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The effect of a high-polyphenol Mediterranean diet (GREEN-MED) combined with physical activity on age-related brain atrophy: the DIRECT PLUS randomized controlled trial.

Alon Kaplan, Hila Zelicha, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Gidon Levakov, Ofer Prager, Moti Salti, Yoram Yovell, Jonathan Ofer, Sebastian Huhn, Frauke Beyer, Veronica Witte, Arno Villringer, Nachshon Meiran, Tamar Bakun Emesh, Peter Kovacs, Martin von Bergen, Uta Ceglarek, Matthias Blüher, Michael Stumvoll, Frank B Hu, Meir J Stampfer, Alon Friedman, Ilan Shelef, Galia Avidan, Iris Shai,

<h4>Background</h4>The effect of diet on age-related brain atrophy is largely unproven.<h4>Objective</h4>To explore the effect of a Mediterranean diet higher in polyphenols and lower in red/processed meat (Green-MED diet) on age-related brain atrophy.<h4>Methods</h4>This 18-month clinical trial longitudinally measured brain structure volumes by magnetic-resonance-imaging using hippocampal-occupancy (HOC) and lateral-ventricle-volume (LVV) expansion scores ... Read more >>

Am J Clin Nutr (The American journal of clinical nutrition)
[2022, :]

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Deconstructing Methanosarcina acetivorans into an acetogenic archaeon.

Christian Schöne, Anja Poehlein, Nico Jehmlich, Norman Adlung, Rolf Daniel, Martin von Bergen, Silvan Scheller, Michael Rother,

The reductive acetyl-coenzyme A (acetyl-CoA) pathway, whereby carbon dioxide is sequentially reduced to acetyl-CoA via coenzyme-bound C1 intermediates, is the only autotrophic pathway that can at the same time be the means for energy conservation. A conceptually similar metabolism and a key process in the global carbon cycle is methanogenesis, ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2022, 119(2):]

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The Eco-Exposome Concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals.

Stefan Scholz, John W Nichols, Beate I Escher, Gerald T Ankley, Rolf Altenburger, Brett Blackwell, Werner Brack, Lawrence Burkhard, Timothy W Collette, Jon A Doering, Drew Ekman, Kellie Fay, Fabian Fischer, Jörg Hackermüller, Joel C Hoffman, Chih Lai, David Leuthold, Dalma Martinovic-Weigelt, Thorsten Reemtsma, Nathan Pollesch, Anthony Schroeder, Gerrit Schüürmann, Martin von Bergen,

Organisms are exposed to ever-changing complex mixtures of chemicals over the course of their lifetime. The need to more comprehensively describe this exposure and relate it to adverse health effects has led to formulation of the exposome concept in human toxicology. Whether this concept has utility in the context of ... Read more >>

Environ Toxicol Chem (Environmental toxicology and chemistry)
[2022, 41(1):30-45]

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Effects of exposure to single and multiple parabens on asthma development in an experimental mouse model and a prospective cohort study.

Kristin M Junge, Lisa Buchenauer, Sandra Strunz, Bettina Seiwert, Loreen Thürmann, Ulrike E Rolle-Kampczyk, Stefan Röder, Michael Borte, Wieland Kiess, Martin von Bergen, Jan C Simon, Ana C Zenclussen, Torsten Schöneberg, Gabriele I Stangl, Gunda Herberth, Irina Lehmann, Thorsten Reemtsma, Tobias Polte,

Parabens are widely used preservatives present in consumer products like cosmetics and food. Although several epidemiological studies suggest that early-life exposure to parabens might alter the immune response and allergy risk in childhood, the evidence with respect to asthma is not clear. Therefore, we investigated the effect of paraben exposure ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 814:152676]

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Bolstering fitness via CO2 fixation and organic carbon uptake: mixotrophs in modern groundwater.

