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Author Martin Salazar

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EFFECT OF CONVALESCENT PLASMA ON MORTALITY IN PATIENTS WITH COVID-19 PNEUMONIA

Martín Salazar, Soledad González, Lorena Regairaz, Noelia Ferrando, Veronica González Martínez, Patricia Carrera Ramos, Laura Muñoz, Santiago Pesci, Juan Vidal, Nicolas Kreplak, Elisa Estenssoro,

Abstract Background Convalescent plasma, widely utilized in viral infections that induce neutralizing antibodies, has been proposed for COVID-19, and preliminary evidence shows that it might have beneficial effect. Our objective was to compare epidemiological characteristics and outcomes between patients who received convalescent plasma for COVID-19 and those who did not, ... Read more >>

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Arterial hypertension and the risk of severity and mortality of COVID-19.

Carlos Enrique Leiva Sisnieguez, Walter Gastón Espeche, Martín Rogelio Salazar,

Eur. Respir. J. (The European respiratory journal)
[2020, 55(6):]

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Classification of the Molecular Defects Associated with Pathogenic Variants of the SLC6A8 Creatine Transporter.

Martin D Salazar, Nathan B Zelt, Robert Saldivar, Charles P Kuntz, Sheng Chen, Wesley D Penn, Richard Bonneau, Julia Koehler Leman, Jonathan P Schlebach,

More than 80 loss-of-function (LOF) mutations in the SLC6A8 creatine transporter (hCRT1) are responsible for cerebral creatine deficiency syndrome (CCDS), which gives rise to a spectrum of neurological defects, including intellectual disability, epilepsy, and autism spectrum disorder. To gain insight into the nature of the molecular defects caused by these ... Read more >>

Biochemistry (Biochemistry)
[2020, 59(13):1367-1377]

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Prevalence of isolated nocturnal hypertension according to 2018 European Society of Cardiology and European Society of Hypertension office blood pressure categories.

Martin R Salazar, Walter G Espeche, Eduardo Balbín, Carlos E Leiva Sisnieguez, Julián Minetto, Betty C Leiva Sisnieguez, Pablo M Maciel, Rodolfo N Stavile, Horacio A Carbajal,

OBJECTIVES:To estimate the prevalence of isolated nocturnal hypertension (INH) and its relationships with office blood pressure (BP) categories defined by 2018 ESC/ESH guidelines. METHODS:We conducted a prospective cohort study in consecutive patients referred to perform an ambulatory blood pressure monitoring (ABPM) for diagnosis or therapeutic purposes. Office BP measurements and ... Read more >>

J. Hypertens. (Journal of hypertension)
[2020, 38(3):434-440]

Cited: 1 time

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Adherence to antihypertensive drug treatment in Argentina: A multicenter study.

Walter Espeche, Martin R Salazar, Rodrigo Sabio, Alejandro Diaz, Carlos Leiva Sisnieguez, Daniel Olano, Eduardo Balbin, Nicolas Renna, Pedro Grosse, Roberto A Flores, Ana C Lagos, Pablo Ferrer, Silvia Poppe, Facundo Risso Patron, Victor D Sotnieczuk Stasiuk, Elina Valentini, Jose R Cardozo, Jose R Romano, Roberto Parodi, Horacio Carbajal,

Adherence to antihypertensive medication is an important challenge that doctors often face in the treatment of hypertension. Good adherence is crucial to prevent cardiovascular complications. In consequence, the present study aimed at determining the prevalence of adherence to antihypertensive treatment and identifying associated clinical variables. A multicenter cross-sectional study was ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2020, 22(4):656-662]

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[Convalescent plasma therapy in COVID-19 patients, in the Province of Buenos Aires].

Soledad E González, Lorena Regairaz, Noelia S Ferrando, Veronica V González Martínez, Martín R Salazar, Elisa Estenssoro,

This is a preliminary, multicenter, retrospective cohort study, including 272 consecutive patients with COVID-19 admitted to hospitals in Buenos Aires Province, between May 15th and July 1st, 2020, included in an expanded access program to convalescent plasma. Our objectives were to analyze mortality and its independent risk factors, and to ... Read more >>

Medicina (B Aires) (Medicina)
[2020, 80(5):417-424]

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Evaluation of ventricular-arterial coupling by impedance cardiography in healthy volunteers.

