Full Text Journal Articles by
Author Martina Hennessy

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Assessment of an Electronic Patient Record System on Discharge Prescribing Errors in a Tertiary University Hospital

Michael O'Shea, Cormac Kennedy, Eileen Relihan, Kieran Harkin, Martina Hennessy, Michael Barry,

<h4>Background: </h4> Prescribing error represent a significant source of preventable harm to patients. Prescribing error at discharge, including omission of pre-admission medications (PAM), are particularly harmful as they frequently propagate following discharge. This study assesses the impact of an educational intervention and introduction of an Electronic Patient Record (EPR) in ... Read more >>

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Feasibility Assessment of an 8-week Attention-based Training Programme in the Management of Chronic Spontaneous Urticaria 

Katie Elizabeth Ridge, Niall Conlon, Martina Hennessy, Pádraic Dunne,

<h4>Background: </h4> Chronic spontaneous urticaria is a common disorder that is poorly understood and frequently misdiagnosed. Psychological difficulties are a significant factor in dermatological diseases and may also aggravate symptom burden. Mind-body interventions are used as a complementary approach to alleviate symptoms in chronic diseases and may represent a valuable ... Read more >>

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Local NO2 concentrations and asthma among over-50s in Ireland: A microdata analysis.

Philip Carthy, Aonghus Ó Domhnaill, Margaret O'Mahony, Anne Nolan, Frank Moriarty, Brian Broderick, Martina Hennessy, Aoife Donnelly, Owen Naughton, Sean Lyons,

BACKGROUND:Links between air pollution and asthma are less well established for older adults than some younger groups. Nitrogen dioxide (NO2) concentrations are widely used as an indicator of transport-related air pollution, and some literature suggests NO2 may directly affect asthma. METHODS:This study used data on 8162 adults >50 years old in ... Read more >>

Int J Epidemiol (International journal of epidemiology)
[2020, :]

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Introduction of an academic internship in Ireland: views of undergraduate medical students.

Elaine Burke, Mary Teeling, Martina Hennessy,

<h4>Introduction</h4>A combined academic and clinical training programme for junior doctors in Ireland, the academic track for internship, has recently been launched. The academic track offers newly graduated doctors protected time within the working week to undertake a research project in addition to funding, an academic supervisor, and additional training in ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2019, 188(3):1025-1032]

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Unmet needs persist in pediatric HIV programs: lessons from selected case studies in Uganda.

Judy Orikiiriza, Jane Nakawesi, Ben Kikaire, Dorothy Turitwenka, Walter Schlech, Andrew Kambugu, Mohammed Lamorde, Johan Normark, Martina Hennessy, Victor Musiime, Joseph Rujumba, Grace Ndeezi, Nazarius M Tumwesigye, Derek G Doherty, Jane Achan,

AIDS (AIDS (London, England))
[2017, 31(8):1196-1199]

Cited: 1 time

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Docemur Docemus: Peer-Assisted Learning Improves the Knowledge Gain of Tutors in the Highest Quartile of Achievement but Not Those in the Lowest Quartile.

Claire L Donohoe, John B Conneely, Nathan Zilbert, Martina Hennessy, Susie Schofield, John V Reynolds,

<h4>Objectives</h4>Peer-assisted learning (PAL) is a form of collaborative learning where members of a peer group act as teachers for each other. A reciprocal PAL program was designed to investigate whether there were differential gains in knowledge acquisition among tutors compared with tutees.<h4>Design</h4>Bayesian statistical analysis was used to quantitatively assess the ... Read more >>

J Surg Educ (Journal of surgical education)
[2015, 72(6):1139-1144]

Cited: 1 time

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Push and stay factors affecting Irish medical student migration intentions.

Pishoy Gouda, Kevin Kitt, David S Evans, Deirdre Goggin, Deirdre McGrath, Jason Last, Martina Hennessy, Richard Arnett, Siun O'Flynn, Fidelma Dunne, Diarmuid O'Donovan,

<h4>Background</h4>A significant proportion of medical students in Ireland have demonstrated strong intentions to migrate following their graduation. Factors influencing these intentions are poorly understood. Our study aimed to investigate 'push' and 'stay' factors that may influence the migration plans of medical students.<h4>Methods</h4>Cross-sectional survey of 2273 medical students in Ireland using ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2017, 186(1):25-31]

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Investigating the Irish brain drain: factors influencing migration intentions among medical students.

Kevin Kitt, Pishoy Gouda, David S Evans, Deirdre Goggin, Deirdre McGrath, Jason Last, Martina Hennessy, Richard Arnett, Siun O'Flynn, Fidelma Dunne, Diarmuid O'Donovan,

BMC Proc (BMC proceedings)
[2015, 9(Suppl 7):A12-A12]

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Evaluation of a "Subintern" Role: Action Over Observation For Final-Year Medical Students in Surgery.

