Full Text Journal Articles by
Author Martin Witzenrath

Advertisement

Find full text journal articles






Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient.

Matthias Ochs, Sara Timm, Sefer Elezkurtaj, David Horst, Jenny Meinhardt, Frank L Heppner, Steffen Weber-Carstens, Andreas C Hocke, Martin Witzenrath,

Eur Respir J (The European respiratory journal)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.

Saskia Trump, Soeren Lukassen, Markus S Anker, Robert Lorenz Chua, Johannes Liebig, Loreen Thürmann, Victor Max Corman, Marco Binder, Jennifer Loske, Christina Klasa, Teresa Krieger, Bianca P Hennig, Marey Messingschlager, Fabian Pott, Julia Kazmierski, Sven Twardziok, Jan Philipp Albrecht, Jürgen Eils, Sara Hadzibegovic, Alessia Lena, Bettina Heidecker, Thore Bürgel, Jakob Steinfeldt, Christine Goffinet, Florian Kurth, Martin Witzenrath, Maria Theresa Völker, Sarah Dorothea Müller, Uwe Gerd Liebert, Naveed Ishaque, Lars Kaderali, Leif-Erik Sander, Christian Drosten, Sven Laudi, Roland Eils, Christian Conrad, Ulf Landmesser, Irina Lehmann,

In coronavirus disease 2019 (COVID-19), hypertension and cardiovascular diseases are major risk factors for critical disease progression. However, the underlying causes and the effects of the main anti-hypertensive therapies-angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs)-remain unclear. Combining clinical data (n = 144) and single-cell sequencing data of airway samples (n = 48) ... Read more >>

Nat Biotechnol (Nature biotechnology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

HLA-C* 04:01 is a Genetic Risk Allele for Severe Course of COVID-19

Weiner January, Suwalski Phillip, Holtgrewe Manuel, Thibeault Charlotte, Melina Müller, Patriki Dimitri, Quedenau Claudia, Ulrike Krüger, Helbig Elisa, Lippert Lena, Stubbemann Paula, Real Luis Miguel, Sanchez Juan Macias, Pineda Juan, Fernandez-Fuertes Marta, Wang Xiaomin, Karadeniz Zehra, Saccomanno Jacopo, Doehn Jan-Moritz, Hübner Ralf-Harto, Hinzmann Bernd, Salvo Mauricio, Blueher Anja, Siemann Sandra, Jurisic Stjepan, Beer Hansjuerg, Rutishauser Jonas, Wiggli Benedikt, Schmid Hansruedi, Danninger Kathrin, Binder Ronald, Victor Corman, Mühlemann Barbara, Braun Alice, Ripke Stephan, Jones Terry, Suttorp Norbert, Witzenrath Martin, Hippenstiel Stefan, Zemojtel Tomasz, Skurk Carsten, Poller Wolfgang, Borodina Tatiana, Sander Leif, Beule Dieter, Landmesser Ulf, Guettouche Toumy, Kurth Florian, Heidecker Bettina, ,

<h4>ABSTRACT</h4> <h4>Background</h4> Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been increasing demand to identify predictors of severe clinical course in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have been suggested as potential genetic host factors. We sought ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection.

Sibylle Schirm, Peter Ahnert, Sarah Berger, Geraldine Nouailles, Sandra-Maria Wienhold, Holger Müller-Redetzky, Norbert Suttorp, Markus Loeffler, Martin Witzenrath, Markus Scholz,

Pneumonia is one of the leading causes of death worldwide. The course of the disease is often highly dynamic with unforeseen critical deterioration within hours in a relevant proportion of patients. Besides antibiotic treatment, novel adjunctive therapies are under development. Their additive value needs to be explored in preclinical and ... Read more >>

PLoS One (PloS one)
[2020, 15(12):e0243147]

Cited: 0 times

View full text PDF listing >>



Pneumolysin induces platelet destruction, not platelet activation, which can be prevented by immunoglobulin preparations in vitro.

