Full Text Journal Articles by
Author Mark K Greenwald

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Incoming medical students' knowledge of and attitudes toward people with substance use disorders: Implications for curricular training.

Tabitha E Moses, May Chammaa, Rafael Ramos, Eva Waineo, Mark K Greenwald,

BACKGROUND:Medical students may be in an ideal position to identify patients with substance use disorders (SUDs) and provide them with information about harm reduction and treatment options. Specific education regarding opioid use disorder (OUD) and naloxone during undergraduate medical training may help students identify these patients and decrease their own ... Read more >>

Subst Abus (Substance abuse)
[2020, :1-7]

Cited: 0 times

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US national treatment admissions with opioids and benzodiazepines.

Cynthia L Arfken, Darlene D Owens, Mark K Greenwald,

INTRODUCTION AND AIMS:Opioids and benzodiazepines (O/BZD) are increasingly involved in drug overdose deaths in the USA. Expanding treatment capacity may reduce these deaths. Knowledge about co-occurring O/BZD admissions compared to opioid admissions (opioid) is needed to plan this expansion. DESIGN AND METHODS:US treatment admissions to specialty facilities for 2011-2017 were ... Read more >>

Drug Alcohol Rev (Drug and alcohol review)
[2020, 39(7):862-869]

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N-acetylcysteine reduces cocaine-seeking behavior and anterior cingulate glutamate/glutamine levels among cocaine-dependent individuals.

Eric A Woodcock, Leslie H Lundahl, Dalal Khatib, Jeffrey A Stanley, Mark K Greenwald,

N-acetylcysteine (NAC) is a cystine prodrug shown to reduce cocaine- and cue-primed reinstatement of cocaine-seeking behavior in preclinical studies. In this inpatient study, the effects of NAC maintenance versus placebo on cocaine-seeking behavior were examined during cocaine-primed and unprimed self-administration sessions among non-treatment-seeking, cocaine-dependent individuals. Twelve participants completed this double-blind, ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12900]

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A Comparison of Substance Use Patterns Among Lifetime Heroin-Injecting Individuals By Racial Groups.

Tabitha E H Moses, Jamey J Lister, Mark K Greenwald,

Background:Studies have identified differential substance use patterns by racial groups. One of the most commonly reported differences is a higher rate of injection drug use (IDU) among Non-Hispanic Whites compared to African Americans, but this is complicated by factors related to IDU (e.g., earlier drug-use initiation) that overlap with being ... Read more >>

Addict Res Theory (Addiction research & theory)
[2020, 28(3):260-268]

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A neurobiological correlate of stress-induced nicotine-seeking behavior among cigarette smokers.

Eric A Woodcock, Jeffrey A Stanley, Vaibhav A Diwadkar, Dalal Khatib, Mark K Greenwald,

Stress is known to influence smoking relapse. Experimental studies indicate that acute stress increases nicotine-seeking behavior, yet neurobiological mechanisms remain poorly understood. Herein, we investigated disrupted excitatory neural activity in the dorsolateral prefrontal cortex (dlPFC) as a mechanism of stress-induced nicotine-seeking behavior. Non-treatment-seeking cigarette smokers were screened for psychiatric, medical, ... Read more >>

Addict Biol (Addiction biology)
[2020, 25(4):e12819]

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Rapid induction onto sublingual buprenorphine after opioid overdose and successful linkage to treatment for opioid use disorder.

Andrew A Herring, Cody W Schultz, Elaine Yang, Mark K Greenwald,

Am J Emerg Med (The American journal of emergency medicine)
[2019, 37(12):2259-2262]

Cited: 0 times

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Heroin delay discounting and impulsivity: Modulation by DRD1 genetic variation.