Marie Catherine Morris, Martina Hennessy, Kevin C Conlon, Paul F Ridgway,

<h4>Background</h4>This study sought to investigate the potential of a subinternship apprentice role as a structured experiential learning opportunity by enabling final-year medical students to learn through action rather than observation.<h4>Methods</h4>A convenience sample of 65 final-year medical students was allocated to "intern shadow" (control group) or "subintern" (research group) for 2 ... Read more >>

J Surg Educ (Journal of surgical education)
[2015, 72(5):862-867]

Cited: 1 time

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Ireland's medical brain drain: migration intentions of Irish medical students.

Pishoy Gouda, Kevin Kitt, David S Evans, Deirdre Goggin, Deirdre McGrath, Jason Last, Martina Hennessy, Richard Arnett, Siun O'Flynn, Fidelma Dunne, Diarmuid O'Donovan,

<h4>Background</h4>To provide the optimum level of healthcare, it is important that the supply of well-trained doctors meets the demand. However, despite many initiatives, Ireland continues to have a shortfall of physicians, which has been projected to persist. Our study aimed to investigate the migration intentions of Irish medical students and ... Read more >>

Hum Resour Health (Human resources for health)
[2015, 13:11]

Cited: 11 times

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Near-peer bedside clinical teaching: example of a successful programme.

Robbie Woods, Ben Ramasubbu, Claire Donohoe, Martina Hennessy,

<h4>Background</h4>Traditionally, the formalised teaching of medical students has begun at senior trainee level, with teaching from junior trainees being very limited and informal. A pilot programme was set up in a large university teaching hospital for interns to provide structured bedside clinical teaching to final-year medical students as an adjunct ... Read more >>

Clin Teach (The clinical teacher)
[2014, 11(6):472-477]

Cited: 8 times

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Pro forma: impact on communication skills?

Marie Morris, Gary Donohoe, Martina Hennessy, Caoilte O Ciardha,

<h4>Background</h4>A doctor performs 160 000-300 000 interviews during a lifetime career, thus making the medical interview the most common procedure in clinical medicine. It is reported that 60-80 per cent of diagnosis is based on history taking, yet there is little published data advising on the best method for medical ... Read more >>

Clin Teach (The clinical teacher)
[2013, 10(5):318-322]

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An alternative certification examination ("ACE") in surgery.

Marie Catherine Morris, Amy E Gillis, Craig O Smoothey, Martina Hennessy, Kevin C Conlon, Paul F Ridgway,

<h4>Background</h4>Medical graduates are required to be competent in many domains of professional practice when joining the health care workforce. Current undergraduate examination methods robustly assess up to 5 of these 8 required skills. This study sought to evaluate an alternative certification examination ("ACE") in assessing all of the 8 required ... Read more >>

J Surg Educ (Journal of surgical education)
[2014, 71(6):779-789]

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HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or Vγ9Vδ2 T lymphocytes.

Alan Kennedy, Andreea Petrasca, Derek G Doherty, Martina Hennessy, J Paul Spiers,

HIV-1 Tat exhibits clade-specific cytokine induction in monocytes. We investigated if Tat clades A-D can alter tumour necrosis factor (TNF)-α and interferon (IFN)-γ production by total and Vγ9Vδ2 T cells in vitro. Tat clade B, but not C, augmented TNF-α production by THP-1 cells. However, Tat clades A-D did not ... Read more >>

AIDS (AIDS (London, England))
[2014, 28(1):131-133]

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Long-term statin therapy in patients with systolic heart failure and normal cholesterol: effects on elevated serum markers of collagen turnover, inflammation, and B-type natriuretic peptide.

Esam Abulhul, Kenneth McDonald, Ramon Martos, Dermot Phelan, J Paul Spiers, Martina Hennessy, John Baugh, Chris Watson, Christina O'Loughlin, Mark Ledwidge,

<h4>Background</h4>The role of statin therapy in heart failure (HF) is unclear. The amino-terminal propeptide of procollagen type III (PIIINP) predicts outcome in HF, and yet there are conflicting reports of statin therapy effects on PIIINP.<h4>Objectives</h4>This study determined whether there was an increase in serum markers of inflammation, fibrosis (including PIIINP), ... Read more >>

Clin Ther (Clinical therapeutics)
[2012, 34(1):91-100]

Cited: 11 times

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Death and dignity through fresh eyes.

Matthew Phillips, Ruth Pilkington, Aileen Patterson, Martina Hennessy,

<h4>Background</h4>Trinity College Dublin remains one of the Medical Schools that uses traditional dissection to teach anatomy, exposing students from the first week of entry to cadavers. This early exposure makes it imperative that issues surrounding death and donor remains are explored early on within the main structure of the curriculum.<h4>Context</h4>The ... Read more >>

Clin Teach (The clinical teacher)
[2011, 8(4):241-244]

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Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans.

