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Four-Year Patient-Level Pooled Mortality Analysis of the ILLUMENATE US Pivotal and EU Randomized Controlled Trials.

Sean P Lyden, Marianne Brodmann, Sahil A Parikh, Prakash Krishnan, Henrik Schroeder, Martin Werner, Andrew Holden, Kenneth Ouriel, Trisha Tarra, William Gray,

<h4>Objective</h4>To perform a meta-analysis of two concordant randomized controlled trials (RCTs) examining the long-term, four-year safety profile of the Stellarex drug-coated balloon (DCB) versus percutaneous transluminal angioplasty (PTA) for the treatment of peripheral artery disease.<h4>Methods</h4>An independent, third-party, meta-analysis of homogenous, patient-level data from the ILLUMENATE Pivotal and ILLUMENATE EU RCTs ... Read more >>

J Vasc Surg (Journal of vascular surgery)
[2021, :]

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Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy.

Alison Halliday, Richard Bulbulia, Leo H Bonati, Johanna Chester, Andrea Cradduck-Bamford, Richard Peto, Hongchao Pan, ,

<h4>Background</h4>Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or ... Read more >>

Lancet (Lancet (London, England))
[2021, 398(10305):1065-1073]

Cited: 1 time

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Ectopic thyroid tissue in the iris: a case report.

Helena Wagner, Claudia Auw-Hädrich, Martin Werner, Thomas Reinhard,

<h4>Background</h4>Ectopic thyroid tissue in the iris, also known as a thyroid glandular epithelial choristoma of the iris, has only been described twice in the literature. In both cases it remained asymptomatic.<h4>Case presentation</h4>A 67-year-old female patient presented for the first time in mid-2017 with corneal endothelial decompensation, with a history of ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2021, 21(1):314]

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A Novel Model for Nephrotic Syndrome Reveals Associated Dysbiosis of the Gut Microbiome and Extramedullary Hematopoiesis.

Jasmin I Maier, Manuel Rogg, Martin Helmstädter, Alena Sammarco, Gerd Walz, Martin Werner, Christoph Schell,

Glomerular kidney disease causing nephrotic syndrome is a complex systemic disorder and is associated with significant morbidity in affected patient populations. Despite its clinical relevance, well-established models are largely missing to further elucidate the implications of uncontrolled urinary protein loss. To overcome this limitation, we generated a novel, inducible, podocyte-specific ... Read more >>

Cells (Cells)
[2021, 10(6):]

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Intravascular Lithotripsy for Peripheral Artery Calcification: 30-Day Outcomes From the Randomized Disrupt PAD III Trial.

Gunnar Tepe, Marianne Brodmann, Martin Werner, William Bachinsky, Andrew Holden, Thomas Zeller, Sarang Mangalmurti, Claus Nolte-Ernsting, Barry Bertolet, Dierk Scheinert, William A Gray, ,

<h4>Objectives</h4>The study sought to compare short-term outcomes in patients with femoropopliteal artery calcification receiving vessel preparation with intravascular lithotripsy (IVL) or percutaneous transluminal angioplasty (PTA) prior to drug-coated balloon (DCB) for symptomatic peripheral artery disease.<h4>Background</h4>Endovascular treatment of calcified peripheral artery lesions is associated with suboptimal vessel expansion and increased complication ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2021, 14(12):1352-1361]

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Alteration of Tissue Marking Dyes Depends on Used Chromogen during Immunohistochemistry.

Selina Kiefer, Julia Huber, Hannah Füllgraf, Kristin Sörensen, Agnes Csanadi, Maren Nicole Stillger, Martin Werner, Hans-Eckart Schaefer, Peter Bronsert, Konrad Aumann,

Pathological biopsy protocols require tissue marking dye (TMD) for orientation. In some cases (e.g., close margin), additional immunohistochemical analyses can be necessary. Therefore, the correlation between the applied TMD during macroscopy and the examined TMD during microscopy is crucial for the correct orientation, the residual tumour status and the subsequent ... Read more >>

Cells (Cells)
[2021, 10(4):]

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Immunohistochemistry-based hypoxia-immune prognostic classifier for head-and-neck cancer patients undergoing chemoradiation - Post-hoc analysis from a prospective imaging trial.