Tabitha E H Moses, Margit Burmeister, Mark K Greenwald,

BACKGROUND:Dopamine D1 receptors (encoded by DRD1) are implicated in drug addiction and high-risk behaviors. Delay discounting (DD) procedures measure decisional balance between choosing smaller/sooner rewards vs larger/later rewards. Individuals with higher DD (rapid discounting) are prone to maladaptive behaviors that provide immediate reinforcement (eg, substance use). DRD1 variants have been ... Read more >>

Addict Biol (Addiction biology)
[2020, 25(3):e12777]

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History of regular nonmedical sedative and/or alcohol use differentiates substance-use patterns and consequences among chronic heroin users.

Tabitha E H Moses, Mark K Greenwald,

BACKGROUND:Concurrent use of sedating substances (e.g. alcohol or benzodiazepines) with opioids is associated with increased negative consequences of opioid use; however, few studies have attempted to differentiate effects of using sedating substances on heroin-use outcomes. This study examines differences between heroin users who use alcohol or misuse sedatives regularly and ... Read more >>

Addict Behav (Addictive behaviors)
[2019, 97:14-19]

Cited: 2 times

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Gender-specific predictors of methadone treatment outcomes among African Americans at an urban clinic.

Jamey J Lister, Suzanne Brown, Mark K Greenwald, David M Ledgerwood,

Background: African American patients with opioid use disorder (OUD) have demonstrated poorer methadone maintenance treatment (MMT) outcomes compared with white patients. This issue is further complicated in urban settings, where African Americans experience high rates of poverty and publicly funded treatment. Despite interrelated factors that disadvantage African Americans, the literature ... Read more >>

Subst Abus (Substance abuse)
[2019, 40(2):185-193]

Cited: 1 time

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Efficacy and safety of a monthly buprenorphine depot injection for opioid use disorder: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.

Barbara R Haight, Susan M Learned, Celine M Laffont, Paul J Fudala, Yue Zhao, Amanda S Garofalo, Mark K Greenwald, Vijay R Nadipelli, Walter Ling, Christian Heidbreder, ,

BACKGROUND:RBP-6000, referred to as BUP-XR (extended-release buprenorphine), is a subcutaneously injected, monthly buprenorphine treatment for opioid use disorder. BUP-XR provides sustained buprenorphine plasma concentrations to block drug-liking of abused opioids over the entire monthly dosing period, while controlling withdrawal and craving symptoms. Administration of BUP-XR in a health-care setting also ... Read more >>

Lancet (Lancet (London, England))
[2019, 393(10173):778-790]

Cited: 11 times

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Risk of incident claims for chemotherapy-induced peripheral neuropathy among women with breast cancer in a Medicare population.

Mark K Greenwald, Julie J Ruterbusch, Jennifer L Beebe-Dimmer, Michael S Simon, Terrance L Albrecht, Ann G Schwartz,

BACKGROUND:Chemotherapy-induced peripheral neuropathy (CIPN) is a common and disabling consequence of neurotoxic therapies, yet factors that modulate the development and clinical impact of CIPN are poorly understood. This epidemiological analysis identifies risk factors for the incidence of CIPN. METHODS:This retrospective analysis of Surveillance, Epidemiology, and End Results-Medicare data examined predictors ... Read more >>

Cancer (Cancer)
[2019, 125(2):269-277]

Cited: 1 time

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Injection opioid use as a predictor of treatment outcomes among methadone-maintained opioid-dependent patients.

David M Ledgerwood, Jamey J Lister, Benjamin LaLiberte, Leslie H Lundahl, Mark K Greenwald,

BACKGROUND:Injection opioid use is associated with more severe health and psychosocial consequences relative to non-injection use, but few studies have examined whether injection use is associated with methadone maintenance treatment outcomes. The present study examined differential MMT outcomes among opioid injectors and non-injectors. METHODS:Data were extracted from the clinic charts ... Read more >>

Addict Behav (Addictive behaviors)
[2019, 90:191-195]

Cited: 2 times

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Pharmacological stress impairs working memory performance and attenuates dorsolateral prefrontal cortex glutamate modulation.