Ricardo D Olano, Walter G Espeche, Martin R Salazar, Pedro Forcada, Julio A Chirinos, Ana de Iraola, Carlos E Leiva Sisnieguez, Betty C Leiva Sisnieguez, Eduardo Balbín, Horacio A Carbajal,

BACKGROUND:The interplay between cardiac function and the arterial system is currently defined as ventricular-arterial coupling (VAC) and it is an expression of global cardiovascular efficiency. VAC involves a variety of complex interactions between the heart and the vasculature. A basic index of VAC is the ratio of effective arterial elastance ... Read more >>

Physiol Meas (Physiological measurement)
[2019, 40(11):115002]

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Office blood pressure values and the necessity of out-of-office measurements in high-risk pregnancies.

Martin R Salazar, Walter G Espeche, Eduardo Balbín, Carlos E Leiva Sisnieguez, Betty C Leiva Sisnieguez, Rodolfo N Stavile, Carlos March, Ricardo D Olano, Adelaida Soria, Osvaldo Yoma, Marcelo Prudente, Soledad Torres, Florencia Grassi, Claudia Santillan, Patricia Carrera Ramos, Horacio A Carbajal,

OBJECTIVES:To determine if there is an office blood pressure (BP) value below which out-of-office measurements are unnecessary in high-risk pregnant women. METHODS:We conducted a prospective cohort study in women in the second half of high-risk pregnancies. Office BP measurements and ambulatory blood pressure monitoring (ABPM) was performed. The cohort was ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, 37(9):1838-1844]

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Hypertension control in Argentina, in the middle of a long road.

Horacio A Carbajal, Martin R Salazar,

In Argentina, cardiovascular diseases are the leading cause of death and represent 1/3 of total mortality. In 2017, hypertension prevalence for inhabitants ≥18 years old was 36.3%, and its level of knowledge and control (<140/90 mm Hg) were 61% and 24%, respectively. Furthermore, 56% of people treated with antihypertensive drugs do not reach ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2019, 21(10):1604-1606]

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Nocturnal hypertension in high-risk mid-pregnancies predict the development of preeclampsia/eclampsia.

Martin R Salazar, Walter G Espeche, Carlos E Leiva Sisnieguez, Betty C Leiva Sisnieguez, Eduardo Balbín, Rodolfo N Stavile, Carlos March, Ricardo D Olano, Adelaida Soria, Osvaldo Yoma, Marcelo Prudente, Soledad Torres, Florencia Grassi, Claudia Santillan, Horacio A Carbajal,

OBJECTIVE:The aim of this study was to test if hypertension detected by ambulatory blood pressure monitoring (ABPM) performed at mid-pregnancy, is a useful predictor for preeclampsia/eclampsia (PEEC). METHODS:The study was performed in women coursing high-risk mid-pregnancies. Office blood pressure (BP) was estimated as the mean of three values, taken by ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, 37(1):182-186]

Cited: 2 times

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Could self-measured office blood pressure be a hypertension screening tool for limited-resources settings?

Martin R Salazar, Walter G Espeche, Rodolfo N Stavile, Eduardo Balbín, Betty C Leiva Sisnieguez, Carlos E Leiva Sisnieguez, Carlos E March, Susana Cor, Irma Eugenio Acero, Horacio A Carbajal,

Blood pressure (BP) was assessed by patients themselves in recently published trials. Self-measured office blood pressure (SMOBP) seems particularly interesting for limited health resources regions. The aim of our study was to evaluate the relationship between SMOBP values and those estimated by ambulatory blood pressure monitoring (ABPM). Six hundred seventy-seven ... Read more >>

J Hum Hypertens (Journal of human hypertension)
[2018, 32(6):415-422]

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Nocturnal but not Diurnal Hypertension Is Associated to Insulin Resistance Markers in Subjects With Normal or Mildly Elevated Office Blood Pressure.

Martin R Salazar, Walter G Espeche, Rodolfo N Stavile, Liliana Disalvo, Andrea Tournier, Betty C Leiva Sisnieguez, Ana Varea, Carlos E Leiva Sisnieguez, Carlos E March, Horacio A Carbajal,

OBJECTIVE:The aim was to evaluate the relationships among insulin resistance markers and nocturnal and diurnal hypertension in normotensive or mildly untreated hypertensive adults. METHODS:The study was performed in both female and male adults referred to the Cardiometabolic Unit of the Hospital San Martín, La Plata, Argentina, in order to perform ... Read more >>

Am. J. Hypertens. (American journal of hypertension)
[2017, 30(10):1032-1038]

Cited: 2 times

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Significance of masked and nocturnal hypertension in normotensive women coursing a high-risk pregnancy.