Alexander Rühle, Anca-L Grosu, Nicole Wiedenmann, Raluca Stoian, Erik Haehl, Constantinos Zamboglou, Dimos Baltas, Martin Werner, Gian Kayser, Nils H Nicolay,

<h4>Purpose</h4>As both tumor hypoxia and an immunosuppressing tumor microenvironment hamper the anti-tumor activity of radiotherapy in head-and-neck squamous cell carcinoma (HNSCC), we aimed to develop an immunohistochemistry-based hypoxia-immune classifier.<h4>Methods</h4>39 patients receiving definitive chemoradiation for HNSCC within a prospective trial were included in this analysis. Baseline tumor samples were analyzed for ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 159:75-81]

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Surgeon vs Pathologist for Prediction of Pancreatic Fistula: Results from the Randomized Multicenter RECOPANC Study.

Sylvia Timme, Gian Kayser, Martin Werner, Stanislav Litkevych, Ambrus Gabor Màlyi, Tobias Keck, Peter Bronsert, Ulrich Friedrich Wellner, Ekaterina Petrova, Kim C Honselmann, ,

<h4>Background</h4>Surgically assessed pancreatic texture has been identified as the strongest predictor of postoperative pancreatic fistula. However, texture is a subjective parameter with no proven reliability or validity. Therefore, a more objective parameter is needed. In this study, we evaluated the fibrosis level at the pancreatic neck resection margin and correlated ... Read more >>

J Am Coll Surg (Journal of the American College of Surgeons)
[2021, 232(6):935-945.e2]

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99mTc-labelled PSMA ligand for radio-guided surgery in nodal metastatic prostate cancer: proof of principle.

Michael Mix, Wolfgang Schultze-Seemann, Moritz von Büren, August Sigle, Mohamed A Omrane, Markus T Grabbert, Martin Werner, Christian Gratzke, Philipp T Meyer, Cordula A Jilg,

<h4>Purpose</h4>Intraoperative identification of prostate cancer (PCa) lymph node (LN) metastases (LNM) detected by preoperative PSMA PET/CT may be facilitated by PSMA radio-guided surgery (RGS) with use of a γ-probe. Earlier we demonstrated excellent performance of the <sup>111</sup>In-labelled PSMA ligand DKFZ-617 ([<sup>111</sup>In]In-PSMA-617) in RGS for ex situ distinction of LN vs ... Read more >>

EJNMMI Res (EJNMMI research)
[2021, 11(1):22]

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One Plus One Makes Three: Triangular Coupling of Correlated Amino Acid Mutations.

Martin Werner, Vytautas Gapsys, Bert L de Groot,

Correlated mutations have played a pivotal role in the recent success in protein fold prediction. Understanding nonadditive effects of mutations is crucial for altering protein structure, as mutations of multiple residues may change protein stability or binding affinity in a manner unforeseen by the investigation of single mutants. While the ... Read more >>

J Phys Chem Lett (The journal of physical chemistry letters)
[2021, 12(12):3195-3201]

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Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis.

Rouven Hoefflin, Adriana Lazarou, Maria Elena Hess, Meike Reiser, Julius Wehrle, Patrick Metzger, Anna Verena Frey, Heiko Becker, Konrad Aumann, Kai Berner, Martin Boeker, Nico Buettner, Christine Dierks, Jesus Duque-Afonso, Michel Eisenblaetter, Thalia Erbes, Ralph Fritsch, Isabell Xiang Ge, Anna-Lena Geißler, Markus Grabbert, Steffen Heeg, Dieter Henrik Heiland, Simone Hettmer, Gian Kayser, Alexander Keller, Anita Kleiber, Alexandra Kutilina, Leman Mehmed, Frank Meiss, Philipp Poxleitner, Justyna Rawluk, Juri Ruf, Henning Schäfer, Florian Scherer, Khalid Shoumariyeh, Andreas Tzschach, Christoph Peters, Tilman Brummer, Martin Werner, Justus Duyster, Silke Lassmann, Cornelius Miething, Melanie Boerries, Anna L Illert, Nikolas von Bubnoff,

