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Author Markus Reindl

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Diagnostic features of initial demyelinating events associated with serum MOG-IgG.

Riccardo Orlandi, Sara Mariotto, Sergio Ferrari, Francesca Gobbin, Elia Sechi, Ruggero Capra, Chiara Rosa Mancinelli, Roberto Bombardi, Luigi Zuliani, Marco Zoccarato, Francesca Rossi, Valentina Camera, Diana Ferraro, Maria Donata Benedetti, Markus Reindl, Alberto Gajofatto,

BACKGROUND:Myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorders are increasingly recognized as a distinct disease entity. However, diagnostic sensitivity and specificity of serum MOG-IgG as well as recommendations for testing are still debated. MATERIALS AND METHODS:Between October 2015 and July 2017 we tested serum MOG-IgG in 91 adult patients (49 females) with ... Read more >>

J. Neuroimmunol. (Journal of neuroimmunology)
[2020, 344:577260]

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Clinical and imaging features of children with autoimmune encephalitis and MOG antibodies.

Andreas Wegener-Panzer, Robert Cleaveland, Eva-Maria Wendel, Matthias Baumann, Annikki Bertolini, Martin Häusler, Ellen Knierim, Edith Reiter-Fink, Markus Breu, Özcan Sönmez, Adela Della Marina, Renate Peters, Christian Lechner, Martin Piepkorn, Claudia Roll, Romana Höftberger, Frank Leypoldt, Markus Reindl, Kevin Rostásy,

OBJECTIVE:To describe the presentations, radiologic features, and outcomes of children with autoimmune encephalitis associated with myelin oligodendrocyte glycoprotein antibodies (MOG abs). METHODS:Identification of children fulfilling the diagnostic criteria for possible autoimmune encephalitis (AE) and testing positive for serum MOG abs. Chart review and comprehensive analysis of serum MOG abs using ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(4):]

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High association of MOG-IgG antibodies in children with bilateral optic neuritis.

Eva-Maria Wendel, Matthias Baumann, Nina Barisic, Astrid Blaschek, Eliana Coelho de Oliveira Koch, Adela Della Marina, Katharina Diepold, Annette Hackenberg, Andreas Hahn, Thekla von Kalle, Michael Karenfort, Barbara Kornek, Christian Lechner, Steffen Leiz, Andreas Merkenschlager, Margherita Nosadini, Stefano Sartori, Kathrin Schanda, Mareike Schimmel, Larissa Seemann, Victoria Tüngler, Stephan Waltz, Andreas Wegener-Panzer, Gert Wiegand, Markus Reindl, Kevin Rostásy,

BACKGROUND:Bilateral optic neuritis (bilON) is a rare clinical presentation often thought to be associated with relapsing disorders such as neuromyelitis optica spectrum disorders (NMOSD) or multiple sclerosis (MS). OBJECTIVE:To characterize the clinical, radiological phenotype and antibody status of children presenting with bilON. MATERIAL AND METHODS:Retrospective multicenter study on children with ... Read more >>

Eur. J. Paediatr. Neurol. (European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society)
[2020, :]

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International multicenter examination of MOG antibody assays.

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan, Jessica Sagen, James P Fryer, John Mills, Bianca Teegen, Swantje Mindorf, Nora Ritter, Ulrike Krummrei, Winfried Stöcker, Juliane Eggert, Eoin P Flanagan, Melanie Ramberger, Harald Hegen, Kevin Rostasy, Thomas Berger, Maria Isabel Leite, Jacqueline Palace, Sarosh R Irani, Russell C Dale, Christian Probst, Monika Probst, Fabienne Brilot, Sean J Pittock, Patrick Waters,

OBJECTIVE:To compare the reproducibility of 11 antibody assays for immunoglobulin (Ig) G and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG and MOG-IgM) from 5 international centers. METHODS:The following samples were analyzed: MOG-IgG clearly positive sera (n = 39), MOG-IgG low positive sera (n = 39), borderline negative sera (n = 13), ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(2):]

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High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy.