Martin R Salazar, Walter G Espeche, Betty C Leiva Sisnieguez, Eduardo Balbín, Carlos E Leiva Sisnieguez, Rodolfo N Stavile, Carlos E March, Florencia Grassi, Claudia Santillan, Susana Cor, Horacio A Carbajal,

The aim was to evaluate the prevalence of nocturnal and masked hypertension and the prognostic values of these blood pressure (BP) abnormalities in normotensive women coursing a high-risk pregnancy.The study was performed in pregnant women with 20 or more weeks of gestation coursing a high-risk pregnancy, sent to a specialized ... Read more >>

J. Hypertens. (Journal of hypertension)
[2016, 34(11):2248-2252]

Cited: 9 times

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Insulin resistance: The linchpin between prediabetes and cardiovascular disease.

Martin R Salazar, Horacio A Carbajal, Walter G Espeche, Marcelo Aizpurúa, Carlos E Leiva Sisnieguez, Betty C Leiva Sisnieguez, Rodolfo N Stavile, Carlos E March, Gerald M Reaven,

The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, ... Read more >>

Diab Vasc Dis Res (Diabetes & vascular disease research)
[2016, 13(2):157-163]

Cited: 11 times

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Risk of cardiovascular disease according to blood pressure categories in an argentinian cohort.

Martin R Salazar, Walter G Espeche, Marcelo Aizpurua, Betty C Leiva Sisnieguez, Carlos D Leiva Sisnieguez, Carlos A Dulbecco, Horacio A Carbajal,

Hypertension is a recognized strong risk factor for cardiovascular disease. However, no data was available in our country to quantify the relationship between blood pressure and cardiovascular event.to quantify the risk of cardiovascular events according to blood pressure categories.A prospective epidemiological study was conducted in 1526 inhabitants from Rauch City, ... Read more >>

Rev Fac Cien Med Univ Nac Cordoba (Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina))
[2016, 73(3):181-187]

Cited: 1 time

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The Reply.

Martin R Salazar, Gerald M Reaven,

Am J Med (The American journal of medicine)
[2015, 128(7):e27]

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Use of the plasma triglyceride/high-density lipoprotein cholesterol ratio to identify cardiovascular disease in hypertensive subjects.

Martin R Salazar, Horacio A Carbajal, Walter G Espeche, Marcelo Aizpurúa, Carlos E Leiva Sisnieguez, Betty C Leiva Sisnieguez, Carlos E March, Rodolfo N Stavile, Eduardo Balbín, Gerald M Reaven,

This analysis evaluated the hypothesis that the plasma triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) concentration ratio can help identify patients with essential hypertension who are insulin-resistant, with the cardiovascular disease (CVD) risk profile associated with that defect. Data from a community-based study developed between 2003 and 2012 were used to compare ... Read more >>

J Am Soc Hypertens (Journal of the American Society of Hypertension : JASH)
[2014, 8(10):724-731]

Cited: 14 times

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Identification of cardiometabolic risk: visceral adiposity index versus triglyceride/HDL cholesterol ratio.

Martin R Salazar, Horacio A Carbajal, Walter G Espeche, Marcelo Aizpurúa, Pablo M Maciel, Gerald M Reaven,

BACKGROUND: The plasma concentration ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) can identify cardiometabolic risk and cardiovascular disease. The visceral adiposity index is a sex-specific index, in which measurements of body mass index and waist circumference are combined with TG and HDL-C concentrations. The current analysis was initiated to see ... Read more >>

Am J Med (The American journal of medicine)
[2014, 127(2):152-157]

Cited: 28 times

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Blood pressure response to a community-based program and long-term cardiovascular outcome.

Martin R Salazar, Walter G Espeche, Marcelo Aizpurúa, Betty C Leiva Sisnieguez, Eduardo Balbín, Carlos A Dulbecco, Horacio A Carbajal,

BACKGROUND: The significance in terms of the cardiovascular outcome of different patterns of blood pressure (BP) response to community-based activities has not been previously studied. The aim of our study was to evaluate the relationship between changes of BP observed during a community-based program and long-term rate of cardiovascular disease ... Read more >>

Am. J. Hypertens. (American journal of hypertension)
[2014, 27(8):1061-1068]

Cited: 3 times

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Do differences in waist circumference modify the relationships among body mass index, insulin resistance, and related cardiometabolic risk factors in apparently healthy women?