Martin Taubert, Will A Overholt, Beatrix M Heinze, Georgette Azemtsop Matanfack, Rola Houhou, Nico Jehmlich, Martin von Bergen, Petra Rösch, Jürgen Popp, Kirsten Küsel,

Current understanding of organic carbon inputs into ecosystems lacking photosynthetic primary production is predicated on data and inferences derived almost entirely from metagenomic analyses. The elevated abundances of putative chemolithoautotrophs in groundwaters suggest that dark CO<sub>2</sub> fixation is an integral component of subsurface trophic webs. To understand the impact of ... Read more >>

ISME J (The ISME journal)
[2021, :]

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Critical Assessment of MetaProteome Investigation (CAMPI): a multi-laboratory comparison of established workflows.

Tim Van Den Bossche, Benoit J Kunath, Kay Schallert, Stephanie S Schäpe, Paul E Abraham, Jean Armengaud, Magnus Ø Arntzen, Ariane Bassignani, Dirk Benndorf, Stephan Fuchs, Richard J Giannone, Timothy J Griffin, Live H Hagen, Rashi Halder, Céline Henry, Robert L Hettich, Robert Heyer, Pratik Jagtap, Nico Jehmlich, Marlene Jensen, Catherine Juste, Manuel Kleiner, Olivier Langella, Theresa Lehmann, Emma Leith, Patrick May, Bart Mesuere, Guylaine Miotello, Samantha L Peters, Olivier Pible, Pedro T Queiros, Udo Reichl, Bernhard Y Renard, Henning Schiebenhoefer, Alexander Sczyrba, Alessandro Tanca, Kathrin Trappe, Jean-Pierre Trezzi, Sergio Uzzau, Pieter Verschaffelt, Martin von Bergen, Paul Wilmes, Maximilian Wolf, Lennart Martens, Thilo Muth,

Metaproteomics has matured into a powerful tool to assess functional interactions in microbial communities. While many metaproteomic workflows are available, the impact of method choice on results remains unclear. Here, we carry out a community-driven, multi-laboratory comparison in metaproteomics: the critical assessment of metaproteome investigation study (CAMPI). Based on well-established ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):7305]

Cited: 3 times

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Differences in the sperm metabolomes of smoking and nonsmoking men†.

Kathrin M Engel, Sven Baumann, Janet Blaurock, Ulrike Rolle-Kampczyk, Jürgen Schiller, Martin von Bergen, Sonja Grunewald,

Currently, spermiogram analysis is the most relevant method used to clarify the potential infertility of a couple. However, in some cases, the reasons for infertility remain obscure. Smoking is among the factors that have been described to adversely affect male fertility. Smoking increases oxidative stress and thus promotes various pathological ... Read more >>

Biol Reprod (Biology of reproduction)
[2021, 105(6):1484-1493]

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Mesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β.

Sandra Nickel, Sebastian Vlaic, Madlen Christ, Kristin Schubert, Reinhard Henschler, Franziska Tautenhahn, Caroline Burger, Hagen Kühne, Silvio Erler, Andreas Roth, Christiane Wild, Janine Brach, Seddik Hammad, Claudia Gittel, Manja Baunack, Undine Lange, Johannes Broschewitz, Peggy Stock, Isabella Metelmann, Michael Bartels, Uta-Carolin Pietsch, Sebastian Krämer, Uwe Eichfeld, Martin von Bergen, Steven Dooley, Hans-Michael Tautenhahn, Bruno Christ,

Post-surgery liver failure is a serious complication for patients after extended partial hepatectomies (ePHx). Previously, we demonstrated in the pig model that transplantation of mesenchymal stromal cells (MSC) improved circulatory maintenance and supported multi-organ functions after 70% liver resection. Mechanisms behind the beneficial MSC effects remained unknown. Here we performed ... Read more >>

NPJ Regen Med (NPJ Regenerative medicine)
[2021, 6(1):84]

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A dual-function RNA balances carbon uptake and central metabolism in Vibrio cholerae.

Kavyaa Venkat, Mona Hoyos, James Rj Haycocks, Liam Cassidy, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Martin von Bergen, Andreas Tholey, David C Grainger, Kai Papenfort,

Bacterial small RNAs (sRNAs) are well known to modulate gene expression by base pairing with trans-encoded transcripts and are typically non-coding. However, several sRNAs have been reported to also contain an open reading frame and thus are considered dual-function RNAs. In this study, we discovered a dual-function RNA from Vibrio ... Read more >>

EMBO J (The EMBO journal)
[2021, 40(24):e108542]

Cited: 1 time

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Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior.

