Full Text Journal Articles by
Author Markus Rupp

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The Incidence of Fractures Among the Adult Population of Germany – and Analysis From 2009 through 2019.

Markus Rupp, Nike Walter, Christian Pfeifer, Siegmund Lang, Maximilian Kerschbaum, Werner Krutsch, Florian Baumann, Volker Alt,

<h4>Background</h4>Detailed analyses of epidemiological data on fractures are an important resource for persons and institutions providing health care services, as they yield information on the effects of current treatment strategies and on the need for preventive measures. The epidemiology of fractures in Germany, however, is unknown. The goal of this ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):]

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Letter in response to article in journal of infection: "The microbiology of chronic osteomyelitis: Changes over ten years".

Nike Walter, Susanne Baertl, Ulrike Engelstaedter, Martin Ehrenschwender, Florian Hitzenbichler, Volker Alt, Markus Rupp,

J Infect (The Journal of infection)
[2021, :]

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Intracellular S. aureus in Osteoblasts in a Clinical Sample from a Patient with Chronic Osteomyelitis-A Case Report.

Nike Walter, Daniel Mendelsohn, Christoph Brochhausen, Markus Rupp, Volker Alt,

The pathophysiological role of intracellular bacteria in osteomyelitis is still a matter of debate. Here, we demonstrate for the first time the presence of <i>Staphylococcus aureus</i> internalized into osteoblasts in human tissue samples of a case with a chronic osteomyelitis using ultrastructural transmission electron microscope analysis. ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2021, 10(8):]

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[Treatment of bone and periprosthetic infections with bacteriophages : A systematic review].

Nike Walter, Li Deng, Christoph Brochhausen, Volker Alt, Markus Rupp,

<h4>Background</h4>The treatment of bone and prosthesis infections remains difficult despite modern treatment concepts. Further tools for the improvement of treatment outcome are desirable. Preclinical studies provide promising evidence of the efficacy of bacteriophages for the treatment of bone and joint infections.<h4>Objectives</h4>The present work provides a systematic review of the clinical application ... Read more >>

Orthopade (Der Orthopade)
[2021, :]

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Is There a Difference in Microbiological Epidemiology and Effective Empiric Antimicrobial Therapy Comparing Fracture-Related Infection and Periprosthetic Joint Infection? A Retrospective Comparative Study.

Markus Rupp, Susanne Baertl, Nike Walter, Florian Hitzenbichler, Martin Ehrenschwender, Volker Alt,

This study aims to investigate (1) microbial patterns in fracture-related infections (FRIs) in comparison to microbiological patterns of periprosthetic joint infections (PJIs), (2) the identification of effective empiric antibiotic therapy for FRIs and PJIs and (3) analysis of difficult-to-treat (DTT) pathogens. Patients treated for FRIs or PJIs from 2017 to ... Read more >>

Antibiotics (Basel) (Antibiotics (Basel, Switzerland))
[2021, 10(8):]

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Recent trends in revision knee arthroplasty in Germany.

Markus Rupp, Nike Walter, Edmund Lau, Michael Worlicek, Steven M Kurtz, Volker Alt,

We aimed to answer the following questions: (1) How did numbers of revision knee arthroplasty procedures develop in Germany over the last decade compared to primary TKA? (2) How high was the percentage of septic interventions in knee prosthesis revisions? (3) Which treatment strategy was chosen for surgical treatment of ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):15479]

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Surgical Drill Guide for Insertion of an Infra-Acetabular Screw Based on an Anatomically Precontoured Plate System: A Cadaveric Study.

Viola Freigang, Maximilian Gottsauner, Markus Rupp, Christian Pfeifer, Stephan Grechenig, Alexander Kerner, Volker Alt, Florian Baumann,

<h4>Purpose</h4>Due to the anatomic structure of the pelvis, free-hand placement of screws in the acetabular fracture management can be difficult. Infra-acetabular screw fixation increases acetabular stability by distal fixation of the cup. Aim of this cadaveric study is to investigate if a plate-referenced drill guide can provide save placement of ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:2321504]

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Erratum zu: Knochentransplantation oder Biomaterial? : Eine Analyse von 99.863 Operationen in Orthopädie und Unfallchirurgie aus dem Jahr 2018 in Deutschland.

Markus Rupp, Maximilian Kerschbaum, Lisa Klute, Leona Frank, Volker Alt,

Unfallchirurg (Der Unfallchirurg)
[2021, :]

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The clinical use of bone graft substitutes in orthopedic surgery in Germany-A 10-years survey from 2008 to 2018 of 1,090,167 surgical interventions.

Markus Rupp, Lisa Klute, Susanne Baertl, Nike Walter, Gopala-Krishna Mannala, Leona Frank, Christian Pfeifer, Volker Alt, Maximilian Kerschbaum,

Aim of the study was to evaluate (1) the overall use of bone graft substitutes, autografts and allografts, (2) of different types of bone graft substitutes (calcium sulfate, calcium phosphate, calcium phosphate ceramics or polymethyl methacrylate) and of different bone grafts (cancellous vs. cortical), and (3) the use of antibiotic-loading ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Erratum zu: PJI-TNM als neues Klassifikationssystem für Endoprotheseninfektionen : Eine Evaluation von 20 Fällen.