Molecular precision oncology faces two major challenges: first, to identify relevant and actionable molecular variants in a rapidly changing field and second, to provide access to a broad patient population. Here, we report a four-year experience of the Molecular Tumor Board (MTB) of the Comprehensive Cancer Center Freiburg (Germany) including ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(5):]

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EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission.

Jasmin I Maier, Manuel Rogg, Martin Helmstädter, Alena Sammarco, Oliver Schilling, Benedikt Sabass, Jeffrey H Miner, Jörn Dengjel, Gerd Walz, Martin Werner, Tobias B Huber, Christoph Schell,

The integrity of the kidney filtration barrier essentially relies on the balanced interplay of podocytes and the glomerular basement membrane (GBM). Here, we show by analysis of in vitro and in vivo models that a loss of the podocyte-specific FERM-domain protein EPB41L5 results in impaired extracellular matrix (ECM) assembly. By using quantitative ... Read more >>

Cell Rep (Cell reports)
[2021, 34(12):108883]

Cited: 1 time

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SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.

Manuel Rogg, Jasmin I Maier, Robert Dotzauer, Nadine Artelt, Oliver Kretz, Martin Helmstädter, Ahmed Abed, Alena Sammarco, August Sigle, Dominik Sellung, Patrick Dinse, Karoline Reiche, Mako Yasuda-Yamahara, Martin L Biniossek, Gerd Walz, Martin Werner, Nicole Endlich, Oliver Schilling, Tobias B Huber, Christoph Schell,

<h4>Background</h4>Previous research demonstrated that small Rho GTPases, modulators of the actin cytoskeleton, are drivers of podocyte foot-process effacement in glomerular diseases, such as FSGS. However, a comprehensive understanding of the regulatory networks of small Rho GTPases in podocytes is lacking.<h4>Methods</h4>We conducted an analysis of podocyte transcriptome and proteome datasets for ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2021, 32(3):563-579]

Cited: 1 time

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The Onset of the Last Interglacial and Fingerprints of Transient Atlantic Meridional Overturning Circulation

Paul Gierz, Gregor Knorr, Aline Govin, Emilie Capron, Nadezhda Sokolova, Martin Werner, Gerrit Lohmann,

Transitions from glacials to interglacials are the largest climate shifts that occurred during the Quaternary. These glacial terminations are characterized by transient changes in the Atlantic Meridional Overturning Circulation (AMOC) and associated alterations in the northward heat transport. It has been a challenge to differentiate between early last interglacial or ... Read more >>

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Delayed non-myeloablative irradiation to induce long-term allograft acceptance in a large animal lung transplantation model.

Karolin S Hacker, Katharina Jansson, Jeanette Pichler, Jawad Salman, Murat Avsar, Thierry Siemeni, Ann-Kathrin Knöfel, Klaus Höffler, Jens Gottlieb, Jörg Frühauf, Martin Werner, Reza Poyanmehr, Danny Jonigk, Michael S Balzer, Marion Hewicker-Trautwein, Axel Haverich, Wiebke Sommer, Gregor Warnecke,

We previously induced long-term allograft acceptance in an allogeneic lung transplantation (LTx) model in miniature swine using perioperative non-myeloablative irradiation (IRR) combined with infusion of donor specific alloantigen. In order to improve clinical applicability, we delayed induction with irradiation in this study. Left sided single LTx was performed in minipigs. ... Read more >>

Transpl Immunol (Transplant immunology)
[2021, 65:101350]

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Lymphocyte Infiltration Determines the Hypoxia-Dependent Response to Definitive Chemoradiation in Head-and-Neck Cancer: Results from a Prospective Imaging Trial.