Eric A Woodcock, Mark K Greenwald, Dalal Khatib, Vaibhav A Diwadkar, Jeffrey A Stanley,

Working memory processes are associated with the dorsolateral prefrontal cortex (dlPFC). Prior research using proton functional magnetic resonance spectroscopy (1H fMRS) observed significant dlPFC glutamate modulation during letter 2-back performance, indicative of working memory-driven increase in excitatory neural activity. Acute stress has been shown to impair working memory performance. Herein, ... Read more >>

Neuroimage (NeuroImage)
[2019, 186:437-445]

Cited: 1 time

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Anti-stress neuropharmacological mechanisms and targets for addiction treatment: A translational framework.

Mark K Greenwald,

Stress-related substance use is a major challenge for treating substance use disorders. This selective review focuses on emerging pharmacotherapies with potential for reducing stress-potentiated seeking and consumption of nicotine, alcohol, marijuana, cocaine, and opioids (i.e., key phenotypes for the most commonly abused substances). I evaluate neuropharmacological mechanisms in experimental models ... Read more >>

Neurobiol Stress (Neurobiology of stress)
[2018, 9:84-104]

Cited: 5 times

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Factors associated with sedative use and misuse among heroin users.

Tabitha E H Moses, Leslie H Lundahl, Mark K Greenwald,

BACKGROUND:Rates of both opioid and sedative use and misuse are rising. Comorbid opioid and sedative use is associated with especially severe consequences (e.g., overdose and poor health outcomes). Heroin users report multiple motivations for sedative use, including self-medication. We aimed to understand differences in lifetime substance use characteristics between heroin ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2018, 185:10-16]

Cited: 3 times

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Mediational Pathways Among Trait Impulsivity, Heroin-use Consequences, and Current Mood State.

Holly H Reid, Leslie H Lundahl, Jamey J Lister, Eric A Woodcock, Mark K Greenwald,

Background:This study examined whether lifetime heroin-use consequences mediate the relationship between trait impulsivity and three current mood outcomes: depression symptoms, stress levels, and perception of life events. Method:Regular heroin users (N = 163) were assessed using the Barratt Impulsiveness Scale (BIS-11) to measure trait impulsivity; a standardized Drug History and ... Read more >>

Addict Res Theory (Addiction research & theory)
[2018, 26(5):421-429]

Cited: 0 times

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Developing a scale of domains of negative consequences of chronic heroin use.

Tabitha E H Moses, Eric A Woodcock, Jamey J Lister, Leslie H Lundahl, Mark K Greenwald,

BACKGROUND:Chronic use of heroin typically leads to numerous negative life consequences and serious clinical impairment. Increased negative consequences can result in poor treatment outcomes as well as adverse health effects and impaired social functioning. Certain risk factors, including early substance use initiation, concurrent use of other illicit substances, and injection ... Read more >>

Addict Behav (Addictive behaviors)
[2018, 77:260-266]

Cited: 3 times

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Baseline risk factors for drug use among African-American patients during first-month induction/stabilization on methadone.

Jamey J Lister, Mark K Greenwald, David M Ledgerwood,

Drug use during methadone induction/stabilization negatively influences later methadone-maintenance-treatment [MMT] outcomes (retention, abstinence). Our study examined the association of baseline risk factors to drug use during the first month of methadone treatment as well as longer-term treatment retention. We conducted these analyses among a race/ethnic minority group at high risk ... Read more >>

J Subst Abuse Treat (Journal of substance abuse treatment)
[2017, 78:15-21]

Cited: 4 times

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Characterizing fentanyl use in methadone-maintained clients.

Cynthia L Arfken, Jessica Suchanek, Mark K Greenwald,

Deaths attributed to fentanyl have increased in the United States. However, little is known about fentanyl use among substance abuse treatment clients. To fill this gap, we assessed prevalence of fentanyl exposure, characteristics of clients testing positive for fentanyl, other substances detected concurrently or simultaneously with fentanyl, and clients' perception ... Read more >>

J Subst Abuse Treat (Journal of substance abuse treatment)
[2017, 75:17-21]

Cited: 6 times

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Magnitude and duration of cue-induced craving for marijuana in volunteers with cannabis use disorder.