Antonio Heras-Garvin, Violetta Refolo, Markus Reindl, Gregor K Wenning, Nadia Stefanova,

AIM:Pre-clinical studies in models of multiple sclerosis and other inflammatory disorders suggest that high-salt diet may induce activation of the immune system and potentiate inflammation. However, high-salt diet constitutes a common non-pharmacological intervention to treat autonomic problems in synucleinopathies such as Parkinson's disease and multiple system atrophy. Since neuroinflammation plays ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2020, 17(1):35]

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An international multicenter examination of MOG antibody assays

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan, Jessica Sagen, Jim Fryer, John Mills, Bianca Tegen, Swantje Mindorf, Nora Ritter, Ulrike Krummrei, Winfried Stocker, Juliane Eggert, Eoin Flanagan, Melanie Ramberger, Harald Hegen, Kevin Rostasy, Thomas Berger, Isabel Leite, Jacqueline Palace, Sarosh Irani, Russell Dale, Christian Probst, Monika Probst, Fabienne Brilot, Sean Pittock, Patrick Waters,

Objectives: To compare the reproducibility of 11 antibody assays for IgG and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG, MOG-IgM) from five international centers. Methods: The following samples were analyzed: MOG-IgG clearly positive sera (n=39), MOG-IgG low positive sera (n=39), borderline negative sera (n=13), clearly negative sera (n=40), and healthy ... Read more >>

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Relevance of antibodies to myelin oligodendrocyte glycoprotein in CSF of seronegative cases.

Sara Mariotto, Alberto Gajofatto, Lucia Batzu, Rachele Delogu, GianPietro Sechi, Stefania Leoni, Maria Immacolata Pirastru, Bruno Bonetti, Mattia Zanoni, Daniela Alberti, Kathrin Schanda, Salvatore Monaco, Markus Reindl, Sergio Ferrari,

OBJECTIVE:To determine the diagnostic relevance of myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) in CSF of seronegative cases by retrospectively analyzing consecutive time-matched CSF of 80 MOG-Ab-seronegative patients with demyelinating disease. METHODS:The cohort included 44 patients with NMOSD and related disorders and 36 patients with multiple sclerosis (MS). Two independent neurologists blinded ... Read more >>

Neurology (Neurology)
[2019, 93(20):e1867-e1872]

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Transient MOG antibody seroconversion associated with immunomodulating therapy.

Marc Pawlitzki, Christin Campe, Leoni Rolfes, Hans-Jochen Heinze, Frank Leypoldt, Klaus-Peter Wandinger, Markus Reindl, Brigitte Wildemann, Sven Jarius, Peter Körtvelyessy,

Immunoglobulin G (IgG) autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG) have recently been associated with autoimmune CNS demyelination. We present the case of a 35-year-old patient who was seronegative for MOG-IgG (as confirmed by means of three independent immunoassays) during two corticosteroid-responsive attacks of brainstem encephalitis and optic neuritis, respectively, but ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 37:101420]

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Clinical Features and Outcomes of Pediatric Monophasic and Recurrent Idiopathic Optic Neuritis.

Soren Jonzzon, Leena Suleiman, Andrew Yousef, Brenda Young, Janace Hart, Patrick Peschl, Markus Reindl, Kristin L Schaller, Jeffrey L Bennett, Emmanuelle Waubant, Jennifer S Graves,

Limited data exist on isolated optic neuritis in children. We report the clinical features and treatment of pediatric subjects with monophasic and recurrent idiopathic optic neuritis. This retrospective cohort study of patients with isolated optic neuritis identified 10 monophasic and 7 recurrent optic neuritis cases. Monophasic optic neuritis patients were ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, 35(1):77-83]

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Anti-thyroid autoantibodies as biomarkers for alemtuzumab associated thyroid autoimmunity.

Markus Reindl,

EBioMedicine (EBioMedicine)
[2019, 47:22-23]

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German translation, cultural adaption and validation of the unidimensional self-efficacy scale for multiple sclerosis: a study protocol.

Barbara Seebacher, Roger J Mills, Markus Reindl, Laura Zamarian, Raija Kuisma, Simone Kircher, Christian Brenneis, Rainer Ehling, Florian Deisenhammer,

INTRODUCTION:Self-efficacy refers to individuals' confidence in their ability to perform relevant tasks to accomplish desired goals. This is independent of their actual abilities. In people with multiple sclerosis (MS), self-efficacy has been shown to powerfully influence motivation and health-related behaviour, such as adherence to prescribed treatment or physical activity. So ... Read more >>

BMJ Open (BMJ open)
[2019, 9(8):e029565]

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Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study.

Frederike C Oertel, Olivier Outteryck, Benjamin Knier, Hanna Zimmermann, Nadja Borisow, Judith Bellmann-Strobl, Astrid Blaschek, Sven Jarius, Markus Reindl, Klemens Ruprecht, Edgar Meinl, Reinhard Hohlfeld, Friedemann Paul, Alexander U Brandt, Tania Kümpfel, Joachim Havla,

BACKGROUND:Serum antibodies against myelin-oligodendrocyte-glycoprotein (MOG-IgG) are detectable in a proportion of patients with acute or relapsing neuroinflammation. It is unclear, if neuro-axonal damage occurs only in an attack-dependent manner or also progressively. Therefore, this study aimed to investigate longitudinally intra-retinal layer changes in eyes without new optic neuritis (ON) in ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2019, 16(1):154]

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Neurofilament light chain serum levels reflect disease severity in MOG-Ab associated disorders.