Kristin Jahn, Stefan Handtke, Raghavendra Palankar, Sabrina Weißmüller, Geraldine Nouailles, Thomas P Kohler, Jan Wesche, Manfred Rohde, Corina Heinz, Axel F Aschenbrenner, Martina Wolff, Jörg Schüttrumpf, Martin Witzenrath, Sven Hammerschmidt, Andreas Greinacher,

Community-acquired pneumonia by primary or superinfections with Streptococcus pneumoniae can lead to acute respiratory distress requiring mechanical ventilation. The pore-forming toxin pneumolysin alters the alveolar-capillary barrier and causes extravasation of protein-rich fluid into the interstitial pulmonary tissue, which impairs gas exchange. Platelets usually prevent endothelial leakage in inflamed pulmonary tissue ... Read more >>

Blood Adv (Blood advances)
[2020, 4(24):6315-6326]

Cited: 0 times

View full text PDF listing >>



Pneumonia in the face of COVID-19.

Martin Witzenrath, Wolfgang M Kuebler,

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2020, 319(5):L863-L866]

Cited: 0 times

View full text PDF listing >>



Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial.

Alexander P J Vlaar, Sanne de Bruin, Matthias Busch, Sjoerd A M E G Timmermans, Ingeborg E van Zeggeren, Rutger Koning, Liora Ter Horst, Esther B Bulle, Frank E H P van Baarle, Marcel C G van de Poll, E Marleen Kemper, Iwan C C van der Horst, Marcus J Schultz, Janneke Horn, Frederique Paulus, Lieuwe D Bos, W Joost Wiersinga, Martin Witzenrath, Simon Rueckinger, Korinna Pilz, Matthijs C Brouwer, Ren-Feng Guo, Leo Heunks, Pieter van Paassen, Niels C Riedemann, Diederik van de Beek,

<h4>Background</h4>Severe COVID-19 is characterised by inflammation and coagulation in the presence of complement system activation. We aimed to explore the potential benefit and safety of selectively blocking the anaphylatoxin and complement protein C5a with the monoclonal antibody IFX-1 (vilobelimab), in patients with severe COVID-19.<h4>Methods</h4>We did an exploratory, open-label, randomised phase ... Read more >>

Lancet Rheumatol (The Lancet Rheumatology)
[2020, 2(12):e764-e773]

Cited: 0 times

View full text PDF listing >>



Delayed viral clearance and exacerbated airway hyperinflammation in hypertensive COVID-19 patients

Saskia Trump, Soeren Lukassen, Markus Anker, Robert Lorenz Chua, Johannes Liebig, Loreen Thürmann, Victor Corman, Marco Binder, Jennifer Loske, Christina Klasa, Teresa Gabriela Krieger, Bianca Hennig, Marey Messingschlager, Fabian Pott, Julia Kazmierski, Sven Twardziok, Jan Philipp Albrecht, Jürgen Eils, Sara Hadzibegovic, Alessia Lena, Bettina Heidecker, Christine Goffinet, Florian Kurth, Martin Witzenrath, Maria Theresa Völker, Sarah Dorothea Müller, Uwe Gerd Liebert, Naveed Ishaque, Lars Kaderali, Leif Erik Sander, Sven Laudi, Christian Drosten, Roland Eils, Christian Conrad, Ulf Landmesser, Irina Lehmann,

In COVID-19, hypertension and cardiovascular diseases have emerged as major risk factors for critical disease progression. Concurrently, the impact of the main anti-hypertensive therapies, angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB), on COVID-19 severity is controversially discussed. By combining clinical data, single-cell sequencing data of airway samples and ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Dynamics of cytokines, immune cell counts and disease severity in patients with community-acquired pneumonia - Unravelling potential causal relationships.

Maciej Rosolowski, Volker Oberle, Peter Ahnert, Petra Creutz, Martin Witzenrath, Michael Kiehntopf, Markus Loeffler, Norbert Suttorp, Markus Scholz,

<h4>Background</h4>Community acquired pneumonia (CAP) is a severe and often rapidly deteriorating disease. To better understand its dynamics and potential causal relationships, we analyzed time series data of cytokines, blood and clinical parameters in hospitalized CAP patients.<h4>Methods</h4>Time series data of 10 circulating cytokines, blood counts and clinical parameters were related to ... Read more >>

Cytokine (Cytokine)
[2020, 136:155263]

Cited: 0 times

View full text PDF listing >>



"Atypische" bakterielle Pneumonie - Tipps zu Diagnostik und Therapie : Infektiologie.

