Full Text Journal Articles by
Author Mark Zimmerman

Advertisement

Find full text journal articles






Is There a Bias in the Diagnosis of Borderline Personality Disorder Among Lesbian, Gay, and Bisexual Patients?

Craig Rodriguez-Seijas, Theresa A Morgan, Mark Zimmerman,

High prevalence of borderline personality disorder (BPD) diagnosis is observed among sexual minority samples. It is unclear if sexual minority individuals are systematically diagnosed with BPD at higher rates than heterosexual individuals, and if potential diagnostic disparity can be explained by differences in maladaptive personality domains. Utilizing data from partial ... Read more >>

Assessment (Assessment)
[2020, :1073191120961833]

Cited: 0 times

View full text PDF listing >>



What Is the General Factor of Psychopathology? Consistency of the p Factor Across Samples.

Holly F Levin-Aspenson, David Watson, Lee Anna Clark, Mark Zimmerman,

Bifactor analyses have become a popular way to model a general psychopathology factor (or p factor) that accounts for correlations among higher order internalizing, externalizing, and thought-disorder dimensions. However, to advance dimensional nosology and construct validation of the p factor, this body of research needs to be synthesized. This study ... Read more >>

Assessment (Assessment)
[2020, :1073191120954921]

Cited: 0 times

View full text PDF listing >>



Advertisement

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types.

Felix Oppel, Dong H Ki, Mark W Zimmerman, Kenneth N Ross, Ting Tao, Hui Shi, Shuning He, Jon C Aster, A Thomas Look,

Polycomb repressive complex 2 (PRC2) is an epigenetic regulator of gene expression that possesses histone methyltransferase activity. PRC2 trimethylates lysine 27 of histone H3 proteins (H3K27me3) as a chromatin modification associated with repressed transcription of genes frequently involved in cell proliferation or self-renewal. Loss-of-function mutations in the PRC2 core subunit ... Read more >>

Dis Model Mech (Disease models & mechanisms)
[2020, 13(8):]

Cited: 0 times

View full text PDF listing >>



Retinoic acid rewires the adrenergic core regulatory circuitry of neuroblastoma but can be subverted by enhancer hijacking of MYC or MYCN

Mark Zimmerman, Adam Durbin, Shuning He, Felix Oppel, Hui Shi, Ting Tao, Zhaodong Li, Alla Berezovskaya, Yu Liu, Jinghui Zhang, Richard Young, Brian Abraham, Thomas Look,

ABSTRACT Neuroblastoma cell identity depends on a core regulatory circuit (CRC) of transcription factors that collaborate with MYCN to drive the oncogenic gene expression program. For neuroblastomas dependent on the adrenergic CRC, treatment with retinoids can inhibit cell growth and induce differentiation in both primary neuroblastomas and cell lines; however, ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Re-examining borderline personality disorder and substance use disorder: The role of emotion dysregulation

Miranda Bethanie Snow, Caroline Balling, Mark Zimmerman,

BACKGROUND:Borderline personality disorder (BPD) and substance use disorder (SUD) frequently co-occur. Although some research has investigated the factors related to this comorbidity, few have isolated the effects of SUD on a BPD diagnosis. METHODS:Patients presenting for treatment were assessed with the Structured Clinical Interview for DSM-IV, the BPD module of ... Read more >>

Ann Clin Psychiatry (Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists)
[2020, 32(3):170-175]

Cited: 0 times

View full text PDF listing >>



Impact of anxiety on dropping out of treatment for major depressive disorderat an intensive partial hospitalization program.

Justine S Thompson, Reina Kiefer, Joseph M Diehl, Mark Zimmerman,

BACKGROUND:Premature treatment discontinuation (dropout) is a common problem among patients seeking treatment for major depressive disorder (MDD). To prevent treatment dropout, it is important to identify its associated risk factors. The impact anxiety has on treatment dropout for MDD is especially critical to investigate due to the high rates of ... Read more >>

Ann Clin Psychiatry (Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists)
[2020, 32(3):e1-e7]

Cited: 0 times

View full text PDF listing >>



DSM-5 anxious distress specifier in patients with bipolar depression.

