Full Text Journal Articles by
Author Markus Hufnagel

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Prevalence of Capsular Serotype, Pilus Island Distribution, and Antibiotic Resistance in Pediatric and Adult Invasive Group B Streptococcus Isolates: Data From a Nationwide Prospective Surveillance Study in Germany.

Florens Lohrmann, Angela Berg, Esther Wicker, Anita Imm, Gérard Krause, Katharina Zürn, Reinhard Berner, Markus Hufnagel, Fabian Lander,

For neonates, group B Streptococcus is life threatening. Current prevention strategies remain insufficient, especially for cases of late-onset sepsis, where intrapartum antibiotic prophylaxis has demonstrated no benefit. One promising approach is the vaccination of pregnant women, which offers protective immunity via transplacental transmission of neutralizing antibodies. Our nationwide, prospective surveillance ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):76-82]

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SARS-CoV-2 testing and infection control strategies in European paediatric emergency departments during the first wave of the pandemic.

Malte Kohns Vasconcelos, Hanna Renk, Jolanta Popielska, Maggie Nyirenda Nyang'wa, Sigita Burokiene, Despoina Gkentzi, Ewelina Gowin, Daniele Donà, Sara Villanueva-Medina, Andrew Riordan, Markus Hufnagel, Sarah Eisen, Liviana Da Dalt, Carlo Giaquinto, Julia A Bielicki,

Between February and May 2020, during the first wave of the COVID-19 pandemic, paediatric emergency departments in 12 European countries were prospectively surveyed on their implementation of SARS-CoV-2 disease (COVID-19) testing and infection control strategies. All participating departments (23) implemented standardised case definitions, testing guidelines, early triage and infection control ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2020, :]

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Anakinra And Etanercept Combination Treatment in a Child With Severe, Nonresponsive Kawasaki Disease.

Matthias Walser, Matthias Hermann, Markus Hufnagel, Nikolaus A Haas, Marcus Fischer, Robert Dalla-Pozza, André Jakob,

Kawasaki disease (KD) patients' resistance to treatment with intravenous immunoglobulins (IVIG) places them at high risk for an unfavorable progression of the disease. In these patients, there has been little evidence that alternative treatments are effective. Nevertheless, biologicals such as an interleukin-1-receptor blocker and tumor-necrosis-factor-α inhibitors increasingly have been used. ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, 39(10):e310-e313]

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Long-term surveillance of biologic therapies in systemic-onset juvenile idiopathic arthritis: data from the German BIKER registry.

Ariane Klein, Jens Klotsche, Boris Hügle, Kirsten Minden, Anton Hospach, Frank Weller-Heinemann, Tobias Schwarz, Frank Dressler, Ralf Trauzeddel, Markus Hufnagel, Ivan Foeldvari, Michael Borte, Jasmin Kuemmerle-Deschner, Jürgen Brunner, Prasad Thomas Oommen, Dirk Föll, Klaus Tenbrock, Andreas Urban, Gerd Horneff,

<h4>Objective</h4>Using data from the German Biologics JIA Registry (BIKER), long-term safety of biologics for systemic-onset JIA with regard to adverse events of special interest was assessed.<h4>Methods</h4>Safety assessments were based on adverse event reports after first dose through 90 days after last dose. Rates of adverse event, serious adverse event and 25 ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(9):2287-2298]

Cited: 1 time

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Management of Care for Neonates Born to SARS-CoV-2 Positive Women with or without Clinical Symptoms (COVID-19).

Arne Simon, Johannes Hübner, Markus Knuf, Markus Hufnagel, Reinhard Berner,

Klin Padiatr (Klinische Padiatrie)
[2020, 232(4):173-177]

Cited: 0 times

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Hospital Admission in Children and Adolescents With COVID-19.

Jakob Peter Armann, Natalie Diffloth, Arne Simon, Maren Doenhardt, Markus Hufnagel, Andreas Trotter, Dominik Schneider, Johannes Hübner, Reinhard Berner,

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2020, 117(21):373-374]

Cited: 5 times

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Microarray Analysis of Group B Streptococci Causing Invasive Neonatal Early- and Late-onset Infection.

Katharina Zürn, Fabian Lander, Markus Hufnagel, Stefan Monecke, Reinhard Berner,

BACKGROUND:Group B Streptococcus is the leading cause of meningitis and sepsis in newborns. Until now, there is no data of fast and simple typing of group B Streptococcus virulence factors using a genetic microarray and comparing these data to clinical manifestations. METHODS:A prospective active surveillance study was conducted via 2 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, 39(5):449-453]

Cited: 1 time

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Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children.