Agata Mikolajewska, Martin Witzenrath,

MMW Fortschr Med (MMW Fortschritte der Medizin)
[2020, 162(15):49-53]

Cited: 0 times

View full text PDF listing >>



[Rare pulmonary infections].

Martin Witzenrath,

Pneumologe (Berl) (Der Pneumologe)
[2020, 17(5):299-300]

Cited: 0 times

View full text PDF listing >>



[Unexpected increase in extravascular lung water after acute lung injury].

Veit-Simon Eckle, Martin Witzenrath, Holger Müller-Redetzky,

HISTORY AND CLINICAL FINDING: We report on a 27-year-old female patient presenting with pneumonia and developing acute respiratory distress syndrome. Using transpulmonary thermodilution, an elevated extravascular lung water was detected (17 ml/kg). Patient required lung-protective mechanical ventilation and received antibiotic therapy. Negative fluid balance was targeted. Under this treatment, respiratory function improved, ... Read more >>

Dtsch Med Wochenschr (Deutsche medizinische Wochenschrift (1946))
[2020, 145(16):1187-1190]

Cited: 0 times

View full text PDF listing >>



Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik, Kevin Baßler, Stephan Schlickeiser, Bowen Zhang, Benjamin Krämer, Tobias Krammer, Sophia Brumhard, Lorenzo Bonaguro, Elena De Domenico, Daniel Wendisch, Martin Grasshoff, Theodore S Kapellos, Michael Beckstette, Tal Pecht, Adem Saglam, Oliver Dietrich, Henrik E Mei, Axel R Schulz, Claudia Conrad, Désirée Kunkel, Ehsan Vafadarnejad, Cheng-Jian Xu, Arik Horne, Miriam Herbert, Anna Drews, Charlotte Thibeault, Moritz Pfeiffer, Stefan Hippenstiel, Andreas Hocke, Holger Müller-Redetzky, Katrin-Moira Heim, Felix Machleidt, Alexander Uhrig, Laure Bosquillon de Jarcy, Linda Jürgens, Miriam Stegemann, Christoph R Glösenkamp, Hans-Dieter Volk, Christine Goffinet, Markus Landthaler, Emanuel Wyler, Philipp Georg, Maria Schneider, Chantip Dang-Heine, Nick Neuwinger, Kai Kappert, Rudolf Tauber, Victor Corman, Jan Raabe, Kim Melanie Kaiser, Michael To Vinh, Gereon Rieke, Christian Meisel, Thomas Ulas, Matthias Becker, Robert Geffers, Martin Witzenrath, Christian Drosten, Norbert Suttorp, Christof von Kalle, Florian Kurth, Kristian Händler, Joachim L Schultze, Anna C Aschenbrenner, Yang Li, Jacob Nattermann, Birgit Sawitzki, Antoine-Emmanuel Saliba, Leif Erik Sander, ,

Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In ... Read more >>

Cell (Cell)
[2020, 182(6):1419-1440.e23]

Cited: 4 times

View full text PDF listing >>



SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19.

Julian Braun, Lucie Loyal, Marco Frentsch, Daniel Wendisch, Philipp Georg, Florian Kurth, Stefan Hippenstiel, Manuela Dingeldey, Beate Kruse, Florent Fauchere, Emre Baysal, Maike Mangold, Larissa Henze, Roland Lauster, Marcus A Mall, Kirsten Beyer, Jobst Röhmel, Sebastian Voigt, Jürgen Schmitz, Stefan Miltenyi, Ilja Demuth, Marcel A Müller, Andreas Hocke, Martin Witzenrath, Norbert Suttorp, Florian Kern, Ulf Reimer, Holger Wenschuh, Christian Drosten, Victor M Corman, Claudia Giesecke-Thiel, Leif Erik Sander, Andreas Thiel,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic<sup>1,2</sup>. Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to respiratory failure. The mechanisms that determine such variable outcomes remain unresolved. Here we investigated CD4<sup>+</sup> T cells that are reactive against the spike ... Read more >>

Nature (Nature)
[2020, 587(7833):270-274]

Cited: 14 times

View full text PDF listing >>



COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.

