge, Mads Melbye, Alfonso Buil, Bjarke Feenstra,

The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 is associated with gestational duration; the association is replicated in ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):3927]

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Early-Life Environmental Exposures and Blood Pressure in Children.

Charline Warembourg, Léa Maitre, Ibon Tamayo-Uria, Serena Fossati, Theano Roumeliotaki, Gunn Marit Aasvang, Sandra Andrusaityte, Maribel Casas, Enrique Cequier, Lida Chatzi, Audrius Dedele, Juan-Ramon Gonzalez, Regina Gražulevičienė, Line Smastuen Haug, Carles Hernandez-Ferrer, Barbara Heude, Marianna Karachaliou, Norun Hjertager Krog, Rosemary McEachan, Mark Nieuwenhuijsen, Inga Petraviciene, Joane Quentin, Oliver Robinson, Amrit Kaur Sakhi, Rémy Slama, Cathrine Thomsen, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Martine Vrijheid, Xavier Basagaña,

BACKGROUND:Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously. OBJECTIVES:This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2019, 74(10):1317-1328]

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Prenatal exposure to organochlorine compounds and lung function during childhood.

Alicia Abellan, Jordi Sunyer, Raquel Garcia-Esteban, Mikel Basterrechea, Talita Duarte-Salles, Amparo Ferrero, Judith Garcia-Aymerich, Mireia Gascon, Joan O Grimalt, Maria-Jose Lopez-Espinosa, Carlos Zabaleta, Martine Vrijheid, Maribel Casas,

INTRODUCTION:Prenatal exposure to organochlorine compounds (OCs) can increase the risk of reported respiratory symptoms in children. It remains unclear whether these compounds can also impact on lung function. We assessed the association between prenatal exposure to OCs and lung function during childhood. METHODS:We included 1308 mother-child pairs enrolled in a ... Read more >>

Environ Int (Environment international)
[2019, 131:105049]

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Sugar-Containing Beverages Consumption and Obesity in Children Aged 4-5 Years in Spain: the INMA Study.

Sandra Gonzalez-Palacios, Eva-María Navarrete-Muñoz, Manoli García-de-la-Hera, Laura Torres-Collado, Loreto Santa-Marina, Pilar Amiano, Maria-Jose Lopez-Espinosa, Adonina Tardon, Isolina Riano-Galan, Martine Vrijheid, Jordi Sunyer, Jesus Vioque,

The consumption of sugar-containing beverages (SCB) has been associated with obesity although the evidence in preschool children is scarce. Cross-sectional analyses were performed to assess the association between obesity and SCB consumption (packaged juices and sugar-sweetened soft drinks) in 1823 children at the age of 4-5 years from the INfancia ... Read more >>

Nutrients (Nutrients)
[2019, 11(8):]

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Prenatal exposure to perfluoroalkyl substances, immune-related outcomes, and lung function in children from a Spanish birth cohort study.

Cyntia B Manzano-Salgado, Berit Granum, Maria-Jose Lopez-Espinosa, Ferran Ballester, Carmen Iñiguez, Mireia Gascón, David Martínez, Mònica Guxens, Mikel Basterretxea, Carlos Zabaleta, Thomas Schettgen, Jordi Sunyer, Martine Vrijheid, Maribel Casas,

BACKGROUND:Prenatal exposure to perfluoroalkyl substances (PFASs) has been associated with impaired immune and respiratory health during childhood but the evidence is inconsistent and limited for lung function. We studied the association between prenatal PFASs exposure and immune and respiratory health, including lung function, up to age 7 years in the ... Read more >>

Int J Hyg Environ Health (International journal of hygiene and environmental health)
[2019, 222(6):945-954]

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Prediction of maternal and foetal exposures to perfluoroalkyl compounds in a Spanish birth cohort using toxicokinetic modelling.

Céline Brochot, Maribel Casas, Cyntia Manzano-Salgado, Florence A Zeman, Thomas Schettgen, Martine Vrijheid, Frédéric Y Bois,

Prenatal exposures to perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) have been associated with child health outcomes, but many of these associations remain poorly characterized. The aim of this work was to provide new indicators of foetal exposure for the Spanish INMA birth cohort. First, a pregnancy and lactation physiologically ... Read more >>

Toxicol. Appl. Pharmacol. (Toxicology and applied pharmacology)
[2019, 379:114640]

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Associations of Maternal Cell-Phone Use During Pregnancy With Pregnancy Duration and Fetal Growth in 4 Birth Cohorts.

Ermioni Tsarna, Marije Reedijk, Laura Ellen Birks, Mònica Guxens, Ferran Ballester, Mina Ha, Ana Jiménez-Zabala, Leeka Kheifets, Aitana Lertxundi, Hyung-Ryul Lim, Jorn Olsen, Llúcia González Safont, Madhuri Sudan, Elisabeth Cardis, Martine Vrijheid, Tanja Vrijkotte, Anke Huss, Roel Vermeulen,

Results from studies evaluating potential effects of prenatal exposure to radio-frequency electromagnetic fields from cell phones on birth outcomes have been inconsistent. Using data on 55,507 pregnant women and their children from Denmark (1996-2002), the Netherlands (2003-2004), Spain (2003-2008), and South Korea (2006-2011), we explored whether maternal cell-phone use was ... Read more >>

Am. J. Epidemiol. (American journal of epidemiology)
[2019, 188(7):1270-1280]

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