Evelyn Medawar, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Beatrice Engelmann, Arne Dietrich, Ronja Thieleking, Charlotte Wiegank, Charlotte Fries, Annette Horstmann, Arno Villringer, Martin von Bergen, Wiebke Fenske, A Veronica Witte,

The gut microbiome has been speculated to modulate feeding behavior through multiple factors, including short-chain fatty acids (SCFA). Evidence on this relationship in humans is however lacking. We aimed to explore if specific bacterial genera relate to eating behavior, diet, and SCFA in adults. Moreover, we tested whether eating-related microbiota ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):500]

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Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance.

Laura Krieg, Konrad Didt, Isabel Karkossa, Stephan H Bernhart, Stephanie Kehr, Narmadha Subramanian, Andreas Lindhorst, Alexander Schaudinn, Shirin Tabei, Maria Keller, Michael Stumvoll, Arne Dietrich, Martin von Bergen, Peter F Stadler, Jurga Laurencikiene, Martin Krüger, Matthias Blüher, Martin Gericke, Kristin Schubert, Peter Kovacs, Rima Chakaroun, Lucas Massier,

<h4>Objective</h4>Human white adipose tissue (AT) is a metabolically active organ with distinct depot-specific functions. Despite their locations close to the gastrointestinal tract, mesenteric AT and epiploic AT (epiAT) have only scarcely been investigated. Here, we aim to characterise these ATs in-depth and estimate their contribution to alterations in whole-body metabolism.<h4>Design</h4>Mesenteric, ... Read more >>

Gut (Gut)
[2021, :]

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Influence of formic acid treatment on the proteome of the ectoparasite Varroa destructor.

Antonia Genath, Hannes Petruschke, Martin von Bergen, Ralf Einspanier,

The ectoparasite Varroa destructor Anderson and Trueman is the most important parasites of the western honey bee, Apis mellifera L. The most widely currently used treatment uses formic acid (FA), but the understanding of its effects on V. destructor is limited. In order to understand the mechanism of action of ... Read more >>

PLoS One (PloS one)
[2021, 16(10):e0258845]

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The Emerging Plasticizer Alternative DINCH and Its Metabolite MINCH Induce Oxidative Stress and Enhance Inflammatory Responses in Human THP-1 Macrophages.

Alexandra Schaffert, Josi Arnold, Isabel Karkossa, Matthias Blüher, Martin von Bergen, Kristin Schubert,

The use of the plasticizer bis(2-ethylhexyl)phthalate (DEHP) and other plasticizers in the manufacture of plastic products has been restricted due to adverse health outcomes such as obesity, metabolic syndrome, and asthma, for which inflammation has been described to be a driving factor. The emerging alternative plasticizer 1,2-cyclohexanedioic acid diisononyl ester ... Read more >>

Cells (Cells)
[2021, 10(9):]

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Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry.

Henning Großkopf, Sarah Vogel, Claudia Damaris Müller, Sebastian Köhling, Jan-Niklas Dürig, Stephanie Möller, Matthias Schnabelrauch, Jörg Rademann, Ute Hempel, Martin von Bergen, Kristin Schubert,

Glycosaminoglycans (GAGs) are essential functional components of the extracellular matrix (ECM). Artificial GAGs like sulfated hyaluronan (sHA) exhibit pro-osteogenic properties and boost healing processes. Hence, they are of high interest for supporting bone regeneration and wound healing. Although sulfated GAGs (sGAGs) appear intracellularly, the knowledge about intracellular effects and putative ... Read more >>

Biol Chem (Biological chemistry)
[2021, 402(11):1427-1440]

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Nanomaterials induce different levels of oxidative stress, depending on the used model system: Comparison of in vitro and in vivo effects.