Robert Lorenz Chua, Soeren Lukassen, Saskia Trump, Bianca P Hennig, Daniel Wendisch, Fabian Pott, Olivia Debnath, Loreen Thürmann, Florian Kurth, Maria Theresa Völker, Julia Kazmierski, Bernd Timmermann, Sven Twardziok, Stefan Schneider, Felix Machleidt, Holger Müller-Redetzky, Melanie Maier, Alexander Krannich, Sein Schmidt, Felix Balzer, Johannes Liebig, Jennifer Loske, Norbert Suttorp, Jürgen Eils, Naveed Ishaque, Uwe Gerd Liebert, Christof von Kalle, Andreas Hocke, Martin Witzenrath, Christine Goffinet, Christian Drosten, Sven Laudi, Irina Lehmann, Christian Conrad, Leif-Erik Sander, Roland Eils,

To investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from five healthy controls. We identified airway epithelial cell types and states vulnerable to severe ... Read more >>

Nat Biotechnol (Nature biotechnology)
[2020, 38(8):970-979]

Cited: 21 times

View full text PDF listing >>



No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020.

Marcus Panning, Julius Wiener, Kathrin Rothe, Jochen Schneider, Mathias W Pletz, Gernot Rohde, Jan Rupp, Martin Witzenrath, Christoph D Spinner, ,

<h4>Purpose</h4>The first SARS-CoV-2 cases in Europe were reported in January 2020. Recently, concern arose on unrecognized infections before this date. For a better understanding of the pandemic, we retrospectively analyzed patient samples for SARS-CoV-2 from the prospective CAPNETZ study cohort.<h4>Methods</h4>We used nasopharyngeal swab samples from a cohort of well characterized ... Read more >>

Infection (Infection)
[2020, 48(6):971-974]

Cited: 0 times

View full text PDF listing >>



Suppressive myeloid cells are a hallmark of severe COVID-19

Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik, Kevin Baßler, Stephan Schlickeiser, Bowen Zhang, Benjamin Krämer, Tobias Krammer, Sophia Brumhard, Lorenzo Bonaguro, Elena De Domenico, Daniel Wendisch, Martin Grasshoff, Theodore Kapellos, Michael Beckstette, Tal Pecht, Adem Saglam, Oliver Dietrich, Henrik Mei, Axel Schulz, Claudia Conrad, Désirée Kunkel, Ehsan Vafadarnejad, Cheng-Jian Xu, Arik Horne, Miriam Herbert, Anna Drews, Charlotte Thibeault, Moritz Pfeiffer, Stefan Hippenstiel, Andreas Hocke, Holger Müller-Redetzky, Katrin-Moira Heim, Felix Machleidt, Alexander Uhrig, Laure Bousquillon de Jarcy, Linda Jürgens, Miriam Stegemann, Christoph Glösenkamp, Hans-Dieter Volk, Christine Goffinet, Jan Raabe, Kim Melanie Kaiser, Michael To Vinh, Gereon Rieke, Christian Meisel, Thomas Ulas, Matthias Becker, Robert Geffers, Martin Witzenrath, Christian Drosten, Norbert Suttorp, Christof von Kalle, Florian Kurth, Kristian Händler, Joachim Schultze, Anna Aschenbrenner, Yang Li, Jacob Nattermann, Birgit Sawitzki, Antoine-Emmanuel Saliba, Leif Erik Sander, ,

‘Severe Acute Respiratory Syndrome - Coronavirus-2’ (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a mild to moderate respiratory tract infection in the majority of patients. A subset of patients, however, progresses to severe disease and respiratory failure with acute respiratory distress syndrome (ARDS). Severe COVID-19 has been associated with increased ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Treatment of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies.