Nils H Nicolay, Alexander Rühle, Nicole Wiedenmann, Gabriele Niedermann, Michael Mix, Wolfgang A Weber, Dimos Baltas, Martin Werner, Gian Kayser, Anca-L Grosu,

Tumor hypoxia in head-and-neck squamous cell carcinoma (HNSCC) leads to an immunosuppressive microenvironment and reduces the response to radiotherapy. In this prospective imaging trial, we investigated potential interactions between functional hypoxia imaging and infiltrating lymphocyte levels as a potential predictor for treatment response in HNSCC patients. <b>Methods:</b> In total, 49 ... Read more >>

J Nucl Med (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2021, 62(4):471-478]

Cited: 4 times

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Prevalence and characteristics of myeloproliferative neoplasms with concomitant monoclonal gammopathy.

Nora Rebeka Javorniczky, Julius Wehrle, Gabriele Ihorst, Valerie Hupfer, Konrad Aumann, Dietmar Pfeifer, Christoph Niemöller, Sabine Bleul, Milena Pantic, Martin Werner, Justus Duyster, Jürgen Finke, Monika Engelhardt, Nikolas von Bubnoff, Cornelius F Waller, Heike L Pahl, Heiko Becker,

Of BCR-ABL negative myeloproliferative neoplasm (MPN) patients, 3-14 % display a concomitant monoclonal gammopathy (MGUS). Nonetheless, literature on co-occurring MPN and MGUS is scarce, the molecular underpinnings are unknown and it is unclear whether patients require a specific management. Here, we compared the clinical and genetic features of MPN patients ... Read more >>

Leuk Res (Leukemia research)
[2020, 98:106454]

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Prognostic impact of tumor budding and EMT in periampullary adenocarcinoma: a quantitative approach.

Éva Kocsmár, Gábor Lotz, András Kiss, Markus Hoerner, Ekaterina Petrova, Nikolaus Freudenberg, Ágnes Csanádi, Birte Kulemann, Martin Werner, Peter Bronsert, Ulrich Friedrich Wellner,

The presence of invasive cell clusters known as tumor budding and the closely related epithelial mesenchymal transition (EMT) have a prognostic impact on cancer patients' overall survival. Interestingly, data quantitatively analyzing and correlating the amount of tumor buds and patient overall survival as well as the impact of expression of ... Read more >>

J Cancer (Journal of Cancer)
[2020, 11(22):6474-6483]

Cited: 1 time

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High Numbers and Densities of PD1+ T-Follicular Helper Cells in Triple-Negative Breast Cancer Draining Lymph Nodes Are Associated with Lower Survival.

Peter Bronsert, Anna von Schoenfeld, Jose Villacorta Hidalgo, Stefan Kraft, Jens Pfeiffer, Thalia Erbes, Martin Werner, Maximilian Seidl,

Breast cancer tumor draining lymph nodes (TDLNs) display distinct morphologic changes depending on the breast cancer subtype. For triple-negative breast cancers (TNBC), draining LNs display a higher amount of secondary lymphoid follicles, which can be regarded as a surrogate marker for an activated humoral immune response. In the present study, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(17):]

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Immunohistochemistry and Radiomic Features for Survival Prediction in Small Cell Lung Cancer.

Eleni Gkika, Matthias Benndorf, Benedict Oerther, Farid Mohammad, Susanne Beitinger, Sonja Adebahr, Montserrat Carles, Tanja Schimek-Jasch, Constantinos Zamboglou, Björn C Frye, Fabian Bamberg, Cornelius F Waller, Martin Werner, Anca L Grosu, Ursula Nestle, Gian Kayser,

<b>Background:</b> The aim of the study was to evaluate the role of different immunohistochemical and radiomics features in patients with small cell lung cancer (SCLC). <b>Methods:</b> Consecutive patients with histologically proven SCLC with limited (<i>n</i> = 47, 48%) or extensive disease (<i>n</i> = 51, 52%) treated with radiotherapy and chemotherapy ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1161]

Cited: 1 time

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Hypoxia dynamics on FMISO-PET in combination with PD-1/PD-L1 expression has an impact on the clinical outcome of patients with Head-and-neck Squamous Cell Carcinoma undergoing Chemoradiation.