Martin Kuntz, Daniela S Kohlfürst, Cornelia Feiterna-Sperling, Renate Krüger, Ulrich Baumann, Laura Buchtala, Roland Elling, Veit Grote, Johannes Hübner, Markus Hufnagel, Petra Kaiser-Labusch, Johannes Liese, Eva-Maria Otto, Markus A Rose, Christian Schneider, Volker Schuster, Maximilian Seidl, Olaf Sommerburg, Markus Vogel, Horst von Bernuth, Michael Weiß, Theodor Zimmermann, Alexandra Nieters, Werner Zenz, Philipp Henneke, ,

Nontuberculous mycobacteria (NTM) are an emerging cause of infections, including chronic lymphadenitis in children. To identify risk factors for NTM lymphadenitis, particularly complicated disease, we collected epidemiologic, clinical, and microbiological data on 138 cases of NTM lymphadenitis in children across 13 centers in Germany and Austria. We assessed lifestyle factors ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2020, 26(3):579-586]

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Long-term, single-center surveillance of non-invasive group A streptococcal (GAS) infections, emm types and emm clusters.

Peter Konrad, Markus Hufnagel, Reinhard Berner, Nicole Toepfner,

Group A streptococci (GAS) are among the most frequent pathogens in children. Many epidemiological studies focus on specific GAS infections (such as tonsillopharyngitis or invasive disease), on GAS carriers or on post-streptococcal sequelae. By comparison, reports on regional GAS characteristics, particularly circulating non-invasive GAS in Europe, are rare. In a ... Read more >>

Eur J Clin Microbiol Infect Dis (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2020, 39(2):273-280]

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Intravenous Artesunate for Imported Severe Malaria in Children Treated in Four Tertiary Care Centers in Germany: A Retrospective Study.

Sabine Bélard, Judith Brand, Ulf Schulze-Sturm, Ales Janda, Ulrich von Both, Costanza Tacoli, Martin Alberer, Caroline Kempf, Miriam S Stegemann, Renate Krüger, Verena Varnholt, Martin Blohm, Karl Reiter, Thomas Zoller, Norbert Suttorp, Marcus Mall, Horst von Bernuth, Alexander Gratopp, Johannes Hübner, Markus Hufnagel, Robin Kobbe, Florian Kurth,

BACKGROUND:Intravenous artesunate (ivA) is the standard treatment for severe malaria. Data systematically evaluating the use of ivA in pediatric patients outside malaria-endemic regions are limited. The aim of this case series was to summarize efficacy and safety of ivA for imported severe malaria in children in Germany. METHODS:Our retrospective case ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(11):e295-e300]

Cited: 0 times

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Epidemiology of Human Parechovirus Type 3 Upsurge in 2 Hospitals, Freiburg, Germany, 2018.

Roland Elling, Sindy Böttcher, Florian du Bois, Alexandra Müller, Christiane Prifert, Benedikt Weissbrich, Jörg Hofmann, Klaus Korn, Anna-Maria Eis-Hübinger, Markus Hufnagel, Marcus Panning,

In 2018, a cluster of pediatric human parechovirus (HPeV) infections in 2 neighboring German hospitals was detected. Viral protein 1 sequence analysis demonstrated co-circulation of different HPeV-3 sublineages and of HPeV-1 and -5 strains, thereby excluding a nosocomial outbreak. Our findings underline the need for HPeV diagnostics and sequence analysis ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2019, 25(7):1384-1388]

Cited: 1 time

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American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus.

Hermine I Brunner, Michael J Holland, Michael W Beresford, Stacy P Ardoin, Simone Appenzeller, Clovis A Silva, Francisco Flores, Beatrice Goilav, Pinar Ozge Avar Aydin, Scott E Wenderfer, Deborah M Levy, Angelo Ravelli, Raju Khubchandani, Tadej Avcin, Marisa S Klein-Gitelman, Nicolino Ruperto, Brian M Feldman, Jun Ying, ,

OBJECTIVE:To develop a Childhood Lupus Improvement Index (CHILI) as a tool to measure response to therapy in childhood-onset systemic lupus erythematosus (cSLE), with a focus on clinically relevant improvement (CRIc SLE ). METHODS:Pediatric nephrology and rheumatology subspecialists (n = 213) experienced in cSLE management were invited to define CRIc SLE ... Read more >>

Arthritis Care Res (Hoboken) (Arthritis care & research)
[2019, 71(5):579-590]

Cited: 0 times

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Group B Streptococci: Declining Incidence in Infants in Germany.