Mark Zimmerman, Sophie Kerr, Caroline Balling, Reina Kiefer, Kristy Dalrymple,

BACKGROUND:DSM-5 introduced the anxious distress specifier in recognition of the significance of anxiety in patients who are depressed. Studies have supported the validity of the specifier in patients with major depressive disorder (MDD). In this report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project, we ... Read more >>

Ann Clin Psychiatry (Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists)
[2020, 32(3):157-163]

Cited: 0 times

View full text PDF listing >>



ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression.

Hui Shi, Ting Tao, Brian J Abraham, Adam D Durbin, Mark W Zimmerman, Cigall Kadoch, A Thomas Look,

Mutations in genes encoding SWI/SNF chromatin remodeling complexes are found in approximately 20% of all human cancers, with ARID1A being the most frequently mutated subunit. Here, we show that disruption of ARID1A homologs in a zebrafish model accelerates the onset and increases the penetrance of MYCN-driven neuroblastoma by increasing cell ... Read more >>

Sci Adv (Science advances)
[2020, 6(29):eaaz3440]

Cited: 0 times

View full text PDF listing >>



LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.

Ting Tao, Hui Shi, Luca Mariani, Brian J Abraham, Adam D Durbin, Mark W Zimmerman, John T Powers, Pavlos Missios, Kenneth N Ross, Antonio R Perez-Atayde, Martha L Bulyk, Richard A Young, George Q Daley, A Thomas Look,

LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis, at least, in part, through inhibition of let-7 microRNA biogenesis. Here, we report that overexpression of either wild-type (WT) LIN28B or a LIN28B mutant that is unable to inhibit let-7 processing increases the penetrance of MYCN-induced neuroblastoma, potentiates the invasion and ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(28):16516-16526]

Cited: 0 times

View full text PDF listing >>



Emotion regulation accounts for associations between mindfulness and depression across and within diagnostic categories.

Joseph M Diehl, Patrick T McGonigal, Theresa A Morgan, Kristy Dalrymple, Lauren M Harris, Iwona Chelminski, Mark Zimmerman,

BACKGROUND:Previous research shows that mindfulness and emotion regulation (ER) are highly related to each other. Preliminary evidence in small clinical populations show that ER may partially account for the relationship between mindfulness and depressive symptoms. The present study aimed to investigate which diagnostic categories were associated with depressive symptoms after ... Read more >>

Ann Clin Psychiatry (Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists)
[2020, 32(2):97-106]

Cited: 0 times

View full text PDF listing >>



Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.

Ken Morita, Shuning He, Radosław P Nowak, Jinhua Wang, Mark W Zimmerman, Cong Fu, Adam D Durbin, Megan W Martel, Nicole Prutsch, Nathanael S Gray, Eric S Fischer, A Thomas Look,

Protein phosphatase 2A (PP2A) enzymes can suppress tumors, but they are often inactivated in human cancers overexpressing inhibitory proteins. Here, we identify a class of small-molecule iHAPs (improved heterocyclic activators of PP2A) that kill leukemia cells by allosterically assembling a specific heterotrimeric PP2A holoenzyme consisting of PPP2R1A (scaffold), PPP2R5E (B56ε, ... Read more >>

Cell (Cell)
[2020, 181(3):702-715.e20]

Cited: 0 times

View full text PDF listing >>



Principal Diagnoses in Psychiatric Outpatients With Posttraumatic Stress Disorder: Implications for Screening Recommendations.