Sara Mariotto, Sergio Ferrari, Matteo Gastaldi, Diego Franciotta, Elia Sechi, Ruggero Capra, Chiara Mancinelli, Kathrin Schanda, Daniela Alberti, Riccardo Orlandi, Roberto Bombardi, Luigi Zuliani, Marco Zoccarato, Maria Donata Benedetti, Raffaella Tanel, Francesca Calabria, Francesca Rossi, Antonino Pavone, Luisa Grazian, GianPietro Sechi, Lucia Batzu, Noemi Murdeu, Francesco Janes, Vincenza Fetoni, Daniela Fulitano, Gianola Stenta, Lisa Federle, Gaetano Cantalupo, Markus Reindl, Salvatore Monaco, Alberto Gajofatto,

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2019, 90(11):1293-1296]

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Distinct serum and cerebrospinal fluid cytokine and chemokine profiles in autoantibody-associated demyelinating diseases.

Livia S Hofer, Sara Mariotto, Sebastian Wurth, Sergio Ferrari, Chiara R Mancinelli, Rachele Delogu, Salvatore Monaco, Alberto Gajofatto, Carmen Schwaiger, Kevin Rostasy, Florian Deisenhammer, Romana Höftberger, Thomas Berger, Markus Reindl,

Background:Demyelinating diseases of the central nervous system associated with autoantibodies against aquaporin-4 and myelin-oligodendrocyte-glycoprotein are mediated by different immunopathological mechanisms compared to multiple sclerosis. Objective:The purpose of this study was to evaluate serum and cerebrospinal fluid cytokine/chemokine profiles in patients with autoantibodies against aquaporin-4 or autoantibodies against myelin-oligodendrocyte-glycoprotein-associated demyelination compared ... Read more >>

Mult Scler J Exp Transl Clin (Multiple sclerosis journal - experimental, translational and clinical)
[2019, 5(2):2055217319848463]

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Tocilizumab treatment in severe recurrent anti-MOG-associated optic neuritis.

Helen Hayward-Koennecke, Markus Reindl, Roland Martin, Sven Schippling,

Neurology (Neurology)
[2019, 92(16):765-767]

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Unfavorable Structural and Functional Outcomes in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis.

Ilijas Jelcic, James V M Hanson, Sebastian Lukas, Konrad P Weber, Klara Landau, Misha Pless, Markus Reindl, Michael Weller, Roland Martin, Andreas Lutterotti, Sven Schippling,

BACKGROUND:Recurrent optic neuritis (rON) associated with myelin oligodendrocyte glycoprotein (MOG)-specific antibodies has been initially reported to show a better clinical outcome than aquaporin-4 (AQP4)-seropositive ON in neuromyelitis optica spectrum disorder (NMOSD). Here, we characterize clinical and neuroimaging findings in severe cases of MOG antibody-positive and AQP4 antibody-negative bilateral rON. METHODS:Three ... Read more >>

J Neuroophthalmol (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society)
[2019, 39(1):3-7]

Cited: 1 time

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Myelin oligodendrocyte glycoprotein antibodies in neurological disease.

Markus Reindl, Patrick Waters,

Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies (MOG-Abs) were first detected by immunoblot and enzyme-linked immunosorbent assay nearly 30 years ago, but their association with multiple sclerosis (MS) was not specific. Use of cell-based assays with native MOG as the substrate enabled identification of a group of MOG-Ab-positive patients with demyelinating phenotypes. ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2019, 15(2):89-102]

Cited: 10 times

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Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat.

Sophie Hillebrand, Kathrin Schanda, Magdalini Nigritinou, Irina Tsymala, Denise Böhm, Patrick Peschl, Yoshiki Takai, Kazuo Fujihara, Ichiro Nakashima, Tatsuro Misu, Markus Reindl, Hans Lassmann, Monika Bradl,

It is well established that the binding of pathogenic aquaporin-4 (AQP4)-specific autoantibodies to astrocytes may initiate a cascade of events culminating in the destruction of these cells and in the formation of large tissue-destructive lesions typical for patients with neuromyelitis optica spectrum disorders (NMOSD). To date, not a single experimental ... Read more >>

Acta Neuropathol. (Acta neuropathologica)
[2019, 137(3):467-485]

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Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient.