Isabel Karkossa, Anne Bannuscher, Bryan Hellack, Wendel Wohlleben, Julie Laloy, Miruna S Stan, Anca Dinischiotu, Martin Wiemann, Andreas Luch, Andrea Haase, Martin von Bergen, Kristin Schubert,

The immense diversity and constant development of nanomaterials (NMs) increase the need for a facilitated risk assessment, which requires knowledge of the modes of action (MoAs) of NMs. This necessitates a comprehensive data basis, which can be obtained using omics. Furthermore, the establishment of suitable in vitro test systems is ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 801:149538]

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Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation.

Alexandra Schaffert, Laura Krieg, Juliane Weiner, Rita Schlichting, Elke Ueberham, Isabel Karkossa, Mario Bauer, Kathrin Landgraf, Kristin M Junge, Martin Wabitsch, Jörg Lehmann, Beate I Escher, Ana C Zenclussen, Antje Körner, Matthias Blüher, John T Heiker, Martin von Bergen, Kristin Schubert,

Bisphenol A (BPA), which is used in a variety of consumer-related plastic products, was reported to cause adverse effects, including disruption of adipocyte differentiation, interference with obesity mechanisms, and impairment of insulin- and glucose homeostasis. Substitute compounds are increasingly emerging but are not sufficiently investigated.We aimed to investigate the mode ... Read more >>

Environ Int (Environment international)
[2021, 156:106730]

Cited: 1 time

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A workflow to identify novel proteins based on the direct mapping of peptide-spectrum-matches to genomic locations.

John Anders, Hannes Petruschke, Nico Jehmlich, Sven-Bastiaan Haange, Martin von Bergen, Peter F Stadler,

<h4>Background</h4>Small Proteins have received increasing attention in recent years. They have in particular been implicated as signals contributing to the coordination of bacterial communities. In genome annotations they are often missing or hidden among large numbers of hypothetical proteins because genome annotation pipelines often exclude short open reading frames or ... Read more >>

BMC Bioinformatics (BMC bioinformatics)
[2021, 22(1):277]

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Pesticide-induced metabolic changes are amplified by food stress.

Naeem Shahid, Ulrike Rolle-Kampczyk, Ayesha Siddique, Martin von Bergen, Matthias Liess,

In natural ecosystems, long-term detrimental effects of pesticides may occur at very low concentrations, below those considered safe by the governmental risk assessment. Mechanisms potentially responsible for this unexpected sensitivity include environmental stress-factors such as food deficiency. To understand this so called "effect-paradox", we investigated how food stress interacts with ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 792:148350]

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Prenatal paraben exposure and atopic dermatitis-related outcomes among children.

Loreen Thürmann, Gunda Herberth, Bettina Seiwert, Linda Schlittenbauer, Ulrike Rolle-Kampczyk, Stefan Röder, Ulrich Sack, Michael Borte, Martin von Bergen, Saskia Trump, Thorsten Reemtsma, Irina Lehmann,

<h4>Background</h4>Parabens, widely used as preservatives in cosmetics, foods, and other consumer products, are suspected of contributing to allergy susceptibility. The detection of parabens in the placenta or amniotic fluid raised concerns about potential health consequences for the child. Recently, an increased asthma risk following prenatal exposure has been reported. Here, ... Read more >>

Allergy (Allergy)
[2021, 76(10):3122-3132]

Cited: 1 time

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Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications.

Ibrahim E Sallam, Amr Abdelwareth, Heba Attia, Ramy K Aziz, Masun Nabhan Homsi, Martin von Bergen, Mohamed A Farag,

Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bioactive compounds. Despite their low bioavailability, tannins have ... Read more >>

Microorganisms (Microorganisms)
[2021, 9(5):]

Cited: 1 time

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Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk.