Alexander Rühle, Anca-L Grosu, Nicole Wiedenmann, Michael Mix, Raluca Stoian, Gabriele Niedermann, Dimos Baltas, Martin Werner, Wolfgang A Weber, Gian Kayser, Nils H Nicolay,

Tumor-associated hypoxia influences the radiation response of head-and-neck cancer (HNSCC) patients, and a lack of early hypoxia resolution during treatment considerably deteriorates outcomes. As the detrimental effects of hypoxia are partly related to the induction of an immunosuppressive microenvironment, we investigated the interaction between tumor hypoxia dynamics and the PD-1/PD-L1 ... Read more >>

Theranostics (Theranostics)
[2020, 10(20):9395-9406]

Cited: 2 times

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Distinct bone marrow morphologic features discriminate myelodysplastic syndromes patients with and without an early platelet response to decitabine.

Annette M May, Julia Stomper, Tina E Joeckel, Peter Bronsert, Pierre W Wijermans, Martin Werner, Michael Lübbert,

Br J Haematol (British journal of haematology)
[2020, 189(5):e194-e197]

Cited: 0 times

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γδ T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity.

Anke Janssen, Jose Villacorta Hidalgo, Dennis X Beringer, Sanne van Dooremalen, Febilla Fernando, Eline van Diest, Antonela R Terrizi, Peter Bronsert, Sylvia Kock, Annette Schmitt-Gräff, Martin Werner, Kerstin Heise, Marie Follo, Trudy Straetemans, Zsolt Sebestyen, Dmitry M Chudakov, Sofya A Kasatskaya, Felix E Frenkel, Sarina Ravens, Eric Spierings, Immo Prinz, Ralf Küppers, Miroslav Malkovsky, Paul Fisch, Jürgen Kuball,

γδ T cells in human solid tumors remain poorly defined. Here, we describe molecular and functional analyses of T-cell receptors (TCR) from tumor-infiltrating γδ T lymphocytes (γδ TIL) that were in direct contact with tumor cells in breast cancer lesions from archival material. We observed that the majority of γδ ... Read more >>

Cancer Immunol Res (Cancer immunology research)
[2020, 8(4):530-543]

Cited: 13 times

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Accessible and reproducible mass spectrometry imaging data analysis in Galaxy.

Melanie Christine Föll, Lennart Moritz, Thomas Wollmann, Maren Nicole Stillger, Niklas Vockert, Martin Werner, Peter Bronsert, Karl Rohr, Björn Andreas Grüning, Oliver Schilling,

BACKGROUND:Mass spectrometry imaging is increasingly used in biological and translational research because it has the ability to determine the spatial distribution of hundreds of analytes in a sample. Being at the interface of proteomics/metabolomics and imaging, the acquired datasets are large and complex and often analyzed with proprietary software or ... Read more >>

Gigascience (GigaScience)
[2019, 8(12):]

Cited: 6 times

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Sclerosing angiomatoid nodular transformation of the spleen, a rare cause for splenectomy: Two case reports.

Sophia Chikhladze, Ann-Kathrin Lederer, Stefan Fichtner-Feigl, Uwe A Wittel, Martin Werner, Konrad Aumann,

BACKGROUND:Sclerosing angiomatoid nodular transformation (SANT) is a rare benign disease of the spleen with unknown origin. Clinical symptoms are inhomogeneous, and suspicious splenic lesion often found incidentally, leading to splenectomy, as malignancy cannot securely be ruled out. Diagnosis is made histologically after resection. CASE SUMMARY:Two cases of German, white, non-smoking, ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2020, 8(1):103-109]

Cited: 3 times

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