Seyed Hamidreza Mohseni, Hanne Pernille Bro Skejoe, Jens Wuerfel, Friedemann Paul, Markus Reindl, Sven Jarius, Nasrin Asgari,

Background:Recently, pathogenic serum immunoglobulin G (IgG) autoantibodies to myelin oligodendrocyte glycoprotein (MOG) have been detected in a subgroup of patients with central nervous system (CNS) demyelination, including in patients with myelitis. Relatively little is known so far about leptomeningeal involvement in MOG-IgG-positive myelitis. Findings:We report the case of a 30-year-old ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2018, 2018:1365175]

Cited: 1 time

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New clinical implications of anti-myelin oligodendrocyte glycoprotein antibodies in children with CNS demyelinating diseases.

Franziska Di Pauli, Markus Reindl, Thomas Berger,

Acquired demyelinating CNS syndromes include a broad spectrum of clinical phenotypes and different entities can overlap. Therefore, differential diagnosis is still challenging. A humoral immune reaction against myelin oligodendrocyte glycoprotein (MOG) is present in a subgroup of these patients, particularly in children. Anti-MOG antibodies indicate a non-multiple sclerosis disease course. ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2018, 22:35-37]

Cited: 3 times

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MRI of the first event in pediatric acquired demyelinating syndromes with antibodies to myelin oligodendrocyte glycoprotein.

Matthias Baumann, Astrid Grams, Tanja Djurdjevic, Eva-Maria Wendel, Christian Lechner, Bettina Behring, Astrid Blaschek, Katharina Diepold, Astrid Eisenkölbl, Joel Fluss, Michael Karenfort, Johannes Koch, Bahadir Konuşkan, Steffen Leiz, Andreas Merkenschlager, Daniela Pohl, Mareike Schimmel, Charlotte Thiels, Barbara Kornek, Kathrin Schanda, Markus Reindl, Kevin Rostásy,

Antibodies against the myelin oligodendrocyte glycoprotein (MOG-Ab) can be detected in various pediatric acquired demyelinating syndromes (ADS). Here, we analyze the spectrum of neuroradiologic findings in children with MOG-Ab and a first demyelinating event. The cerebral and spinal MRI of 69 children with different ADS was assessed in regard to ... Read more >>

J. Neurol. (Journal of neurology)
[2018, 265(4):845-855]

Cited: 8 times

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Change of olfactory function as a marker of inflammatory activity and disability progression in MS.

Gabriel Bsteh, Harald Hegen, Felix Ladstätter, Klaus Berek, Matthias Amprosi, Sebastian Wurth, Michael Auer, Franziska Di Pauli, Florian Deisenhammer, Markus Reindl, Thomas Berger, Andreas Lutterotti,

BACKGROUND:Impaired olfactory threshold has been reported in early inflammatory phases of MS, while impaired odor identification was associated with more widespread disability. OBJECTIVE:To prospectively assess the development of olfactory function and its correlation with relapse and disability progression. METHODS:In this prospective, 3-year longitudinal study on 151 MS patients and 30 ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, 25(2):267-274]

Cited: 2 times

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Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination.

Patrick Peschl, Kathrin Schanda, Bleranda Zeka, Katherine Given, Denise Böhm, Klemens Ruprecht, Albert Saiz, Andreas Lutterotti, Kevin Rostásy, Romana Höftberger, Thomas Berger, Wendy Macklin, Hans Lassmann, Monika Bradl, Jeffrey L Bennett, Markus Reindl,

Antibodies to the myelin oligodendrocyte glycoprotein (MOG) are associated with a subset of inflammatory demyelinating diseases of the central nervous system such as acute disseminated encephalomyelitis and neuromyelitis optica spectrum disorders. However, whether human MOG antibodies are pathogenic or an epiphenomenon is still not completely clear. Although MOG is highly ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2017, 14(1):208]

Cited: 20 times

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Clinical course of MOG antibody-associated recurrent demyelinating diseases.

Markus Reindl,

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2018, 89(2):118]

Cited: 3 times

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MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome.

Sara Mariotto, Salvatore Monaco, Patrick Peschl, Ilaria Coledan, Romualdo Mazzi, Romana Höftberger, Markus Reindl, Sergio Ferrari,

The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults the core clinical feature is usually characterised by acute myelitis and/or optic neuritis. We here report an atypical case with serum and cerebrospinal ... Read more >>

BMC Neurol (BMC neurology)
[2017, 17(1):190]

Cited: 1 time

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