Reina Kiefer, Iwona Chelminski, Kristy Dalrymple, Mark Zimmerman,

In this study, we examined the prevalence of posttraumatic stress disorder (PTSD) in 3800 psychiatric outpatients with different principal diagnoses. For all disorders identified as a principal diagnosis, we compared patients' odds ratios of PTSD to all other patients in the sample. Approximately one-sixth of the sample (n = 663, ... Read more >>

J. Nerv. Ment. Dis. (The Journal of nervous and mental disease)
[2020, 208(4):283-287]

Cited: 0 times

View full text PDF listing >>



Patients with borderline personality disorder and bipolar disorder: a descriptive and comparative study.

Mark Zimmerman, Caroline Balling, Iwona Chelminski, Kristy Dalrymple,

BACKGROUND:Bipolar disorder and borderline personality disorder (BPD) are each significant public health problems. It has been frequently noted that distinguishing BPD from bipolar disorder is challenging. Consequently, reviews and commentaries have focused on differential diagnosis and identifying clinical features to distinguish the two disorders. While there is a burgeoning literature ... Read more >>

Psychol Med (Psychological medicine)
[2020, :1-12]

Cited: 0 times

View full text PDF listing >>



Is the DSM-5 Anxious Distress Specifier Interview a valid measure of anxiety in patients with generalized anxiety disorder: A comparison to the Hamilton Anxiety Scale.

Mark Zimmerman, Justine S Thompson, Joseph M Diehl, Caroline Balling, Reina Kiefer,

DSM-5 includes criteria for an anxious distress specifier for major depressive disorder, and measures have been developed to assess these criteria. The validity of measures of the severity of anxious distress has been established in depressed patients. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, 286:112859]

Cited: 0 times

View full text PDF listing >>



Is the DSM-5 anxious distress specifier sufficient for measuring anxiety in depressed patients? Implications for measurement-based care.

Mark Zimmerman, Sophie Kerr, Caroline Balling, Reina Kiefer, Kristy Dalrymple,

BACKGROUND:We examined whether a self-report measure of the DSM-5 anxious distress specifier, the Clinically Useful Depression Outcome Scale Anxious Distress Specifier Subscale (CUDOS-A), was as valid as a broader measure of the severity of anxiety, the Clinically Useful Anxiety Outcome Scale (CUXOS), in patients with depression. METHODS:Two hundred ninety-four patients ... Read more >>

Ann Clin Psychiatry (Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists)
[2020, 32(1):5-11]

Cited: 0 times

View full text PDF listing >>



A comparison of the dimensionality of the Hamilton Rating Scale for anxiety and the DSM-5 Anxious-Distress Specifier Interview.

Craig Rodriguez-Seijas, Justine S Thompson, Joseph M Diehl, Mark Zimmerman,

The Hamilton Rating Scale for Anxiety (HAM-A) is one of the most widely used measures for assessing anxiety in research settings. However, it has been criticized for its inclusion of items that assess depressive symptoms. The DSM-5 Anxious Distress Specifier Interview (DADSI), developed as one assessment tool for measuring anxiety ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, 284:112788]

Cited: 0 times

View full text PDF listing >>



Screening for Borderline Personality Disorder With the McLean Screening Instrument: A Review and Critique of the Literature.

Mark Zimmerman, Caroline Balling,

Borderline personality disorder (BPD) is underdiagnosed in clinical practice. One approach towards improving diagnostic detection is the use of screening questionnaires. It is important for a screening test to have high sensitivity because the more time-intensive/expensive follow-up diagnostic inquiry will presumably only occur in patients who are positive on the ... Read more >>

J. Pers. Disord. (Journal of personality disorders)
[2019, :1-11]

Cited: 2 times

View full text PDF listing >>



Associations between maladaptive personality domains and premature termination in an acute clinical setting.

Craig Rodriguez-Seijas, Theresa A Morgan, Mark Zimmerman,

Maladaptive personality has been positioned as one overarching framework with the potential to streamline conceptualization of both personality- and nonpersonality-related psychopathology. However, few studies have examined maladaptive personality in relation to (a) clinical outcomes in a naturalistic setting and (b) using measures short enough to be incorporated into standard clinical ... Read more >>

Personal Disord (Personality disorders)
[2020, 11(5):339-347]

Cited: 0 times

View full text PDF listing >>



ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry.