Markus Rupp, Maximilian Kerschbaum, Viola Freigang, Susanne Bärtl, Florian Baumann, Andrej Trampuz, Volker Alt,

Orthopade (Der Orthopade)
[2021, 50(7):587-588]

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What is the burden of osteomyelitis in Germany? An analysis of inpatient data from 2008 through 2018.

Nike Walter, Susanne Baertl, Volker Alt, Markus Rupp,

<h4>Background</h4>The epidemiology of osteomyelitis in Germany is unknown, which makes it difficult to estimate future demands. Therefore, we aimed to analyse how the numbers of cases have developed over the last decade as a function of osteomyelitis subtype, age group, gender, and anatomical localization.<h4>Methods</h4>Osteomyelitis rates were quantified based on annual ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2021, 21(1):550]

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Long-term patient-related quality of life after fracture-related infections of the long bones.

Nike Walter, Markus Rupp, Katja Hierl, Christian Pfeifer, Maximilian Kerschbaum, Thilo Hinterberger, Volker Alt,

<h4>Aims</h4>We aimed to evaluate the long-term impact of fracture-related infection (FRI) on patients' physical health and psychological wellbeing. For this purpose, quality of life after successful surgical treatment of FRIs of long bones was assessed.<h4>Methods</h4>A total of 37 patients treated between November 2009 and March 2019, with achieved eradication of ... Read more >>

Bone Joint Res (Bone & joint research)
[2021, 10(5):321-327]

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[Polymethyl methacrylate cement coating of intramedullary implants : A new technique for revision surgery with the example of a temporary knee arthrodesis. Video article].

Markus Rupp, Nike Walter, Abdullah Ismat, Volker Alt,

<h4>Background</h4>The coating of intramedullary rods with polymethyl methacrylate (PMMA) bone cement containing antibiotics ensures a high concentration of antibiotics locally and stability in fractures that are not yet consolidated. However, bone cement can detach when the implant is removed and remain in the medullary cavity of the long bones.<h4>Case report</h4>After ... Read more >>

Orthopade (Der Orthopade)
[2021, 50(9):758-762]

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[Infections of the spine : Pyogenic spondylodiscitis and implant-associated vertebral osteomyelitis].

Siegmund Lang, Markus Rupp, Frank Hanses, Carsten Neumann, Markus Loibl, Volker Alt,

Pyogenic (unspecific) spondylodiscitis and implant-associated vertebral osteomyelitis (IAVO) are important diseases with the risk of neurological and septic complications. An early diagnosis is essential in which magnetic resonance imaging (MRI), histopathology and microbiological identification of the pathogen play key roles. The goals of conservative treatment in uncomplicated spondylodiscitis are antibiotic ... Read more >>

Unfallchirurg (Der Unfallchirurg)
[2021, 124(6):489-504]

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Molecular enhancement of fracture healing - Is there a role for Bone Morphogenetic Protein-2, parathyroid hormone, statins, or sclerostin-antibodies?

Leopold Henssler, Maximilian Kerschbaum, Moldakulov Z Mukashevich, Markus Rupp, Volker Alt,

Enhancement of fracture healing has been a hot topic over the last two decades. This narrative review article is aimed to provide an update on current clinical use and evidence on four clinically available agents in the treatment of fracture healing: bone morphogenetic proteins-2 (BMP-2), parathyroid hormone, statins and sclerostin-antibodies. ... Read more >>

Injury (Injury)
[2021, 52 Suppl 2:S49-S57]

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The epidemiology of fracture-related infections in Germany.

Nike Walter, Markus Rupp, Siegmund Lang, Volker Alt,

The epidemiology of fracture-related infection (FRI) is unknown, which makes it difficult to estimate future demands and evaluate progress in infection prevention. Therefore, we aimed to determine the nationwide burden's development over the last decade as a function of age group and gender. FRI prevalence as a function of age ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):10443]

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Long-term patient-related quality of life after successfully treated aseptic non-unions of the long bones.

Nike Walter, Maximilian Kerschbaum, Christian Pfeifer, Daniel Popp, Viola Freigang, Thilo Hinterberger, Volker Alt, Markus Rupp,

<h4>Background</h4>Non-union after fracture depicts a devastating complication in trauma surgery and studies assessing patient-reported outcome measures after stable bone consolidation are rare. Therefore, we aimed to evaluate the long-term impact of aseptic long bone non-union on the patients' physical health state and psychological wellbeing. For this purpose, quality of life ... Read more >>

Injury (Injury)
[2021, 52(7):1880-1885]

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[Comparison of DRG revenues between fast and slow-track procedures for a two-stage replacement of prostheses for periprosthetic hip infections in the aG-DRG system 2020].