Leslie H Lundahl, Mark K Greenwald,

AIMS:Evaluate magnitude and duration of subjective and physiologic responses to neutral and marijuana (MJ)-related cues in cannabis dependent volunteers. METHODS:33 volunteers (17 male) who met DSM-IV criteria for Cannabis Abuse or Dependence were exposed to neutral (first) then MJ-related visual, auditory, olfactory and tactile cues. Mood, drug craving and physiology ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2016, 166:143-149]

Cited: 3 times

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A pilot randomized clinical trial of an intervention to reduce overdose risk behaviors among emergency department patients at risk for prescription opioid overdose.

Amy S B Bohnert, Erin E Bonar, Rebecca Cunningham, Mark K Greenwald, Laura Thomas, Stephen Chermack, Frederic C Blow, Maureen Walton,

BACKGROUND AND AIMS:Prescription opioid overdose is a significant public health problem. Interventions to prevent overdose risk behaviors among high-risk patients are lacking. This study examined the impact of a motivational intervention to reduce opioid misuse and overdose risk behaviors. METHODS:This study was a pilot randomized controlled trial set in a ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2016, 163:40-47]

Cited: 25 times

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Behavioral Economic Factors Related to Pediatric Obesity.

Angela J Jacques-Tiura, Mark K Greenwald,

Behavioral economics (BE) suggests that food and activity choices are governed by costs, available alternatives, and reinforcement. This article reviews basic, translational, and intervention research using a BE framework with overweight or obese children up to age 18. We address BE concepts and methods, and discuss developmental issues, the continuum ... Read more >>

Pediatr Clin North Am (Pediatric clinics of North America)
[2016, 63(3):425-446]

Cited: 4 times

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Sustained-Release Buprenorphine (RBP-6000) Blocks the Effects of Opioid Challenge With Hydromorphone in Subjects With Opioid Use Disorder.

Azmi F Nasser, Mark K Greenwald, Bradley Vince, Paul J Fudala, Philip Twumasi-Ankrah, Yongzhen Liu, J P Jones, Christian Heidbreder,

A major goal for the treatment of opioid use disorder is to reduce or eliminate the use of illicit opioids. Buprenorphine, a μ-opioid receptor partial agonist and kappa opioid receptor antagonist, is now being developed as a monthly, sustained-release formulation (RBP-6000). The objective of this study was to demonstrate that ... Read more >>

J Clin Psychopharmacol (Journal of clinical psychopharmacology)
[2016, 36(1):18-26]

Cited: 13 times

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Methadone maintenance dose modulates anterior cingulate glutamate levels in heroin-dependent individuals: A preliminary in vivo (1)H MRS study.

Mark K Greenwald, Eric A Woodcock, Dalal Khatib, Jeffrey A Stanley,

Mu-opioid receptor agonists alter brain glutamate (GLU) levels in laboratory animals. This clinical study used proton magnetic resonance spectroscopy ((1)H MRS) to examine regional brain GLU levels during experimental manipulation of methadone (MTD) maintenance dose under double-blind, within-subject conditions in seven heroin-dependent volunteers. Subjects were scanned first at a high ... Read more >>

Psychiatry Res (Psychiatry research)
[2015, 233(2):218-224]

Cited: 6 times

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Heroin delay discounting: Modulation by pharmacological state, drug-use impulsivity, and intelligence.

Jonathan J K Stoltman, Eric A Woodcock, Jamey J Lister, Leslie H Lundahl, Mark K Greenwald,

Delay discounting (DD) refers to how rapidly an individual devalues goods based on delays to receipt. DD usually is considered a trait variable but can be state dependent, yet few studies have assessed commodity valuation at short, naturalistically relevant time intervals that might enable state-dependent analysis. This study aimed to ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2015, 23(6):455-463]

Cited: 2 times

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