Jiesi Chen, Nadine Haase, Sven-Bastiaan Haange, Robert Sucher, Julia Münzker, Elisabeth Jäger, Kristin Schischke, Florian Seyfried, Martin von Bergen, Mohammed K Hankir, Ute Krügel, Wiebke K Fenske,

<h4>Objective</h4>Hypothalamic inflammation and endoplasmic reticulum (ER) stress are extensively linked to leptin resistance and overnutrition-related diseases. Surgical intervention remains the most efficient long-term weight-loss strategy for morbid obesity, but mechanisms underlying sustained feeding suppression remain largely elusive. This study investigated whether Roux-en-Y gastric bypass (RYGB) interacts with obesity-associated hypothalamic inflammation ... Read more >>

Mol Metab (Molecular metabolism)
[2021, 48:101214]

Cited: 3 times

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Critical Assessment of Metaproteome Investigation (CAMPI): A Multi-Lab Comparison of Established Workflows

Tim Van Den Bossche, Benoit Kunath, Kay Schallert, Stephanie Schäpe, Paul Abraham, Jean Armengaud, Magnus Arntzen, Ariane Bassignani, Dirk Benndorf, Stephan Fuchs, Richard Giannone, Timothy Griffin, Live Hagen, Rashi Halder, Céline Henry, Robert Hettich, Robert Heyer, Pratik Jagtap, Nico Jehmlich, Marlene Jensen, Catherine Juste, Manuel Kleiner, Olivier Langella, Theresa Lehmann, Emma Leith, Patrick May, Bart Mesuere, Guylaine Miotello, Samantha Peters, Olivier Pible, Pedro Queiros, Udo Reichl, Bernhard Renard, Henning Schiebenhoefer, Alexander Sczyrba, Alessandro Tanca, Kathrin Trappe, Jean-Pierre Trezzi, Sergio Uzzau, Pieter Verschaffelt, Martin von Bergen, Paul Wilmes, Maximilian Wolf, Lennart Martens, Thilo Muth,

Metaproteomics has matured into a powerful tool to assess functional interactions in microbial communities. While many metaproteomic workflows are available, the impact of method choice on results remains unclear. Here, we carried out the first community-driven, multi-laboratory comparison in metaproteomics: the critical assessment of metaproteome investigation study (CAMPI). Based on ... Read more >>

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Bidirectional Role of NLRP3 During Acute and Chronic Cholestatic Liver Injury.

Mick Frissen, Lijun Liao, Kai Markus Schneider, Sonja Djudjaj, Johannes Haybaeck, Alexander Wree, Ulrike Rolle-Kampczyk, Martin von Bergen, Eicke Latz, Peter Boor, Christian Trautwein,

<h4>Background and aims</h4>Cholestatic liver injury leads to cell death and subsequent inflammation and fibrosis. As shown for primary biliary cholangitis (PBC), the mechanisms and circuits between different cell death pathways leading to disease progression are incompletely defined. Common bile duct ligation (BDL) is a well-established murine model to mimic cholestatic ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, 73(5):1836-1854]

Cited: 3 times

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Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behaviour

Evelyn Medawar, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Beatrice Engelmann, Arne Dietrich, Ronja Thieleking, Charlotte Wiegank, Charlotte Fries, Annette Horstmann, Arno Villringer, Martin von Bergen, Wiebke Fenske, Veronica Witte,

<h4>Background</h4> The gut microbiome modulates human brain function and eating behavior through multiple factors, including short-chain fatty acid (SCFA) signaling. We aimed to explore which bacterial genera relate to eating behavior, diet and SCFA metabolites in overweight adults. In addition, we tested whether eating-related microbiota relate to treatment success in ... Read more >>

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Wood emissions and asthma development: Results from an experimental mouse model and a prospective cohort study.

Kristin M Junge, Lisa Buchenauer, Elena Elter, Katja Butter, Tibor Kohajda, Gunda Herberth, Stefan Röder, Michael Borte, Wieland Kiess, Martin von Bergen, Jan C Simon, Ulrike E Rolle-Kampczyk, Irina Lehmann, Richard Gminski, Martin Ohlmeyer, Tobias Polte,

<h4>Background</h4>Increased use of renewable resources like sustainably produced wood in construction or for all sorts of long-lived products is considered to contribute to reducing society's carbon footprint. However, as a natural, biological material, wood and wood products emit specific volatile organic compounds (VOCs). Therefore, the evaluation of possible health effects ... Read more >>

Environ Int (Environment international)
[2021, 151:106449]

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