Katja Hierl, Markus Rupp, Michael Worlicek, Florian Baumann, Christian Pfeifer, Volker Alt,

<h4>Background</h4>The treatment of periprosthetic hip infections is usually cost intensive, so it is generally not cost effective for hospitals. In chronic infections, a two-stage procedure is often indicated, which can be done as a fast-track procedure with a short prosthetic-free interim interval (2-4 weeks) or as a slow-track procedure with a long prosthetic-free interim interval (over ... Read more >>

Orthopade (Der Orthopade)
[2021, 50(9):728-741]

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Treatment of severely open tibial fractures, non-unions, and fracture-related infections with a gentamicin-coated tibial nail-clinical outcomes including quality of life analysis and psychological ICD-10-based symptom rating.

Nike Walter, Daniel Popp, Viola Freigang, Michael Nerlich, Volker Alt, Markus Rupp,

<h4>Background</h4>Implant-associated infections depict a major challenge in orthopedics and trauma surgery putting a high burden on the patients and health care systems, strongly requiring improvement of infection prevention and of clinical outcomes. One strategy includes the usage of antimicrobial-coated implants. We evaluated outcomes after surgical treatment using a gentamicin-coated nail on ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2021, 16(1):270]

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Awareness of predatory journals and open access publishing among orthopaedic and trauma surgeons - results from an online survey in Germany.

Elke Maurer, Nike Walter, Tina Histing, Lydia Anastasopoulou, Thaqif El Khassawna, Lisa Wenzel, Volker Alt, Markus Rupp,

<h4>Background</h4>Along with emerging open access journals (OAJ) predatory journals increasingly appear. As they harm accurate and good scientific research, we aimed to examine the awareness of predatory journals and open access publishing among orthopaedic and trauma surgeons.<h4>Methods</h4>In an online survey between August and December 2019 the knowledge on predatory journals ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2021, 22(1):365]

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Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model.

Markus Rupp, Christoph Biehl, Deeksha Malhan, Fathi Hassan, Sameh Attia, Sebastian Rosch, Annemarie B Schäfer, Erin McMahon, Marian Kampschulte, Christian Heiss, Thaqif El Khassawna,

Osteoporosis is a common metabolic disorder diagnosed by lower bone density and higher risk of fracture. Fragility fractures because of osteoporosis are associated with high mortality rate. Deep understanding of fracture healing in osteoporosis is important for successful treatment. Therefore, the FDA approved the use of small and large animal ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(3):]

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Surgical treatment outcome after serial debridement of infected nonunion-A retrospective cohort study.

Markus Rupp, Stefanie Kern, Nike Walter, Lydia Anastasopoulou, Reinhard Schnettler, Christian Heiss, Volker Alt,

<h4>Purpose</h4>Reported outcome after multiple staged surgical treatment of infected nonunion is scarce. We, therefore, asked: (1) What is the clinical outcome in infected nonunion patients after multiple staged revision surgery? (2) Are different pathogens evidenced after surgical treatment in patients who have undergone more or less surgeries?<h4>Methods</h4>All enrolled patients were ... Read more >>

Eur J Orthop Surg Traumatol (European journal of orthopaedic surgery & traumatology : orthopedie traumatologie)
[2021, :]

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Post-operative septic arthritis after arthroscopy: modern diagnostic and therapeutic concepts.

Andreas Voss, Christian G Pfeifer, Maximilian Kerschbaum, Markus Rupp, Peter Angele, Volker Alt,

<h4>Purpose</h4>Septic arthritis is a significant complication following arthroscopic surgery, with an estimated overall incidence of less than 1%. Despite the low incidence, an appropriate diagnostic and therapeutic pathway is required to avoid serious long-term consequences, eradicate the infection, and ensure good treatment outcomes. The aim of this current review article ... Read more >>

Knee Surg Sports Traumatol Arthrosc (Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA)
[2021, :]

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[Prosthetic infections and the increasing importance of psychological comorbidities : An epidemiological analysis for Germany from 2009 through 2019].

Nike Walter, Markus Rupp, Thilo Hinterberger, Volker Alt,

<h4>Background</h4>Periprosthetic joint infection (PJI) is a devastating complication in orthopedics and trauma surgery. A potential increase in PJI diagnoses, especially in combination with psychological comorbidities may become a significant challenge for healthcare stakeholders. So far, the prevalence for Germany is unknown, which makes it difficult to estimate future treatment demand or to predict ... Read more >>

Orthopade (Der Orthopade)
[2021, :]

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A retrospective analysis of trends in primary knee arthroplasty in Germany from 2008 to 2018.

Michael Worlicek, Matthias Koch, Popp Daniel, Viola Freigang, Peter Angele, Volker Alt, Maximilian Kerschbaum, Markus Rupp,

Unicompartimental and total knee arthroplasty is one of the most successful and most performed operations worldwide. In the last years the number of primary knee arthroplasty increased constantly. The aim of this study is to analyze the rising numbers of primary knee arthroplasty and to see how it is used ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):5225]

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