Esther Wicker, Fabian Lander, Felix Weidemann, Markus Hufnagel, Reinhard Berner, Gérard Krause,

Group B streptococcus (GBS) is a leading cause of morbidity and mortality in newborns worldwide. From 2000 to 2008, national guidelines in Germany recommended intrapartum antibiotic prophylaxis for pregnant women displaying risk factors (eg, perinatal anogenital GBS colonization, rupture of the membranes ≥18 hours before birth) for the vertical transmission ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(5):516-519]

Cited: 1 time

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High Rates of Prescribing Antimicrobials for Prophylaxis in Children and Neonates: Results From the Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey.

Markus Hufnagel, Ann Versporten, Julia Bielicki, Nico Drapier, Mike Sharland, Herman Goossens, ,

BACKGROUND:This study was conducted to assess the variation in prescription practices for systemic antimicrobial agents used for prophylaxis among pediatric patients hospitalized in 41 countries worldwide. METHODS:Using the standardized Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey protocol, a cross-sectional point-prevalence survey was conducted at 226 pediatric hospitals ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2019, 8(2):143-151]

Cited: 2 times

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Failure to Predict High-risk Kawasaki Disease Patients in a Population-based Study Cohort in Germany.

André Jakob, Rudiger von Kries, Judith Horstmann, Markus Hufnagel, Brigitte Stiller, Reinhard Berner, Eva Schachinger, Karoline Meyer, Viola Obermeier,

BACKGROUND:Diverse scores on high-risk Kawasaki disease (KD) patients have proven a good prognostic validity in the Japanese population. However, data on non-Japanese have been inconclusive. Do the Kobayashi, Egami and Sano scores or application of up-to-date statistical methods (Random Forest) predict response to standard intravenous immunoglobulin (IVIG) therapy and the ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2018, 37(9):850-855]

Cited: 5 times

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Cystic Encephalomalacia following Vasculopathy and Vasospasm of Proximal Intracranial Arteries Due to Pneumococcal Meningitis in a Infant.

Alexander Pschibul, Wibke G Janzarik, Peter Franck, Markus Hufnagel, Christopher Beck, Rudolf Korinthenberg,

Despite the availability of modern antibiotics, pneumococcal meningitis in both children and adults remains a severe disease-one known to frequently cause grave complications and residual disability. Although the appearance of arterial vasospasms in bacterial meningitis systematically has been investigated and reported on for adult patients, such research is lacking when ... Read more >>

Neuropediatrics (Neuropediatrics)
[2018, 49(3):213-216]

Cited: 1 time

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[Recommendations for Diagnostics and Therapy of Children with Cancer Presenting with Fever and Neutropenia - Comparison of Two Current Guidelines].

Thomas Lehrnbecher, Andreas Groll, Philipp Agyeman, Roland A Ammann, Andishe Attarbaschi, Uta Behrends, Christoph Berger, Axel Hamprecht, Markus Hufnagel, Hans-Jürgen Laws, Max Scheler, Christian Temme, Simon Vieth, Arne Simon,

Immunocompromised children and adolescents receiving treatment for cancer have a considerably increased risk for infection. Neutropenia is the most important single risk factor for infectious complications, and fever in neutropenia is considered as an emergency. Whereas guidelines for the management of fever in neutropenic adults have been established for decades, ... Read more >>

Klin Padiatr (Klinische Padiatrie)
[2018, 230(3):115-121]

Cited: 2 times

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Rational Diagnostics and Therapies in Child Refugees.

Johannes Pfeil, Markus Hufnagel,

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2018, 37(3):272-274]

Cited: 1 time

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Practice and consensus-based strategies in diagnosing and managing systemic juvenile idiopathic arthritis in Germany.

Claas H Hinze, Dirk Holzinger, Elke Lainka, Johannes-Peter Haas, Fabian Speth, Tilmann Kallinich, Nikolaus Rieber, Markus Hufnagel, Annette F Jansson, Christian Hedrich, Hanna Winowski, Thomas Berger, Ivan Foeldvari, Gerd Ganser, Anton Hospach, Hans-Iko Huppertz, Kirsten Mönkemöller, Ulrich Neudorf, Elisabeth Weißbarth-Riedel, Helmut Wittkowski, Gerd Horneff, Dirk Foell, ,

Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease associated with chronic arthritis. Early diagnosis and effective therapy of SJIA is desirable, so that complications are avoided. The PRO-KIND initiative of the German Society for Pediatric Rheumatology (GKJR) aims to define consensus-based strategies to harmonize diagnostic and therapeutic approaches in ... Read more >>

Pediatr Rheumatol Online J (Pediatric rheumatology online journal)
[2018, 16(1):7]

Cited: 10 times

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An international SUrvey on non-iNvaSive tecHniques to assess the mIcrocirculation in patients with RayNaud's phEnomenon (SUNSHINE survey).