Julio A Ramirez, Daniel M Musher, Scott E Evans, Charles Dela Cruz, Kristina A Crothers, Chadi A Hage, Stefano Aliberti, Antonio Anzueto, Francisco Arancibia, Forest Arnold, Elie Azoulay, Francesco Blasi, Jose Bordon, Steven Burdette, Bin Cao, Rodrigo Cavallazzi, James Chalmers, Patrick Charles, Jean Chastre, Yann-Erick Claessens, Nathan Dean, Xavier Duval, Muriel Fartoukh, Charles Feldman, Thomas File, Filipe Froes, Stephen Furmanek, Martin Gnoni, Gustavo Lopardo, Carlos Luna, Takaya Maruyama, Rosario Menendez, Mark Metersky, Donna Mildvan, Eric Mortensen, Michael S Niederman, Mathias Pletz, Jordi Rello, Marcos I Restrepo, Yuichiro Shindo, Antoni Torres, Grant Waterer, Brandon Webb, Tobias Welte, Martin Witzenrath, Richard Wunderink,

<h4>Background</h4>Community-acquired pneumonia (CAP) guidelines have improved the treatment and outcomes of patients with CAP, primarily by standardization of initial empirical therapy. But current society-published guidelines exclude immunocompromised patients.<h4>Research question</h4>There is no consensus regarding the initial treatment of immunocompromised patients with suspected CAP.<h4>Study design and methods</h4>This consensus document was created by ... Read more >>

Chest (Chest)
[2020, 158(5):1896-1911]

Cited: 0 times

View full text PDF listing >>



Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).

Florian Kurth, Maria Roennefarth, Charlotte Thibeault, Victor M Corman, Holger Müller-Redetzky, Mirja Mittermaier, Christoph Ruwwe-Glösenkamp, Katrin M Heim, Alexander Krannich, Saskia Zvorc, Sein Schmidt, Lucie Kretzler, Chantip Dang-Heine, Matthias Rose, Michael Hummel, Andreas Hocke, Ralf H Hübner, Bastian Opitz, Marcus A Mall, Jobst Röhmel, Ulf Landmesser, Burkert Pieske, Samuel Knauss, Matthias Endres, Joachim Spranger, Frank P Mockenhaupt, Frank Tacke, Sascha Treskatsch, Stefan Angermair, Britta Siegmund, Claudia Spies, Steffen Weber-Carstens, Kai-Uwe Eckardt, Dirk Schürmann, Alexander Uhrig, Miriam S Stegemann, Thomas Zoller, Christian Drosten, Norbert Suttorp, Martin Witzenrath, Stefan Hippenstiel, Christof von Kalle, Leif Erik Sander,

<h4>Purpose</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide causing a global health emergency. Pa-COVID-19 aims to provide comprehensive data on clinical course, pathophysiology, immunology and outcome of COVID-19, to identify prognostic biomarkers, clinical scores, and therapeutic targets for improved clinical management and preventive interventions.<h4>Methods</h4>Pa-COVID-19 is a prospective observational ... Read more >>

Infection (Infection)
[2020, 48(4):619-626]

Cited: 2 times

View full text PDF listing >>



Pemetrexed-Based Chemotherapy Is Inferior to Pemetrexed-Free Regimens in Thyroid Transcription Factor 1 (TTF-1)-Negative, EGFR/ALK-Negative Lung Adenocarcinoma: A Propensity Score Matched Pairs Analysis.

Nikolaj Frost, Tamar Zhamurashvili, Maximilian von Laffert, Frederick Klauschen, Christoph Ruwwe-Glösenkamp, Matthias Raspe, Matthias Brunn, Sebastian Ochsenreither, Bettina Temmesfeld-Wollbrück, Norbert Suttorp, Christian Grohé, Martin Witzenrath,

INTRODUCTION:Thyroid transcription factor 1 (TTF-1) is a prognostic biomarker in lung adenocarcinoma; however, TTF-1-positive patients also display more favorable factors like actionable target mutations. In contrast, TTF-1-negative cancer is a poorly described entity. We performed a retrospective study to characterize a TTF-1-negative phenotype and to evaluate outcome depending on the ... Read more >>