Jenny Svärd, J Paul Spiers, Fiona Mulcahy, Martina Hennessy,

<h4>Background</h4>Antiretroviral therapy including HIV protease inhibitors and nonnucleoside reverse transcriptase inhibitors can both inhibit and induce expression of cytochrome P450s, potentially leading to drug interactions. However, information is lacking on the impact of genetic polymorphism on this interaction.<h4>Methods</h4>This study examines the prevalence of 33 polymorphisms in NR1I2 (pregnane X receptor ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2010, 55(5):536-549]

Cited: 38 times

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Ribavirin and interferon alter MMP-9 abundance in vitro and in HIV-HCV-coinfected patients.

Alan Kennedy, Martina Hennessy, Colm Bergin, Fiona Mulcahy, Susan Hopkins, J Paul Spiers,

<h4>Background</h4>Matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) are central to tissue remodelling during HIV-HCV infection. Here, we assess the potential for antiviral therapy to modulate MMP abundance in THP-1 monocyte/macrophages and LX-2 hepatic stellate cells, and in a coinfected patient cohort.<h4>Methods</h4>THP-1 and LX-2 cells were treated with ribavirin ... Read more >>

Antivir Ther (Antiviral therapy)
[2011, 16(8):1237-1247]

Cited: 7 times

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Prevalence of renal artery stenosis in flash pulmonary oedema: determination using gadolinium-enhanced MRA.

Colm J McMahon, Martina Hennessy, Gerard Boyle, John Feely, James F M Meaney,

<h4>Purpose</h4>The primary purpose was to determine the prevalence of renal artery stenosis (RAS) in patients presenting with acute ("flash") pulmonary oedema (FPE), without identifiable cause using contrast-enhanced magnetic resonance angiography (CE-MRA) of renal arteries. A secondary goal was to correlate clinical parameters at presentation with the presence or absence of ... Read more >>

Eur J Intern Med (European journal of internal medicine)
[2010, 21(5):424-428]

Cited: 1 time

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Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension: effects of endothelin receptor blockade.

James P Spiers, Elizabeth J Kelso, Wei F Siah, Gillian Edge, Guojie Song, Barbara J McDermott, Martina Hennessy,

<h4>Objective</h4>To determine the effects of age and dual endothelin (ET)A/ETB receptor antagonism (bosentan) on aortic matrix metalloproteinase (MMP) abundance and tissue inhibitor of metalloproteinase (TIMP) expression in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR).<h4>Methods</h4>Male SHR and control WKY rats were randomly assigned to receive placebo or bosentan (100 mg/kg ... Read more >>

J Hypertens (Journal of hypertension)
[2005, 23(9):1717-1724]

Cited: 25 times

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Intracellular accumulation of nelfinavir and its relationship to P-glycoprotein expression and function in HIV-infected patients.

Martina Hennessy, Susan Clarke, J Paul Spiers, Dermot Kelleher, Fiona Mulcahy, Patrick Hoggard, David Back, Michael Barry,

<h4>Objective</h4>To compare plasma and intracellular nelfinavir pharmacokinetics, and determine their relationship to P-glycoprotein (P-gp) expression and function in lymphocytes of HIV-infected patients.<h4>Methods</h4>A pharmacokinetic study of 12 patients receiving nelfinavir plus dual nucleoside analogue therapy. Blood samples were taken at intervals to 12 h. Peripheral blood mononuclear cells (PBMCs) were isolated ... Read more >>

Antivir Ther (Antiviral therapy)
[2004, 9(1):115-122]

Cited: 23 times

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Intracellular indinavir pharmacokinetics in HIV-infected patients: comparison with plasma pharmacokinetics.

Martina Hennessy, Susan Clarke, J Paul Spiers, Fiona Mulcahy, Dermot Kelleher, Emma Meadon, Bridget Maher, Colm Bergin, Saye Khoo, John Tjia, Patrick Hoggard, David Back, Michael Barry,

OBJECTIVE: To determine intracellular concentrations of indinavir (IDV) and investigate the relationship between plasma and intracellular IDV pharmacokinetics in HIV-infected patients. METHODS: A pharmacokinetic study of 10 patients receiving IDV plus dual nucleoside analogue therapy. Peripheral blood mononuclear cells were isolated by density gradient centrifugation and cell counts estimated. IDV ... Read more >>

Antivir Ther (Antiviral therapy)
[2003, 8(3):191-198]

Cited: 11 times

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St Johns wort increases expression of P-glycoprotein: implications for drug interactions.

Martina Hennessy, D Kelleher, J P Spiers, M Barry, P Kavanagh, D Back, F Mulcahy, J Feely,

<h4>Aims</h4>St John's Wort (SJW) is widely used in the treatment of depression but concerns have been raised about its potential to interact with other drugs. Co-administration with SJW has resulted in significant reductions in trough plasma concentrations of indinavir and cyclosporin [1, 2]. Induction of cytochrome P450 3A4 (CYP3A4) has ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2002, 53(1):75-82]

Cited: 130 times

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