Lu Wang, Tze King Tan, Adam D Durbin, Mark W Zimmerman, Brian J Abraham, Shi Hao Tan, Phuong Cao Thi Ngoc, Nina Weichert-Leahey, Koshi Akahane, Lee N Lawton, Jo Lynne Rokita, John M Maris, Richard A Young, A Thomas Look, Takaomi Sanda,

A heritable polymorphism within regulatory sequences of the LMO1 gene is associated with its elevated expression and increased susceptibility to develop neuroblastoma, but the oncogenic pathways downstream of the LMO1 transcriptional co-regulatory protein are unknown. Our ChIP-seq and RNA-seq analyses reveal that a key gene directly regulated by LMO1 and ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):5622]

Cited: 0 times

View full text PDF listing >>



Understanding the severity of depression: do nondepressive symptoms influence global ratings of depression severity?

Mark Zimmerman, Caroline Balling, Iwona Chelminski, Kristy Dalrymple,

OBJECTIVE.:Almost all depression measures have been developed without discussing how to best conceptualize and assess the severity of depression. It is therefore not surprising that measures differ in both how items are rated and item content. The question that we address in the present report from the Rhode Island Methods ... Read more >>

CNS Spectr (CNS spectrums)
[2020, 25(4):557-560]

Cited: 0 times

View full text PDF listing >>



Using the 9-Item Patient Health Questionnaire to Screen for and Monitor Depression.

Mark Zimmerman,

JAMA (JAMA)
[2019, :]

Cited: 0 times

View full text PDF listing >>



Stability and consistency of maladaptive personality domains across multiple admissions to an acute care setting.

Craig Rodriguez-Seijas, Theresa A Morgan, Mark Zimmerman,

Personality has recently been positioned as one overarching framework for conceptualizing psychopathology. Further, the DSM-5 put forth an alternative dimensional model of personality pathology which includes measurement of maladaptive personality domains. Few studies have examined the stability of maladaptive personality scores, and even fewer have done so using clinical samples ... Read more >>

Psychol Assess (Psychological assessment)
[2020, 32(2):123-131]

Cited: 0 times

View full text PDF listing >>



Applying the inclusion/exclusion criteria in placebo-controlled studies to a clinical sample: A comparison of medications.

Mark Zimmerman, Caroline Balling, Iwona Chelminski, Kristy Dalrymple,

BACKGROUND:We previously compared the inclusion/exclusion criteria in the studies of vortioxetine to other antidepressants and found that they were significantly more restrictive in the vortioxetine studies. In the present study, we tested the hypothesis that the differences in psychiatric inclusion/exclusion criteria used in the studies of some antidepressants resulted in ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 260:483-488]

Cited: 0 times

View full text PDF listing >>



How should the severity of depression be rated on self-report depression scales?

Mark Zimmerman, Sophie Kerr,

Almost all depression measures have been developed without discussing how to best conceptualize and assess the severity of depression. The most valid rating format of depression severity scales is unsettled and has been little studied. In the present study from the Rhode Island Methods to Improve Diagnostic Assessment and Services ... Read more >>

Psychiatry Res (Psychiatry research)
[2019, 280:112512]

Cited: 2 times

View full text PDF listing >>



The Firearm Safety Among Children and Teens (FACTS) Consortium: defining the current state of the science on pediatric firearm injury prevention.

Rebecca M Cunningham, Patrick M Carter, Mark Zimmerman,

Five teams of FACTS researchers conducted a series of rigorous scoping reviews of the existing published scientific literature from the fields of medicine, public health, psychology, behavioral health, and criminology from January of 1985 through April of 2018 utilizing the Preferred Reporting Items for Scoping Reviews (Tricco et al., Ann ... Read more >>

J Behav Med (Journal of behavioral medicine)
[2019, 42(4):702-705]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
0.9099 s