Francesca Ingegnoli, Nicola Ughi, Graham Dinsdale, Annalisa Orenti, Patrizia Boracchi, Yannick Allanore, Ivan Foeldvari, Alberto Sulli, Maurizio Cutolo, Vanessa Smith, Ariane L Herrick, ,

To canvas opinion concerning the role of non-invasive techniques in the assessment of patients with Raynaud's phenomenon (Rp) in clinical and research settings: four nailfold capillaroscopy methods [videocapillaroscopy (NVC), dermoscopy, stereomicroscopy, digital USB microscopy], four laser Doppler methods (laser Doppler flowmetry, imaging, anemometry/velocimetry, laser speckle contrast analysis), thermographic imaging, and ... Read more >>

Rheumatol Int (Rheumatology international)
[2017, 37(11):1879-1890]

Cited: 3 times

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Diffuse Unilateral Subacute Neuroretinitis Caused by Ancylostoma Hookworm.

Sven Poppert, Martin Heideking, Hansjürgen Agostini, Moritz Fritzenwanker, Nicole Wüppenhorst, Birgit Muntau, Philipp Henneke, Winfried Kern, Jürgen Krücken, Bernd Junker, Markus Hufnagel,

Diffuse unilateral subacute neuroretinitis is an ocular infectious disease caused by several distinct nematodes. Definite identification of the involved nematodes is rarely achieved. We report on the molecular-based genetic identification of an Ancylostoma ceylanicum hookworm implicated in a case of diffuse unilateral subacute neuroretinitis in a child. ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2017, 23(2):343-344]

Cited: 4 times

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Outcome and Trends in Treatment of Systemic Juvenile Idiopathic Arthritis in the German National Pediatric Rheumatologic Database, 2000-2013.

Jens Klotsche, Anna Raab, Martina Niewerth, Claudia Sengler, Gerd Ganser, Tilmann Kallinich, Tim Niehues, Markus Hufnagel, Angelika Thon, Toni Hospach, Gerd Horneff, Kirsten Minden,

<h4>Objective</h4>To investigate the clinical presentation and medical treatment of patients with systemic juvenile idiopathic arthritis (JIA) during the first year of illness. Our study focused on 3-year outcomes in a subsample of patients who were followed up longitudinally.<h4>Methods</h4>From 2000 to 2013, 597 patients with systemic JIA and a disease duration ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2016, 68(12):3023-3034]

Cited: 11 times

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Importance of Local Epidemiology in Prevalence and Resistance of Cystic Fibrosis-related Pathogens.

Markus Hufnagel, Stefanie König, Christian Theilacker,

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2016, 35(2):229]

Cited: 0 times

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Kawasaki Disease in Germany: A Prospective, Population-based Study Adjusted for Underreporting.

André Jakob, Jane Whelan, Matthaeus Kordecki, Reinhard Berner, Brigitte Stiller, Raoul Arnold, Rudiger von Kries, Elena Neumann, Nicholas Roubinis, Mirna Robert, Jochen Grohmann, René Höhn, Markus Hufnagel,

<h4>Background</h4>National estimates of Kawasaki disease (KD) incidence often do not include incomplete cases (diagnosed based on only laboratory or echocardiographic criteria), and/or they rely on retrospective case reports and data registries where underreporting is known to be a problem.<h4>Methods</h4>We conducted a prospective nationwide KD surveillance study in children younger than ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2016, 35(2):129-134]

Cited: 17 times

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The Worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) point prevalence survey: developing hospital-quality indicators of antibiotic prescribing for children.

Ann Versporten, Julia Bielicki, Nico Drapier, Mike Sharland, Herman Goossens, ,

<h4>Objectives</h4>Previously, web-based tools for cross-sectional antimicrobial point prevalence surveys (PPSs) have been used in adults to develop indicators of quality improvement. We aimed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children worldwide.<h4>Methods</h4>A standardized antimicrobial PPS method was employed. ... Read more >>

J Antimicrob Chemother (The Journal of antimicrobial chemotherapy)
[2016, 71(4):1106-1117]

Cited: 61 times

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