Clin Lung Cancer (Clinical lung cancer)
[2020, 21(6):e607-e621]

Cited: 0 times

View full text PDF listing >>



Studying the pathophysiology of coronavirus disease 2019 – a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19)

Florian Kurth, Maria Roennefarth, Charlotte Thibeault, Victor Corman, Holger Müller-Redetzky, Mirja Mittermaier, Christoph Ruwwe-Glösenkamp, Alexander Krannich, Sein Schmidt, Lucie Kretzler, Chantip Dang-Heine, Matthias Rose, Michael Hummel, Andreas Hocke, Ralf Hübner, Marcus Mall, Jobst Röhmel, Ulf Landmesser, Burkert Pieske, Samuel Knauss, Matthias Endres, Joachim Spranger, Frank Mockenhaupt, Frank Tacke, Sascha Treskatsch, Stefan Angermair, Britta Siegmund, Claudia Spies, Steffen Weber-Carstens, Kai-Uwe Eckardt, Alexander Uhrig, Thomas Zoller, Christian Drosten, Norbert Suttorp, Martin Witzenrath, Stefan Hippenstiel, Christof von Kalle, Leif Erik Sander,

<h4>Purpose</h4> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide causing a global health emergency. Pa-COVID-19 aims to provide comprehensive data on clinical course, pathophysiology, immunology and outcome of COVID-19, in order to identify prognostic biomarkers, clinical scores, and therapeutic targets for improved clinical management and preventive interventions. <h4>Methods</h4> ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Chronic liver disease negatively affects outcome in hospitalised patients with community-acquired pneumonia.

Carla Bellinghausen, Mathias W Pletz, Jan Rupp, Martin Witzenrath, Christoph Welsch, Stefan Zeuzem, Jonel Trebicka, Gernot G U Rohde, ,

Gut (Gut)
[2021, 70(1):221-222]

Cited: 0 times

View full text PDF listing >>



Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis.

Holger Müller-Redetzky, Ute Kellermann, Sandra-Maria Wienhold, Birgitt Gutbier, Jasmin Lienau, Katharina Hellwig, Katrin Reppe, Eleftheria Letsiou, Thomas Tschernig, Markus Scholz, Peter Ahnert, Christian Maasch, Kai Hoehlig, Sven Klussmann, Axel Vater, Theresa C Firsching, Judith Hoppe, Norbert Suttorp, Martin Witzenrath,

BACKGROUND:Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory functions and is associated with tissue damage in various inflammatory conditions. The authors hypothesized that C5a ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):795-807]

Cited: 2 times

View full text PDF listing >>



Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry.

Daniel Lauster, Simon Klenk, Kai Ludwig, Saba Nojoumi, Sandra Behren, Lutz Adam, Marlena Stadtmüller, Sandra Saenger, Stephanie Zimmler, Katja Hönzke, Ling Yao, Ute Hoffmann, Markus Bardua, Alf Hamann, Martin Witzenrath, Leif E Sander, Thorsten Wolff, Andreas C Hocke, Stefan Hippenstiel, Sacha De Carlo, Jens Neudecker, Klaus Osterrieder, Nediljko Budisa, Roland R Netz, Christoph Böttcher, Susanne Liese, Andreas Herrmann, Christian P R Hackenberger,

Multivalent interactions at biological interfaces occur frequently in nature and mediate recognition and interactions in essential physiological processes such as cell-to-cell adhesion. Multivalency is also a key principle that allows tight binding between pathogens and host cells during the initial stages of infection. One promising approach to prevent infection is ... Read more >>

Nat Nanotechnol (Nature nanotechnology)
[2020, 15(5):373-379]

Cited: 7 times

View full text PDF listing >>



Endoscopic Lung Volume Reduction: Can Endobronchial Valves Be Safely Removed?

Ralf-Harto Hübner, Christoph Ruwwe-Glösenkamp, Jacopo Saccomanno, Pavlina Lenga, Christian Grah, Carmen Pizarro, Martin Witzenrath, Dirk Skowasch,

Respiration (Respiration; international review of thoracic diseases)
[2020, 99(5):459-460]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0563 s