Martin R Salazar, Horacio A Carbajal, Walter G Espeche, Eduardo Balbín, Marcelo Aizpurúa, Alberto G Marillet, Gerald M Reaven,

OBJECTIVE: The aims of the study were to (1) compare the cardiometabolic risk profile between insulin-resistant and non-insulin-resistant women within similar body mass indexes (BMIs) and waist circumference (WC) groupings and (2) test the hypothesis that measurements of BMI are not inferior to WC in identifying insulin resistance. METHODS: The ... Read more >>

J Am Coll Nutr (Journal of the American College of Nutrition)
[2014, 33(1):32-38]

Cited: 2 times

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Comparison of the abilities of the plasma triglyceride/high-density lipoprotein cholesterol ratio and the metabolic syndrome to identify insulin resistance.

Martin R Salazar, Horacio A Carbajal, Walter G Espeche, Carlos E Leiva Sisnieguez, Carlos E March, Eduardo Balbín, Carlos A Dulbecco, Marcelo Aizpurúa, Alberto G Marillet, Gerald M Reaven,

This study compares the ability of an elevated triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio, using sex-specific cut-points, to identify insulin-resistant individuals within a population without known cardiac disease or diabetes with that obtained using the diagnostic criteria of the metabolic syndrome (MetS). Measurements were made of waist circumference (WC), systolic and ... Read more >>

Diab Vasc Dis Res (Diabetes & vascular disease research)
[2013, 10(4):346-352]

Cited: 23 times

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Relation among the plasma triglyceride/high-density lipoprotein cholesterol concentration ratio, insulin resistance, and associated cardio-metabolic risk factors in men and women.

Martin R Salazar, Horacio A Carbajal, Walter G Espeche, Carlos E Leiva Sisnieguez, Eduardo Balbín, Carlos A Dulbecco, Marcelo Aizpurúa, Alberto G Marillet, Gerald M Reaven,

Results of recent studies using the ratio of plasma triglyceride (TG) to high-density lipoprotein (HDL) cholesterol concentration to identify insulin-resistant patients at increased cardiometabolic risk have emphasized that the cut point used for this purpose will vary with race. Because TG and HDL cholesterol concentrations vary with gender, this analysis ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2012, 109(12):1749-1753]

Cited: 61 times

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Sex-related difference in left ventricular mass in nonhypertensive young adults: role of arterial pressure.

Eduardo M Escudero, Oscar A Pinilla, Martín R Salazar, Irene L Ennis,

BACKGROUND: Blood pressure (BP) is higher in men than in women at similar ages through adult life. Interestingly, a similar pattern is detected in left ventricular mass (LVM), classically attributed to differences in body size. However, the existing difference in BP between sexes might be relevant in determining LVM and ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2012, 28(4):464-470]

Cited: 0 times

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Thrombin-receptor antagonist vorapaxar in acute coronary syndromes.

Pierluigi Tricoci, Zhen Huang, Claes Held, David J Moliterno, Paul W Armstrong, Frans Van de Werf, Harvey D White, Philip E Aylward, Lars Wallentin, Edmond Chen, Yuliya Lokhnygina, Jinglan Pei, Sergio Leonardi, Tyrus L Rorick, Ann M Kilian, Lisa H K Jennings, Giuseppe Ambrosio, Christoph Bode, Angel Cequier, Jan H Cornel, Rafael Diaz, Aycan Erkan, Kurt Huber, Michael P Hudson, Lixin Jiang, J Wouter Jukema, Basil S Lewis, A Michael Lincoff, Gilles Montalescot, José Carlos Nicolau, Hisao Ogawa, Matthias Pfisterer, Juan Carlos Prieto, Witold Ruzyllo, Peter R Sinnaeve, Robert F Storey, Marco Valgimigli, David J Whellan, Petr Widimsky, John Strony, Robert A Harrington, Kenneth W Mahaffey, ,

BACKGROUND: Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation. METHODS: In this multinational, double-blind, randomized trial, we compared vorapaxar with placebo in 12,944 patients who had acute coronary syndromes without ST-segment elevation. The primary end point was a composite of death from cardiovascular causes, ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2012, 366(1):20-33]

Cited: 376 times

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Structure, electronic, and optical properties of TiO2 atomic clusters: an ab initio study.

Letizia Chiodo, Martin Salazar, Aldo H Romero, Savio Laricchia, Fabio Della Sala, Angel Rubio,

Atomic clusters of TiO(2) are modeled by means of state-of-the-art techniques to characterize their structural, electronic and optical properties. We combine ab initio molecular dynamics, static density functional theory, time-dependent density functional theory, and many body techniques, to provide a deep and comprehensive characterization of these systems. TiO(2) clusters can ... Read more >>

J Chem Phys (The Journal of chemical physics)
[2011, 135(24):244704]

Cited: 10 times

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